Preparation method of apocynum venetum antihypertensive effervescent tablet

The technology of apocynum and effervescent tablets is applied in the field of preparation of apocynum antihypertensive effervescent tablets, which can solve the problems of slow absorption, low oral bioavailability, and imprecise process, so as to achieve low hygroscopicity and improve bioavailability Degree, the effect of reducing plant investment

Inactive Publication Date: 2013-02-20
哈药集团中药二厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a preparation method of Apocynum antihypertensive tablets in order to solve the problems of slow absorption, low oral bioavailability, and imprecise process of the existing Apocynum antihypertensive tablets

Method used

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  • Preparation method of apocynum venetum antihypertensive effervescent tablet
  • Preparation method of apocynum venetum antihypertensive effervescent tablet

Examples

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specific Embodiment approach 1

[0020] Specific embodiment one: the preparation method of a kind of Apocynum antihypertensive effervescent tablet of the present embodiment is carried out according to the following steps:

[0021] Step 1, weighing raw materials: weigh 300-400 parts of apocynum, 50-100 parts of Prunella vulgaris, 50-100 parts of Uncaria, 60-90 parts of Alisma, 30-70 parts of Mother of pearl, 30~70 parts of Achyranthes bidentata, 30~70 parts of hawthorn, 30~70 parts of chrysanthemum, 20~40 parts of sodium bicarbonate, 20~40 parts of citric acid and 1~5 parts of stearin Magnesium acid;

[0022] Step 2, decocting, extraction: add 8 to 12 times the weight of water to decoct the apocynum, Prunella vulgaris and chrysanthemums weighed in step 1 for 2 times, each time for 1 hour, combine the decoction liquid, filter; weigh in step 1 Add Achyranthes bidentata and hawthorn with 8-12 times the weight of water and decoct twice, each time for 2 hours, combine the decoction liquid, and filter; decoct the U...

specific Embodiment approach 2

[0032] Specific embodiment two: the difference between this embodiment and specific embodiment one is: described in step 1, take by weight 370 parts of apocynum, 80 parts of Prunella vulgaris, 80 parts of Uncaria, 70 parts of Alisma, 50 parts mother of pearl, 50 parts achyranthes, 50 parts hawthorn, 50 parts chrysanthemum, 30 parts sodium bicarbonate, 30 parts citric acid and 3 parts magnesium stearate. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0033] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that: described in step two, the apocynum, Prunella vulgaris and chrysanthemum taken in step one are decocted with 8 times the weight of water. Others are the same as in the first or second embodiment.

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Abstract

The invention provides a preparation method of an apocynum venetum antihypertensive effervescent tablet, and relates to a preparation method of an antihypertensive effervescent tablet, and the preparation method is used for solving the problems that an existing apocynum venetum antihypertensive effervescent tablet is slow in absorption, slow in disintegration and low in bioavailability. The preparation method comprises the following steps: 1, weighing raw materials; 2, decocting and extracting; 3, concentrating; 4, drying and crushing; 5, adding effervescent disintegrants; 6, granulating; 7, mixing; and 8, tabletting to obtain the finished product. The apocynum venetum antihypertensive effervescent tablet prepared by the preparation method provided by the invention is quick in disintegration, convenient to take, fast in onset of action, and high in bioavailability under an oral taking way. The preparation method provided by the invention is applied to the field of hypertension treatment.

Description

technical field [0001] The invention relates to a preparation method of apocynum antihypertensive effervescent tablet. Background technique [0002] Hypertension is a systemic disease characterized by elevated arterial blood pressure accompanied by functional or organic changes in the heart, blood vessels, brain and kidneys. Hypertensive patients who get up early may show symptoms such as headache, dizziness, tinnitus, palpitations, vertigo, inability to concentrate, memory loss, numbness in hands and feet, fatigue, and irritability. In the later stage, blood pressure continues to be at a high level, often accompanied by various symptoms. In my country, the main direct complication of hypertension is cerebrovascular disease, especially cerebral hemorrhage. The higher the blood pressure, the higher the incidence of complications, and the relative risk of cerebrovascular disease in hypertension is 32 times that of normal blood pressure. Hypertension is also one of the import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61K9/46A61P9/12A61K36/24
Inventor 肇静静王英新李殿明裴福成刘景国李文军郑玥单钰毓隋艳君
Owner 哈药集团中药二厂
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