Serum metabolic marker for tuberculosis drug resistance diagnosis and application thereof

A technique for metabolites, tuberculosis, applied in the field of molecular biomedicine

Active Publication Date: 2020-04-28
佛山市第四人民医院 +1
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  • Abstract
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Problems solved by technology

But so far there are no reports about drug-resistant TB serum metabolites

Method used

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  • Serum metabolic marker for tuberculosis drug resistance diagnosis and application thereof
  • Serum metabolic marker for tuberculosis drug resistance diagnosis and application thereof
  • Serum metabolic marker for tuberculosis drug resistance diagnosis and application thereof

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Experimental program
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Embodiment 1

[0040] The inventors based on the determination of a total of 30 cases of tuberculosis drug sensitivity (drug sensitivity, DS), 8 cases of monoresistance isoniazid (monoresistance isoniazide, MR-INH), 2 cases of monoresistance rifampin (monoresistance rifampin, MR-RFP) ), 14 cases of multidrug resistance (MDR), 24 cases of multidrug resistance (polyresistance, PR) serum samples of metabolites were analyzed, and the metabolic markers were identified.

[0041] The relative abundance of differential metabolites in drug-resistant and drug-sensitive groups is shown in Table 1.

[0042] Table 1 Relative abundance of differential metabolites in TB drug resistance and DS groups

[0043]

[0044] By comparing the abundance of metabolites in the serum samples of tuberculosis drug-resistant individuals and tuberculosis drug-susceptible individuals, stearoyl glutamic acid, 5-Pentacosyl-1,3-benzonediol, 25-hydroxycholesterol, dihydroxy-26,27-dimethyl-20,21-didehydro-23-oxavitamin D3, 2...

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Abstract

The invention discloses a serum metabolic marker for tuberculosis drug resistance diagnosis and application thereof. The serum metabolite is selected from at least one of 30 serum metabolite such as stearoyl glutamic acid; analysis is performed according to the serum metabolite of individuals with different tuberculosis drug resistance types; and a novel thought is provided for tuberculosis drug resistance diagnosis from the perspective of the serum metabolite.

Description

technical field [0001] The invention relates to the field of molecular biomedicine, in particular to serum metabolic markers for tuberculosis drug resistance diagnosis and applications thereof. Background technique [0002] Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (MTB) and mainly transmitted through the respiratory tract. In recent years, multidrug resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (Extensively resistant tuberculosis, XDR-TB) phenomenon has become increasingly serious. According to the 2018 WHO report, among the 6.7 million new tuberculosis patients worldwide in 2017, about 6.8% were MDR-TB, of which India, China and Russia accounted for 24%, 13% and 10% respectively. MDR-TB is the resistance of Mycobacterium tuberculosis to at least two first-line anti-tuberculosis drugs, isoniazid (INH) and rifampicin (RIF). of deaths could be prevented through early diagnosis and treatment, suggesting th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/569
CPCG01N33/5695G01N2800/44Y02A50/30
Inventor 林东子王威林炳耀马燕雷春燕高志良周杰
Owner 佛山市第四人民医院
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