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Method for preparing pterocarpus indicus ethanol extract used for endothelium-dependent vasodilation agent and applications of method

A technique for relaxing agents and blood vessels, which is used in the application field of medicines or health care products

Inactive Publication Date: 2013-04-24
北京富华安德生物医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0015] But at this stage, the ethanol extract of sandalwood pterostilbene is used as a vasodilator to treat hypertension or a health product, and there is no report yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1: Concentration is 0.0025g / ml Pterocarpus ethanol extract endothelium-dependent inhibition of the vasoconstriction of phenylephrine

[0024] experiment method:

[0025] The mouse thoracic aorta ring has been used in the present experiment. The preparation was oxidized with saline solution, and then mixed with the following composition: ① sodium chloride (119); ② potassium chloride (4.7); ③ potassium dihydrogen phosphate (1.2); ④ magnesium sulfate (1.2); Sodium hydrogen (25); ⑥ calcium chloride (1.6); ⑦ glucose (11), keep the temperature at 4 degrees Celsius. Prepare two arterial rings (each 4 mm long) and remove the endothelium by gently rubbing the inner surface with a smooth wooden stick. Successful endothelium removal can be confirmed by meeting the aortic ring with phenylephrine (1 μM) lack of a relaxing response to acetylcholine. Isovolumetric stretches of the aortic annulus were recorded using a computerized myograph system. After equilibration with a...

Embodiment 2

[0029] Example 2: Concentration is 0.004g / ml Pterostilbene ethanol extract endothelium-dependent inhibition of the vasoconstriction of phenylephrine

[0030] experiment method:

[0031] The mouse thoracic aorta ring has been used in the present experiment. The preparation was oxidized with saline solution, and then mixed with the following composition: ① sodium chloride (119); ② potassium chloride (4.7); ③ potassium dihydrogen phosphate (1.2); ④ magnesium sulfate (1.2); Sodium hydrogen (25); ⑥ calcium chloride (1.6); ⑦ glucose (11), keep the temperature at 4 degrees Celsius. Prepare two arterial rings (each 4 mm long) and remove the endothelium by gently rubbing the inner surface with a smooth wooden stick. Successful endothelium removal can be confirmed by meeting the aortic ring with phenylephrine (1 μM) lack of a relaxing response to acetylcholine. Isovolumetric stretches of the aortic annulus were recorded using a computerized myograph system. After equilibration with ...

Embodiment 3

[0035] Example 3: Concentration is 0.006g / ml Pterocarpus ethanol extract endothelium-dependent inhibition of the vasoconstriction of phenylephrine

[0036] experiment method:

[0037] The mouse thoracic aorta ring has been used in the present experiment. The preparation was oxidized with saline solution, and then mixed with the following composition: ① sodium chloride (119); ② potassium chloride (4.7); ③ potassium dihydrogen phosphate (1.2); ④ magnesium sulfate (1.2); Sodium hydrogen (25); ⑥ calcium chloride (1.6); ⑦ glucose (11), keep the temperature at 4 degrees Celsius. Prepare two arterial rings (each 4 mm long) and remove the endothelium by gently rubbing the inner surface with a smooth wooden stick. Successful endothelium removal can be confirmed by meeting the aortic ring with phenylephrine (1 μM) lack of a relaxing response to acetylcholine. Isovolumetric stretches of the aortic annulus were recorded using a computerized myograph system. After equilibration with at...

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Abstract

The invention relates to a method for preparing pterocarpus santalinus ethanol extract used for endothelium-dependent vasodilator and applications of the extract on the medicine or health products of endothelium-independent vasodilator. The preparation method comprises the steps of extracting the pterocarpus santalinus powders thrice in a back-flow way by 70% of ethanol of 6 times, 5 times and 3 times respectively for 2.5h, 2h and 1.5h, decompressing, concentrating, cooling and drying the extract, and finally obtaining the pterocarpus santalinus extract. Suitable auxiliary material is added into the pterocarpus santalinus extract so as to prepare the medicines or health products such as powder injection, drops, troche, capsule, oral liquid, grain agents and the like.

Description

technical field [0001] The invention relates to an ethanol extract of sandalwood and pterostilbene used as a direct vasodilator, and the application of the extract in medicines or health care products for treating cardiovascular diseases such as hypertension. Background technique [0002] In addition to serving as a physiological barrier between blood and vascular smooth muscle, the vascular endothelium also has an active metabolic endocrine function to maintain the balance of the vascular environment. Endothelium-dependent Vasodilation (EDD) is one of the important functions of vascular endothelium, and its dysfunction plays a leading role in the early formation, development and complications of atherosclerosis (AS), especially cardiovascular diseases. effect. [0003] There are two ways of vasodilation: EDD: ① Refers to endothelial cells releasing EDRF under the action of chemical substances such as acetylcholine, bradykinin, etc. or physiological stimuli (such as reactiv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P9/10A61P9/12A61K135/00A61K129/00
Inventor 陈丽华弗里德·穆拉德陈振兴赵勇
Owner 北京富华安德生物医药科技开发有限公司
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