Nutritional composition for promoting health of bones and joints as well as application and preparation method of nutritional composition

Abstract

The invention discloses a nutritional composition for promoting health of bones and joints as well as application and a preparation method of the nutritional composition. The composition comprises the following raw materials: bovine bone collagen peptide, L-calcium lactate, chondropeptide, yak bone marrow peptide, ginseng oligopeptide, a rehmannia extract, a cistanche extract, a fructus alpiniae oxyphyllae extract, a raspberry extract, a dogwood extract, a folium cortex eucommiae extract, a fructus lycii extract, a Chinese yam extract, angelica oligopeptide, dendrobium officinale peptide and vitamin D. The fructus lycii extract adopts fructus lycii peptide, the rhizoma dioscoreae extract adopts rhizoma dioscoreae peptide, and the radix rehmanniae extract adopts radix rehmanniae preparata extract. The invention also provides application and a preparation method of the composition. The nutritional composition disclosed by the invention can improve osteoporosis, repair joint protective membranes, promote cartilage regeneration and supplement body nutrition, and provides an effective nutritional food formula for meeting physiological metabolism states and athletic abilities of middle-aged and elderly people and sports people and meeting special requirements on certain nutritional ingredients.

Description

Technical Field

[0001] The present invention relates to a nutritional composition in the field of nutritional food having the effect of promoting the health of bones and joints, its use and a preparation method, and in particular to a nutritional composition for promoting the health of bones and joints, its use and a preparation method. Background Art

[0002] Bones are hard organs that make up the skeleton of vertebrates. Their functions are to move, support and protect the body; to produce red and white blood cells; and to store minerals. Bones are made up of various shapes and have complex internal and external structures, which allow bones to remain hard while reducing weight. One of the components of bones is mineralized bone tissue, which has a hard honeycomb-like three-dimensional structure inside; other tissues include bone marrow, periosteum, nerves, blood vessels and cartilage. The human skeleton plays a role in supporting the body and is part of the human movement system.

[0003] There are many types of bone diseases, but the most common ones are osteoporosis, osteoarthritis, and lumbar disc herniation. Osteoporosis is a metabolic bone disease that causes decreased bone strength and increased fracture risk. It causes multiple complications such as osteoporotic fractures, which seriously threaten people's health. Osteoporosis is a common and frequently occurring disease among middle-aged and elderly people. It is a systemic bone disease characterized by decreased bone mass and damage to bone microstructure, which leads to increased bone brittleness and susceptibility to fractures. It is common in postmenopausal women and middle-aged and elderly people.

[0004] Various bone and joint diseases that middle-aged and elderly people are prone to, such as arthritis, bursitis, synovitis, cervical spondylosis, lumbar spondylosis, frozen shoulder, bone hyperplasia, rheumatoid arthritis, femoral head necrosis, osteoporosis, etc., have a great impact on the patients' lives. Severe cases can cause fractures, joint deformities, paralysis and other consequences. This result causes great physical and mental torture to people and also brings a lot of pain to the patients' families.

[0005] Osteoarthritis (OA), also known as degenerative bone and joint disease, is the most common joint disease, especially harmful to the health of the elderly and a heavy burden on society. The prevalence of radiographic OA in people over 65 years old can reach more than 50%, and in people over 75 years old, this figure can reach about 80%. With the acceleration of population aging in the world and my country, OA has become a hot topic of concern to doctors, patients and even society.

[0006] Traditional Chinese medicine believes that osteoarthritis is caused by deficiency of the liver and kidneys, the invasion of wind, cold and dampness into the tendons and bones, and the accumulation of phlegm, dampness and blood in the joints, which then cause pain. It is a combination of deficiency of the underlying cause and excess of the superficial cause, so the treatment should focus on tonifying the liver and kidneys, eliminating rheumatism, and replenishing qi and blood.

[0007] Although the diet of normal people can ensure that it contains rich nutrients such as protein, fat, vitamins, minerals, etc. through reasonable allocation, it is difficult for the middle-aged and elderly people and those who exercise to meet the needs of bone growth and joint repair.

[0008] Therefore, special nutritional foods are prepared to meet the special nutritional needs of bones and joints of middle-aged and elderly people and those who exercise, which is more conducive to promoting the recovery of bone and joint diseases. Summary of the invention

[0009] The purpose of the present invention is to provide a nutritional composition having the effect of promoting the health of bones and bone joints, as well as its use and preparation method. The composition can solve existing problems and is used to improve osteoporosis, repair joint protective membranes, promote cartilage regeneration, supplement body nutrition, etc.

[0010] In order to achieve the above-mentioned purpose, the present invention provides a nutritional composition for promoting bone and joint health, wherein the raw materials of the composition include: bovine collagen peptide, L-calcium lactate, chondroitin, yak bone marrow extract, ginseng extract, rehmannia extract, Cistanche extract, Alpinia oxyphylla extract, raspberry extract, Cornus officinalis extract, Eucommia leaf extract, Lycium barbarum extract, yam extract, angelica extract, Dendrobium officinale extract, and vitamin D.

[0011] The above-mentioned nutritional composition for promoting bone and joint health, wherein the raw materials of the composition are yak bone marrow extract using yak bone marrow peptide, ginseng extract using ginseng oligopeptide, wolfberry extract using wolfberry peptide, yam extract using yam peptide, angelica extract using angelica oligopeptide, Dendrobium officinale extract using Dendrobium officinale peptide, and Rehmannia glutinosa extract using Rehmannia glutinosa extract.

[0012] The above-mentioned nutritional composition for promoting bone and joint health, wherein the raw materials of the composition, by weight, include: 10-50 parts of bovine collagen peptide, 5-40 parts of yak bone marrow peptide, 5-40 parts of cartilage peptide, 5-30 parts of ginseng oligopeptide, 3-20 parts of wolfberry peptide, 3-20 parts of yam peptide, 2-15 parts of angelica oligopeptide, and 2-15 parts of Dendrobium officinale peptide.

[0013] The above-mentioned nutritional composition for promoting bone and joint health, wherein the molecular weight of each component of the raw materials of the composition ranges from 500 to 1000 Da.

[0014] The above-mentioned nutritional composition for promoting bone and joint health, wherein the raw materials of the composition, by weight, also include: 5-30 parts of Rehmannia glutinosa extract, 5-30 parts of Cistanche deserticola extract, 5-30 parts of Alpinia oxyphylla extract, 5-30 parts of Rubus idaeus extract, 3-20 parts of Cornus officinalis extract, and 3-20 parts of Eucommia ulmoides leaf extract.

[0015] The above-mentioned nutritional composition for promoting bone and joint health, wherein the raw materials of the composition, by weight, further comprise: 5 to 50 parts of L-calcium lactate; the calcium content of the L-calcium lactate, by mass percentage, is 15 to 40%.

[0016] The above-mentioned nutritional composition for promoting bone and joint health, wherein the raw materials of the composition further include: 0.05 to 1 part of vitamin D by weight.

[0017] The present invention also provides a use of the above-mentioned nutritional composition for promoting bone and joint health, wherein the composition is used to prepare edible nutritional products.

[0018] The present invention also provides a method for preparing the above-mentioned nutritional product, wherein the method is as follows: weigh each raw material in proportion, then grind each raw material into powder and sieve it, then mix the components with similar weight ratios into several groups, and then add each group of mixtures into a three-dimensional motion mixer in order from small to large weight ratio to mix all the raw materials evenly, and then use an automatic packaging machine to pack the mixed materials into bags, seal them, and store them for future use after disinfection and sterilization.

[0019] The preparation method of the above-mentioned nutritional product further comprises: adding the mixed materials to auxiliary materials, mixing them evenly, and then making them into several dosage forms including powders, tablets, pills, granules or capsules.

[0020] The nutritional composition for promoting bone and joint health, its use and preparation method provided by the present invention have the following advantages:

[0021] The present invention targets the physiological characteristics of bone and joint diseases, nutritional requirements and the deficiencies of conventional diets, adopts a health concept that combines nutrition science with traditional Chinese medicine theory, uses nutritional supplements, new resource raw materials and nutritional ingredients that are both medicinal and edible, and is made in scientific proportions. It can meet the physiological metabolic state, athletic ability and special needs of middle-aged and elderly people and athletes for certain nutrients.

[0022] The main ingredients of the invention have the effects of nourishing qi and blood, nourishing the liver and kidney, consolidating essence and reducing urine, strengthening tendons and bones, and can be used to improve osteoporosis, repair joint protective membranes, promote cartilage regeneration, and supplement body nutrition. In addition, each component mainly adopts small molecule peptides and active extracts with a molecular weight range of 500 to 1000Da, which are easily absorbed by the human body, and its effect is better than the existing technology and traditional Chinese medicine. DETAILED DESCRIPTION

[0023] The specific embodiments of the present invention are further described below.

[0024] The nutritional composition for promoting bone and joint health provided by the present invention comprises the following raw materials: bovine collagen peptide, L-calcium lactate, chondroitin, yak bone marrow extract, ginseng extract, rehmannia extract, cistanche extract, alpinia oxyphylla extract, raspberry extract, cornus officinalis extract, eucommia leaf extract, wolfberry fruit extract, yam extract, angelica extract, dendrobium officinale extract and vitamin D.

[0025] Preferably, among the raw materials of the composition, yak bone marrow extract uses yak bone marrow peptide, ginseng extract uses ginseng oligopeptide, wolfberry extract uses wolfberry peptide, yam extract uses yam peptide, angelica extract uses angelica oligopeptide, Dendrobium officinale extract uses Dendrobium officinale peptide, and Rehmannia glutinosa extract uses Rehmannia glutinosa extract.

[0026] The raw materials of the composition include, by weight: 10 to 50 parts of bovine collagen peptide, 5 to 40 parts of yak bone marrow peptide, 5 to 40 parts of cartilage peptide, 5 to 30 parts of ginseng oligopeptide, 3 to 20 parts of wolfberry peptide, 3 to 20 parts of yam peptide, 2 to 15 parts of angelica oligopeptide, and 2 to 15 parts of dendrobium officinale peptide.

[0027] The molecular weight of each component in the raw materials of the composition is in the range of 500 to 1000 Da.

[0028] The raw materials of the composition further include, by weight: 5-30 parts of Rehmannia glutinosa extract, 5-30 parts of Cistanche deserticola extract, 5-30 parts of Alpinia oxyphylla extract, 5-30 parts of Rubus idaeus extract, 3-20 parts of Cornus officinalis extract, and 3-20 parts of Eucommia ulmoides leaf extract.

[0029] The raw materials of the composition further comprise, by weight: 5 to 50 parts of L-calcium lactate; by weight percentage, the calcium content of the L-calcium lactate is 15 to 40%.

[0030] The raw materials of the composition further include: 0.05 to 1 part of vitamin D by weight.

[0031] In the nutritional composition, new resources and food with medicinal and edible properties are used as raw materials, and effective active ingredients are extracted through modern preparation methods such as enzymatic hydrolysis, microbial fermentation, acid hydrolysis, alkaline extraction and enzymatic extraction, and the molecular weight range is between 500 and 1000 Da.

[0032] The various nutritional supplements used in the present invention, including calcium lactate and vitamins, as well as new resource raw material ingredients, have the following effects:

[0033] 1. Bovine collagen peptide: Bovine collagen peptide is a physiologically active substance prepared by enzymatic hydrolysis, separation and purification of bovine bones. Its main component is bovine collagen. It has the functions of increasing bone density, nourishing joint cartilage, promoting wound healing, improving skin elasticity, and relieving fatigue.

[0034] 2. Yak bone marrow peptide: Yak bone marrow peptide is a bioactive peptide made from fresh yak bone marrow through processes such as crushing, sterilization, bio-enzymatic hydrolysis, enzyme inactivation, purification, concentration, centrifugal spray drying, etc. Modern analysis shows that yak bones contain calcium, copper, zinc and other elements as well as bone gelatin peptides, polysaccharides, etc. The content of components that promote bone development and bone wound healing is higher than that of general herbivorous animal bones. Yak bone marrow peptide powder has a significant therapeutic effect on degenerative knee arthritis and can effectively relieve patients' clinical symptoms such as joint pain, swelling, and limited function.

[0035] 3. Chondroitin: Chondroitin is a small molecule active peptide component extracted from animal articular cartilage. It can promote chondrocyte proliferation and differentiation by stimulating extracellular matrix synthesis and inhibiting collagenase activity, thereby promoting the repair and regeneration of cartilage damage. It is suitable for joint dysfunction caused by cartilage damage; it can increase the amount of synovial fluid and improve its viscosity, reduce joint friction and wear, and achieve a lubricating effect. It has a better effect on patients with joint effusion or dryness symptoms.

[0036] 4. L-Calcium lactate: L-calcium lactate has better biological activity and solubility, can be directly absorbed by the human body, does not consume gastric acid, and therefore does not cause stomach discomfort or indigestion. It is suitable for the relief and prevention of various calcium deficiency symptoms. It is often used for osteoporosis, tetany, bone dysplasia, rickets, and calcium supplementation for children, pregnant and lactating women, menopausal women, and the elderly.

[0037] 5. Vitamin D: The present invention mainly refers to vitamin D3, which is a bone nutrient. Its main function is to promote the intestinal absorption of calcium and phosphorus, enhance their deposition in bones, and maintain the normal growth and development of bones. It can strengthen bones and mainly prevent vitamin D deficiency rickets and osteoporosis.

[0038] The nutritional composition of the present invention also uses food with medicinal and edible properties as raw materials, and extracts its effective active ingredients through steam distillation, immersion, percolation, decoction, reflux and other methods or modern preparation methods such as semi-bionic extraction, dynamic countercurrent extraction or supercritical extraction.

[0039] The main ingredients of the nutritious composition, which are both medicinal and edible, are modified according to the formula of "Dabuyuan Decoction" recorded in "Jingyue Complete Book", which has the effects of invigorating qi and nourishing blood, and nourishing the liver and kidneys. The specific ingredients and effects are:

[0040] 1. Ginseng: It has the effects of replenishing vital energy, restoring pulse and strengthening deficiency, nourishing spleen and lungs, promoting body fluid and nourishing blood, calming the mind and improving intelligence.

[0041] 2. Rehmannia root: nourishes yin and replenishes blood.

[0042] 3. Cistanche deserticola: It has the effects of nourishing kidney yang, replenishing essence and marrow, and moistening the intestines and promoting bowel movements.

[0043] 4. Alpinia oxyphylla: It has the effects of warming the spleen, stopping diarrhea, stimulating salivation, warming the kidneys, reducing urine and consolidating semen.

[0044] 5. Raspberry: It has the effects of benefiting the kidney, consolidating essence, reducing urine, nourishing the liver and improving eyesight.

[0045] 6. Wolfberry: It has the effect of nourishing the liver and kidneys, improving intelligence and vision.

[0046] 7. Yam: It has the effects of nourishing the kidneys, strengthening the stomach and resolving phlegm, replenishing the middle and replenishing qi, dispelling cold wind, calming the mind, and growing muscles and marrow.

[0047] 8. Eucommia leaves: nourish the liver and kidneys, strengthen the tendons and bones.

[0048] 9. Cornus officinalis: It has the effect of nourishing the liver and kidneys, astringing and strengthening the lungs.

[0049] 10. Angelica: It has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and promoting bowel movements.

[0050] 11. Dendrobium officinale: It has the effects of benefiting the stomach, promoting salivation, nourishing yin and clearing away heat.

[0051] Modern research shows that polypeptides extracted and prepared from certain plants have a wide range of pharmacological activities and functions such as analgesia, anti-inflammation, anti-tumor, anti-coagulation, anti-oxidation and anti-aging, and have great development and application potential in the field of health care products. The specific ingredients used in the present invention include:

[0052] Ginseng oligopeptide is a bioactive peptide extracted from ginseng, which has multiple physiological activities, including anti-fatigue, anti-aging, and immunity enhancement.

[0053] Lycium barbarum peptide is a bioactive peptide refined from wolfberry fruit. Its main functions and effects generally include protecting the liver and kidneys, anti-fatigue, anti-oxidation, anti-inflammation, and immune regulation.

[0054] Yam peptide is a small molecule active peptide derived from yam, which has the functions and effects of regulating blood sugar, nourishing the kidney and stomach, enhancing immunity, anti-oxidation, anti-aging, and improving sleep.

[0055] Angelica oligopeptide is an angelica extract with protein functional properties, which is hydrolyzed by biotechnology into water-soluble small molecule fragments composed of 2 to 10 amino acids. It has antioxidant and anti-aging effects.

[0056] Dendrobium officinale peptide is a small molecule oligopeptide with a relative molecular weight of 500-800 Daltons obtained by enzymatic hydrolysis of Dendrobium officinale with food-grade protease. Its main effects include improving immunity, anti-oxidation, anti-fatigue and improving gastrointestinal function.

[0057] The extracts and peptides in each raw material are all derived from natural Chinese herbal medicines. If they are derived from wild rare animals and plants, if conditions do not permit, materials derived from artificial breeding and planting, or other substitutes with equivalent or similar effects may be used.

[0058] The invention also provides the use of the nutritional composition for promoting bone and joint health, wherein the composition is used for preparing edible nutritional products.

[0059] The present invention also provides a preparation method of the nutritional product, which comprises the following steps: weighing each raw material in proportion, grinding each raw material into powder and sieving, mixing components with similar weight ratios into several groups, and then sequentially adding each group of mixtures into a three-dimensional motion mixer in increasing weight ratios to mix all the raw materials evenly, and then using an automatic packaging machine to pack the mixed materials into bags, seal the bags, and sterilize the bags for storage for future use.

[0060] The three-dimensional motion mixer is a type of mixer. It is used for high-uniform mixing of powdered and granular materials in the pharmaceutical, chemical, food, light industry, electronics, machinery, mining and metallurgy, national defense industry and scientific research units.

[0061] Automatic packaging machines are mainly used for automatic packaging of materials in the food, medicine, chemical and other industries and plant seeds. The materials can be in the form of granules, tablets, liquids, powders, pastes, etc. Automatic packaging machines have the functions of automatically completing metering, filling, bag making, sealing, cutting, conveying, printing production batch numbers, adding easy-to-cut edges, no-material warning, stirring, etc.

[0062] Preferably, the method further comprises: adding appropriate auxiliary materials to the mixed materials, mixing them evenly, and then preparing them into several dosage forms including powders, tablets, pills, granules or capsules.

[0063] The nutritional composition for promoting bone and joint health, its use and preparation method provided by the present invention are further described below in conjunction with the embodiments.

[0064] Example 1

[0065] A nutritional composition for promoting bone and joint health, the raw materials of the composition comprising: bovine collagen peptide, L-calcium lactate, chondroitin, yak bone marrow extract, ginseng extract, rehmannia extract, cistanche extract, alpinia oxyphylla extract, raspberry extract, cornus officinalis extract, eucommia leaf extract, wolfberry extract, yam extract, angelica extract, dendrobium officinale extract, and vitamin D.

[0066] Preferably, among the raw materials of the composition, yak bone marrow extract uses yak bone marrow peptide, ginseng extract uses ginseng oligopeptide, wolfberry extract uses wolfberry peptide, yam extract uses yam peptide, angelica extract uses angelica oligopeptide, Dendrobium officinale extract uses Dendrobium officinale peptide, and Rehmannia glutinosa extract uses Rehmannia glutinosa extract.

[0067] More preferably, the raw materials of the composition include, by weight: 10 parts of bovine collagen peptide, 5 parts of yak bone marrow peptide, 5 parts of cartilage peptide, 5 parts of ginseng oligopeptide, 3 parts of wolfberry peptide, 3 parts of yam peptide, 2 parts of angelica oligopeptide, and 3 parts of dendrobium officinale peptide. The molecular weight of each of the above components ranges from 500 to 1000 Da.

[0068] The raw materials of the composition further include, by weight: 5 parts of Rehmannia glutinosa extract, 5 parts of Cistanche deserticola extract, 5 parts of Alpinia oxyphylla extract, 5 parts of Rubus idaeus extract, 3 parts of Cornus officinalis extract, and 3 parts of Eucommia ulmoides leaf extract; as well as 0.06 parts of vitamin D and 5 parts of L-calcium lactate; the calcium content of the L-calcium lactate is 15-40% by mass percentage.

[0069] This embodiment also provides the use of the nutritional composition for promoting bone and joint health, wherein the composition is used for preparing edible nutritional products.

[0070] This embodiment also provides a method for preparing the nutritional product, which comprises: weighing each raw material in proportion, grinding each raw material into powder and passing through a 120-mesh sieve, mixing components with similar weight ratios into several groups, and then adding each group of mixtures into a three-dimensional motion mixer in order from small to large weight ratio to mix all the raw materials evenly, and then using an automatic packaging machine to pack the mixed materials into bags, seal the bags, and sterilize and store them for later use.

[0071] Preferably, the method further comprises: adding the mixed material to auxiliary materials, mixing evenly, and then making tablets.

[0072] Example 2

[0073] A nutritional composition for promoting bone and joint health, the raw materials of the composition comprising: bovine collagen peptide, L-calcium lactate, chondroitin, yak bone marrow extract, ginseng extract, rehmannia extract, cistanche extract, alpinia oxyphylla extract, raspberry extract, cornus officinalis extract, eucommia leaf extract, wolfberry extract, yam extract, angelica extract, dendrobium officinale extract, and vitamin D.

[0074] Preferably, among the raw materials of the composition, yak bone marrow extract uses yak bone marrow peptide, ginseng extract uses ginseng oligopeptide, wolfberry extract uses wolfberry peptide, yam extract uses yam peptide, angelica extract uses angelica oligopeptide, Dendrobium officinale extract uses Dendrobium officinale peptide, and Rehmannia glutinosa extract uses Rehmannia glutinosa extract.

[0075] More preferably, the raw materials of the composition include, by weight: 50 parts of bovine collagen peptide, 40 parts of yak bone marrow peptide, 40 parts of cartilage peptide, 30 parts of ginseng oligopeptide, 20 parts of wolfberry peptide, 20 parts of yam peptide, 15 parts of angelica oligopeptide, and 15 parts of dendrobium officinale peptide. The molecular weight of each of the above components ranges from 500 to 1000 Da.

[0076] The raw materials of the composition further include, by weight: 30 parts of Rehmannia glutinosa extract, 30 parts of Cistanche deserticola extract, 30 parts of Alpinia oxyphylla extract, 30 parts of Rubus idaeus extract, 20 parts of Cornus officinalis extract, 20 parts of Eucommia ulmoides leaf extract; 1 part of vitamin D, and 50 parts of L-calcium lactate; the calcium content of the L-calcium lactate is 15-40% by mass percentage.

[0077] This embodiment also provides the use of the nutritional composition for promoting bone and joint health, wherein the composition is used for preparing edible nutritional products.

[0078] This embodiment also provides a method for preparing the nutritional product, which comprises: weighing each raw material in proportion, grinding each raw material into powder and passing through a 50-mesh sieve, mixing components with similar weight ratios into several groups, and then adding each group of mixtures into a three-dimensional motion mixer in order from small to large weight ratio to mix all the raw materials evenly, and then using an automatic packaging machine to pack the mixed materials into bags, seal the bags, and sterilize and store them for later use.

[0079] Preferably, the method further comprises: adding the mixed material to auxiliary materials, mixing evenly, and then making into pills.

[0080] Example 3

[0081] A nutritional composition for promoting bone and joint health, the raw materials of the composition comprising: bovine collagen peptide, L-calcium lactate, chondroitin, yak bone marrow extract, ginseng extract, rehmannia extract, cistanche extract, alpinia oxyphylla extract, raspberry extract, cornus officinalis extract, eucommia leaf extract, wolfberry extract, yam extract, angelica extract, dendrobium officinale extract, and vitamin D.

[0082] Preferably, among the raw materials of the composition, yak bone marrow extract uses yak bone marrow peptide, ginseng extract uses ginseng oligopeptide, wolfberry extract uses wolfberry peptide, yam extract uses yam peptide, angelica extract uses angelica oligopeptide, Dendrobium officinale extract uses Dendrobium officinale peptide, and Rehmannia glutinosa extract uses Rehmannia glutinosa extract.

[0083] More preferably, the raw materials of the composition include, by weight: 30 parts of bovine collagen peptide, 15 parts of yak bone marrow peptide, 20 parts of cartilage peptide, 10 parts of ginseng oligopeptide, 12 parts of wolfberry peptide, 8 parts of yam peptide, 6 parts of angelica oligopeptide, and 5 parts of dendrobium officinale peptide. The molecular weight of each of the above components ranges from 500 to 1000 Da.

[0084] The raw materials of the composition further include, by weight: 10 parts of Rehmannia glutinosa extract, 15 parts of Cistanche deserticola extract, 20 parts of Alpinia oxyphylla extract, 25 parts of Rubus idaeus extract, 5 parts of Cornus officinalis extract, 8 parts of Eucommia ulmoides leaf extract; 0.5 parts of vitamin D, and 30 parts of L-calcium lactate; the calcium content of the L-calcium lactate is 15-40% by mass percentage.

[0085] This embodiment also provides the use of the nutritional composition for promoting bone and joint health, wherein the composition is used for preparing edible nutritional products.

[0086] This embodiment also provides a method for preparing the nutritional product, which comprises: weighing each raw material in proportion, grinding each raw material into powder and passing through a 150-mesh sieve, mixing components with similar weight ratios into several groups, and then adding each group of mixtures into a three-dimensional motion mixer in order from small to large weight ratio to mix all the raw materials evenly, and then using an automatic packaging machine to pack the mixed materials into bags, seal the bags, and sterilize and store them for later use.

[0087] Preferably, the method further comprises: adding the mixed material to auxiliary materials, mixing them evenly, and then preparing into granules or capsules.

[0088] Example 4

[0089] A special dietary formula powder suitable for people with bone and joint diseases is prepared by using a nutritional composition for promoting bone and joint health. The formula composition by weight is as follows (total weight is about 10 kg):

[0090] 1.5kg bovine collagen peptide, 1.5kg L-calcium lactate, 0.8kg yak bone marrow peptide, 0.8kg chondroitin peptide, 0.6kg ginseng oligopeptide, 0.6kg Rehmannia glutinosa (Rehmannia glutinosa) extract, 0.6kg Cistanche deserticola extract, 0.6kg Alpinia oxyphylla extract, 0.6kg raspberry extract, 0.5kg Cornus officinalis extract, 0.5kg Eucommia ulmoides leaf extract, 0.5kg wolfberry peptide, 0.4kg yam peptide, 0.3kg angelica oligopeptide, 0.2kg Dendrobium officinale peptide, 5g vitamin D.

[0091] The preparation method of the powder is:

[0092] According to the formula ratio, weigh the above materials, grind them into powder and sieve them separately; then mix the components with similar weight ratio into several groups, and then gradually enlarge them from the smaller groupings, and mix them evenly in a three-dimensional mixer. Then use an automatic packaging machine to pack the mixed powdered materials, 10g per bag.

[0093] Example 5

[0094] The powder of Example 4 was used to conduct an efficacy verification test.

[0095] The experiment was conducted to increase bone density, promote joint repair and improve joint function. The experimental population was 100 patients aged 48-78 years old with osteoporosis and degenerative osteoarthritis diagnosed by conventional methods. They were randomly divided into a trial group of 50 cases (13 males and 37 females) and a control group of 50 cases (15 males and 35 females). Before the trial, the symptom scores of the two groups were not much different and were comparable.

[0096] The test group took the product of Example 4 of the present invention, twice a day, 10 g each time, with warm water; the control group took a starch placebo with the same appearance as the product, and the method of taking was the same as that of the test group. The taking time was 60 days, and the subjects did not use other oral or external drugs for improving bone quality and osteoarthritis before and during taking.

[0097] Before, during and after taking the medicine, the subjects used an ultrasonic bone densitometer to measure the bone density of the distal end of the left radius of the patient, and used magnetic resonance imaging and instruments to detect the patient's joint space and cartilage collagen content for comprehensive comparison.

[0098] MAIN OUTCOME MEASURES: Morning stiffness index, joint pain index, functional disability index, bone density T value, joint space collagen index, and cartilage collagen index.

[0099] Morning stiffness index: Morning stiffness refers to tightness, stiffness, and stiffness of joints after waking up or getting up in the morning, discomfort or limited limb movement, which is relieved after movement. The morning stiffness duration is 0, 1, 2, 3, 4, and 5 points respectively, according to the morning stiffness duration of none, 30, 60, 90, 120, and more than 150 minutes.

[0100] Joint pain index: score and grade joint pain, 1 to 3 points for mild pain, the pain is tolerable and has no obvious impact on rest or work; 4 to 6 points for moderate pain, the pain is unbearable and seriously affects rest or work; 7 to 10 points for severe pain, the pain is unbearable and even makes it impossible to rest or work, and analgesics or therapy are needed.

[0101] Functional impairment index: The functional measurement standard for joint movement impairment is Grade I, which means that the patient can do various activities with slight discomfort but basically no restriction, and the score is 1; Grade II, although one or more joints are uncomfortable or restricted in movement, the patient can engage in normal activities, and the score is 2; Grade III, the joint movement is obviously restricted and the patient cannot engage in general occupational activities, and the score is 3; Grade IV, the patient has joint movement impairment and can take care of himself partially, but needs care, and the score is 4; Grade V, the patient is bedridden or in a wheelchair and cannot take care of himself at all, and the score is 5.

[0102] There were 100 participants in the experiment, and the follow-up period was 60 days, with 96 participants actually followed up. SPSS variance statistical analysis was used, and the comparison of the improvement of the two groups of subjects before, during, and after the treatment is shown in Table 1 below.

[0103] Table 1. Efficacy validation test results.

[0104]

[0105] Combined with the comparison of the indexes before and after the trial, the morning stiffness, joint pain and dysfunction symptom indexes were significantly reduced, and the joint space collagen, cartilage collagen index and bone density T value increased significantly. All subjects did not experience adverse reactions and side effects during the 60-day trial.

[0106] The above test results show that the product of the present invention helps to increase bone density, promote joint repair and improve joint function.

[0107] The nutritional composition for promoting bone and joint health provided by the present invention, as well as its use and preparation method, has been experimentally confirmed to have the synergistic effect of promoting the recovery of bone and joint diseases, and its effect is better than that of the prior art.

[0108] The main components of the nutritional composition with the effect of promoting the health of bones and joints are composed of bovine collagen peptide, L-calcium lactate, yak bone marrow peptide, cartilage peptide, ginseng oligopeptide, Rehmannia glutinosa (prepared rehmannia) extract, Cistanche deserticola extract, Alpinia oxyphylla extract, Raspberry extract, Cornus officinalis extract, Eucommia ulmoides leaf extract, Lycium barbarum peptide, Chinese yam peptide, Angelica oligopeptide, Dendrobium officinale peptide, vitamin D, etc. Each component mainly adopts small molecule peptides and active extracts with a molecular weight range of 500 to 1000Da, which have a small molecular weight and are easily absorbed by the human body, and the effect is better than the existing technology and traditional Chinese medicine.

[0109] The combination, also known as the Jin Gu Tai formula, is mainly used to improve osteoporosis, repair joint protective membranes, promote cartilage regeneration, and supplement body nutrition. It serves as a nutritional food formula that meets the physiological metabolic state, athletic ability, and special needs of middle-aged and elderly people and athletes for certain nutrients.

[0110] Although the content of the present invention has been described in detail through the above preferred embodiments, it should be appreciated that the above description should not be considered as a limitation of the present invention. After reading the above content, it will be apparent to those skilled in the art that various modifications and substitutions of the present invention will occur. Therefore, the protection scope of the present invention should be limited by the appended claims.

Claims

1. A nutritional composition for promoting bone and joint health, characterized in that: The raw materials of the composition include bovine collagen peptide, L-calcium lactate, cartilage peptide, yak bone marrow extract, ginseng extract, rehmannia extract, cistanche extract, alpinia oxyphylla extract, raspberry extract, cornus officinalis extract, eucommia leaf extract, wolfberry extract, yam extract, angelica extract, dendrobium officinale extract and vitamin D.

2. The nutritional composition for promoting bone and joint health according to claim 1, characterized in that: The raw materials of the composition are: yak bone marrow extract using yak bone marrow peptide, ginseng extract using ginseng oligopeptide, wolfberry extract using wolfberry peptide, yam extract using yam peptide, angelica extract using angelica oligopeptide, dendrobium officinale extract using dendrobium officinale peptide, and rehmannia glutinosa extract using prepared rehmannia extract.

3. The nutritional composition for promoting bone and joint health according to claim 2, characterized in that: The raw materials of the composition include, by weight: 10 to 50 parts of bovine collagen peptide, 5 to 40 parts of yak bone marrow peptide, 5 to 40 parts of cartilage peptide, 5 to 30 parts of ginseng oligopeptide, 3 to 20 parts of wolfberry peptide, 3 to 20 parts of yam peptide, 2 to 15 parts of angelica oligopeptide, and 2 to 15 parts of dendrobium officinale peptide.

4. The nutritional composition for promoting bone and joint health according to claim 3, characterized in that: The molecular weight of each component of the raw material of the composition is in the range of 500 to 1000 Da.

5. The nutritional composition for promoting bone and joint health according to claim 3, characterized in that: The raw materials of the composition further include, by weight: 5-30 parts of Rehmannia glutinosa extract, 5-30 parts of Cistanche deserticola extract, 5-30 parts of Alpinia oxyphylla extract, 5-30 parts of Rubus idaeus extract, 3-20 parts of Cornus officinalis extract, and 3-20 parts of Eucommia ulmoides leaf extract.

6. The nutritional composition for promoting bone and joint health according to claim 5, characterized in that: The raw materials of the composition further comprise, by weight: 5 to 50 parts of L-calcium lactate; by weight percentage, the calcium content of the L-calcium lactate is 15 to 40%.

7. The nutritional composition for promoting bone and joint health according to claim 6, characterized in that: The raw materials of the composition further include: 0.05 to 1 part of vitamin D by weight.

8. Use of a nutritional composition for promoting bone and joint health as claimed in any one of claims 1 to 7, characterized in that: The composition is used for preparing edible nutritional products.

9. A method for preparing a nutritional product according to claim 8, characterized in that: The method is as follows: weigh each raw material in proportion, grind each raw material into powder and sieve, mix components with similar weight ratios into several groups, add each group of mixtures into a three-dimensional motion mixer in order from small to large weight ratio, mix all the raw materials evenly, and then use an automatic packaging machine to pack the mixed materials into bags, seal them, and store them for future use after disinfection and sterilization.

10. The method for preparing a nutritional product according to claim 9, characterized in that: The method further comprises: adding auxiliary materials to the mixed materials, mixing them evenly, and then preparing them into several dosage forms including powder, tablets, pills, granules or capsules.

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