Blood transcriptional signature of mycobacterium tuberculosis infection

A technology for Mycobacterium tuberculosis and blood, which is applied in analytical materials, biological material analysis, and microbial determination/inspection, etc., and can solve problems such as health hazards, difficulties in anti-mycobacterial drug treatment, and side effects.

Inactive Publication Date: 2011-08-10
BAYLOR RES INST +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reactivation of latent / latent tuberculosis (TB) presents serious health hazards with risk of transmission to other individuals, thus biomarkers reflecting the distinction between latent and active TB patients may be useful in disease control Useful, especially since antimycobacterial drug therapy is difficult and can cause serious side effects

Method used

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  • Blood transcriptional signature of mycobacterium tuberculosis infection
  • Blood transcriptional signature of mycobacterium tuberculosis infection
  • Blood transcriptional signature of mycobacterium tuberculosis infection

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Embodiment Construction

[0041] While the making and using of various embodiments of the present invention are discussed in detail below, it should be appreciated that the present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts. The specific embodiments discussed herein are merely illustrative of specific ways to make and use the invention, and do not limit the scope of the invention.

[0042] In order to facilitate the understanding of the present invention, a number of terms are defined below. Terms defined herein have meanings as commonly understood by those of ordinary skill in the art to which the present invention pertains. Terms such as "a / an", "a / an" and "the" are not intended to refer only to a singular entity, but include the general class of which a specific instance may be used as an illustration. As used herein, the terms are used to describe particular embodiments of the invention, however their usage does not delimit the...

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Abstract

The present invention includes methods, systems and kits for distinguishing between active and latent mycobacterium tuberculosis infection in a patient suspected of being infected with mycobacterium tuberculosis, and distinguishing such patients from uninfected individuals, the method including the steps of obtaining a gene expression dataset from a whole blood obtained sample from the patient and determining the differential expression of one or more transcriptional gene expression modules that distinguish between infected and non-infected patients, wherein the dataset demonstrates an aggregate change in the levels of polynucleotides in the one or more transcriptional gene expression modules as compared to matched non- infected patients, thereby distinguishing between active and latent mycobacterium tuberculosis infection.

Description

[0001] invention technical field [0002] The present invention relates generally to the field of M. tuberculosis infection and, more particularly, to methods for diagnosing, prognosing and monitoring latent and active M. tuberculosis infection and disease progression before, during and after treatment. [0003] long form [0004] This patent application includes long table sections. A copy of the table is available electronically from the USPTO website (http: / / seqdata.uspto.gov / ). Electronic copies of this form are available from the USPTO upon request and payment of the fee specified in 37 CFR 1.19(b)(3). Background of the invention [0005] Without limiting the scope of the invention, its context is described in connection with the identification and treatment of M. tuberculosis infection. [0006] Pulmonary tuberculosis (PTB) is a major and growing cause of morbidity and mortality caused by M. tuberculosis worldwide. However, most individuals infected with M. tubercul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/50G01N33/53C12Q1/00
CPCC12Q2600/112C12Q1/6883C12Q2600/158G01N2800/60G01N33/5695
Inventor J·F·班彻罗D·肖萨贝尔A·奥加拉M·贝里O·M·康
Owner BAYLOR RES INST
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