Method for establishing animal model for senile dementia, special liquid medicine and dosing device

Abstract

The invention relates to a method for establishing an animal model for senile dementia, a special liquid medicine and a dosing device, and belongs to the technical field of neurosciences. The method comprises the following steps: obtaining positioning coordinates of paraceles according to brain atlases or/and magnetic resonance image data of an experimental animal; respectively burying a conduit of the dosing device in left and right paraceles of the animal, and injecting the special liquid medicine to the paraceles at a constant speed in 14-16 minutes under a sterile environment within 2-3 weeks, wherein the liquid medicine amount is 100-250 ml methanol per day; alternately dosing the left and right paraceles, wherein the dosing frequency is 18-30 hours at an interval; and continuously dosing for 2-10 months to obtain a non-human primate animal model for senile dementia. With the adoption of a novel dosing mode: dosing to the paraceles at the constant speed, medicine can circulate to whole brain through the cerebrospinal fluid to exert the toxic effect, so that peripheral damage by the medicine is avoided. The AD model is established by injecting methanol or formaldehyde to the paraceles, so that behaviors and pathological symptoms are typical, the basic physiological status is good and the individual difference is relatively smaller.

Description

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AI Technical Summary

Benefits of technology

The technical effects described in this patented technology include two modes - one where drugs from both sides enter the bloodstream while flowing throughout it's entire body (bilaterals), resulting in harmful side effects) and another where they travel around within their own veins called laterally before reaching its destination inside your head. These methods allow researchers to study animals without having them come close enough together during testing sessions but still have some common behaviors like being able to swallow liquids safely when needed.

Problems solved by technology

This patented technical problem addressed in this patent relates to improving understanding how different types of substances affect cellular function during development processes associated with cognitive disorders including memory impairment caused by oxynapotropic receptor proteins called α-synuclein fuzzy fibril adductor domain containing serine residue (α-SAM) and gliadin peptides.

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