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Degradable bone repair/degradable anti-infection bone repair composite scaffold material and preparation method thereof

A composite scaffold and bone repair technology, applied in additive processing, medical science, prosthesis, etc., can solve the problems of weak biodegradability and single activity of materials

Inactive Publication Date: 2016-11-16
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The invention provides a degradable bone repair, degradable anti-infection bone repair composite scaffold material and a preparation method thereof, aiming at overcoming one or more of the existing bone repair materials with single activity, antibiotic resistance, and material biodegradability. A variety of defects, providing a composite scaffold material that is degradable, has both antibacterial and bone repair activities, and solves the current anti-infection problem of clinically complicated bone defects

Method used

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  • Degradable bone repair/degradable anti-infection bone repair composite scaffold material and preparation method thereof
  • Degradable bone repair/degradable anti-infection bone repair composite scaffold material and preparation method thereof
  • Degradable bone repair/degradable anti-infection bone repair composite scaffold material and preparation method thereof

Examples

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Embodiment 1

[0028] Example 1, a degradable bone repair composite scaffold material, comprising the following raw materials in parts by weight: phosphate inorganic substance solution 5, high molecular polymer solution 50, wherein the mass percentage concentration of the phosphate inorganic substance solution is 1 % to 50%, preferably 5% to 40%; the mass percent concentration of the polymer solution is 1% to 50%, preferably 5% to 40%; phosphate inorganic substances are calcium hydrogen phosphate, tricalcium phosphate, At least one of calcium dihydrogen phosphate, tetracalcium phosphate, octacalcium phosphate, and hydroxyapatite; the high molecular polymer is polytrimethylene carbonate, polyanhydride, polylactic acid, lactic acid glycolic acid copolymer, polyvinyl alcohol and at least one of polycaprolactones.

Embodiment 2

[0029] Example 2, a degradable composite scaffold material for bone repair, comprising the following raw materials in parts by weight: phosphate inorganic substance solution 40, high molecular polymer solution 90, wherein the mass percent concentration of the phosphate inorganic substance solution is 1 % to 50%, preferably 5% to 40%; the mass percent concentration of the polymer solution is 1% to 50%, preferably 5% to 40%; phosphate inorganic substances are calcium hydrogen phosphate, tricalcium phosphate, At least one of calcium dihydrogen phosphate, tetracalcium phosphate, octacalcium phosphate, and hydroxyapatite; the high molecular polymer is polytrimethylene carbonate, polyanhydride, polylactic acid, lactic acid glycolic acid copolymer, polyvinyl alcohol and at least one of polycaprolactones.

Embodiment 3

[0030] Example 3, a degradable antibacterial composite scaffold material for bone repair, comprising the following raw materials in parts by weight: phosphate inorganic substance solution 5, high molecular polymer solution 50, natural polysaccharide derivative antibacterial solution 1; wherein phosphate The mass percent concentration of the inorganic substance solution is 1% to 50%, preferably 5% to 40%; the mass percent concentration of the polymer solution is 1% to 50%, preferably 5% to 40%, and the natural polysaccharide derivative The degree of substitution is 5% to 60%, preferably 10% to 50%, more preferably 15% to 40%, and the concentration of the natural polysaccharide derivative antibacterial solution is kept at 5.0 to 50 mg / ml; the phosphate inorganic substances are calcium hydrogen phosphate, phosphoric acid At least one of tricalcium, dicalcium phosphate, tetracalcium phosphate, octacalcium phosphate, and hydroxyapatite; the polymer is polytrimethylene carbonate, pol...

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Abstract

The invention provides a degradable bone repair, degradable anti-infection bone repair composite scaffold material and a preparation method thereof. The composite scaffold material of the present invention is prepared through three-dimensional printing rapid prototyping, and is mainly composed of biological main body scaffold materials and antibacterial materials with bone repair function, wherein the main body support material is a composite of phosphate inorganic substances and high molecular polymers Antibacterial drugs are formulated by dissolving natural polysaccharide derivatives in phosphate buffer. The invention uses a three-dimensional printer to print a biological scaffold with bone repair activity that can be customized in specifications, and compounded with materials with antibacterial activity. Repair of bone defects.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, in particular to a degradable bone repair, degradable antibacterial bone repair composite scaffold material and a preparation method thereof. Background technique [0002] The treatment of large-segment bone defects is one of the main clinical tasks of orthopedics at present, but clinically large-segment bone defects are often combined with open injuries, and there is a greater risk of bacterial contamination and infection. With the development of materials science and clinical medicine, personalized bone repair materials that meet the needs of implant sites have gradually replaced autologous / allogeneic bone grafts and become a research hotspot and a new clinical treatment. Using 3D printing technology, the shape and internal structure of the porous scaffold, such as porosity, pore size, connectivity, etc., can be precisely and flexibly controlled through the design of the preparation paramete...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/54A61L27/58B33Y10/00
CPCA61L27/46A61L27/54A61L27/58A61L2300/208A61L2300/232A61L2300/404A61L2430/02
Inventor 汤亭亭杨盛兵杨颖
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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