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Bone wax with bone repair function as well as preparation method and application thereof

A technology for bone repair and bone wax, applied in the field of biomedical engineering materials, can solve problems such as hindering blood components (fibrin and platelet aggregation, reducing tissue anti-infection ability, increasing risks, etc., to achieve excellent bone repair function and improve bone differentiation. effect, the effect of the best hemostatic effect

Active Publication Date: 2019-03-08
BEOGENE BIOTECH GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biocompatibility is poor and it is difficult to be degraded and absorbed by the body, and the residue in the local area will greatly hinder bone healing, because the hemostatic mechanism is only a mechanical physical barrier, which can hinder the aggregation of blood components (fibrin and platelets). Conducive to the formation of the original callus, resulting in bone nonunion, the traditional bone wax remains in the body as a foreign body for a long time, forming foreign body granuloma, causing local pain, exudate and other symptoms, which not only reduces the anti-infection ability of the tissue, but also increases risk of postoperative infection

Method used

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  • Bone wax with bone repair function as well as preparation method and application thereof
  • Bone wax with bone repair function as well as preparation method and application thereof
  • Bone wax with bone repair function as well as preparation method and application thereof

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preparation example Construction

[0051] In some embodiments, the present invention provides a method for preparing bone wax with bone repair function, comprising the following steps:

[0052] (1) Synthesis of Alkylated Chitosan (HMCS):

[0053] Chitosan was first dissolved in acetic acid solution, then stirred at room temperature until completely dissolved, then added to the ethanol solution, continued to stir until dissolved, then added a certain amount of laurylaldehyde, then adjusted the pH, and continued to stir at room temperature. Slowly add a certain amount of sodium cyanoborohydride dropwise, stir and react for a period of time and then adjust the pH value of the solution. If a precipitate is produced, filter and wash with 70, 80, and 100% ethanol / water solution to neutrality. The product is firstly pre-frozen and then freeze-dried, and finally ground into a powder by a grinder and stored in a desiccator.

[0054] (2) Synthesis of nano strontium-doped carbon-containing hydroxyapatite (Sr-CHAP):

[0...

Embodiment 1

[0062] A kind of embodiment of the preparation method of the bone wax with bone repair function of the present invention, comprises the following steps:

[0063] (1) Synthesis of Alkylated Chitosan (HMCS)

[0064] Get 4g chitosan and dissolve in the 0.2mol / L acetic acid solution of 220mL. After stirring and dissolving at room temperature, add 150 mL of ethanol solution, continue stirring until dissolved, add a certain amount of lauryl aldehyde, then adjust the pH to 5.1, and continue stirring at room temperature for 4 hours. Slowly add sodium cyanoborohydride (chitosan unit / NaBH 3 CN=1 / 3). After stirring the reaction for 12 hours, the pH of the solution was adjusted to 10, the precipitated product was filtered and washed with 70, 80, and 100% ethanol / water solution until neutral. The product is firstly pre-frozen and then freeze-dried, and finally ground into a powder by a grinder and stored in a desiccator. And the characteristic peak changes of HMCS were characterized by...

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Abstract

The invention discloses bone wax with a bone repair function and a preparation method thereof. The bone wax is prepared from the following raw materials in percentage by weight: 5% to 45% of polypropylene oxide polyoxyethylene segmented copolymer, 50% to 90% of polypropylene oxide polyoxyethylene random copolymer, 0.1% to 20% of alkylate chitosan and 0.1% to 20% of strontium-doped carbon-containing nano hydroxyapatite, wherein the mass ratio of the alkylate chitosan to the strontium-doped carbon-containing nano hydroxyapatite is 1 to 1. The degradable bone wax with the bone repair function disclosed by the invention has a better hemostatic effect on hemostasis of cancellous bone wound surfaces and simultaneously has an excellent bone repair function; in addition, a bone differentiation effect is improved; the degradable bone wax is hopeful to be widely applied in clinical medicine.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering materials, in particular to bone wax with bone repair function and its preparation method and application. Background technique [0002] The cancellous bone structure is loose and the blood supply is rich. The wound bleeding is mostly oozing, and it is difficult to stop the bleeding by vasoconstriction. Traditional bone wax is commonly used clinically to stop bleeding on cancellous bone wounds. Traditional bone wax has poor biocompatibility and is difficult to be degraded and absorbed by the body. Its residue in the local area will greatly hinder bone healing. It will remain in the body as a foreign body for a long time, affecting the repair of soft tissues. The healing of the surgical incision causes symptoms such as local pain and exudate, which not only reduces the anti-infection ability of the tissue, but also increases the risk of postoperative infection. [0003] Clinically,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/02A61L24/00
CPCA61L24/0042A61L24/0094A61L2400/04C08L71/02
Inventor 蓝咏冯龙宝刘玉郭瑞
Owner BEOGENE BIOTECH GUANGZHOU
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