Methods of treating diarrhea in companion animals

A companion animal, animal technology, applied in the direction of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of premature death, effective or possibly ineffective, insufficient or timely response, etc.

Inactive Publication Date: 2017-08-29
JAGUAR HEALTH INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Depending on the cause, time period, severity and course of the diarrhea and / or its associated disease or condition, various known treatments may or may not be effective, and the animal may or may not respond adequately or promptly reaction, leading to premature death in many cases

Method used

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  • Methods of treating diarrhea in companion animals
  • Methods of treating diarrhea in companion animals
  • Methods of treating diarrhea in companion animals

Examples

Experimental program
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preparation example Construction

[0061] Preparation of proanthocyanidin polymer compositions and preparations

[0062] The proanthocyanidin polymer composition effective for treating secretory diarrhea according to the present invention consists of or includes monomeric units of leucoanthocyanidin. More specifically, the composition is composed of flavonoid units having 2 to 30 flavonoid units, preferably 2 to 15 flavonoid units, more preferably 2 to 11 flavonoid units, most preferably an average of 7 to 8 flavonoid units Proanthocyanidin polymer composition (number average molecular weight about 2500 Da). The proanthocyanidin polymer composition is preferably dissolved in an aqueous solution. Preferred for use in the method according to the invention are proanthocyanidin polymers from Peruvian croton; such Peruvian croton proanthocyanidin polymers may be in the form of a pharmaceutically acceptable composition.

[0063] Examples of the proanthocyanidin polymer composition used in the present invention are ...

Embodiment 1

[0105] Evaluation of Oral Administration of the Peruvian Croton Proanthocyanidin Polymer Composition Crolam (SP 303) to Dogs

[0106] Described in this Example is a multicenter proof-of-concept study of dogs with acute watery diarrhea. The study was performed in a veterinary hospital to provide a controlled environment. The study was a double-blind randomized block format used to compare five different treatment groups based on cause of diarrhea with each of five relevant placebo groups and for global analysis. The study included recruitment of dogs presenting with usual acute watery diarrhea of ​​less than 3 days. A thorough clinical examination was performed on each dog to determine whether the cause of the diarrhea was chemotherapy, bacterial infection, pancreatitis, dietary inadvertence, or Giardia infection. Each of these five causes was considered a subgroup, and dogs with any other cause of diarrhea were excluded from the study.

[0107] The recruited dogs were hospi...

Embodiment 2

[0110] Evaluation of the Clinical Efficacy of Oral Administration of the Peruvian Croton Proanthocyanidin Polymer Composition Crolam (SP 303) for the Treatment of Diarrhea in Dogs

[0111] This example relates to a blinded randomized controlled study evaluating the clinical efficacy of oral administration of a Peruvian croton proanthocyanidin polymer composition product, Crolam SP303, in the treatment of diarrhea (used by veterinarians through rescue organizations, shelters and customer owners obtained from canines). Investigators were blinded to the treatment task until the end of the study. A minimum of 60 dogs per trial site were recruited over a 4-month period from different veterinary clinics from the same geographical area. Provide financial incentives to rescue organizations, shelters, and owners for recruiting their animals into trials. Animals were given consent to be confined to the study site for a maximum of 6 days. During the first 24 hours of isolation, diarrh...

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Abstract

Provided are methods and compositions for treating diarrhea, particularly secretory diarrhea, watery diarrhea and chemotherapy induced diarrhea (CID), in young and adult non-human companion animals, such as dogs and cats, with a therapeutically effective amount of a proanthocyanidin polymer from Croton lechleri, in either enteric or non-enteric form.

Description

field of invention [0001] The present invention relates to, for example, the treatment of various forms of diarrhea, such as watery diarrhea caused by various conditions, pathologies or therapies, in companion animals such as dogs, cats and other animal pets. Methods of treatment include the use of enteric or non-enteric formulations of proanthocyandin polymer compositions isolated from the plants Croton spp. or Calophyllum spp. and form, or latex, extract or food supplement derived therefrom. More specifically, the composition is effective in the treatment of secretory or watery diarrhea caused by or secondary to a cancer treatment or therapy (chemotherapy-induced diarrhea or CID), whereby in It is effective in reducing the severity and duration of diarrhea in companion animals, particularly dogs, and in increasing their tolerance to and recovery from treatment. Background of the invention [0002] Diarrhea is one of the most common reasons for veterinary office visits fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/355A61K9/50A61K47/38A61K47/32A61K47/14A61K36/47A61P1/12
CPCA61P1/12A61K9/0056A61K9/2081A61K9/5026A61K9/5078A61K36/47A61K9/20A61K9/48A61K31/352
Inventor S·马尔蒂诺德
Owner JAGUAR HEALTH INC
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