Improvement of personalized health care in patients with dyskinesia

A technology of patient and exercise data, applied in medical science, diagnosis, diagnostic recording/measurement, etc., can solve the problem of lack of authoritative tests for Parkinson's disease

Pending Publication Date: 2022-07-08
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Currently, there is no authoritative test for Parkinson's disease

Method used

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  • Improvement of personalized health care in patients with dyskinesia
  • Improvement of personalized health care in patients with dyskinesia
  • Improvement of personalized health care in patients with dyskinesia

Examples

Experimental program
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example 1

[0072] The EQ-5D-5L is a self-assessed, health-related QoL questionnaire used to estimate PD patients. The scale measures QoL on a 5-part scale, including: 1) mobility; 2) self-care; 3) activities of daily living; 4) pain / discomfort; and 5) anxiety / depression. Each level is rated on a scale that describes the extent of the problem in that area (ie, no problem walking, mild problem, moderate problem, severe problem, or inability to walk). The questionnaire also features an overall health scale, in which PD patients choose a number between 1 and 100 to describe their health, with 100 being the best value imaginable. The EQ-5D-5L contains 3125 possible health states defined by combining a level from each scale, ranging from 11111 (full health) to 55555 (worst health).

[0073] As discussed above and in accordance with one aspect disclosed herein, sensors from smartphones and / or wearable devices (such as smart watches) can be used in daily life to measure the mobility behavior of...

example 2

[0078] The Parkinson's Disease Questionnaire 39 (PDQ-39) is a self-assessed QoL questionnaire used to estimate the health-related quality of Parkinson's disease. The PDQ-39 is used to assess patient difficulties on eight major QoL dimensions, each with several sub-items, including mobility, activities of daily living, emotional well-being, stigma, social support, cognition, communication, and physical uncomfortable. The QoL dimension can be scored on a five-point ordinal system: 0=never, 1=occasionally, 2=sometimes, 3=often, 4=always.

[0079] The total score for each PDQ-39 dimension can range from 0 (never had difficulty) to 100 (always had difficulty). Dimension scores can be calculated by determining the sum of the children on each dimension and multiplying by 100. Lower scores may reflect better QoL. The PDQ-39 total score can be calculated as the sum of the dimension scores divided by eight. The PDQ-39 questionnaire is used to help health and social care professional...

example 3

[0087] The Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a comprehensive QoL assessment designed to monitor the severity of Parkinson's disease over a longitudinal disease course and provide clinical advice to healthcare providers. The MDS-UPDRS assessment consists of 50 comprehensive questions to assess motor and non-motor symptoms associated with PD. The MDS-UPDRS consists of four components that add up to give a total score. The components of the assessment include: Part I, Non-Mobility Experiences of Daily Living (13 items); Part II, Activities of Daily Living (13 items); Part III, Mobility Examination (18 items); and Part IV, Mobility Complications (six items) ). Part I consists of two components, Part IA, which involves multiple behaviors assessed by investigators with relevant patient and caregiver information, and Part IB, which is completed by patients only. Each subscale is rated from 0 to 4, where 0=normal, 1=mild, 2=mild, 3=mo...

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Abstract

Disclosed herein are medical device systems and methods for assessing action symptoms of a Parkinson's disease patient and generating an action system assessment from passively and / or actively acquired sensor data of action behavior. Passive motion data and / or active action performance data collected from a Parkinson's disease patient represents EQ-5D-5L, PDQ-39, and / or MDS-UPDRS health measurement data to more accurately predict the quality of life, health, and disease severity of the Parkinson's disease patient. The generated action system evaluations may be used to provide more accurate treatment suggestions and disease management protocols for neurologists and other health care professionals, rather than using only patient investigations.

Description

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS [0002] This application claims priority to US Provisional Application No. 62 / 901,461, filed September 17, 2019, the disclosure of which is incorporated by reference in its entirety. technical field [0003] Aspects described herein generally relate to digital health tools for medical diagnosis and analysis for use by patients diagnosed with movement disorders (eg, Parkinson's disease). Additional aspects described herein analyze correlations between passive sensor data and health status measurements. Other aspects described herein analyze the correlation between passive and / or active sensor data and quality of life measurements. Still other aspects described herein analyze associations between passive sensor data and / or active sensor data and disease severity ratings for patients with Parkinson's disease. Additional aspects described herein, for example, use sensor data from wearable devices and / or smartphones to analyze (pass...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/1101A61B5/1116A61B5/1124A61B5/4088A61B5/7267A61B5/7275A61B5/4082A61B5/6898G16H20/10A61B5/7264A61B5/746
Inventor F·利普斯梅尔M·林德曼克尔斯滕·泰勒亚历山德拉·埃琳娜·托曼叶卡捷琳娜·沃尔科娃-沃尔克玛郑维逸
Owner F HOFFMANN LA ROCHE & CO AG
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