Chinese medicinal composition for relieving hormone side effect

A composition and side effect technology, applied in the direction of drug combination, drug delivery, medical formula, etc., can solve the problems of unknown etiology, electrolyte disorder, aggravating the body's blood hypercoagulation state, etc., and achieve the goal of reducing triglyceride level and improving clinical symptoms Effect

Active Publication Date: 2011-09-14
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

The etiology of SLE is unknown, the incidence rate is increasing year by year, the clinical manifestations are complex and diverse, the lesion range is extensive, the disease is protracted and difficult to heal, and the prognosis is poor
At present, Western medicine mainly uses adrenal cortex hormones, immunosuppressants and other drugs to treat SLE, which have certain effects in controlling the disease and reducing the mortality rate. However, the disease often recurs and aggravates after the drug is reduced or stopped. When used in large doses, while patients obtain a certain curative effect, it brings many adverse reactions such as reducing normal cellular immune function, easily secondary or aggravating bacterial, viral and fungal infections, aggravating the body's blood hypercoagulability state, leading to osteoporosis, femoral head Necrosis, diabetes, hypertension, hyperlipidemia, electrolyte disturbance, etc., instead bring higher risks and difficulties to the treatment of SLE, affecting the therapeutic effect

Method used

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  • Chinese medicinal composition for relieving hormone side effect
  • Chinese medicinal composition for relieving hormone side effect
  • Chinese medicinal composition for relieving hormone side effect

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0046] [Experimental Example 1] Observation of curative effect of TCM symptoms

[0047] Methods: In the 2nd, 4th, 8th, 12th, 16th, 20th and 24th weeks, each pair of relevant clinical symptoms, facial erythema, fever, joint swelling and pain, Raynaud's phenomenon, hair loss, mouth sores, chest pain, palpitations, shortness of breath, fatigue, upset, edema, etc. Observe and score according to the TCM syndrome scoring table. Scores were scored according to the severity of symptoms as none (0 points), mild (1 point), moderate (2 points), and severe (3 points).

[0048] The clinical symptoms of the two groups were scored once before treatment and at 1, 2, 4, 8, 12, 16, 20, and 24 weeks after treatment. The change of symptoms was evaluated by comparing the scores before and after treatment. Among the clinical symptoms of the patients in the two groups, hot hands, feet, heart, irritability, facial erythema, and arthralgia accounted for most of the symptoms, while shortness of breat...

experiment example 2

[0057] [Experimental Example 2] Changes in blood system-related indicators

[0058] Routine blood examinations were performed at 1, 4, 12, and 24 weeks after treatment. The data before and after treatment in the two groups were compared using the paired t test, and the comparison between the two groups was performed using the independent sample t test. The changes are shown in Table 3.

[0059] Table 3 Changes in blood system-related indicators

[0060]

[0061] ▲ is the comparison between before and after treatment, P < 0.05, ★ is the comparison between the two groups after treatment, P < 0.05 Changes in red blood cell values:

[0062] (1) Comparison between the two groups before treatment: P=0.88>0.05, indicating that there was no statistical difference in the distribution of red blood cell indicators between the two groups of patients when they enrolled, and they were comparable;

[0063] (2) Comparison of the control group before and after treatment: P<0.05, suggesti...

experiment example 3

[0067] 【Experiment 3】Changes in blood lipids

[0068] 1. Changes in triglycerides: After treatment, blood lipids were checked at 1, 4, 12, and 24 weeks. Comparisons between the two groups before and after treatment were performed using paired t tests, and comparisons between groups were performed using independent sample t tests. The changes in triglycerides are shown in the table below 4 shown

[0069] Table 4 Changes in serum triglycerides

[0070]

[0071] Note: ▲ is the comparison between before and after treatment, P<0.05, ★ is the comparison between the two groups after treatment, P<0.05

[0072] (1) Comparison between the two groups before treatment: P=0.907>0.05, indicating that there was no statistical difference in the distribution of triglyceride indicators between the two groups when they enrolled, and they were comparable;

[0073] (2) Comparison of the control group before and after treatment: P>0.05, indicating that there was no statistical difference bef...

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Abstract

The invention relates to a Chinese medicinal composition for relieving the hormone side effect of a western medicament when systemic lupus erythematosus (SLE) is treated. In the medicament, drying rehmannia root, mix-fried turtle shell, largetrifoliolious bugbane rhizome, spreading hedyotis herb, sweet wormwood herb, asiatic pennywort herb, red paeony root, fried coix seed, fingercitronsliced andraw liquoric root are combined, so that the Chinese medicinal composition can improve clinical symptoms of an SLE patient, contributes to raising the red blood cell count of the patient, lowers levels of triglyceride, cholesterol, erythrocyte sedimentation rate, urine protein and hematuresis of the SLE patient, reduces the using amount of the hormone, reduces the relapse rate, improves the overall curative effect, and can be combined with the western medicament to treat the systemic lupus erythematosus.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition capable of alleviating hormone side effects of western medicines when treating systemic lupus erythematosus, belonging to the field of traditional Chinese medicines. Background technique [0002] Systemic lupus erythematosus (SLE) is an autoimmune disease with multi-organ and multi-system damage, and immune regulation disorder is the main pathogenesis. The etiology of SLE is unknown, the incidence rate is increasing year by year, the clinical manifestations are complex and diverse, the lesion range is extensive, the disease is protracted and difficult to heal, and the prognosis is poor. At present, Western medicine mainly uses adrenal cortex hormones, immunosuppressants and other drugs to treat SLE, which have certain effects in controlling the disease and reducing the mortality rate. However, the disease often recurs and aggravates after the drug is reduced or stopped. When used in l...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K9/00A61P39/02A61P13/12A61K35/56A61K35/32A61K35/586
Inventor 范永升温成平谢志军俞颖
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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