Preparation method of Tibetan medicine pellet

Abstract

The invention relates to a preparation method of Tibetan medicine pellets. The preparation method comprises the following steps: step 1, weighing medicinal materials: respectively weighing 75 medicinal materials according to a formula of Tibetan medicine'coral seventy-ingredient pills'; step 2, pretreatment; step 3, grinding for the first time; step 4, grinding for the second time; step 5, mixing; and step 6, preparation: mixing the medicinal powder with purified water to prepare a soft material, smelting in a medicine smelting machine, pelleting and screening by using a pelleting machine, drying, coating, adding the cinnabar fine powder in the coating process, airing and selecting pills to obtain the required pill preparation. The prepared pill is looser in texture, medicine dissolution can be accelerated, and the medicine dissolution rate is increased; the appearance quality of pills is improved, the pills are more uniform and complete, and the pill weight difference problem is reduced; the drying time is effectively shortened, and the loss risk of effective components is reduced; the pill is convenient to take and does not need to be taken after being crushed.

Description

Technical Field

[0001] The invention relates to the field of Tibetan medicine, and in particular to a method for preparing Tibetan medicine micropills. Background Art

[0002] So far, the traditional Tibetan medicine production process adopts a semi-artificial water-flooded pill preparation process. Due to the relatively backward process technology and weak quality controllability, it is difficult to meet the requirements of quality control, standardized management and industrial development. The products have unstable properties, large differences in pill weight, long dissolution time, and are extremely inconvenient to take. This is not only a major problem common to Tibetan medicine manufacturers, but has also become a major barrier to the Tibetan medicine market and large-scale production, and a major factor restricting the market share of Tibetan medicine products and achieving better social and economic benefits.

[0003] In order to solve this problem in the production process and dosage form of Tibetan medicine, some adopt the method of filling capsules with powder. However, since Tibetan medicine production basically uses raw medicine as medicine, the powder that meets the process fineness requirements has very poor fluidity when filled into capsules, which can easily cause differences in the amount of capsules filled. Therefore, coarse powder is directly filled into capsules, but this method violates the theoretical requirements of Tibetan medicine. Tibetan medicine theory believes that "the efficacy of the drug depends on the fineness of the powder. The finer the powder, the more effective it can be in improving the solubility, dissolution, absorption and bioavailability of the drug, thereby maximizing the efficacy of the drug. Therefore, directly filling coarse powder into capsules can only solve the product appearance problems of "inconvenience in taking and large differences in pill weight", but affects the intrinsic quality of the drug, that is, its clinical efficacy.

[0004] Some use concentrated capsules, but the demand for medicinal materials will be greatly increased. At present, the supply of local plant medicinal materials required for Tibetan medicine production is completely dependent on the collection of natural medicinal materials. Due to the high altitude and lack of oxygen in the Qinghai-Tibet Plateau, plants grow slowly and have poor regeneration ability. The ecological environment is extremely fragile and it is an area that is easily destroyed. At present, due to the lack of effective protection measures for natural wild medicinal materials, there are inevitably problems such as focusing on finished product production and neglecting the source of medicinal materials, and focusing on the development and utilization of medicinal materials and neglecting the protection of medicinal materials, which has also caused great damage to resources. The contradiction between the supply and demand of Tibetan medicinal materials is becoming more and more prominent. Therefore, the use of process technology with high consumption of medicinal materials is not suitable for the strategic requirements of the sustainable development of the Tibetan medicine industry. Summary of the invention

[0005] Aiming at the process defects of the traditional preparation method of the Tibetan medicine "Coral Seventy Flavor Pills", we designed a new preparation method to replace the existing preparation method and solve the problems of difficult quality control during the preparation process, unstable product properties, large differences in pill weight, long dissolution time, and inconvenience in taking.

[0006] The purpose of the present invention is achieved by the following technical solutions:

[0007] A method for preparing Tibetan medicine pellets comprises the following steps:

[0008] Step 1, weighing medicinal materials: weighing a total of 75 medicinal materials according to the formula of the Tibetan medicine "Coral Seventy Flavor Pills";

[0009] Step 2, pre-treatment: among the weighed medicinal materials, except coral, pearl, agate, magnet, calamine (Gangdi), dragon bone, brain stone, amber, cinnabar, and Bangna (Gongbu Wutou), the medicinal materials are processed separately; the medicinal materials except Bangna (Gongbu Wutou) are ground into powder; the medicinal materials except musk (artificial), bezoar (in vitro cultivated bezoar), saffron, and bear bile powder are purified separately;

[0010] Step 3, first grinding: except for coral, pearl, agate, magnet, calamine (Gangdi), dragon bone, brain stone, amber, cinnabar, musk (artificial), bezoar (in vitro cultured bezoar), saffron, bear bile powder, safflower and clove in the medicinal materials, the other 60 kinds of pure medicinal materials are weighed and mixed according to the mass ratio, and crushed into fine powder together, sieved, and obtained 60 kinds of pure medicinal material mixed powder;

[0011] Step 4, grinding for the second time: sterilize the 60 kinds of clean medicinal material mixed powders after crushing and sieving in step 3, and weigh the sterilized 60 kinds of medicinal material fine powders and mix them with 12 kinds of medicinal material fine powders including coral, pearl, agate, magnet, calamine, dragon bone, brain stone, amber, musk (artificial), bezoar (in vitro cultivated bezoar), saffron, and bear bile powder, and grind them, and then sieve them to obtain 72 kinds of clean medicinal material mixed powders;

[0012] Step 5, mixing: putting the 72 kinds of clean medicinal materials mixed powder and the cleaned cloves (powder) and safflower (powder) into a mixer for mixing;

[0013] Step 6, preparation: Mix the drug powder with purified water to form a soft material, then refine it in a medicine refining machine, and then use a pill making machine to make and screen the pills. After drying and coating, add cinnabar powder during the coating process, and then dry and select the pills to obtain the desired pill preparation.

[0014] Preferably, in step 1, the seventy-five medicinal materials include:

[0015] Coral, pearl, agate, magnet, calamine (Gangdi), dragon bone, brain stone, amber, cinnabar, musk (artificial), bezoar (in vitro cultured bezoar), saffron, bear bile powder, safflower, clove, mother of pearl, gastrodia, nutmeg, Tibetan aster, agarwood, black sesame, Indian deer sprout (dida), daisy, myrobalan, hairy myrobalan, costus root, ginseng (red ginseng), Tibetan calamus, Bangna (Gongbu Aconitum), Tibetan madder, cardamom, Tibetan lithospermum, red sandalwood, sunflower seed, cassia seed, frankincense (Puga), Ba Xia Ga, sea gold sand, licorice paste, crystal sugar, sword bean, crab shell, gentian, multi-spined meconopsis, qinjiao flower, Tibetan wood fragrance, wide tendon vine, hook wood, galangal, emblica, capsule-spurred delphinium, drynaria, asparagus, polygonatum, Ganqingqinglan, travertine, cold water stone, rhodiola rosea, ligado, honey, winter mallow fruit, sweet pine, short-spiked rabbit ear grass (Zhi Dasazeng), pine, etc., berberis bark, grass fruit, angelica, Tibetan codonopsis, snow lotus, cinnamon, yak blood, peach kernel, pine seed, gourd, stone wolfberry (reticulated stone wolfberry).

[0016] Preferably, in step 2, the processing method is a repair method, including the steps of sorting, cleaning and cutting the medicinal materials.

[0017] Preferably, in step 2, the medicinal materials except Aconitum gongbuensis (Aconitum gongbuensis) are ground into powder with a fineness of 200 mesh or more.

[0018] Preferably, in step 2, the purification process is to remove impurities and moldy products mixed in the medicinal materials.

[0019] Preferably, in step 3, the fineness of the fine powder reaches 80 mesh or more.

[0020] Preferably, in step 4, sterilization is performed in a traditional Chinese medicine sterilization cabinet at a set temperature of 100-105° C. for 30 minutes.

[0021] Preferably, in step 4, the sterilized 60 medicinal material powders are divided into two parts during grinding, and the mass ratio of the first part to the second part is 0.25:6; the specific grinding process includes: first laying the first part on the bottom of the grinder, and then adding the 12 medicinal material powders, grinding for 10 minutes, and then adding the second part, and the second part is added three times, each time with an interval of 10 minutes, and after grinding, passing through a 100-mesh sieve.

[0022] Preferably, in step 5, the mixing time in the mixer is 35 minutes.

[0023] Preferably, in step 6, the medicinal powder and purified water are mixed in a weight ratio of 1:0.7.

[0024] Preferably, in step 6, the pill making machine is an automatic double-bar pill making machine, and the parameters of the pill making machine are: the nozzle number is Φ10.2mm, the medicine stick number is Φ13.5mm, the pill making machine mold specification is Φ12mm, and the gap between the two roller molds shall not be less than 0.3mm.

[0025] Preferably, in step 6, during the pelletizing operation, the strip making speed is controlled at 16-22 r / min, the rubbing roller speed is controlled at 20-25 r / min, and the strip cutting speed is controlled at 350-580 r / min.

[0026] Preferably, in step 6, the screening is performed using a horizontal pill selecting machine with a screen drum specification of Φ12-13-14 mm. The wet pills that pass through the Φ14 mm sieve hole are standard wet pills, while the wet pills that do not meet the standards are put back into the pellet making machine silo for pill making operation.

[0027] Preferably, in step 6, the drying process is carried out using a vacuum drying device at a set temperature of 40° C., and the moisture limit of the pills is checked by a rapid moisture meter to be between 3.0% and 9.0%.

[0028] Preferably, in step 6, the drying is to air-dry the coated and polished pills until the moisture limit of the pills is between 3.0 and 9.0%.

[0029] Preferably, in step 6, the pills are selected by using a horizontal pill selecting machine with a sieve cylinder specification of Φ11-12-13 mm, and the pills passing through the sieve hole of 13 mm are standard vegetarian pills.

[0030] The beneficial effects of the present invention are:

[0031] 1. The present invention specifically designs a new preparation method for the existing Tibetan medicine "Coral Seventy Flavor Pills", and designs the semi-manual sugar-coating machine to make pills automatically, which more than doubles the production efficiency; realizes standardized control of the production process, and can continuously and stably produce products that meet the quality standards by determining the process parameters; and improves the hygienic control quality of the production process.

[0032] 2. The pills prepared by the present invention have a looser texture, which can accelerate drug dissolution and improve drug solubility; improve the appearance quality of the pills, make the pills more uniform and complete, and reduce the problem of pill weight difference; effectively shorten the drying time and reduce the risk of loss of effective ingredients; and are convenient to take, without the need to crush the pills before taking.

[0033] 3. According to the pill dissolution time comparison experiment, the pills made by the current sugar coating machine water-flooded pill preparation process have a dissolution time of more than 3 hours. Therefore, the pills can only be crushed before taking. The pills made by the newly designed preparation method will dissolve completely within 1 hour, which is much better than the sugar coating machine water-flooded pill preparation process and is also convenient for taking. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] The present invention is further described using the accompanying drawings, but the embodiments in the accompanying drawings do not constitute any limitation to the present invention. A person skilled in the art can obtain other drawings based on the following drawings without creative work.

[0035] Figure 1 It is a process flow chart of the Tibetan medicine pellets prepared according to the embodiment of the present invention. DETAILED DESCRIPTION

[0036] The technical solution of the present invention is described below through specific examples. It should be understood that the one or more method steps mentioned in the present invention do not exclude the existence of other method steps before and after the combination step or the insertion of other method steps between these explicitly mentioned steps; it should also be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of the present invention. Moreover, unless otherwise specified, the numbering of each method step is only a convenient tool for identifying each method step, and is not intended to limit the order of arrangement of each method step or to limit the scope of the present invention. The change or adjustment of the relative relationship thereof shall also be regarded as the scope of the present invention without substantially changing the technical content.

[0037] In order to better understand the above technical scheme, the exemplary embodiments of the present invention are described in more detail below. Although exemplary embodiments of the present invention are shown, it should be understood that the present invention can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided in order to enable a more thorough understanding of the present invention and to enable the scope of the present invention to be fully communicated to those skilled in the art.

[0038] The present invention will be further described below in conjunction with the following examples.

[0039] Example

[0040] A method for preparing Tibetan medicine pellets comprises the following steps:

[0041] Step 1: The 75 medicinal ingredients of the Tibetan medicine "Coral Seventy Flavor Pills" include:

[0042] Coral, pearl, agate, magnet, calamine (Gangdi), dragon bone, brain stone, amber, cinnabar, musk (artificial), bezoar (in vitro cultured bezoar), saffron, bear bile powder, safflower, clove, mother of pearl, gastrodia, nutmeg, Tibetan aster, agarwood, black sesame, Indian deer sprout (dida), daisy, myrobalan, hairy myrobalan, costus root, ginseng (red ginseng), Tibetan calamus, Bangna (Gongbu Aconitum), Tibetan madder, cardamom, Tibetan lithospermum, red sandalwood, sunflower seed, cassia seed, frankincense (Puga), Ba Xia Ga, sea gold sand, licorice paste, crystal sugar, sword bean, crab shell, gentian, multi-spined meconopsis, qinjiao flower, Tibetan wood fragrance, wide tendon vine, hook wood, galangal, emblica, capsule-spurred delphinium, drynaria, asparagus, polygonatum, Ganqingqinglan, travertine, cold water stone, rhodiola rosea, ligado, honey, winter mallow fruit, sweet pine, short-spiked rabbit ear grass (Zhi Dasazeng), pine, etc., berberis bark, grass fruit, angelica, Tibetan codonopsis, snow lotus, cinnamon, yak blood, peach kernel, pine seed, gourd, stone wolfberry (reticulated stone wolfberry).

[0043] Step 2: Process the 75 prescription herbs separately except coral, pearl, agate, magnet, calamine (Gangdi), dragon bone, brain stone, amber, cinnabar, and bangna (Gongbu Wutou), and grind the rest into powder with a fineness of more than 200 mesh. The rest except musk (artificial), bezoar (in vitro cultured bezoar), saffron, and bear bile powder are purified separately.

[0044] Step 3: In addition to the coral, pearl, agate, magnet, calamine (Gangdi), dragon bone, brain stone, amber, cinnabar, musk (artificial), bezoar (in vitro cultured bezoar), saffron, bear bile powder, safflower and two cloves in the prescription, the rest of the mother of pearl, gastrodia, nutmeg, Tibetan aster, agarwood, black sesame, Indian deer sprouts (dida), daisy, terminalia chebula, hairy terminalia chebula, costus root, ginseng (red ginseng), Tibetan calamus, Bangna (Gongbu Aconitum), Tibetan madder, cardamom, Tibetan lithospermum, red sandalwood, sunflower seed, cassia seed, frankincense (Puga), Bashaga, sea gold sand, licorice paste, Rock sugar, sword bean, crab shell, gentian, multi-spined meconopsis, qinjiao flower, Tibetan wood fragrance, wide tendon vine, Rubus, galangal, emblica, delphinium, drynaria, asparagus, polygonatum, Ganqingqinglan, travertine, cold water stone, rhodiola, legadu, honey, winter mallow fruit, sweet pintail, short-spiked rabbit ear grass (Zhidasazeng), pine, berberis bark, grass fruit, angelica, Tibetan codonopsis, snow lotus, cinnamon, yak blood, peach kernel, pine seed, bottle gourd, pyrrosia (net-shaped pyrrosia) 60 kinds of pure medicinal materials are weighed and mixed according to the mass ratio, and crushed into fine powder together, sieved, and the grinding fineness should reach 80 mesh or more.

[0045] Step 4: The powder after crushing and sieving is sterilized in a multifunctional Chinese medicine sterilizing cabinet at a set temperature of 100-105°C for 30 minutes. Weigh 60 sterilized medicinal materials powders (6.25 kg), take 250 g and spread them on the bottom of the mortar grinder, then add weighed coral, pearl, agate, magnet, Gangdi (calamine), dragon bone, brain stone, amber, musk (artificial), bezoar (in vitro cultured bezoar), saffron, bear bile powder 12 medicinal materials powders and grind for 10 minutes, the remaining 6.00 kg of powder is divided into three times and added to the mortar grinder successively, each grinding time is 10 minutes, a total of four grinding times, the time is 40 minutes. The ground powder is sieved with a 100-mesh screen, and all should pass through the 100-mesh screen.

[0046] Step 5: Put the sterilized 60 kinds of medicinal material powders, the ground 12 kinds of medicinal material powders, and the purified cloves (powder) and safflower (powder) into a mixer and mix for 35 minutes.

[0047] Step 6: Preparation

[0048] 6.1 Preparation of soft material: Use a blender to mix the powder with purified water at a ratio of 1:0.70 to make the soft material.

[0049] 6.2 Refining: Start the medicine refining machine and put the prepared soft materials into the material bin of the medicine refining machine in turn for refining operation until the extruded medicine strips reach the quality requirements of appropriate hardness and smooth and uniform surface.

[0050] 6.3 Pellet making

[0051] 6.3.1 When using an automatic double-strip pill-making machine with a nozzle size of Φ10.2mm, a medicine stick size of Φ13.5mm, and a pill-making machine mold size of Φ12mm for pill-making operations, first adjust the gap between the two roller dies of the pill-making machine and align the tooth tips. The gap between the two roller dies must not be less than 0.3mm. Pay special attention that the two roller dies cannot be squeezed to death, otherwise the equipment will be damaged. The tooth tips between the two rollers must be aligned and the gap must be adjusted, otherwise the surface smoothness of the pills will be affected. Check the tightness of the strip conveyor belt. If it is loose, turn the tensioning screw, then pinch the belt by hand. It is appropriate to feel elastic. If it is too tight, the cutting wire is easy to break, and if it is too loose, the belt is easy to slip. If the strip conveyor belt deviates, tighten the screw on the deviated side until it is adjusted. Adjust the strip cutting knife to the appropriate position.

[0052] 6.3.2 After the equipment is adjusted to normal working state, the strip making speed, roller speed and strip cutting speed are strictly controlled within the following parameter range: the strip making speed is controlled at 16-22r / min, the roller speed is controlled at 20-25r / min, and the strip cutting speed is controlled at 350-580r / min. The qualified medicine balls are put into the pellet making machine silo in turn for pellet making operation.

[0053] 6.3.3 The wet pills are screened by a horizontal pill-selecting machine with a screen drum specification of Φ12-13-14mm. The wet pills that pass through the Φ14mm sieve hole are standard wet pills, while the wet pills that do not meet the standards are put back into the pellet-making machine silo for pill-making operation.

[0054] 6.3.4 The qualified wet pills screened out shall be passed through a sugar coating machine and added with an appropriate amount of purified water for pill-shaping operation to ensure that the pills meet the quality requirements of smoothness, roundness and uniformity.

[0055] 6.3.5 Wet Pellets Drying

[0056] According to the characteristics of the medicinal ingredients contained in this product, low-temperature drying should be used. Therefore, vacuum drying equipment is used to dry the pills at a set temperature of 40°C. If the moisture limit of the pills is between 3.0% and 9.0% after checking with a rapid moisture meter, it can be considered to meet the drying standard requirements.

[0057] 6.3.6 Coating and polishing: Key points for using a sugar coater for coating and polishing: After drying and screening, qualified pills are coated and polished in batches according to the capacity of the sugar coater. First, turn on the sugar coater and add pills. The amount of pills added must not exceed the maximum capacity of the sugar coater. While the sugar coater is running, spray purified water evenly inside to make the pills evenly moist. Then, according to the weight of qualified pills put into the sugar coater, evenly sprinkle the cinnabar powder in the prescription into it; turn on the warm air of the sugar coater and let the sugar coater rotate until the pills reach the requirements of roundness, smoothness and uniform color.

[0058] 6.3.7 Drying: The coated and polished pills are considered to have met the drying standard if they are air-dried until the moisture content is between 3.0% and 9.0%.

[0059] 6.3.8 Pill selection: Use a horizontal pill selection machine with a sieve size of Φ11-12-13mm to select pills. Pills that pass through a sieve hole of 13mm are standard pills.

[0060] Experimental test and description:

[0061] 1. Comparative data on production efficiency

[0062] The current process for preparing water-coated pills with a sugar coating machine is to go through the steps of demoulding and pilling, and then manually add powder and preparation water repeatedly to make the pills larger. It takes more than 16 hours to complete one batch of pills, but the newly designed preparation method can be completed in just 6 hours.

[0063] 2. Improve the sanitary quality of products

[0064] Minimizing the risks of contamination, cross-contamination, confusion, and errors in the drug production process is the core content of drug production quality management, and the human body is the biggest source of pollution in drug production. The current sugar coating machine water-flooded pill preparation process is achieved by repeatedly adding drug powder and preparation water manually, while the newly designed preparation method is completed through the process steps of making soft materials, refining, pilling, and pilling. The intermediate links are all completed by equipment. As long as the equipment is cleaned in place, there is no direct contact with the human body in the production process, reducing the risk of human pollution.

[0065] 3. Achieve standardized control of production processes

[0066] The current sugar coating machine water-flooded pill preparation process is achieved by repeatedly adding powder and preparation water to increase the volume. The process parameters cannot be determined by the powder and preparation water added by different operators each time, and are completely determined by the operator's experience. Therefore, the moisture content of each batch is different, and the drying time is different. With the newly designed preparation method, the ratio of powder to purified water in the preparation of soft materials, the number of times of refining in the refining process, the specifications of the nozzle and the medicine stick, the mold specifications of the pill making process, the sieve cylinder of the wet pill screening machine and the standard wet pill specifications can all be determined by process parameters, avoiding the drawbacks of the traditional process that can only rely on human experience, and realizing the standardized control requirements of the preparation operation that everyone can achieve by operating according to the process regulations.

[0067] 4. Improving drug dissolution

[0068] In the current sugar coating machine water-flooded pill preparation process, during the process of repeatedly adding drug powder and preparation water to continuously increase the size of the pill, the pill rotates in the sugar coating machine for a long time, making the pill harder and harder during the rotation process, and the final disintegration time is difficult to meet the standard requirements. However, with the newly designed preparation method, the medicine strip can be formed once it is out of the die, avoiding the long-term rotation of the pill in the sugar coating machine, making the pill looser. According to the pill dissolution time comparison experiment, the pill dissolution time of the pill made by the current sugar coating machine water-flooded pill preparation process exceeds 3 hours. Therefore, when taking it, the pill can only be crushed before taking it. The pills made by the newly designed preparation method are completely dissolved within 1 hour, which is much better than the sugar coating machine water-flooded pill preparation process and is also convenient for taking.

[0069] 5. Improve the measurement indicators

[0070] Under the same set temperature conditions, the pills produced by the current sugar coating machine water-flooded pill preparation process need 40 to 60 hours to reach the drying standard. Due to the long drying time, it is very easy to cause the loss of easily oxidized and volatile components. The pills produced by the newly designed preparation method only need 20 to 25 hours to reach the drying standard, and the drying time is shortened by more than 1 times, which not only improves production efficiency and achieves energy saving, but more importantly, according to the comparison of the test results based on the content measurement index, the pills produced by the newly designed preparation method have a content measurement index higher than that of the pills produced by the current sugar coating machine water-flooded pill preparation process by more than 10%.

[0071] 6. Reducing the difference in pill weight

[0072] The pills currently produced by the sugar coating machine water-flooded pill preparation process adopt a newly designed preparation method. The entire preparation process can be determined by process parameters, realizing standardized control of the entire process. The produced pills are formed in one time according to the designed mold, and the appearance of the pills is more uniform and complete, reducing the rate of pill weight differences.

[0073] 7. Convenient to take

[0074] The existing pills made by the sugar coating machine water-flooded pill preparation process are hard and have a long disintegration time. When taking the pills, they must be crushed into fine powder or soaked in water before taking them. The pills made by the newly designed preparation method have a loose texture, a short disintegration time, and a small size. When taking the pills, there is no need to crush the pills into fine powder or soak them in water first. The pills can be swallowed directly, which is convenient for patients to take the medicine.

[0075] Table 1 Test results of finished drug products

[0076]

[0077] It can be seen from Table 1 that the moisture content of the pills obtained in the embodiment of the present invention is lower and the dissolution time meets the requirements of the standard, while the dissolution time of the traditional pills is too long and the effect is slow, and they need to be crushed before taking.

[0078] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms should not be understood as necessarily being directed to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine different embodiments or examples described in this specification.

[0079] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A method for preparing Tibetan medicine pellets, characterized in that: The following steps are involved: Step 1, weighing medicinal materials: weighing a total of 75 medicinal materials according to the formula of the Tibetan medicine "Coral Seventy Flavor Pills"; Step 2, pre-treatment: among the weighed medicinal materials, except coral, pearl, agate, magnet, calamine, dragon bone, brain stone, amber, cinnabar, and bangna, respectively, process and treat them; grind the medicinal materials except bangna into powder; and purify and treat the medicinal materials except musk, bezoar, saffron, and bear bile powder; Step 3, first grinding: weigh and mix the remaining 60 kinds of pure medicinal materials except coral, pearl, agate, magnet, calamine, dragon bone, brain stone, amber, cinnabar, musk, bezoar, saffron, bear bile powder, safflower and clove according to the mass ratio, grind them into fine powder together, sieve them, and obtain the mixed powder of 60 kinds of pure medicinal materials; Step 4, grinding for the second time: sterilize the mixed powder of 60 kinds of clean medicinal materials after crushing and sieving in step 3, weigh the sterilized fine powder of 60 kinds of medicinal materials and mix them with fine powder of 12 kinds of medicinal materials including coral, pearl, agate, magnet, calamine, dragon bone, brain stone, amber, musk, bezoar, saffron and bear bile powder, and grind them, then sieve them to obtain the mixed powder of 72 kinds of clean medicinal materials; Step 5, mixing: putting the 72 kinds of clean medicinal materials mixed powder and the cleaned cloves and safflower into a mixer for mixing; Step 6, preparation: Mix the drug powder with purified water to form a soft material, then refine it in a medicine refining machine, and then use a pill making machine to make and screen the pills. After drying and coating, add cinnabar powder during the coating process, and then dry and select the pills to obtain the desired pill preparation.

2. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In step 1, the seventy-five medicinal materials include: Coral, pearl, agate, magnet, calamine, keel, brain stone, amber, cinnabar, musk, bezoar, saffron, bear bile powder, safflower, clove, mother of pearl, gastrodia, nutmeg, Tibetan aster, agarwood, black sesame, Indian deer sprout, arrow chrysanthemum, myrobalan, hairy myrobalan, costus root, ginseng, Tibetan calamus, bangna, Tibetan madder, cardamom, Tibetan lithospermum, red sandalwood, sunflower seed, cassia seed, frankincense, Bashaga, sea gold sand, licorice paste, Rock sugar, sword bean, crab shell, gentian, spiny meconopsis, qinjiao flower, Tibetan wood fragrance, wide tendon vine, hook wood, galangal, emblica, delphinium, drynaria, asparagus, polygonatum, Ganqingqinglan, travertine, cold water stone, rhodiola rosea, ligado, honey, winter mallow fruit, sweet pine, short-spiked rabbit ear grass, pine, etc., berberis bark, grass fruit, angelica, Tibetan codonopsis, snow lotus, cinnamon, yak blood, peach kernel, pine seed, gourd, pyrrosia.

3. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In the step 2, the medicinal materials except for Bangna (Gongbu Aconitum) are ground into powder with a fineness of more than 200 meshes; in the step 3, the fineness of the fine powder is more than 80 meshes.

4. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In step 4, the sterilized 60 medicinal materials are ground into fine powder and divided into two parts, and the mass ratio of the first part to the second part is 0.25:6; The specific grinding process includes: first spreading the first part on the bottom of the grinder, then adding 12 kinds of medicinal material powder, grinding for 10 minutes, adding the second part, and the second part is added three times, each time with an interval of 10 minutes, and after grinding, passing through a 100-mesh sieve.

5. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In step 6, the drug powder and purified water are mixed in a weight ratio of 1:0.

7.

6. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In step 6, during the pill making operation, the strip making speed is controlled at 16-22 r / min, the rubbing roller speed is controlled at 20-25 r / min, and the strip cutting speed is controlled at 350-580 r / min.

7. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In step 6, the screening is performed using a horizontal pill selecting machine with a screen drum specification of Φ12-13-14 mm. The wet pills that pass through the Φ14 mm sieve hole are standard wet pills, while the wet pills that do not meet the standards are put back into the pill making machine silo for pill making operation.

8. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In step 6, the drying process is performed using a vacuum drying device at a set temperature of 40° C. The moisture limit of the pills is checked by a rapid moisture meter and is between 3.0% and 9.0%.

9. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In step 6, air drying is to air dry the coated and polished pills until the moisture limit of the pills is between 3.0 and 9.0%.

10. The method for preparing Tibetan medicine pellets according to claim 1, characterized in that: In step 6, the pills are selected by using a horizontal pill selecting machine with a sieve cylinder specification of Φ11-12-13mm, and the pills passing through the sieve hole of 13mm are standard vegetarian pills.

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