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A temperature-responsive slow-release oxygen nanocomposite material and its preparation method and application

A nano-composite material and temperature-responsive technology, which can be used in splitting materials, wave energy or particle radiation treatment materials, medical preparations of non-active ingredients, etc., can solve the problem of insensitivity of tumor cells to chemotherapeutic drugs or radiotherapy

Active Publication Date: 2021-06-29
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

In addition, the hypoxic microenvironment further enhances the malignancy of tumors, resulting in insensitivity of tumor cells to chemotherapeutic drugs or radiotherapy

Method used

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  • A temperature-responsive slow-release oxygen nanocomposite material and its preparation method and application
  • A temperature-responsive slow-release oxygen nanocomposite material and its preparation method and application

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0020] 1. Preparation of hollow mesoporous silica nanoparticles (hollow mesoporous silica, HMS):

[0021] Step 1.1:

[0022] Absolute ethanol (74mL), deionized water (10mL) and ammonia water (3.14mL) were placed in a 30°C constant temperature water bath for magnetic stirring, and mixed uniformly as a precursor reaction solution for subsequent reactions; ethyl orthosilicate ( TEOS, 6mL) was quickly added to the above precursor reaction solution, and reacted at 30°C for 1h to obtain a milky white colloidal solution;

[0023] Centrifuge the white colloidal solution, wash it several times with ethanol, and dry it in vacuum to obtain solid silica nanoparticles (SSNs);

[0024] The prepared SSNs (200mg) were dispersed into 40mL deionized water and ultrasonicated for 15min; at the same time, hexadecyltrimethylammonium bromide (C 16 TAB, 300mg), deionized water (60mL), absolute ethanol (60mL) and ammonia water (1.3mL) were uniformly mixed and stirred for 30min, all were added to the...

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Abstract

The invention discloses a temperature-responsive oxygen-releasing nano-composite material, a preparation method and application thereof. The nano-composite material uses hollow mesoporous silicon oxide nanoparticles as carriers, and supports high iron in the hollow mesoporous silicon oxide nanoparticles. Potassium ferrate, hollow mesoporous silica nanoparticles are also loaded with a water-insoluble temperature sensitive compound for plugging the potassium ferrate. In the in vitro environment, due to the low temperature, the melting point of the temperature-sensitive compound has not been reached, and the potassium ferrate in the pores of the nanocomposite cannot be in contact with water. The local temperature of the tumor increases, the temperature-sensitive compound melts after reaching the melting point, and the potassium ferrate generates oxygen locally in the tumor after contacting with water in the body fluid. The preparation prepared by using the nanocomposite material has the application prospect of improving the hypoxic microenvironment of the tumor.

Description

technical field [0001] The invention relates to the technical field of nano-biological materials, in particular to a temperature-responsive oxygen-releasing nano-composite material and its preparation method and application. Background technique [0002] The hypoxic microenvironment is an important feature of solid tumors. Under hypoxic conditions, tumor cells secrete a variety of angiogenic growth factors to promote the formation of abnormal blood vessels. At the same time, in order to find a more suitable soil, the invasion and metastasis ability of tumor cells will be further improved. In addition, the hypoxic microenvironment further enhances the malignancy of tumors, making tumor cells insensitive to chemotherapeutic drugs or radiation therapy. The hypoxic microenvironment is an important factor for the poor prognosis of tumors. Improving the tumor hypoxic microenvironment is expected to become a new method to improve the efficacy of solid tumors. Contents of the i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K33/00A61K9/51A61K47/04A61K47/10A61K47/12A61K47/06A61P35/00
CPCA61K9/0004A61K9/5115A61K9/5123A61K33/00A61K41/0033A61P35/00
Inventor 符静珂郝永强姜闻博富灵杰贺超马思聪
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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