Analgesia composition containing peony seed oil, analgesia plaster and preparation and application

A technology of peony seed oil and composition, which is applied in the field of medicine, can solve the problems of slow drug absorption and poor drug absorption effect, and achieve reliable curative effect, wide application range of drug properties, and pain relief effects

Inactive Publication Date: 2018-09-14
尹卫平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the deficiencies and shortcomings of the prior art, the primary purpose of the present invention is an analgesic composition containing peony seed oil, which uses peony seed oil as a base and is scientifically compatible with other plant volatile oils with significant analgesic effects, wherein , Peony seed oil has good transdermal properties, as a good transdermal agent, it can promote the transdermal absorption of drugs, and quickly exert the drug effect through transdermal absorption, so that the drug effect absorption effect caused by the matrix problem is not good or the drug effect absorption is slow In addition, the addition of plant volatile oils such as asarum oil, myrrh oil, frankincense oil, rosemary oil, borneol, mint ice, and methyl salicylate for pain relief and anti-inflammation greatly improves the effect of reducing swelling and pain

Method used

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  • Analgesia composition containing peony seed oil, analgesia plaster and preparation and application
  • Analgesia composition containing peony seed oil, analgesia plaster and preparation and application
  • Analgesia composition containing peony seed oil, analgesia plaster and preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) 35.4 parts of methyl salicylate are placed in beaker 1, after adding 35.4 parts of ethanol to dissolve, leave standstill for 20min to obtain methyl salicylate solution;

[0044] (2) Put 1.8 parts of asarum oil, 1.8 parts of myrrh oil, 0.8 part of frankincense oil and 0.8 part of rosemary oil in beaker 2 and mix evenly to obtain a mixed oil, and then add 0.21 parts of 1 part of borneol and 0.05 part of mint ice, stirred evenly to obtain a mixed solution;

[0045] (3) Under stirring conditions, the methyl salicylate solution prepared in step (1) and the mixed solution prepared in step (2) were added successively to 54.3 parts of peony seed oil, stirred evenly, and left to stand for 20min to obtain Analgesic composition containing peony seed oil ( figure 1 );

[0046] (4) Add the analgesic composition containing peony seed oil prepared in step (3) dropwise to a commercially available PU waterproof liquid plaster (7×7mm, inner diameter 3cm, figure 2 ) to obtain an a...

Embodiment 2

[0048] (1) 37.4 parts of methyl salicylate are placed in beaker 1, after adding 37.4 parts of ethanol to dissolve, leave standstill for 25min to obtain methyl salicylate solution;

[0049] (2) Put 2.0 parts of asarum oil, 2.0 parts of myrrh oil, 1.0 part of frankincense oil and 1.0 part of rosemary oil in beaker 2 and mix evenly to obtain a mixed oil, and then add 0.23 1 part of borneol and 0.07 part of mint ice, stirred evenly to obtain a mixed solution;

[0050] (3) Under stirring conditions, the methyl salicylate solution prepared in step (1) and the mixed solution prepared in step (2) were successively added to 56.3 parts of peony seed oil, stirred evenly, and left standing for 25min to obtain Analgesic compositions containing peony seed oil;

[0051] (4) Add the analgesic composition containing peony seed oil prepared in step (3) dropwise onto a commercially available PU waterproof liquid plaster (7×7mm, inner diameter 3cm) with a dropper to obtain an analgesic plaster, ...

Embodiment 3

[0053](1) 39.4 parts of methyl salicylate are placed in beaker 1, after adding 39.4 parts of ethanol to dissolve, leave standstill for 30min to obtain methyl salicylate solution;

[0054] (2) Put 2.2 parts of asarum oil, 2.2 parts of myrrh oil, 1.2 parts of frankincense oil and 1.2 parts of rosemary oil in beaker 2 and mix evenly to obtain a mixed oil, and then add 0.25 parts of 1 part of borneol and 0.09 part of mint ice, stirred evenly to obtain a mixed solution;

[0055] (3) Under stirring conditions, the methyl salicylate solution prepared in step (1) and the mixed solution prepared in step (2) were added successively to 58.3 parts of peony seed oil, stirred evenly, and left standing for 30min to obtain Analgesic compositions containing peony seed oil;

[0056] (4) Add the analgesic composition containing peony seed oil prepared in step (3) dropwise onto a commercially available PU waterproof liquid plaster (7×7mm, inner diameter 3cm) with a dropper to obtain an analgesic...

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Abstract

The invention belongs to the field of medicine and particularly relates to an analgesia composition containing peony seed oil and a preparation method and application of the composition. The analgesiacomposition containing the peony seed oil comprises, by mass, 54.3-58.3 parts of peony seed oil, 1.8-2.2 parts of asarum sieboldii oil, 35.4-39.4 parts of methyl salicylate, 1.8-2.2 parts of myrrh oil, 0.8-1.2 parts of frankincense oil, 0.8-1.2 parts of rosemary oil, 0.21-0.25 part of borneol and 0.05-0.09 part of menthol. The invention further provides plaster of the analgesia composition containing the peony seed oil. The composition and the plaster have obvious anti-tumor, analgesia and anti-inflammation effects through transdermal absorption, has a good conservative treatment effect on tumors, has no toxic or side effect, and can be used as a local medicine application transdermal preparation for treating bone tumors.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an analgesic composition containing peony seed oil, an analgesic plaster and its preparation and application. Background technique [0002] Cancer pain is the most common and most feared symptom of cancer patients. The pain of cancer seriously affects the quality of life of patients, and patients often have the idea of ​​dying. In cancer patients, cancer pain is mainly manifested as bone cancer pain. Many malignant tumors have a tendency to metastasize to bone. About 70% of patients with bone metastases suffer from moderate or severe pain during their illness. [0003] Currently the main analgesic drugs opioids (such as morphine) and non-steroidal anti-inflammatory drugs (such as indomethacin, fenbid) have side effects that cannot be ignored, such as non-steroidal anti-inflammatory drugs (indomethacin) can produce gastric ulcers , Liver and kidney dysfunction, opioid painkil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/70A61K47/44A61P29/00A61P35/00A61K31/618A61K31/045
CPCA61K9/7023A61K31/045A61K31/618A61K36/268A61K36/324A61K36/328A61K36/53A61K47/44A61P29/00A61P35/00A61K2300/00
Inventor 尹卫平
Owner 尹卫平
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