The invention discloses moisturizing gel containing hydrolyzed pearl powder flexible nano liposome. The moisturizing gel is prepared by heating, mixing and homogenizing the hydrolyzed pearl powder flexible nano liposome, sodium hyaluronate, beta-glucan, acryloyl dimethyl ammonium taurine copolymer, hydroxyethyl urea, panthenol, nicotinamide, skin moistening esters, N,N'-1,2-ethanediylbis-1-aspartic acid and deionized water. The moisturizing gel is simple in process, multiple nutrition substances including amino acid, microelements, polypeptide and the like contained in the hydrolyzed pearl powder are utilized, metabolism of skin epithelial cells and dermal fibroblasts is effectively enhanced, and the skin repair function is promoted. The moisturizing gel is natural, mild, nearly free of stimulation and capable of penetrating through the skin surface of the human body easily, is infused with cells to achieve effects, can be used for moistening skin, preserving moisture and repairing skin barriers for a long time, has good water supplementation, moisture preservation and repairing effects for oily and mixed skin, sensitive skin and the like, and the skin can also be effectively whitened.