Medicinal application of radix aristolochiae lactam derivative

A green woody, lactam technology, applied in drug combinations, nervous system diseases, organic chemistry, etc., can solve problems such as adverse reactions and unsatisfactory drug treatment effects, and achieve the effect of practical therapeutic activity

Inactive Publication Date: 2016-07-06
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs related to the prevention and / or treatment of neurodegenerative diseases, these drugs are likely to cause multiple and severe adverse reactions, and the therapeutic effect of the existing drugs is still not ideal

Method used

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  • Medicinal application of radix aristolochiae lactam derivative
  • Medicinal application of radix aristolochiae lactam derivative
  • Medicinal application of radix aristolochiae lactam derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Cinnamon lactam malate

[0048] Dissolve 2.93 g (0.01 mol) of the compound agarolactam and 1.34 g (0.01 mol) of malic acid in 100 ml of boiling ethanol. The hot solution is filtered through diatomaceous earth, then slowly cooled under gentle stirring, and left to stand for several hours in a temperature environment of 0-5°C, and the crystals of clove lactam malate are precipitated, and clove lactam malic acid is filtered out Salt crystals, washed with ethanol and dried under vacuum at 50°C, yielded 4.18 g of product.

Embodiment 2

[0050] Cinnamon lactam malate

[0051] Stir 2.93 g of the compound agarolactam malate and 1.34 g of malic acid in 100 ml of refluxing ethanol until all the solids are dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. Standing for several hours in a temperature environment of 0-5°C, the crystals of aloe lactam malate were precipitated, filtered out the crystals of aloe lactam malate, washed with ethanol and dried under vacuum at 50°C to obtain 4.17 grams of product.

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Abstract

The invention relates to radix aristolochiae lactam malate or a pharmaceutically acceptable solvate thereof, and an application thereof in preparation of a medicine preventing and / or treating neurodegenerative diseases.

Description

field of invention [0001] The present invention relates to the field of medicinal chemistry. Specifically, the present invention relates to the organic acid salt of arganolactam and its pharmaceutical application. Background technique [0002] For now, although there are many kinds of drugs related to the prevention and / or treatment of neurodegenerative diseases, the existing drugs are likely to cause multiple and severe adverse reactions, and the therapeutic effects of the existing drugs are still not ideal. Some active compounds for preventing and / or treating neurodegenerative diseases are described in the patent specification of China Invention Patent Granted Publication No. CN1245983C. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit go...

Claims

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Application Information

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IPC IPC(8): C07D209/80A61K31/404A61P25/00
Inventor 不公告发明人
Owner SHANGHAI YIZHI MEDICAL TECH
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