A kind of compound ivermectin praziquantel bicontinuous phase emulsion and preparation method thereof

Abstract

The invention relates to compound ivermectin praziquantel bi-continuous phase emulsion. The emulsion per 100 g comprises the following components by weight: 0.1-2 g of ivermectin, 0.1-25 g of praziquantel, 0.01-3 g of arecoline hydrobromide, 1-10 g of solvent oil, 0.1-5 g of co-solvent, 20-30 g of an emulsifying agent, 10-20 g of an auxiliary emulsifying agent and the balance of deionized water. The emulsion prepared by the invention is wide in insect-resistant spectrum and obvious in treatment effect and not only can be used for injection after being diluted by oil, but also can be drunk or used for injection after being diluted by water when in use, so that the selection is flexible according to the clinical specific circumstances. Meanwhile, the invention further discloses a preparation method of the compound ivermectin praziquantel bi-continuous phase emulsion, which is strong in process operability and facilitates conversion.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicines, and in particular relates to a compound ivermectin praziquantel bicontinuous phase emulsion and a preparation method thereof. Background technique [0002] Animal parasitic diseases are common infectious diseases in the process of livestock and poultry breeding, among which nematodes, tapeworms, trematodes and insect parasites account for more than 80% of the incidence, and are common and frequently-occurring diseases in veterinary clinics. After livestock and poultry are infected with parasites, the worms reproduce and develop in the host body, absorbing the nutrients in the animals, and the nutrients eaten by the animals are used by the parasites, resulting in emaciated appearance and malnutrition, which seriously affect the production level of livestock and poultry. Some insect parasites, in addition to causing malnutrition in livestock and poultry, can also cause local ulceration...

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Problems solved by technology

[0006] At present, the dosage forms of praziquantel are mainly concentrated in tablets and powders, and there are relatively few liquid preparations. There are reports on the research of liquid dosage forms in the literature, but the general drug loading is not high, and there is a high clinical demand for compound praziquantel liquid preparations. The amount of ivermectin is very large. Although ivermectin has a liquid preparation, it is only effective against nematodes and insect parasites when used alone. If it can be used in conjunction with praziquantel against tapeworms and trematodes, a single dose can kill a variety of worms. It is bound to have broad application prospects

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