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A method for rapid screening of 5 illegally added chemical substances in Xiaohuoluo Pills

A technology of Xiaohuoluo pills and chemical substances, applied in the field of quality testing of traditional Chinese medicines, can solve the problems of inability to achieve rapid screening, high maintenance costs, expensive instruments, etc., and achieve the effects of solving false "positive" interference, low cost, and easy operation.

Inactive Publication Date: 2015-11-04
焦琦
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because infrared spectrometers, HPLC-MS, and GC-MS instruments are expensive and must be operated by professional technicians, the maintenance costs are also extremely high, and rapid screening cannot be achieved to achieve the purpose of monitoring

Method used

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  • A method for rapid screening of 5 illegally added chemical substances in Xiaohuoluo Pills
  • A method for rapid screening of 5 illegally added chemical substances in Xiaohuoluo Pills
  • A method for rapid screening of 5 illegally added chemical substances in Xiaohuoluo Pills

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Embodiment Construction

[0018] Detailed examples are given below.

[0019] The present invention adopts: instruments and reagents: Sartoris BP211D electronic balance; AUTO SCIENCE AS10200BT type ultrasonic cleaner; P / G2007 type constant temperature oven; thin layer plate: silica gel GF 254 Thin layer plate (German MERCK batch number: HX929689 Specification: 20×20cm); reagents are all analytical grade; prednisone acetate reference substance (batch number: 100012-200706), dexamethasone acetate reference substance (batch number: 100122-201206), Indomethacin reference substance (batch number: 100258-200904), naproxen reference substance (batch number: 100198-201205), diclofenac sodium reference substance (batch number: 100334-200302) Provided: Xiaohuoluo Pills (marked batch numbers: 130110, 20130715, 130401, 120801, 20121201, 120012, 2111105).

[0020] Chromatographic conditions: developing solvent: n-hexane-ethyl acetate-glacial acetic acid=15:5:1 (volume ratio); developing conditions: temperature: 23°...

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Abstract

The invention relates to a method for fast screening of five illegally added chemicals in small collateral activating pills. The method comprises the following steps of: firstly, preparing a reference substance and a sample solution, then absorbing a reference substance solution and the sample solution respectively, spotting on a same silica gel thin-layer plate, expanding upward by a developer, taking out and drying, observing thin-layer chromatography by placing under an ultraviolet lamp respectively, spraying a sulfuric acid ethanol solution, and placing in an oven to be heated by constant temperature until color development of spots on the thin-layer plate is clear, observing the thin-layer chromatography by placing under sunlight again, if fluorescence quenching spots, fluorescence spots or spots, which have the same color, appear simultaneously at the part of a rate of flow (RF) value the same as that of the reference substance, judging that a sample result is positive. Obviously, the method is simple and fast to operate and low in cost, solves the problem of false 'positive' interference therein, and further avoids high cost and plenty of time caused by using traditional determinations such as infrared spectrum and HPLC-MS (High Performance Liquid Chromatography- Mass Spectrum), thereby being capable of effectively monitoring whether small collateral activating pills of Chinese patent medicines are illegally added with the chemicals.

Description

technical field [0001] The invention relates to the field of quality detection of traditional Chinese medicines, in particular to a method for quickly screening five kinds of illegally added chemical substances in Xiaohuoluo pills. Background technique [0002] Xiaohuoluo Pills is a traditional Chinese medicine preparation composed of 6 Chinese medicine decoction pieces including Dannanxing, Zhichuanwu, Zhicaowu, Dilong, frankincense (made) and myrrh (made). The main effects are dispelling wind and cold, resolving phlegm and dehumidification, promoting blood circulation and relieving pain. It is used for arthralgia caused by wind-cold-damp pathogen blockage and phlegm-stasis blockage of collaterals. Symptoms include limb joint pain, or cold pain, or tingling pain, or pain that is worse at night, joint flexion and extension difficulties, numbness and spasm. Its preparation method is to grind Dannanxing, Zhichuanwu, Zhicaowu, Dilong, frankincense (made), and myrrh (made) into...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/90
Inventor 焦琦吴爱英张春辉
Owner 焦琦
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