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A preparation method of folic acid-coupled gold nanorod/polypyrrole/ferric oxide multifunctional composite nano-diagnosis and treatment agent

A technology of ferric tetroxide and gold nanorods, which can be used in preparations for in vivo experiments, medical preparations containing active ingredients, and drug combinations, etc., can solve the problems of low immunity and lack of targeting of patients, and achieve Conducive to mass production, good imaging effect, and strong tumor targeting effect

Inactive Publication Date: 2017-02-08
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

To a certain extent, although traditional tumor chemotherapy methods can achieve the effect of treating tumors, due to the lack of targeting, as the treatment progresses, the patient's immunity will be weakened, which will bring great pain to the patient's body and mind.

Method used

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  • A preparation method of folic acid-coupled gold nanorod/polypyrrole/ferric oxide multifunctional composite nano-diagnosis and treatment agent
  • A preparation method of folic acid-coupled gold nanorod/polypyrrole/ferric oxide multifunctional composite nano-diagnosis and treatment agent
  • A preparation method of folic acid-coupled gold nanorod/polypyrrole/ferric oxide multifunctional composite nano-diagnosis and treatment agent

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) prepare the gold nanorod solution that sodium lauryl sulfate is stable;

[0041] (2) Add 0.373g ferric chloride to 10mL 8% polyvinyl alcohol solution, heat and stir thoroughly;

[0042] (3) Add 1 mL of the gold nanorod solution prepared in step (1) to the polymer solution prepared in step (2), ultrasonically disperse, and stir evenly;

[0043] (4) Add 70 μL of pyrrole monomer dropwise to the mixed solution prepared in step (3) after ice-bathing, stir for 10 minutes, quickly place it in a refrigerator at 4°C, and keep it for 12 hours. The solution turns black, and the mixture containing Suspension of gold nanorods / polypyrrole nanoparticles;

[0044] (5) Measure 2 mL of the suspension of gold nanorods / polypyrrole nanoparticles prepared in step (4), dilute with 12 mL of ionized water and 1.6 mL of ethanol, raise the temperature to 60 ° C, and quickly add 0.8 mL of the suspension under nitrogen protection After reacting for 25 minutes, 0.8 mL of ammonia solution was a...

Embodiment 2

[0049] (1) prepare the gold nanorod solution that sodium lauryl sulfate is stable;

[0050] (2) Add 180mg of ferric chloride into 10mL of 8% polyvinyl alcohol solution, heat and stir thoroughly;

[0051] (3) Add 2 mL of the gold nanorod solution prepared in step (1) to the polymer solution prepared in step (2), ultrasonically disperse, and stir evenly;

[0052] (4) Add 100 μL of pyrrole monomer dropwise to the mixed solution prepared in step (3) after ice-bathing, stir for 10 minutes, quickly place it in a refrigerator at 4°C, and keep it for 12 hours. The solution turns black, and the mixture containing Suspension of gold nanorods / polypyrrole nanoparticles;

[0053] (5) Measure 5 mL of the gold nanorod / polypyrrole nanoparticle suspension prepared in step (4), dilute it with 16 mL of ionized water and 2 mL of ethanol, raise the temperature to 70 ° C, and quickly add 1.2 mL of Ammonia solution, after reacting for 25 minutes, add 1.2 mL of ammonia solution again, and continue ...

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Abstract

The invention relates to a preparation method of a folic acid coupled gold nano-rod / polypyrrole / ferroferric oxide multifunctional composite nano diagnosis and treatment agent. The preparation method comprises the following steps: by adopting composite nanoparticles consisting of gold nano-rods, polypyrrole and ferroferric oxide as a substrate, modifying the surfaces of the composite nanoparticles by using polycationic electrolyte chitosan and polyanionic electrolyte sodium alginate respectively by virtue of a layer-by-layer self-assembly process to ensure that the surfaces of the nanoparticles contain amino groups, and then connecting with carboxy groups of folic acid. The prepared multifunctional composite nano diagnosis and treatment agent disclosed by the invention has the advantages of high photo-thermal conversion efficiency, good biocompatibility, active tumor targeting performance, strong cancer cell killing ability, significant imaging effect, a function of being controlled for a long time, and the like, and can be applied to treatment, pathological magnetic resonance imaging analysis and medical diagnosis of X-ray computer tomography and ultrasonic imaging of tumors or cancers of human bodies or other mammals.

Description

technical field [0001] The invention belongs to the field of nano-diagnosis and treatment agents, and in particular relates to a preparation method of a gold nanorod / polypyrrole / ferric oxide multifunctional composite nano-diagnosis and treatment agent coupled with folic acid. Background technique [0002] Tumor has become one of the main diseases that cause human death. Every year, tens of millions of cancer patients are diagnosed worldwide, and millions of patients die from cancer. At present, early diagnosis, radiotherapy and chemotherapy are still used for tumor treatment. To a certain extent, although traditional tumor chemotherapy methods can achieve the effect of treating tumors, due to the lack of targeting, as the treatment progresses, the patient's immunity will be weakened, which will bring great pain to the patient's body and mind. In addition, cancer is a complex disease with multiple mechanisms, and 80% of cancer patients have metastasized when they are diagnos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K41/00A61K49/12A61K47/22A61P35/00
Inventor 何创龙冯炜秦明周小军陈良
Owner DONGHUA UNIV
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