Treatment of fragile X syndrome

A syndromic, brittle technology that can be used in drug combinations, organic active ingredients, medical formulations containing active ingredients, etc., and can solve problems such as lack of clear success

Pending Publication Date: 2022-04-08
HEALX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Overall, efforts to treat Fragile X syndrome have opened up some exciting possibilities but, despite efforts, have not yielded definitive success

Method used

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  • Treatment of fragile X syndrome
  • Treatment of fragile X syndrome

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Embodiment Construction

[0013] Because Fragile X disease is a syndrome, patients can have many different presentations and symptoms. These include: intellectual disability, such as difficulties with cognition, executive and language performance, short-term memory, executive function, visual memory, and visuospatial relationships; autism; social anxiety (ie, difficulties with social interactions), such as poor eye contact, aversion Staring, prolonged time before initiating social interactions, and challenges forming peer bonds; hyperactivity and repetitive behaviors, including very short attention spans, hypersensitivity to visual, auditory, tactile, and olfactory stimuli, distraction, impulsivity, Restlessness and hyperactivity; disruptive behavior, including mood swings, irritability, self-injury, and aggression; obsessive-compulsive disorder (OCD); ophthalmic problems, such as strabismus; seizures; working memory difficulties, including temporary storing information; difficulties with phonological ...

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Abstract

The present invention relates to a composition comprising ibudilast or a pharmaceutically acceptable salt thereof for use in the treatment of Fragile X Syndrome, wherein the composition does not comprise sulindac or a pharmaceutically acceptable salt thereof or bumetanib or a pharmaceutically acceptable salt thereof.

Description

technical field [0001] The present invention relates to the application of ibudilast in treating fragile X syndrome (FXS). Background technique [0002] Fragile X syndrome, commonly referred to as Fragile X, is the most common genetic cause of intellectual disability and the most common monogenic cause of autism. It affects approximately 1 in 4000 men and 1 in 6000 women worldwide. [0003] There is a wide range of traits associated with Fragile X, and typically men are more affected than women. One of the main features associated with Fragile X syndrome is intellectual disability, such as difficulties with cognitive, executive, and language performance. Individuals with Fragile X syndrome often have social anxiety disorder, which is characterized by social, emotional, and communication difficulties associated with extreme shyness, poor eye contact, and challenges forming peer relationships. Fragile X syndrome is also associated with hyperactivity and disruptive behaviors...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61P25/00A61P43/00
CPCA61K31/437A61P25/00A61P43/00
Inventor D·布朗
Owner HEALX
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