Use of water clove extract for preparing composition for enhancing memory function and delaying neurodegeneration
A technology that enhances memory and neurodegeneration, and is applied in drug combinations, nervous system diseases, medical preparations containing active ingredients, etc., and can solve the problems of inaccurate diagnosis and effective treatment of Alzheimer's disease
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example 1
[0044] Example 1: Preparation of Water Clove Extract
[0045] Firstly, grind the cloves and immerse them in the extraction working liquid at a low temperature of 2-10°C for 4-12 hours, and then heat them at a temperature of 50-100°C for 10-60 minutes to obtain the extract and residue of cloves . The working liquid is water or ethanol solution. Then, the residue was separated by centrifugal filtration. Next, the separated residue is immersed in another extraction working liquid, and the extraction working liquid is heated at a temperature of 50-100°C for 10-60 minutes and then centrifugally filtered to produce a secondary extract of cloves monohydrate , and then dissolve the water clove secondary extract into the water clove extract. After that, use a drying process to dry the water clove extract to a water clove extract; wherein, when the extraction working liquid is water, freeze-drying can be used, and when the extraction working liquid is ethanol solution, decompression ...
example 2
[0046] Example 2: Water clove extract improves memory function
[0047] Drosophila learning and memory experiment (Pavlovianolfactory associative learning&memory) was used to study the effect of water clove extract on memory function, mainly using the way of Drosophila olfactory aversion learning to teach Drosophila to remember the correlation between odor and slight electric shock stimulation: in Drosophila smell An electric shock is given when a smell is detected, and then the fruit fly will run away when it smells the smell, so as to get a score for choosing the right one, so as to judge the learning and memory function based on this test. The fruit flies were raised in an environment of 25°C, and the fruit flies were divided into four groups. The concentration of clove extract contained in the food fed to the control group was 0%, and the concentration of clove extract contained in the food fed to the experimental group was respectively 0.005%, 0.01% and 0.1%, on the 20th ...
example 3
[0048] Example 3: Water clove extract delays neurodegeneration
[0049] Experiments were carried out on 3-month-old progeria mice (senescence-accelerated mouseprone-8, SAMP8, hereinafter referred to as mice), adding water clove extract to the drinking water of the mice, and performing memory tests after 3-4 months; the experiment The mice used are short-lived and suffer from memory loss, making them suitable experimental animal models for Alzheimer's disease (neurodegeneration). The mouse memory experiment was first to place mice drinking 0% and 0.01% water clove extract individually in an open space box (20x20x10 inches) during the three-day training period to make the mice accustomed to the open space box; then, Two different training objects were placed in the open space box during the training period and the mice were allowed to explore the two different training objects for 5 minutes. When the memory test was performed after a period of time, the mice were placed in the ...
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