Flumatinib mesylate crystal form A and preparation method and use thereof

A technology of flumatinib mesylate and its crystal form is applied in the application field of preparing medicines for the treatment of chronic myeloid leukemia, and can solve the problems of inability to combine with Gleevec, structural changes, and the occurrence of chronic myeloid leukemia patients.

Inactive Publication Date: 2012-12-12
JIANGSU HANSOH PHARMA CO LTD
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many chronic myeloid leukemia patients taking Gleevec have been found to develop drug resistance in recent years
In most c

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Flumatinib mesylate crystal form A and preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Put 1.0 g of flumatinib mesylate and 8.0 ml of isopropanol in a reaction flask, heat to reflux, and dissolve completely quickly, then naturally cool to room temperature under stirring conditions, stir for 24 hours, precipitate a solid, filter, Drying in vacuo yielded Form A.

Embodiment 2

[0018] Put 100g of flumatinib mesylate and 800ml of isopropanol in a reaction flask, heat to reflux, dissolve completely quickly, cool to room temperature naturally under stirring conditions, stir for 24 hours, precipitate solid, filter, and vacuum dry Form A was obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to flumatinib mesylate crystal form A and a preparation method and the use thereof. Specifically, one crystal form of the flumatinib mesylate, the preparation method thereof, medicine combination of the compound and with treatment effective quantity and application of the crystal form in preparation of medicine for treating chronic myelogenous leukemia are further provided.

Description

technical field [0001] The invention relates to a crystal form of flumatinib mesylate and a preparation method thereof, a pharmaceutical composition containing a therapeutically effective amount of the compound, and an application thereof in preparing medicines for treating chronic myelogenous leukemia. Background technique [0002] More than 95% of patients with chronic myelogenous leukemia are due to chromosomal translocation to produce BCR-ABL fusion protein, resulting in high expression of ABL tyrosine activating enzyme activity and a large number of abnormal white blood cells. [0003] In the prior art, drugs used to treat chronic myelogenous leukemia include recombinant interferon α-2a, cytarabine, homoharringtonine and imatinib. Gleevec (imatinib) is the main drug for the treatment of chronic myelogenous leukemia. The therapeutic mechanism is to inhibit the proliferation of cancer cells by inhibiting the activity of BCR-ABL, and at the same time induce apoptosis of ca...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07D401/04A61K31/506A61P35/02
Inventor 何雷杨宝海张亮
Owner JIANGSU HANSOH PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap