Pain-alleviating compound oil containing peony seed oil as well as preparation method and application thereof

A technology of peony seed oil and compound oil, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and pharmaceutical formulas, can solve the problem of confusion about the effective parts of volatile oils of Chinese herbal medicines, and it is difficult to ensure the safety and effectiveness of drugs. Lack of scientific basis and other issues, to achieve the effect of wide application range, reliable curative effect and good therapeutic effect

Inactive Publication Date: 2018-11-13
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] (1) The understanding of the effective parts of the volatile oil of Chinese herbal medicine is confused, and the prescription lacks scientific basis;
[0004] (2) There is a lack of effective quality control in the prescription. The content of medicinal active ingredients depends on the source of raw materials or different harvesting seasons. The biological activity may be different, and the intensity of the drug effect is quite different. It is difficult to guarantee the safety and effectiveness of the drug;

Method used

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  • Pain-alleviating compound oil containing peony seed oil as well as preparation method and application thereof
  • Pain-alleviating compound oil containing peony seed oil as well as preparation method and application thereof
  • Pain-alleviating compound oil containing peony seed oil as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) After dissolving 34 parts of methyl salicylate in 5.0 parts of ethanol, let it stand for 20 minutes to obtain methyl salicylate solution;

[0045] (2) Mix 1.8 parts of safflower oil, 6 parts of turpentine oil and 1.8 parts of rosemary oil to obtain a mixed oil, then add 0.21 part of borneol and 0.08 part of mint ice to the mixed oil under stirring conditions to obtain a mixed solution;

[0046] (3) Under stirring conditions, the methyl salicylate solution prepared in step (1) and the mixed solution prepared in step (2) were added successively to 49.7 parts of peony seed oil, stirred evenly, and left standing for 20min to obtain Pain Relief Complex with Peony Seed Oil ( figure 1 );

[0047] (4) Add the analgesic compound oil containing peony seed oil prepared in step (3) dropwise to a commercially available PU waterproof liquid plaster (7×7mm, inner diameter 3cm, figure 2 ) to obtain an analgesic compound oil plaster, wherein, in the analgesic plaster, the content...

Embodiment 2

[0049] (1) After dissolving 36 parts of methyl salicylate in 7.0 parts of ethanol, leave it for 25 minutes to obtain a methyl salicylate solution;

[0050] (2) Mix 2.0 parts of safflower oil, 8.0 parts of turpentine oil and 2.0 parts of rosemary oil to obtain a mixed oil, then add 0.23 parts of borneol and 0.1 part of mint ice to the mixed oil under stirring conditions to obtain a mixed solution;

[0051] (3) Under stirring conditions, the methyl salicylate solution prepared in step (1) and the mixed solution prepared in step (2) were added successively to 51.7 parts of peony seed oil, stirred evenly, and left standing for 25min to obtain Analgesic complex oil with peony seed oil;

[0052](4) Add the analgesic compound oil containing peony seed oil prepared in step (3) dropwise onto a commercially available PU waterproof liquid plaster (7×7mm, inner diameter 3cm) with a dropper to obtain an analgesic compound oil plaster, Wherein, in the analgesic plaster, the content of the ...

Embodiment 3

[0054] (1) After dissolving 38 parts of methyl salicylate in 6.0 parts of ethanol, let it stand for 30 minutes to obtain a methyl salicylate solution;

[0055] (2) Mix 2.2 parts of safflower oil, 10.0 parts of turpentine oil and 2.2 parts of rosemary oil to obtain a mixed oil, then add 0.25 part of borneol and 0.12 part of mint ice to the mixed oil under stirring conditions to obtain a mixed solution;

[0056] (3) Under stirring conditions, the methyl salicylate solution prepared in step (1) and the mixed solution prepared in step (2) were added successively to 53.7 parts of peony seed oil, stirred evenly, and left to stand for 30min to obtain Analgesic complex oil with peony seed oil;

[0057] (4) Add the analgesic compound oil containing peony seed oil prepared in step (3) dropwise onto a commercially available PU waterproof liquid plaster (7×7mm, inner diameter 3cm) with a dropper to obtain an analgesic compound oil plaster, Wherein, in the analgesic plaster, the content o...

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Abstract

The invention belongs to the field of preparation of external preparations of medicines and in particular relates to pain-alleviating compound oil containing peony seed oil as well as a preparation method and application thereof. The pain-alleviating compound oil containing the peony seed oil is prepared from the following components in parts by mass: 49.7 to 53.7 parts of the peony seed oil, 1.8to 2.2 parts of safflower oil, 34 to 38 parts of methyl salicylate, 6 to 10 parts of turpentine oil, 1.8 to 2.2 parts of rosemary oil, 0.21 to 0.25 part of borneol and 0.08 to 0.12 part of menthol; the compound oil takes the natural peony seed oil as a base material and the peony seed oil has good transdermal performance; the methyl salicylate and other types of essential oil are easily dispersedin the base material; the pain-alleviating compound oil has a remarkable anti-tumor, pain-alleviating and anti-inflammatory effects through transdermal absorption, and has a good conservative treatment effect on tumors and no toxic or side effects; the pain-alleviating compound oil can be used as a local administration transdermal preparation for treating bone tumors.

Description

technical field [0001] The invention belongs to the field of preparation of pharmaceutical preparations for external use, and in particular relates to an analgesic compound oil containing peony seed oil, a preparation method and application thereof. Background technique [0002] Plant volatile oils generally have the characteristics of small molecular weight and strong permeability, and become a class of compounds with strong pharmacological activity, which have important pharmacological effects in Chinese patent medicines. The long-standing application of Chinese herbal medicine shows that plant volatile oils generally have the functions of diverging and relieving the exterior, aromatic and resuscitating, regulating qi and relieving pain, expelling wind and dampness, promoting blood circulation and removing blood stasis, dispelling cold and warming the interior, clearing away heat and detoxification, and killing insects and bacteria. The administration of external preparati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K9/70A61P29/00A61P35/00A61K31/618A61K31/045
CPCA61K9/7023A61K31/045A61K31/618A61K36/15A61K36/286A61K36/53A61K36/65A61K36/71A61P29/00A61P35/00A61K2300/00
Inventor 尹卫平李明付改玲黄满玉刘坤刘闪闪薛昕
Owner HENAN UNIV OF SCI & TECH
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