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Antiviral drugs

A virus and virus target technology, which is applied in the field of angiotensin II signal inhibitors, treatment or prevention of single-strand retrovirus infection of subjects, and can solve problems such as the difficulty of designing safe and effective antiviral drugs

Inactive Publication Date: 2020-04-10
COMMONWEALTH SCI & IND RES ORG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, because the virus will use the cells of the host organism to replicate, designing safe and effective antiviral drugs is difficult
This makes it challenging to find targets for antiviral drugs to interfere with the virus without damaging the cells of the host organism

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0391] Example 1 - Antiviral Properties of Angiotensin II Signaling Inhibitors

[0392] Materials and methods

[0393] Cells: HeLa cells (ATCC CCL-2) were cultured in growth medium (supplemented with 10% (v / v) fetal calf serum (FCS), 10 mM HEPES, 2 mM L-glutamine, 100 U / mL penicillin and 100 μg / mL Streptomycin in EMEM). African green monkey renal epithelial Vero cells (ATCC CRL-81 ) were cultured in DMEM supplemented with 10% (v / v) FCS, 100 U / mL penicillin and 100 μg / mL streptomycin. All cells at 37°C and 5% CO 2 / 95% air atmosphere.

[0394] Viruses: All virology work was performed at the Australian Animal Health Laboratory, part of the Commonwealth Scientific and Industrial Research Organization (CSIRO). HeV (Hendra / Equus / 1994 / Hendra), NiV (Nipah / Malaysia / Human / 99) and RSV (strain A2) were passaged in Vero cells. Influenza A / WSN / 33 (H1N1) (a gift from Professor Lorna Brown, University of Melbourne) was passaged in the allantoic fluid of 10-day-old embryonated specific p...

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Abstract

The present disclosure relates to methods of treating or preventing a viral infection in a subject. More specifically, the invention relates to methods of treating or preventing a Mononegavirales viral infection in a subject that comprises administering an effective amount of an angiotensin II signalling inhibitor.

Description

technical field [0001] The present invention relates to a method of treating or preventing viral infection in a subject. More specifically, the present invention relates to methods of treating or preventing infection with a virus of the order Single-stranded Retrovirales in a subject comprising administering an effective amount of an inhibitor of angiotensin II signaling. Background technique [0002] Viruses are small infectious bodies that replicate only inside the living cells of an organism. While viruses can infect all forms of life, common viral pathogens known to infect humans include the common cold, flu, chickenpox, and chilblains. Diseases with more serious complications, such as Ebola virus disease, avian influenza, human immunodeficiency virus and acquired immunodeficiency syndrome (HIV / AIDS), and severe acute respiratory syndrome (SARS), are also caused by viruses . In addition, viral infections are an established cause of cancer in humans and other species. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4184A61K31/41A61K31/495A61P31/14
CPCA61K31/4184A61P31/14A61K31/14A61K31/4245A61K31/4178A61K9/0053A61K45/06
Inventor C·斯图尔特A·比恩
Owner COMMONWEALTH SCI & IND RES ORG