Antidiarrhetic composition, product containing the same and method of preventing diarrhea

A technology of composition and pharmaceutical composition, applied in the field of diarrhea prevention and antidiarrheal pharmaceutical composition

Inactive Publication Date: 2010-11-03
静冈县公立大学法人 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no findings have been made on whether this cooling sensation has a therapeutic effect on diarrhea

Method used

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  • Antidiarrhetic composition, product containing the same and method of preventing diarrhea
  • Antidiarrhetic composition, product containing the same and method of preventing diarrhea
  • Antidiarrhetic composition, product containing the same and method of preventing diarrhea

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0062] image 3The line graph shows the administration of the adenylyl cyclase activator FK followed by the administration of 2-methyl-3-(1-menthyloxy)propane-1,2-diol on the serosa side for Isc Effect. When FK, which can increase intracellular cAMP levels, was administered to the serosal side, Isc was significantly increased. At least part of this cAMP-dependent increase in Isc can be attributed to Cl - Secretory Activation Mechanism. Next, when 20 μM 2-methyl-3-(1-menthyloxy)propane-1,2-diol was administered to the serosal side, Isc decreased by approximately 100 μA / cm 2 . This effect was almost equivalent to the administration of menthol at 500 μM. This dose dependence was observed at doses above 50 [mu]M, although saturation was not observed at doses of 150 [mu]M or more.

experiment example 2

[0064] In the same manner as in Experimental Example 1, the effect of 3-(1-menthoxy)propanol on Isc on the serosa side after administration of the adenylate cyclase activator FK was measured. According to the results of administration of 3-(1-menthoxy)propanol on the serosal side, Isc decreased by about 50 μA / cm at a dose of 20 μM 2 , dropped by about 70μA / cm at 50μM 2 .

experiment example 3

[0066] In the same manner as in Experimental Example 1, the effect of 3-(1-menthyloxy)propane-1,2-diol on Isc on the serosa side after administration of the adenylyl cyclase activator FK was measured. As a result of administration of 3-(1-menthyloxy)propane-1,2-diol to the serosal side, Isc decreased by approximately 50 μA / cm at a dose of 20 μM 2 , dropped by about 70μA / cm at 50μM 2 .

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PUM

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Abstract

To provide an antidiarrhetic composition which is efficacious against diarrhea, in particular, the predominant secretory diarrhea; an antidiarrhetic medicinal composition containing the same; a food containing the antidiarrhetic composition; and a method of preventing diarrhea using the same. A composition for relieving diarrhea which is a cool composition capable of acting on the digestive tract in the recipient's body and inhibiting the secretion of the intestinal Cl-. In other words, a composition containing one or more kinds of cool act compounds. It may be provided by adding to medicines, foods or drinks.

Description

technical field [0001] The present invention relates to an anti-diarrhea composition for relieving diarrhea, an anti-diarrhea pharmaceutical composition containing the composition, a food and drink containing the anti-diarrhea composition, and a method for preventing diarrhea using the same. Background technique [0002] Diarrhea is a common problem in people of all ages and in animals in general, such as livestock. Adults can suffer from diarrhea due to stress. In infants, severe dehydration may result, thereby threatening life support. [0003] Usually, the stool volume of a healthy adult is about 150g / day, and the amount of liquid in the stool is about 100 to 150ml / day after being concentrated. Diarrhea is indicated by a daily volume of fluid in the stool of 200ml or more, or a daily stool weight of 200g or more. The amount of liquid that flows into the small intestine every day is approximately as follows: 2L of orally digested liquid, 1L of saliva, 2L of gastric juic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/045A61K31/047A61K31/075A61K31/16A61K31/215A61P1/12
CPCA61K31/16A61K31/12A61K31/045A61K31/075A61K31/215A61P1/12A61K2300/00
Inventor 铃木裕一石田贤哉
Owner 静冈县公立大学法人
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