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Method for finding biomarkers for monitoring IgA nephropathy

A biomarker, nephropathy technology, applied in the field of medical detection, can solve problems such as being unsuitable for monitoring disease progression, complications, etc.

Inactive Publication Date: 2018-12-21
深圳慈海医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Kidney biopsy is invasive and can lead to complications and is not suitable for monitoring disease progression

Method used

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  • Method for finding biomarkers for monitoring IgA nephropathy
  • Method for finding biomarkers for monitoring IgA nephropathy
  • Method for finding biomarkers for monitoring IgA nephropathy

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Embodiment Construction

[0204]In order to better explain the technical solutions of the present invention, the embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. The following examples are used to further illustrate the present invention, but should not be construed as fixing or limiting the present invention. Unless otherwise specified, the technical features used in the embodiments may be replaced with other technical features known in the art that have equivalent or similar functions or effects without departing from the inventive concept.

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Abstract

The invention provides a method for finding small RNA biomarkers for monitoring or detecting a pathogenetic process and / or a treatment process of IgA nephropathy. The method comprises the following steps: comparing with examination results of clinical biochemical markers of the IgA nephropathy, screening a small RNA biomarker which has lower expression abundance in untreated patients with the IgAnephropathy than that in healthy subjects while has higher expression abundance for the patients with the IgA nephropathy after treatment than that before treatment; screening a small RNA biomarker has higher expression abundance in the untreated patients with the IgA nephropathy than that in the healthy subjects while has lower expression abundance for the patients with the IgA nephropathy aftertreatment than before treatment. The markers can well detect the treatment process.

Description

technical field [0001] The invention belongs to the field of medical detection and relates to a method for discovering biomarkers for monitoring IgA nephropathy. Background technique [0002] IgA nephropathy (IgAnephropathy, IgAN) is the most common primary glomerulonephritis in the world. Although the prevalence of IgAN in the general population is low, its prevalence is high, especially in Asia, estimated at 30–40% in renal biopsies. Approximately 30-40% of IgAN patients will progress to end- (ERSD) within 20-30 years, making IgAN the leading cause of ERSD worldwide. However, the pathogenesis of IgAN remains unclear and available treatments only relieve symptoms and delay the need for dialysis and kidney transplantation. Among patients with IgAN, some respond well to treatment and maintain renal function for long periods of time, however, it is less understood that some patients are resistant to treatment and require dialysis more rapidly, and that mortality in IgAN pati...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/158C12Q2600/178
Inventor 何永成陈小波
Owner 深圳慈海医院
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