A kind of complex of vitamin D and omeprazole and coupling method thereof
An omeprazole and vitamin technology, which is applied in the field of vitamin D and omeprazole complexes and their coupling, can solve problems such as the poor effect of vitamin D and omeprazole alone, and achieve anti-cancer ulcer healing, The effect of high yield and mild reaction conditions
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Embodiment 1
[0028] Example 1 Vitamin D 3 Synthesis, purification and MTT cancer cell toxicity test of a novel drug complex coupled with omeprazole.
[0029] (1) Vitamin D 3 Synthesis of novel drug complex coupled with omeprazole, its synthetic route is as follows:
[0030]
[0031] Weigh 100mg (0.26mmol) vitamin D 3 Dissolve in 3ml of anhydrous dichloromethane solution, under N 2 Add 115mg (0.39mmol) of triphosgene (0.39mmol) and 54μL (0.39mmol) of triethylamine under ambient conditions, and stir the reaction at 0°C for 3-4h until the reaction is complete. The mixed solution is vacuum-dried for 0.5h and dissolved in 3ml of dichloromethane solution, N 2 Add 134mg (0.39mmol) omeprazole dichloromethane solution dropwise under ambient conditions, stir at 0°C for 3-5h, then react overnight at room temperature. Add 20ml NaHCO 3 aqueous solution, extracted three times with dichloromethane, washed with saturated brine, and then washed with anhydrous Na 2 SO 4 Dry, filter and concentrate...
Embodiment 2
[0056] Embodiment 2 Vitamin D 2 Synthesis, purification and MTT cancer cell activity test of a novel drug complex coupled with omeprazole.
[0057] (1) Vitamin D 2 Synthesis and purification of a novel drug complex coupled with omeprazole, the synthesis route is as follows:
[0058]
[0059] Weigh 200mg (0.504mmol) vitamin D 2 Dissolve in 5ml of anhydrous dichloromethane solution, under N 2 Add 115mg (0.756mmol) of triphosgene and 105μL (0.756mmol) of triethylamine under ambient conditions, and stir the reaction at 0°C for 3-4h until the reaction is complete. The mixed solution is vacuum-dried for 0.5h and dissolved in 5ml of dichloromethane solution, N 2 Add 260mg (0.756mmol) omeprazole dichloromethane solution dropwise under ambient conditions, stir at 0°C for 3-5h, then react overnight at room temperature. Add 30ml NaHCO 3 aqueous solution, extracted three times with dichloromethane, washed with saturated brine, and then washed with anhydrous Na 2 SO 4 Dry, filter...
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