A kind of bone wax with bone repair function and its preparation method and application

A bone repair and bone wax technology, applied in the field of biomedical engineering materials, can solve the problems of increasing risk, hindering the aggregation of blood components (fibrin and platelets, reducing tissue anti-infection ability, etc.), achieving the best hemostatic effect and excellent bone repair function , Improve the effect of bone differentiation

Active Publication Date: 2021-08-13
BEOGENE BIOTECH GUANGZHOU
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the biocompatibility is poor and it is difficult to be degraded and absorbed by the body, and the residue in the local area will greatly hinder bone healing, because the hemostatic mechanism is only a mechanical physical barrier, which can hinder the aggregation of blood components (fibrin and platelets). Conducive to the formation of the original callus, resulting in bone nonunion, the traditional bone wax remains in the body as a foreign body for a long time, forming foreign body granuloma, causing local pain, exudate and other symptoms, which not only reduces the anti-infection ability of the tissue, but also increases risk of postoperative infection

Method used

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  • A kind of bone wax with bone repair function and its preparation method and application
  • A kind of bone wax with bone repair function and its preparation method and application
  • A kind of bone wax with bone repair function and its preparation method and application

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preparation example Construction

[0051] In some embodiments, the present invention provides a method for preparing bone wax with bone repair function, comprising the following steps:

[0052] (1) Synthesis of Alkylated Chitosan (HMCS):

[0053] Chitosan was first dissolved in acetic acid solution, then stirred at room temperature until completely dissolved, then added to the ethanol solution, continued to stir until dissolved, then added a certain amount of laurylaldehyde, then adjusted the pH, and continued to stir at room temperature. Slowly add a certain amount of sodium cyanoborohydride dropwise, stir and react for a period of time and then adjust the pH value of the solution. If a precipitate is produced, filter and wash with 70, 80, and 100% ethanol / water solution to neutrality. The product is firstly pre-frozen and then freeze-dried, and finally ground into a powder by a grinder and stored in a desiccator.

[0054] (2) Synthesis of nano strontium-doped carbon-containing hydroxyapatite (Sr-CHAP):

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Embodiment 1

[0062] A kind of embodiment of the preparation method of the bone wax with bone repair function of the present invention, comprises the following steps:

[0063] (1) Synthesis of Alkylated Chitosan (HMCS)

[0064] Get 4g chitosan and dissolve in the 0.2mol / L acetic acid solution of 220mL. After stirring and dissolving at room temperature, add 150 mL of ethanol solution, continue stirring until dissolved, add a certain amount of lauryl aldehyde, then adjust the pH to 5.1, and continue stirring at room temperature for 4 hours. Slowly add sodium cyanoborohydride (chitosan unit / NaBH 3 CN=1 / 3). After stirring the reaction for 12 hours, the pH of the solution was adjusted to 10, the precipitated product was filtered and washed with 70, 80, and 100% ethanol / water solution until neutral. The product is firstly pre-frozen and then freeze-dried, and finally ground into a powder by a grinder and stored in a desiccator. And the characteristic peak changes of HMCS were characterized by...

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Abstract

The invention discloses a bone wax with bone repair function and a preparation method thereof. The raw material for the preparation of the bone wax includes the following components in percentage by weight: polyoxypropylene polyoxyethylene block copolymer 5%-45% , polyoxypropylene polyoxyethylene random copolymer 50% to 90%, alkylated chitosan 0.1% to 20%, and strontium-doped carbon-containing nano-hydroxyapatite 0.1% to 20%, wherein the alkylated shell The mass ratio of polysaccharide and strontium-doped carbon nano-hydroxyapatite is 1:1. The degradable bone wax with bone repair function provided by the present invention shows a better hemostasis effect on cancellous bone wound bleeding, and has excellent bone repair function. In addition, it improves the bone differentiation effect and is expected to be used in It is widely used in clinical medicine.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering materials, in particular to bone wax with bone repair function and its preparation method and application. Background technique [0002] The cancellous bone structure is loose and the blood supply is rich. The wound bleeding is mostly oozing, and it is difficult to stop the bleeding by vasoconstriction. Traditional bone wax is commonly used clinically to stop bleeding on cancellous bone wounds. Traditional bone wax has poor biocompatibility and is difficult to be degraded and absorbed by the body. Its residue in the local area will greatly hinder bone healing. It will remain in the body as a foreign body for a long time, affecting the repair of soft tissues. The healing of the surgical incision causes symptoms such as local pain and exudate, which not only reduces the anti-infection ability of the tissue, but also increases the risk of postoperative infection. [0003] Clinically,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04A61L24/02A61L24/00
CPCA61L24/0042A61L24/0094A61L2400/04C08L71/02
Inventor 蓝咏冯龙宝刘玉郭瑞
Owner BEOGENE BIOTECH GUANGZHOU
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