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Methods and compositions for diagnosing, prognosing, and confirming preeclampsia

A pre-eclampsia, weighting factor technology for use in the diagnosis, prognosis, and confirmation of pre-eclampsia and a composition that addresses difficulties in determining PE and clinical management decisions, and uncertainty about the etiology and pathogenesis of pre-eclampsia

Inactive Publication Date: 2017-09-12
马修库珀 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The etiology and pathogenesis of preeclampsia remain uncertain, and current laboratory signs and clinical symptoms of PE occur late in the disease process, sometimes making determination of PE and clinical management decisions difficult

Method used

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  • Methods and compositions for diagnosing, prognosing, and confirming preeclampsia
  • Methods and compositions for diagnosing, prognosing, and confirming preeclampsia
  • Methods and compositions for diagnosing, prognosing, and confirming preeclampsia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0666] Example 1 - Analysis of samples from normal subjects and subjects with preeclampsia by ELISA

[0667] This example illustrates the use of the disclosure described herein for the analysis of a panel of samples derived from pregnant women, some of which did not have preeclampsia and some of which had preeclampsia, using the ELISA method. The use of the biomarkers set forth herein is for diagnosis, prognosis, monitoring, characterization, prediction of pre-eclampsia or confirmation of the presence or absence of pre-eclampsia in a female subject.

[0668] equipment

[0669] Equipment used to perform ELISA assays includes Eppendorf plus calibrated single and multichannel pipettes, pro pipette manager, 2°C to 8°C deli refrigerator or freezer, -80°C freezer, non-humidified laboratory incubator set to 37°C, orbital microplate shaker, automatic microplate washer (Titretek TM , M384Washer with Stacker), microplate spectrophotometer (Molecular Devices, 340PC), Pro softwar...

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Abstract

Methods, compositions, kits, algorithms, systems, specialized computer, software, business methods and reagents are provided for diagnosing, prognosing, monitoring, characterizing, determining the severity of preeclampsia, confirming the presence of preeclampsia or confirming the absence of preeclampsia in a female subject. The methods and compositions find use in a number of applications, including, for example, predicting if an individual will develop preeclampsia, diagnosing whether the individual has preeclampsia, characterizing preeclampsia, monitoring an individual with preeclampsia, determining the severity of preeclampsia, confirming the presence of preeclampsia or confirming the absence of preeclampsia in a subject.

Description

[0001] This application claims U.S. Provisional Patent Application 62 / 031,132, filed July 30, 2014, U.S. Provisional Patent Application 62 / 031,834, filed July 31, 2014, and U.S. Provisional Patent Application, filed February 11, 2015 62 / 115,077 interest and priority. The content and disclosure of each of the foregoing patent applications is incorporated herein by reference in its entirety. [0002] Related field [0003] The present disclosure relates to providing a diagnosis and prognosis of preeclampsia. Background of the invention [0004] Preeclampsia (PE) is a serious multisystem complication of pregnancy with adverse effects on mother and infant. The disorder occurs in approximately 5-8% of all pregnancies in the United States and worldwide, and is responsible for 18% of all maternal deaths in the United States. The etiology and pathogenesis of preeclampsia remain uncertain, and current laboratory signs and clinical symptoms of PE occur late in the disease process, so...

Claims

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Application Information

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IPC IPC(8): G01N33/50
CPCG01N33/689G01N33/6893G01N2333/515G01N2333/912G01N2400/00G01N2800/368
Inventor 马修·库珀林达尔·赫斯特贝格埃里克·孔克尔埃万杰洛斯·希托普洛斯金伯利·施瓦茨
Owner 马修库珀
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