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Fuyanting granule and preparation method thereof

A technology of Fuyanting and granules, which is applied in the field of Fuyanting granules and its preparation, can solve the problems of easy loss of active ingredients, small loading capacity of tablets, and incomplete active ingredients, so as to promote extraction, accelerate dissolution rate, and promote high-efficiency and the overall effect

Active Publication Date: 2018-01-30
ZHEJIANG SHENGBOKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to overcome the problems of easy loss of active ingredients, incomplete extraction of active ingredients, and small loading capacity of prepared tablets in the preparation methods of the prior art, and provides a Fuyanting granule and its preparation method , effectively extract the active ingredients in the drug, and increase the drug loading of the prepared drug granules

Method used

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  • Fuyanting granule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Weigh 1000g of Solidago, 1000g of Hedyotis diffusa and 667g of Radix Paeoniae Rubra, add 15 and 10 times the amount of glycerin to the water solution and decoct twice, among which Hedyotis diffusa is added to the solution twice for decoction Boil, each time for 1.5 hours, and filter in several times to obtain the primary extract and the secondary extract respectively, and then mix the two extracts; wherein the volume fraction of glycerin in the aqueous solution is 10%, and each component is decocted before Place in a ball mill jar equipped with dry ice for ball milling, and pass through 350 meshes to obtain a fine powder;

[0030] (2) Use a centrifuge at 4000rpm / min to separate the mixture of the two extracts for 30 minutes, take the upper layer of the centrifuge for ultrafiltration, and then concentrate the obtained filtrate under reduced pressure to obtain a concentrated solution with a relative density of 1.15. The density of water is measured at 65°C, and a memb...

Embodiment 2

[0035] (1) Weigh 800g of goldenrod, 800g of Hedyotis diffusa and 500g of Radix Paeoniae Rubra, add 15 and 10 times the amount of glycerin solution to decoct twice according to the weight ratio, and add Hedyotis diffusa into the solution twice for decoction Boil, each time for 1 hour, and filter in several times to obtain the primary extract and the secondary extract respectively, and then mix the two extracts; the volume fraction of glycerol in the aqueous solution is 10%, and each component is mixed before decocting Place in a ball mill jar equipped with dry ice for ball milling, and pass through 350 meshes to obtain a fine powder;

[0036] (2) Use a centrifuge at 4000rpm / min to separate the mixture of the two extracts for 60 minutes, take the upper layer of the centrifuge for ultrafiltration, and then concentrate the obtained filtrate under reduced pressure to obtain a concentrated solution with a relative density of 1.25. The density of water is measured at 65°C, and a memb...

Embodiment 3

[0041](1) Weigh 900g of Solidago, 900g of Hedyotis diffusa and 600g of Radix Paeoniae Rubra, add 15 and 10 times the amount of glycerin to the water solution and decoct twice, among which Hedyotis diffusa is added to the solution twice for decoction Boil for 2 hours each time, and filter in several times to obtain the primary extract and the secondary extract respectively, and then mix the two extracts; the volume fraction of glycerin in the aqueous solution is 10%, and each component is mixed before decocting Place in a ball mill jar equipped with dry ice for ball milling, and pass through 350 meshes to obtain a fine powder;

[0042] (2) Use a centrifuge at 4000rpm / min to separate the mixture of the two extracts for 45 minutes, take the upper layer of the centrifuge for ultrafiltration, and then concentrate the obtained filtrate under reduced pressure to obtain a concentrated solution with a relative density of 1.20. The density of water is measured at 65°C, and a membrane wi...

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Abstract

The invention discloses a Fuyanting granule and a preparation method of the Fuyanting granule. The Fuyanting granule is prepared from 800-1000 parts of solidago virgaurea, 800-1000 parts of oldenlandia diffusa, 500-700 parts of radix paeoniae rubra and 500-650 parts of rhizoma corydalis according to the raw material ratio through the processes of decoction, ultrafiltration, vacuum concentration and granulation. The prepared Fuyanting granule improves the extracting efficiency of the various components and the drug loading capacity of the prepared drug granule, and the various effective ingredients are guaranteed to be completely extracted and take effects together.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a Fuyanting granule and a preparation method thereof. Background technique [0002] Pelvic inflammatory disease refers to inflammation of the female reproductive organs, connective tissue around the uterus and pelvic peritoneum. Chronic pelvic inflammatory disease is often caused by incomplete treatment in the acute phase, and its onset time is long and the condition is more stubborn. Bacteria retrograde infection, through the uterus, fallopian tubes and reach the pelvic cavity. In recent years, the incidence of chronic pelvic inflammatory disease is on the rise, and the disease has a long course and is easy to relapse, which seriously affects the physical and mental health of women. Although there are many clinical treatments at present, the curative effect is limited, and the disease of many patients has not been effectively controlled. The development...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/748A61K9/16A61K47/10A61P15/00A61P31/04A61P31/10A61P29/00
Inventor 姜艳王魁余琪张晓明周丹英施佳
Owner ZHEJIANG SHENGBOKANG PHARMA CO LTD
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