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Salt of crinum asiaticum novacine derivative

A manjulan and compound technology, which is applied to manjuranine organic acid salt and its pharmaceutical application field, can solve the problems of adverse reactions, unsatisfactory therapeutic effect, drug resistance and the like, and achieves the effect of practical therapeutic activity

Inactive Publication Date: 2013-09-11
SHANGHAI YIZHI MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] For now, although there are many kinds of drugs for the treatment of cancer, these existing drugs are likely to cause multiple and severe adverse reactions, and some produce drug resistance, and the therapeutic effect of the existing drugs is still not ideal.

Method used

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  • Salt of crinum asiaticum novacine derivative
  • Salt of crinum asiaticum novacine derivative
  • Salt of crinum asiaticum novacine derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Manjusriline fumarate

[0048] 3.37 g (0.01 mol) of the compound manjulancine and 1.17 g (0.01 mol) of fumaric acid were dissolved in 90 ml of boiling ethanol. The hot solution is filtered through diatomaceous earth, then slowly cooled under gentle stirring, and left to stand for several hours in a temperature environment of 0-5°C to precipitate crystals of manjuicine fumarate, and then filter out manjuricine fumarate Salt crystals were washed with ethanol and dried under vacuum at 50°C to obtain 4.52 g of product.

Embodiment 2

[0050] Manjusriline fumarate

[0051] The compound manjulancine fumarate 3.37 g and fumaric acid 1.17 g were stirred in 90 ml of refluxing ethanol until all the solids were dissolved. Add activated carbon, filter the hot solution through diatomaceous earth, and cool down to room temperature while stirring. Standing for several hours in a temperature environment of 0-5°C, the crystals of manjublidine fumarate are precipitated, filtered out, washed with ethanol and dried under vacuum at 50°C to obtain 4.53 g of product.

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Abstract

The invention relates to crinum asiaticum novacine and fumarate of a derivative or a pharmaceutically acceptable solvate and an application of poison bulb novacine in preparation of medicines for treating cancer.

Description

field of invention [0001] The invention relates to the field of medicinal chemistry, in particular, the invention relates to manjulancine organic acid salt and its pharmaceutical application. Background technique [0002] For now, although there are many kinds of drugs for treating cancer, these existing drugs are likely to cause multiple and severe adverse reactions, and some produce drug resistance, and the therapeutic effect of the existing drugs is still not ideal. Chinese patent application publication number CN 101244061A describes some active compounds for treating cancer. Contents of the invention [0003] The present invention discloses some new compounds, preparation methods of these compounds, pharmaceutical compositions containing these compounds and pharmaceutical applications of these compounds and compositions. [0004] These compounds exhibit good water solubility stability and solid form stability. Some of these compounds exhibit exceptional stability. ...

Claims

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Application Information

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IPC IPC(8): C07D455/03C07C57/15C07C51/41A61K31/4375A61P35/00
Inventor 王先友金赢瀛其他发明人请求不公开姓名
Owner SHANGHAI YIZHI MEDICAL TECH
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