A kind of traditional Chinese medicine compound preparation with lipid-lowering function

A technology for compound preparations and traditional Chinese medicines, which is applied in the directions of medical preparations, pharmaceutical formulations, and drug combinations containing active ingredients, and can solve the problems of unavoidable toxic and side effects, unsatisfactory effects of a single traditional Chinese medicine, and large toxic and side effects.

Active Publication Date: 2021-07-16
北京博奥晶方生物科技有限公司
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In order to solve the defects that western medicines have high lipid-lowering effects, other toxic and side effects are brought about while treating hyperlipidemia, and the toxic and side effects are difficult to avoid, and the single traditional Chinese medicine has unsatisfactory effects. Chinese medicine compound preparation with fat function

Method used

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  • A kind of traditional Chinese medicine compound preparation with lipid-lowering function
  • A kind of traditional Chinese medicine compound preparation with lipid-lowering function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1, the preparation of Chinese medicine compound preparation

[0037] Green tea extract, crape myrtle extract, Tangli fruit extract, bitter melon seed extract according to figure 1 The proportion shown is made into 6 kinds of Chinese medicine compound preparations.

Embodiment 2

[0038] Embodiment 2, drug efficacy experiment

[0039] Utilize fluorescent real-time quantitative PCR technology (RT-qPCR) to detect that green tea extract, crape myrtle extract, tangli fruit extract and balsam pear extract are prepared according to a certain ratio (such as figure 1 As shown, compound 1:85:5:5:5; compound 2:5:85:5:5; compound 3:25:25:45:5; compound 4:25:25:5:45; compound 5: 45:45:5:5; Compound 6:25:25:25:25) the effect of the traditional Chinese medicine compound on lipid metabolism-related genes, confirming that the traditional Chinese medicine compound has lipid-lowering effect. Among them, the gene of focus is LDLR. The gene LDLR, low-density lipoprotein receptor, is located on the liver cell membrane and mediates the clearance of LDL in the blood through endocytosis. More than 75% of LDL in the blood is cleared through LDLR. Up-regulation of LDLR is beneficial for lowering blood lipids.

[0040] The present invention finds that the compound composed of g...

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Abstract

The invention provides a traditional Chinese medicine compound preparation with lipid-lowering function, which contains green tea extract, crape myrtle extract, tangli fruit extract and bitter melon seed extract. Wherein, the mass ratio of green tea extract, crape myrtle extract, Tangli fruit extract and bitter melon seed extract is 5‑85:5‑85:5‑45:5‑45. Fluorescence real-time quantitative PCR technology (RT-qPCR) was used to detect the influence of the traditional Chinese medicine compound preparation on genes related to lipid metabolism. The experimental results showed that the compound preparation can up-regulate the LDLR gene and has the function of lowering blood lipids.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a Chinese medicine compound preparation with lipid-lowering function. Background technique [0002] Hyperlipidemia refers to blood cholesterol (TC, LDL-c) and / or triglyceride (TG) is too high or high-density lipoprotein cholesterol (HDL-c) is too low. Around the world, 30 million people die every year from related diseases caused by hyperlipidemia, and the most serious one is cardiovascular disease. With the improvement of living standards, the morbidity and mortality of coronary heart disease in my country have also increased significantly, and the number of patients with hypertension has increased by 25% in 10 years, reaching about 200 million people at present. According to statistics from the Ministry of Health, one-third of patients with cardiovascular and cerebrovascular diseases in my country are under the age of 60 for the first time, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/82A61P3/06
CPCA61K36/185A61K36/42A61K36/73A61K36/82A61K2300/00
Inventor 谢兰冯娟郭弘妍邢婉丽程京
Owner 北京博奥晶方生物科技有限公司
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