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Method for preparing pterocarpus indicus ethanol extract used for direct vasodilation agent and applications of method

A vasodilator and ethanol reflux extraction technology, which is used in the application field of medicine or health care products

Inactive Publication Date: 2014-01-15
北京富华安德生物医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But at this stage, the ethanol extract of sandalwood pterostilbene is used as a vasodilator to treat hypertension or a health product, and there is no report yet

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: The ethanol extract of Pterocarpus sandalwood inhibits the vasoconstriction of phenylephrine independently of endothelium

[0015] experiment method:

[0016] The mouse thoracic aorta ring has been used in the present experiment. The preparation was oxidized with saline solution, and then mixed with the following composition: ① sodium chloride (119); ② potassium chloride (4.7); ③ potassium dihydrogen phosphate (1.2); ④ magnesium sulfate (1.2); Sodium hydrogen (25); ⑥ calcium chloride (1.6); ⑦ glucose (11), keep the temperature at 4 degrees Celsius. Prepare two arterial rings (each 4 mm long) and remove the endothelium by gently rubbing the inner surface with a smooth wooden stick. Successful endothelium removal can be confirmed by meeting the aortic ring with phenylephrine (1 μM) lack of a relaxing response to acetylcholine. Isovolumetric stretches of the aortic annulus were recorded using a computerized myograph system. After equilibration with at least ...

Embodiment 2

[0029] Example 2: The ethanol extract of Pterocarpus sandalwood inhibits the vasoconstriction of dopamine independently of endothelium

[0030] experiment method:

[0031] The mouse thoracic aorta ring has been used in the present experiment. The preparation was oxidized with physiological saline ethanol solution, and then mixed with the following compounds: ① sodium chloride (119); ② potassium chloride (4.7); ③ potassium dihydrogen phosphate (1.2); ④ magnesium sulfate (1.2); ⑤ Sodium bicarbonate (25); ⑥ calcium chloride (1.6); ⑦ glucose (11), keep the temperature at 4 degrees Celsius. Prepare two arterial rings (each 4 mm long) and remove the endothelium by gently rubbing the inner surface with a smooth wooden stick. Successful endothelium removal can be confirmed by meeting the aortic ring with phenylephrine (1 μM) lack of a relaxing response to acetylcholine. Isovolumetric stretches of the aortic annulus were recorded using a computerized myograph system. After equilibr...

Embodiment 3

[0044] Embodiment 3: the non-endothelium-dependent ethanol extract of pterostilbene inhibits the vasoconstriction of serotonin in the blood

[0045] experiment method:

[0046]The mouse thoracic aorta ring has been used in the present experiment. The preparation was oxidized with physiological saline ethanol solution, and then mixed with the following compounds: ① sodium chloride (119); ② potassium chloride (4.7); ③ potassium dihydrogen phosphate (1.2); ④ magnesium sulfate (1.2); ⑤ Sodium bicarbonate (25); ⑥ calcium chloride (1.6); ⑦ glucose (11), keep the temperature at 4 degrees Celsius. Prepare two arterial rings (each 4 mm long) and remove the endothelium by gently rubbing the inner surface with a smooth wooden stick. Successful endothelium removal can be confirmed by meeting the aortic ring with phenylephrine (1 μM) lack of a relaxing response to acetylcholine. Isovolumetric stretches of the aortic annulus were recorded using a computerized myograph system. After equi...

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Abstract

The invention relates to a method for preparing pterocarpus indicus ethanol extract used for non-endothelium-dependent vasodilation agent and applications of the extract on the medicines or health products of non-endothelium-dependent vasodilation agent. The preparation method comprises the steps of extracting the pterocarpus indicus powders thrice by 70% of ethanol circumfluence of 6 times, 5 times and 3 times respectively for about 2.5h, 2h and 1.5h, distilling and concentrating the extract by decompressing, cooling and drying the extract, and finally obtaining the pterocarpus indicus extract. Suitable auxiliary material is added into the obtained pterocarpus indicus extract in normal pharmacy method so as to prepare the medicines or health products such as powder injection, drops, troche, capsule, oral liquid, grain agents and the like.

Description

technical field [0001] The invention relates to an ethanol extract of sandalwood and pterostilbene used as a direct vasodilator, and the application of the extract in medicines or health care products for treating cardiovascular diseases such as hypertension. Background technique [0002] Currently, there are two types of vasodilators for the treatment of hypertension. One is indirect relaxation of vascular smooth muscle, including alpha receptor blockers, calcium antagonists and angiotensin-converting enzyme inhibitors, known as indirect vasodilators. Another class acts directly on vascular smooth muscle to cause vasodilation, known as direct vasodilators. Indirect vasodilators are new antihypertensive drugs widely used clinically. However, direct vasodilators, especially vasodilators extracted from natural medicines, are still very rare in clinical practice. [0003] The botanical name of "Red Sandalwood" is Sandalwood, which belongs to the genus Pterostilbene of the fa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/48A61P9/10A61P9/12A61K135/00A61K129/00
Inventor 陈丽华弗里德·穆拉德陈振兴赵勇
Owner 北京富华安德生物医药科技开发有限公司
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