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Medicinal composition for preventing helicobacter pylori

A technology of plants and extracts, applied in the field of medicine, can solve problems such as the destruction of bacteria in the digestive tract and indigestion

Inactive Publication Date: 2008-07-02
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology helps improve how well people work by providing benefits that make them better at doing their job more efficiently or with less effort than traditional methods like manual laboring.

Problems solved by technology

This patented technical issue addressed by this patents relates to identifying effective treatments against heliovirus infections such as gastroenteritis caused by Helicobapprovae or MALT lymophytes associated with inflammatory bowel disease.

Method used

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  • Medicinal composition for preventing helicobacter pylori
  • Medicinal composition for preventing helicobacter pylori
  • Medicinal composition for preventing helicobacter pylori

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Take 100 g of Geranium dahuricum (Geranium dahuricum), crush it, add 8 times the amount of 40% ethanol, and reflux three times for 2 hours each time. Filter off the medicinal residues and combine the extracts for 3 times, concentrate to 1 / 6 volume, until there is no alcohol smell, add water to dilute to twice the volume of medicinal materials, filter, apply HPD100 macroporous resin to the filtrate, water, 10%, 50%, 90% alcohol Eluted separately, verified by ultraviolet absorption, collected and combined 10%, 50%, and 90% alcohol eluents, and concentrated to dryness to obtain 2.13 g of solid matter, which was the extract. Wherein compound 1,2,3,6-tetra-O-galloyl-β-D-glucose (1,2,3,6-Tetra-O-galloyl-β-D-glucose) accounts for 2.2% of the total mass of the extract %.

Embodiment 2

[0035] Take 1 kg of Geranium caroliniznum, crush it, add 8 times the amount of 60% ethanol and extract it by cold soaking at room temperature for three times, soaking for 24 hours each time. Filter off the medicinal residues and combine the extracts for 3 times, concentrate to 1 / 7 volume, evaporate the alcohol, apply HPD100 macroporous resin, elute with water, 30%, 50%, and 90% alcohol respectively, and collect and combine 30% after verification by ultraviolet absorption. %, 50%, 90% eluate, concentrated to dryness to obtain 22.7 g of solid matter, which is the extract. Wherein compound 1,2,3,6-tetra-O-galloyl-β-D-glucose (1,2,3,6-Tetra-O-galloyl-β-D-glucose) accounts for 4.6% of the total mass of the extract %.

Embodiment 3

[0037]Take 200 g of Qingdao geranium (Geranium tsingtauense), crush it, add 8 times the amount of 80% ethanol to reflux and extract three times, each time for 2 hours. Filter off the medicinal residues and combine the extracts for 3 times, concentrate to 1 / 6 volume, until there is no alcohol smell, add water to dilute to twice the volume of medicinal materials, filter, apply HPD100 macroporous resin to the filtrate, water, 20%, 50%, 70% alcohol Eluted separately, verified by ultraviolet absorption, collected 20%, 50%, and 70% alcohol eluents, concentrated to dryness to obtain 4.18 g of solid matter as the present extract. Wherein compound 1,2,3,6-tetra-O-galloyl-β-D-glucose (1,2,3,6-Tetra-O-galloyl-β-D-glucose) accounts for 11.4% of the total mass of the extract %.

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Abstract

The invention provides an extract which is extracted from geraniaceae plants, an extraction method of the extract, an application of the extract in the prepration of anti-helicobacter pylori infection drugs and the drugs for the treatment or prevention of gastrointestinal diseases which are caused by helicobacter pylori infection, and an application of the composition in the preparation of drugs for the treatment of hepatitis.

Description

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Claims

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Application Information

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Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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