68results about How to "Play the role of medicine" patented technology

The invention relates to a loaded aprepitant nanocrystal lipid microcapsule and a preparation method thereof, and belongs to the technical field of a medicine. The microcapsule is prepared by the method comprising the following steps: preparing an aprepitant nanocrystal from aprepitant by virtue of a grinding process, high-speed air jet pulverization or high-pressure homogenization, then mixing and emulsifying the aprepitant nanocrystal with phospholipid, removing a liquid phase and drying so as to obtain the aprepitant nanocrystal lipid microcapsule. The prepared loaded aprepitant nanocrystal lipid microcapsule can improve the stability of the aprepitant nanocrystal and the lipid loaded nanocrystal can increase the speed and the amount of being absorbed by gastrointestinal mucosa of a body, so that the effects of relatively high bioavailability and accelerated development of efficacy are achieved; and the preparation method of the loaded aprepitant nanocrystal lipid microcapsule is mild in condition, simple and controllable, low in preparation cost and is suitable for large-scale production.

The invention relates to a novel loratadine oral quickly soluble film and a preparation method thereof. The oral quickly soluble film comprises the following components: loratadine, a surfactant, a film-forming material, a flavoring agent, a corrigent and a small amount of ethanol. The invention further provides a preparation method of the novel loratadine oral quickly soluble film. The oral quickly soluble film is small in size and convenient to carry; the dosage is convenient to control, a preparation process is simple and controllable, special production equipment is not required, the novel loratadine oral quickly soluble film is suitable for industrial massproduction, can be quickly dissolved in the oral cavity of a patient who does not need to drink water or chew, and tastes good; compliance of medication for children is greatly improved; the dissolution condition of the novel loratadine oral quickly soluble film in a citric acid-disodium hydrogen phosphate buffer solution with pH of 4.0 is remarkably better than the dissolution condition of commercially available tablets; and the novel loratadine oral quickly soluble film has significance on gerontal patients and other patients with achlorhydria.

The invention relates to a three-cavity dosing device for sewage treatment. The device comprises a chemical dissolving case and a control case, wherein the inside of the chemical dissolving case is divided into a dissolving cavity, a curing cavity and a storing cavity, a feed hopper is arranged on the dissolving cavity, a water supply system and a dry powder dosing system are arranged above the feed hopper, and a motor-controlled stirrer is arranged in the dissolving cavity; a stirrer and a curing cavity liquid level meter are arranged in the storage cavity; a metering pump is arranged at thebottom of the storage cavity, and is communicated with a chemical discharge tube which passes through a pipeline and penetrates out of the storage cavity; an air release valve is arranged at the bottom of the storage cavity; the dissolving cavity and the curing cavity are communicated at the bottom of the chemical dissolving case, while the curing cavity and the storage cavity are communicated onthe top of the chemical dissolving case; a horizontal pipeline communicated with the storage cavity from the dissolving cavity is arranged at the bottom of the chemical dissolving case, and an electromagnetic valve at one end, positioned in the dissolving cavity, of the horizontal pipeline; the middle part of the horizontal pipeline is connected with a vertical pipeline in the curing cavity through a tee-joint; and an electromagnetic valve is arranged on the vertical pipeline.

The invention discloses a gynaecological flushing device. The device comprises a flushing basin and a supporting frame, a hip bath basin comprises a basin bottom and a basin wall, a cleaning tank is formed by the basin bottom and the basin wall, the basin wall is provided with a first through hole, the supporting frame is provided with a liquid storage bottle, a liquid storage bottle is provided with a first guiding tube, the first guiding tube penetrates through the first through hole to enter the cleaning tank, a cleaning head is arranged at the end, located on the cleaning tank, of the first guiding tube, the cleaning head comprises a plurality of water outlets, the first guiding tube is provided with a first air bag, an inflation device is arranged at the upper edge of the flushing basin, the inflation device comprises an installing seat, a second air bag, a pressing rod and a fixing mechanism, the second air bag is located in the installing seat, the second guiding tube is arranged on the second air bag, the installing seat comprises a side wall, one end of the second guiding tube is connected with the second air bag, the other end penetrates through the side wall and is connected with the first air bag, a first spring is arranged in the installing seat, one end of the first spring is connected with the installing seat, and the other end is connected with the pressing rod.According to the flushing device, a vaginal orifice is blocked by the first air bag to seal medicinal liquid.

The invention relates to a novel compound colla corii asini pulp and a preparation technology thereof. As the conventional colla corii asini oral liquid is not suitable for people with yin deficiency habitus, the novel compound colla corii asini pulp is prepared from raw materials such as colla corii asini, ginseng, scrophularia, prepared rehmannia root, codonopsis pilosula and orange immature fruit according to the new technology. The preparation technology of the novel compound colla corii asini pulp comprises the following steps: immersing the ginseng and the scrophularia into ethyl alcohol, then adding into a high pressure alcohol extraction tank, inflating and pressurizing the high pressure alcohol extraction tank to be under the pressure of 8-10 kgf / cm<2>, soaking for 2 hours, and then putting into the tank body of a novel traditional Chinese medicine extractor. Meanwhile a membrane concentration device is preferentially adopted for concentrating during liquid medicine concentration. The novel compound colla corii asini pulp has the effects of nourishing yin, tonifying qi and enriching blood, can also be taken by patients with yin, spleen and stomach deficiencies, is suitable for various crowds for taking, and is particularly suitable for women; according to the preparation technology, a new mixing extraction technology of high-normal pressure alcohol extraction / water extraction is adopted for the liquid medicine raw materials, so that the effective constituents of the components are prevented from loosing.

The invention relates to a long-effect mildew-proof degerming agent. The agent includes raw materials including, by weight, 0.1-2% of a mildew preventive, 0.2-2% of a thickener, 0.005-5% of a sterilizing agent, 5-50% of a solvent, 0.1-5% of a surfactant, 0-1% of an auxiliary and 40-90% of water. The degerming agent can achieve continuous mildew prevention for 90 days or longer, has high spreadingadhesiveness and is suitable for household mildew prevention.

The invention discloses a traditional Chinese medicine composition for treating anxiety and insomnia and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from, by weight, raw jujube kernels, poria cum ligno hospite, radix polygalae, fructus citri sarcodactylis, salivia chinensis, dwarf elm fruits, flos albiziae, rhizoma chuanxiong, apricot kernels, tuber fleeceflower stems, seman platycladi, semen nelumbinis, fried medulla junci, retinervus luffae fructus, retinervus citri reticulatae, fried jujube kernel, raw fructus hordei germinatus, fructus tritici levis, fructus toosendan, caulis bambusae in taenia, radix salviae miltiorrhizae, medulla tetrapanacis and periostracum cicadae. The traditional Chinese medicine composition is in a scientific and reasonable formula, has various components in synergistic compatibility, can take effect quickly, has efficacy of tranquilizing mind, calming nerves, soothing the liver, purging intense heat and the like, is capable of conditioning viscera dysfunction state, avoiding the anxiety and the insomnia, protecting patients from the anxiety and the insomnia and treating both symptoms and root causes, and is positive in efficacy, safe, convenient and free of toxic and side effects. The preparation method of the traditional Chinese medicine composition is efficient, good in active ingredient extraction effect and suitable for industrial production.

The present invention discloses a transdermal delivery based pharmaceutical composition. The composition comprises a compound as shown in a formula (I) or pharmaceutically acceptable salt thereof, a macromolecular dispersing carrier material, a hot melting protecting agent and an optional fluxing agent. A preparation method of the transdermal delivery based pharmaceutical composition comprises thesteps of micronizing the compound as shown in the formula (I) or the pharmaceutically acceptable salt thereof, the macromolecular dispersing carrier material and the hot melting protecting agent, optionally adding the fluxing agent, mixing the components uniformly, and performing hot melting extrusion and micronizing to obtain microparticles of the compound as shown in the formula (I) or the pharmaceutically acceptable salt thereof. In addition, the invention provides an application of the pharmaceutical composition. The transdermal delivery based pharmaceutical composition can enable the compound as shown in the formula (I) to be quickly absorbed, so that the purpose of calming before anesthesia is achieved, breathing is not affected, and the adverse psychological effects on children dueto intramuscular injection or intravenous injection are avoided. Meanwhile, the pharmaceutical composition also can be used for preventing and / or treating hyperactivity.

The invention provides a traditional Chinese medicine composition for treating benign prostatic hyperplasia. The composition is prepared from the following main raw materials in parts by weight: semen cuscutae, crotalaria sessiliflora, affine cudweed, endothelium corneum gigeriae galli, charred radix et rhizoma rhei, cinnamon, rhizoma alismatis, trogopterus dung, cortex mori radicis, radix aucklandiae, Chinese lobelia, black Chinese olive leaves, resina liquidamberis, herba epimedii, siegesbeckia orientalis, agrimonia pilosa, radix angelicae pubescentis, radix curcumae longae, uncaria rhynchophylla, Chinese yam, ipomoea cairica, morinda officinalis, mistletoe, edible tulip and herba houttuyniae. The invention further provides a method for preparing the traditional Chinese medicine composition for treating benign prostatic hyperplasia. The traditional Chinese medicine composition has a scientific and reasonable formula, can quickly achieve medicinal effect due to synergistic combination of the components, and has the effects of tonifying kidneys, boosting essence, relieving stranguria by diuresis, and dredging channels and relieving pain. A great number of tests prove that the traditional Chinese medicine composition has a remarkable curative effect on benign prostatic hyperplasia, excellent curative effect, symptom and root cause treatment, is safe and convenient, does not have toxic or side effect, and does not contain western medicine or hormone ingredient.

The invention provides a traditional Chinese medicine composition for treating bedsores and diabetic ulcers and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: catechu, galla chinensis, sanguis draconis, moschus, radix notoginseng, venenum bufonis, olibanum, myrrha, borneolum syntheticum, radix ampelopsis, corium elephantis, rhizoma curcumae longae, alumen and plumbum preparatium. The traditional Chinese medicine composition for treating bedsores and diabetic ulcers provided by the invention is scientific and reasonable in prescription, has components synergistic and compatible with each other, can exert the medicinal effect quickly, has the effect of dispelling blood stasis and relieving pain, and dispersing swelling and promoting granulation, has a good treatment effect for bedsores, diabetes-induced non-healing wounds and skin ulcers, treats both symptoms and root causes, has definite effect, is safe and convenient, has no toxic or side effect, and has no western medicine or hormone drug ingredients.

The invention provides a preparation method of an apocynum venetum antihypertensive effervescent tablet, and relates to a preparation method of an antihypertensive effervescent tablet, and the preparation method is used for solving the problems that an existing apocynum venetum antihypertensive effervescent tablet is slow in absorption, slow in disintegration and low in bioavailability. The preparation method comprises the following steps: 1, weighing raw materials; 2, decocting and extracting; 3, concentrating; 4, drying and crushing; 5, adding effervescent disintegrants; 6, granulating; 7, mixing; and 8, tabletting to obtain the finished product. The apocynum venetum antihypertensive effervescent tablet prepared by the preparation method provided by the invention is quick in disintegration, convenient to take, fast in onset of action, and high in bioavailability under an oral taking way. The preparation method provided by the invention is applied to the field of hypertension treatment.

The invention provides a Chinese herbal medicine additive for health restoration of grass carp parent fish after spawning induction. The additive contains various health-care Chinese herbal medicines with capacities of blood circulation promotion and immuno-enhancement. With a special processing manner, effective components in the Chinese herbal medicines are extracted, and residues of the Chinese herbal medicines are also fully used, therefore, the medicinal efficacy can be truly and rapidly produced. When the Chinese herbal medicine additive is added to feed for feeding the grass carp parent fish, the health of the grass carp parent fish can be effectively promoted to restore, injured positions of the parent fish are prompted to heal rapidly, and the survival rate of the parent fish is increased; the nature, flavor and functions of the components of the Chinese herbal medicines are scientifically combined, and better effect is obtained by means of the synergistic effect among the medicines; the Chinese herbal medicine additive is safe, effective, free of stimulation, or toxic or side effects, convenient to use and good in effect, and the Chinese herbal medicine raw materials are easily available .

The invention provides a traditional Chinese medicinal preparation for treating lung cancer. The traditional Chinese medicinal preparation consists of the following components in formula: raw radix astragalis, American ginseng, pseudo-ginseng, lucid ganoderma, adenophora tetraphylla, gecko, bombyx batryticatus, folium artemisiae argyi, asarum, radix asteris, flos farfarae, inula flower, flos magnoliae officinalis, cynanchum glaucescens, radix clematidis, greenish lily flower, herba selaginellae doederleinii, polyporus umbellatus, hairyvein agrimony, folium mori, campsis grandiflora, cottonrose hibiscus leaf, houttuynia cordata, herba patriniae, solidago virgaurea, eclipta alba, dandelion, seaweed and bighead atractylodes rhizome. The traditional Chinese medicinal preparation disclosed by the invention is rigorous in formula, superior and unique and is reasonable in medicinal compatibility. The medicine can directly and fully reach into lung and cancer cell tissues by virtue of an inhalation method, so as to rapidly develop efficacy and to quickly relieve symptoms; and the preparation is significant in curative effect.

The invention relates to the technical field of mask preparation, and particularly discloses an epidemic prevention traditional Chinese medicine mask. The mask contains the following traditional Chinese medicinal materials: agastache rugosus, elsholtzia, folium artemisiae argyi, raw rhizoma atractylodis, rhizoma kaempferiae and honeysuckle. The epidemic prevention traditional Chinese medicine maskis prepared from selected traditional Chinese medicines with the effects of resolving dampness with aromatics, dispelling turbidity, clearing away heat and toxic materials and the like according to the traditional Chinese medicine aromatic dirt-avoiding theory, the air disinfection effect can be enhanced, and qi of the fragrant traditional Chinese medicine pungent powder permeates into the Yingxiang acupoint and nasal mucosa to mobilize the external function of a body, so the mask is beneficial to resisting exogenous evil. Therefore, the effects of resisting viruses and enhancing the resistance of a human body are effectively achieved; the epidemic prevention traditional Chinese medicine mask effectively improves the effect of preventing the new coronal pneumonia of a wearer especially during the epidemic situation of the new coronal pneumonia.

The invention discloses a traditional Chinese medicine preparation for treating thromboangiitis obliterans through oral administration and external application. The traditional Chinese medicine preparation comprises ingredients such as radix millettiae speciosae, prepared rehmannia roots, radix angelicae sinensis, radix achyranthis bidentatae, spatholobus stems, herba hedyotidis diffusae, zanthoxylum nitidum and rhizoma anemones raddeanae. A preparation method comprises the following steps: S1. preparation of a radix achyranthis bidentatae concentrate; S2. preparation of an external-application liquid medicine; S3. preparation of clear paste A; S4. preparation of clear paste B; and S5. preparation of oral-administration granules. Compared with common oral-administration traditional Chinesemedicine mixtures in clinical application, the traditional Chinese medicine preparation provided by the invention and a use method have the advantages that the preparation process and the use methodare combined with the traditional traditional Chinese medicine theories and clinical application requirements and have a targeted medication advantage, the drug effect is better guaranteed, and the use is more convenient.

The invention provides a stomach medicine preparation, a preparation method and application thereof and relates to the technical field of traditional Chinese medicines. The stomach medicine preparation is prepared from 60-80 parts of rhizoma coptidis, 20-30 parts of boussingaultia gracilis Miers var, 20-30 parts of poria cocos, 10-20 parts of pilose asiabell roots, 20-30 parts of cinnamon, 50-60 parts of bletilla striata, 20-30 parts of astragalus membranaceus, 80-100 parts of costustoot, 80-100 parts of hawthorn, 20-30 parts of white atractylodes rhizomes and 20-30 parts of endothelium corneum gigeriae galli. The components adopted in the stomach medicine preparation are traditional Chinese medicine components, the medicine effect is mild and does not irritate the intestines and stomach, the stomach medicine preparation can be taken in scientific proportion for a long term and has no side effect on a human body, and the stomach illness treatment purpose is achieved.

The invention discloses a pharmaceutical composition for transdermal administration. The pharmaceutical composition contains tapentadol or a pharmaceutically acceptable salt thereof, a polymer dispersion carrier material, a hot-melt protective agent and an optional solubilizer. A preparation method of the pharmaceutical composition includes the following steps: mixing the tapentadol or the pharmaceutically acceptable salt thereof, the polymer dispersion carrier material, the hot-melt protective agent and the optional solubilizer, performing hot-melt extrusion, and performing micronization to obtain the microparticles of the tapentadol or the pharmaceutically acceptable salt thereof. The pharmaceutical composition for the transdermal administration can make the tapentadol or the pharmaceutically acceptable salt thereof rapidly absorbed, and achieve the purpose of sedation before anesthesia without affecting breathing, thereby avoiding the adverse psychological effects of intramuscular injection or intravenous injection acupuncture on children; and at the same time, the pharmaceutical composition can also be used to prevent and / or treat and delay the development of Parkinson disease.

The invention discloses a traditional Chinese medicine composition for treating depression and capsules and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is mainly prepared from the following main raw materials in parts by weight: codonopsis pilosula, deep-fried Atractylodes macrocephala koidz, rhizoma cimicifugae, polygala tenuifolia, rhizoma acori graminei, paenoiae alba, rhizoma cyperi, chrysanthemum, liquorice, lotus leaf, mint, fructus viticis, fried jujube kernel, amber, poria cocos, ginger jasmine, ginger processed pinellia, vinegar radix curcumae, bulbus fritillariae cirrhosae, elecampane, arisaema cum bile, red tangerine peel, cinnabar, green tangerine peel processed with vinegar and fructus tritici levis. According to the traditional Chinese medicine composition for treating depression, provided by the invention, the traditional Chinese medicine composition is scientific and reasonable in formula is scientific and reasonable in formula, the components are synergetic in compatibility, the drug effects can be rapidly exerted, the traditional Chinese medicine composition has the characteristics of excellent curative effects, fast efficacy, short course of treatment and the like, is low in cost, does not have any toxic or side reaction at all and does not contain any Western medicine or hormone drug component; the capsules can achieve the effect of improving drug efficacy of the traditional Chinese medicine composition, the stability is improved, and the capsules are conveniently taken by patients. Moreover, the preparation method of the traditional Chinese medicine composition is simple and convenient in operation, high-efficiency and excellent in effect of extracting active ingredients and is suitable for industrial production.

The invention discloses a modified amylase-based nanometer helical oil phase-triggered quick-release material and a preparation method thereof. The preparation method comprises that amylase which can form a helical structure is modified, then is coated with hydrophobic vein center action drugs such as propofol and forms a helical brain localization quick-release system. The helical brain localization quick-release system has good dispersibility in a water phase, has uniform particle sizes, has a stable particle size for a long time, does not leak propofol easily, can be stored easily, and reduces propofol injection pain. After being triggered by the oil phase, the modified amylase-based nanometer helical oil phase-triggered quick-release material can fast release propofol and is conducive to fast release of propofol at the blood-brain barrier. The preparation method has simple processes, adopts the nontoxic raw materials, does not produce toxic substances in production, carries out disinfection easily and can be industrialized easily.

The invention relates to a loaded aprepitant nanocrystal lipid microcapsule and a preparation method thereof, and belongs to the technical field of a medicine. The microcapsule is prepared by the method comprising the following steps: preparing an aprepitant nanocrystal from aprepitant by virtue of a grinding process, high-speed air jet pulverization or high-pressure homogenization, then mixing and emulsifying the aprepitant nanocrystal with phospholipid, removing a liquid phase and drying so as to obtain the aprepitant nanocrystal lipid microcapsule. The prepared loaded aprepitant nanocrystal lipid microcapsule can improve the stability of the aprepitant nanocrystal and the lipid loaded nanocrystal can increase the speed and the amount of being absorbed by gastrointestinal mucosa of a body, so that the effects of relatively high bioavailability and accelerated development of efficacy are achieved; and the preparation method of the loaded aprepitant nanocrystal lipid microcapsule is mild in condition, simple and controllable, low in preparation cost and is suitable for large-scale production.

The invention provides a traditional Chinese medicine composition for treating mammary gland hyperplasia nodules. The traditional Chinese medicine composition is mainly prepared from the following main raw materials in parts by weight: astragalus, angelica sinensis, codonopsis pilosula, red paeony root, ligusticum wallichii, the root of three-nerved spicebush, szechwan Chinaberry fruit, pericarpium citri reticulatae viride, the bulb of fritillary, radix bupleuri, fingered citron, corydalis tuber, root of rehmannia, centipede, trichosanthes kirilowii maxim, raw oyster shell, bighead atractylodes rhizome, liquorice, manis pentadactyla, semen impatientis, rhizoma sparganii, curcuma zedoary, stiff silkworm, edible tulip and the fruit of Chinese wolfberry. The invention further provides a method for preparing the traditional Chinese medicine composition for treating mammary gland hyperplasia nodules. The traditional Chinese medicine composition is scientific and reasonable in formula, and the components are synergetic in compatibility, can rapidly exert the drug effects and have the effects of descending ministerial fire, dispersing the liver and rectifying qi and softening hard mass and eliminating stasis. Lots of experiments prove that the traditional Chinese medicine composition can achieve the effect of effectively improving human liver qi stagnation and primordial qi insufficiency, has an obvious curative effect on the mammary gland hyperplasia nodules, is excellent in curative effects, capable of treating both symptoms and root causes, exact in curative effects, safe and convenient, does not have any toxic or side effect and does not have any Western medicine or hormone drug component.

The invention provides a traditional Chinese medicine composition for treating lipoma. The traditional Chinese medicine composition is prepared from the following main raw materials in parts by weight: radix bupleuri, dried tangerine peel, pinellia tuber, Indian buead, liquorice root, green tangerine peel, cape jasmine fruit, white mustard seed, tangerine pith, raw malt, raw fructus setariae germinatus, towel gourd vegetable sponge, arisaema with bile and villous amomum fruit. The invention provides a preparation method of the traditional Chinese medicine composition for treating lipoma. The traditional Chinese medicine composition is scientific and reasonable in formulation, has synergistic compatibility of components, can quickly give play to the effects and has the effects of relieving the depressed liver, eliminating phlegm and freeing channels and removing blood stasis and resolving static blood. Plenty of tests prove that the traditional Chinese medicine composition can activate human body dysfunction, has obvious curative effects on lipoma, has excellent and definite curative effects, gives consideration to both symptoms and root causes, is safe and convenient, does not have toxic or side effect and does not have any western medicine or hormone medicine component.

The invention discloses a pesticide spraying unmanned aerial vehicle for crop planting, and relates to the technical field of agricultural machinery. The unmanned aerial vehicle comprises a vehicle body, both sides of the outer wall of the vehicle body are fixedly connected with side wings, a pesticide box is fixedly connected to the bottom of the inner wall of the vehicle body, the top of the vehicle body is provided with a top cover, a liquid adding pipe penetrates through the top of the pesticide box, and the top end of the liquid adding pipe is fixedly connected with a liquid adding funnel. A motor box is fixedly connected to the top of the pesticide box, a first motor is fixedly connected to the inner wall of the motor box, and an output shaft of the first motor is fixedly connected with a stirring shaft. According to the pesticide spraying unmanned aerial vehicle for crop planting and a using method thereof, the function of atomizing pesticide through worm wheel wind pressure isachieved, the use of an air compressor is omitted, the burden of the unmanned aerial vehicle is reduced, a nozzle can spray the pesticide in a swinging mode, the spraying area is enlarger, the unmanned aerial vehicle is flexible and convenient to use, the spraying efficiency of the unmanned aerial vehicle is greatly improved, resource consumption is reduced, and the production cost is reduced.

The invention discloses a Fuyanting granule and a preparation method of the Fuyanting granule. The Fuyanting granule is prepared from 800-1000 parts of solidago virgaurea, 800-1000 parts of oldenlandia diffusa, 500-700 parts of radix paeoniae rubra and 500-650 parts of rhizoma corydalis according to the raw material ratio through the processes of decoction, ultrafiltration, vacuum concentration and granulation. The prepared Fuyanting granule improves the extracting efficiency of the various components and the drug loading capacity of the prepared drug granule, and the various effective ingredients are guaranteed to be completely extracted and take effects together.

The invention discloses compound bromelain ointment and a preparation method thereof. A formula of the compound bromelain ointment is prepared from the following components in percentage by mass: 30 to 40 percent of bromelain, 3 to 7 percent of lysozyme, 0.1 percent of vitamin A, 20 to 50 percent of a matrix and 12.9 to 46.9 percent of water. According to the formula disclosed by the invention, natural decrustation time is quickened through the bromelain, specific sterilization mechanism and broad-spectrum sterilization ability can be increased through the lysozyme, the infection situation during a wound decrustation period can be effectively prevented and controlled, and the vitamin A is beneficial for matural collagen synthesis, epithelialisation and vascularization, so that the compoundbromelain ointment can be used for decrustation of deep II-degree and III-degree burn wounds and has the function of controlling wound infection and inflammation, and the time for skin grafting of patients suffering from deep II-degree and III-degree burn can be quickened. The preparation method is designed according to physicochemical characteristics of the formula, and the drug effect can be expressed to the maximum.

The invention discloses a pharmaceutical composition for transdermal administration. The pharmaceutical composition comprises sufentanil or a pharmaceutically acceptable salt thereof, a polymer dispersion carrier material, a hot-melt protective agent and an optional solubilizer. The pharmaceutical composition for transdermal administration is obtained by the following steps: mixing the sufentanilor the pharmaceutically acceptable salt thereof, the polymer dispersion carrier material, the hot-melt protective agent and the optional solubilizer, performing hot-melt extrusion and micronization toobtain microparticles of the sufentanil or the pharmaceutically acceptable salt of the sufentanil. In addition, the invention provides a preparation method and application of the above pharmaceuticalcomposition. According to the pharmaceutical composition for transdermal administration, the sufentanil can be quickly absorbed, the purpose of treating postoperative pain without affecting breathingcan be achieved, and adverse psychological effects of intramuscular injection or intravenous injection acupuncture on patients can be avoided; and at the same time, the pharmaceutical composition canbe used to prevent and / or treat postherpetic neuralgia.

The invention discloses a pharmaceutical betaine conjugate and a pharmaceutical composition and an application thereof. The pharmaceutical composition contains the pharmaceutical betaine conjugate or a pharmaceutic composition composed of the pharmaceutical betaine conjugate and a pharmacologically acceptable carrier and is made into liquid preparations, solid preparations, semi-solid preparations, capsules, granules, gels and injections. The pharmaceutical composition is of liposomal nano-particles made of the pharmaceutical betaine conjugate or the composition of the pharmaceutical betaine conjugate and auxiliaries, to be specific, 10-100nm in particle size. The pharmaceutical betaine conjugate and the liposomal nano-particles thereof can serve as the liquid preparations, the solid preparations, the semi-solid preparations, sterilization preparations and sterile preparations and are low in toxicity and applicable to various tumor efficient treatments.

The invention discloses an effervescent tablet for treating breast cyst and a preparation method of the effervescent tablet for treating the breast cyst. The effervescent tablet comprises traditional Chinese medicines and pharmaceutical excipients, wherein active ingredients of the traditional Chinese medicines include sargassum, turtle shell, concha meretricis seu cyclinae, radix ranunculus ternati, oyster meat, eriobotrya japonia nut, radix aristolochiae, flos citri sarcodactylis, stemmacantha carthamoides (Willd.) Dittrich, peppermint, malt, elopichthys bambusa, root of silverweed cinquefoil, rhizoma atractylodis, rhizoma drynariae, rhizoma bletillae, cucubalus root, lamiophlomis rotata, trogopterus dung, honey, costustoot and fructus amomi. The effervescent tablet has the advantages that according to the principle of monarch, minister, assistant and guide, the effects of the medicines supplement each other and promote mutually to enable the medicines to 'focus on the affected part directly', and accordingly the effervescent tablet acts on the breasts directly to improve breast blood circulation, soften and resolve hard masses, soothe the liver, regulate the circulation of qi, invigorate the spleen and kidney, harmonize Chong and Ren channels and remove blood stasis to achieve detumescence.

The invention provides an alfentanil pharmaceutical composition for transdermal administration as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition for transdermal administration disclosed by the invention comprises alfentanil or a pharmaceutically acceptable salt thereof, a polymer dispersion carrier material, a hot-melt protective agent and an optional solubilizer, the pharmaceutical composition is obtained by the steps of mixing the alfentanil or the pharmaceutically acceptable salt thereof, the polymer dispersion carrier material, the hot-melt protective agent and the optional solubilizer, and performing hot-melt extrusion and micronization to obtain microparticles of the alfentanil or the pharmaceutically acceptable salt ofthe alfentanil. In addition, the invention provides the preparation method and application of the above pharmaceutical composition. According to the pharmaceutical composition for transdermal administration, the alfentanil or the pharmaceutically acceptable salt thereof can be quickly absorbed to achieve the purpose of pain anesthesia in treating without affecting breathing, and avoids the adversepsychological effects brought to patients by intramuscular injection or intravenous injection; and at the same time, the pharmaceutical composition can also be used to prevent and / or treat skin itching.

The invention discloses a traditional Chinese medicine composition for treating heart disease and a capsule and preparation method thereof. The traditional Chinese medicine composition is mainly prepared by, ardisia quinquegona, chorion ovi, fructus leonuri, endothelium corneum gigeriae galli, charred Radix et Rhizoma Rhei, Rosa laevigata Michx, arisacma consanguineum, trogopterus dung, herba houttuyniae, calcined dens draconis, sanders, Toona sinensis, Ficus tikoua, Ottelia alismoides, Siegesbeckia pubescens Makino, Agrimonia pilosa, Neolepisorus ovatus, flos caryophylli, crotalaria sessiliflora, Silene adenantha Franch., Ventilago leiocarpa Benth, Eupolyphaga, zaocys dhumnade, Smilax china L. leaf and placenta hominis. The traditional Chinese medicine composition for treating the heart disease has the advantages that the traditional Chinese medicine composition is scientific and reasonable in formula, unique in curative effect on diseases such as myocardial ischemia, angina, palpitation, suppression in the chest, insomnia and dreamful sleep and heart and cerebral angiosclerosis, quick in action, short in treatment course, high in cure rate, low in cost, excellent in curative effect, safe, convenient, free of toxic and side effect, and free of western medicine or hormone components.