Bone wax with bone repair function as well as preparation method and application thereof

Abstract

The invention discloses bone wax with a bone repair function and a preparation method thereof. The bone wax is prepared from the following raw materials in percentage by weight: 5% to 45% of polypropylene oxide polyoxyethylene segmented copolymer, 50% to 90% of polypropylene oxide polyoxyethylene random copolymer, 0.1% to 20% of alkylate chitosan and 0.1% to 20% of strontium-doped carbon-containing nano hydroxyapatite, wherein the mass ratio of the alkylate chitosan to the strontium-doped carbon-containing nano hydroxyapatite is 1 to 1. The degradable bone wax with the bone repair function disclosed by the invention has a better hemostatic effect on hemostasis of cancellous bone wound surfaces and simultaneously has an excellent bone repair function; in addition, a bone differentiation effect is improved; the degradable bone wax is hopeful to be widely applied in clinical medicine.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering materials, in particular to bone wax with bone repair function and its preparation method and application. Background technique [0002] The cancellous bone structure is loose and the blood supply is rich. The wound bleeding is mostly oozing, and it is difficult to stop the bleeding by vasoconstriction. Traditional bone wax is commonly used clinically to stop bleeding on cancellous bone wounds. Traditional bone wax has poor biocompatibility and is difficult to be degraded and absorbed by the body. Its residue in the local area will greatly hinder bone healing. It will remain in the body as a foreign body for a long time, affecting the repair of soft tissues. The healing of the surgical incision causes symptoms such as local pain and exudate, which not only reduces the anti-infection ability of the tissue, but also increases the risk of postoperative infection. [0003] Clinically,...

AI Technical Summary

Problems solved by technology

However, the biocompatibility is poor and it is difficult to be degraded and absorbed by the body, and the residue in the local area will greatly hinder bone healing, because the hemostatic mechanism is only a mechanical physical barrier, which can hinder the aggregation of blood components (fibrin and platelets). Conducive to the formation of the original callus, resulting in bone nonunion, the traditional bone wax remains in the body as a foreign body for a long time, forming foreign body granuloma, causing local pain, exudate and other symptoms, which not only reduces the anti-infection ability of the tissue, but also increases risk of postoperative infection

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