A kind of preparation method of prednisolone acetate

A technology of prednisolone acetate and acetic acid, which is applied in the field of preparation of steroid compounds, can solve problems such as complex operation, easy decomposition, and heavy metal residue, and achieve simple separation and purification operations, high material utilization rate, and fewer reaction steps Effect
CN103396468BInactive Publication Date: 2015-08-12WUHAN LANGJI TECH DEV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WUHAN LANGJI TECH DEV
Publication Date
2015-08-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a synthesis method of prednisolone acetate. A compound disclosed as Formula I is subjected to double bond bromination, reduction debromination, bromization and replacement reaction to generate prednisolone acetate. The method provided by the invention is high in yield, simple to operate and suitable for industrial production.
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Description

technical field

[0001] The present invention relates to a kind of preparation method of steroid compound, especially relate to the preparation of prednisolone acetate. Background technique

[0002] Prednisolone acetate is the acetate of prednisolone, English name Prednisolone Acetate, chemical name: 11β, 17α, 21-trihydroxypregna-1,4-diene-3,20-dione-21- Acetate, molecular structure see formula V in the reaction formula.

[0003] Prednisolone acetate is white or off-white crystalline powder; odorless, bitter, slightly soluble in methanol, ethanol or chloroform, almost insoluble in water.

[0004] Prednisolone acetate is a glucocorticoid drug used externally to treat allergic, non-infectious skin diseases and some proliferative skin diseases. Such as dermatitis, eczema, neurodermatitis, seborrheic dermatitis and pruritus. For allergic and autoimmune inflammatory diseases, collagen diseases. Such as rheumatism, rheumatoid arthritis, lupus erythematosus, severe bronchial ast...

Claims

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