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Aiegens for cancer cell imaging

A technology for aggregation-induced luminescence and luminophores, which is applied in the field of luminophores and can solve problems such as interference with binding affinity

Active Publication Date: 2019-02-05
THE HONG KONG UNIV OF SCI & TECH
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Problems solved by technology

However, this high labeling ratio may interfere with binding affinity

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  • Aiegens for cancer cell imaging
  • Aiegens for cancer cell imaging
  • Aiegens for cancer cell imaging

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[0066] definition

[0067] The following definitions are provided to aid in the understanding of this application and the appended claims.

[0068] It should be noted that, as used in this specification and the appended claims, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise.

[0069] "Aggregation-induced emission", or AIE, refers to the activation of fluorescence / phosphorescence upon formation of aggregates or solid states. The material is non-luminous when the molecules are dissolved, but it glows when the intramolecular rotation is restricted.

[0070] "Emission intensity" refers to the intensity of fluorescence / phosphorescence usually measured by a fluorescence spectrometer or a fluorescence microscope; "fluorophore" or "fluorophore" refers to a molecule that exhibits fluorescence; Molecules; "AIEgen" refers to molecules with AIE properties.

[0071] Unless defined otherwise, all technical and scientific term...

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Abstract

A luminogen exhibiting aggregation induced emission is provided, wherein Tl, T2 and T3 comprise one or more polyynes as a conjugated bridge. Another AIEgen comprising a hydrophilic pydium group as a strong electron- withdrawing group, a piperazine group as an electron-donating group, and a a-cyanostilbene, wherein the AIEgen exhibits aggregation induced emission. A method of synthesizing an AIEgenand a method of labeling are also provided.

Description

[0001] Instructions for application [0002] This patent application claims priority to Provisional U.S. Patent Application No. 62 / 493,902, filed July 21, 2016, and Provisional U.S. Patent Application No. 62 / 495,029, filed August 31, 2016, which were filed by the present inventors and which The entire content of is incorporated herein by reference. technical field [0003] The present application relates to water-soluble aggregation-induced luminescence (AIEgens) for cancer cell imaging, especially AIEgens for antibody labeling. This application relates to strategies for designing red-emitting or near-infrared (NIR) emitting AIEgens, and the application of AIEgens in targeted imaging of cancer cells. Background technique [0004] Organic dyes with red emission are advantageous in many fields, such as organic light-emitting diodes (OLEDs), fluorescence imaging, and anti-counterfeiting technology, among others. For example, fluorescence imaging, as a biocompatible imaging te...

Claims

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Application Information

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IPC IPC(8): G01N21/64G01N33/53C09K11/06C12Q1/04
CPCC09K11/06G01N33/533G01N33/582A61N5/06C07D221/14C07D213/57C07C211/43C07D401/12C07D285/14C09K2211/1007C09K2211/1018
Inventor 唐本忠石秀娟余义勇郭子健赵征张鹏飞苏会芳
Owner THE HONG KONG UNIV OF SCI & TECH
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