Traditional Chinese medicine composition for tonifying yang and resisting fatigue as well as preparation method, application and pharmaceutical preparation thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for tonifying yang and resisting fatigue as well as a preparation method, application and a medicinal preparation thereof. The traditional Chinese medicine composition is prepared from the following components: herba cistanche, herba epimedii, cornu cervi pantotrichum, gecko, herba cynomorii, rhizoma dioscoreae, fructus psoraleae, dog kidneys, radix morindae officinalis, rhizoma polygonati, radix polygoni multiflori, radix aconiti carmichaeli, saffron crocus, radix ginseng, radix astragali, radix angelicae sinensis, okra, fructus lycii, royal jelly, L-carnitine and folium ginkgo extract. A compound preparation is prepared according to the traditional Chinese medicine compatibility theory and the traditional Chinese and western medicine combination theory, the traditional Chinese medicine composition for tonifying yang and resisting fatigue is not warm or dry, has the effects of tonifying kidney, tonifying yang and resisting fatigue, and is remarkable in curative effect, mild in effect and free of toxic and side effects; the preparation method is simple, and the traditional Chinese medicine is an ideal medicine for invigorating the kidney, strengthening yang and resisting fatigue.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and specifically relates to a Chinese medicine composition for strengthening sexual function and resisting fatigue, a preparation method and application thereof, and a pharmaceutical preparation. Background Art

[0002] The kidney governs water, and maintains the body's water balance by opening the yang and closing the yin; the kidney governs bone and marrow production, and its beauty is in the hair. When the kidney qi is sufficient, the bones are strong and the teeth are firm, and the brain is full and prosperous; the kidney governs the intake of qi, and qi originates from the kidney and returns to the lung, so the intake of kidney qi helps the lung qi to descend; kidney water goes up to the heart, and the heart fire goes down to the kidney. When the heart and kidney interact, water and fire are in harmony, and yin and yang are balanced; the kidney belongs to fire, and the spleen belongs to earth. The warmth of kidney yang can help the spleen to function well; the kidney also belongs to water, and the liver belongs to wood. When the kidney water is sufficient, the liver wood can be nourished. The kidney veins are connected to the bladder, and they are the exterior and interior of the bladder. The transpiration of kidney qi can help the bladder gasification and facilitate the metabolism of water. Kidney deficiency is a dialectical term in traditional Chinese medicine. It is based on the dialectical theory of the five internal organs of traditional Chinese medicine. It is manifested by insufficient kidney qi transformation, and symptoms include spermatorrhea, premature ejaculation, dripping after urination, frequent and clear urination, sore waist and knees, hearing loss, shortness of breath, cold limbs, and weak pulse.

[0003] Generally speaking, when using Western medicine to treat kidney deficiency, it can only have a short-term effect on the patient, and cannot achieve a fundamental therapeutic effect. Moreover, taking Western medicine will aggravate the damage to the patient's organs such as the kidneys, leading to further deterioration of the condition. The current Western medicine treatment methods have disadvantages such as large side effects, single effects, and many contraindications. The medicinal treatment strategy using Chinese medicinal materials as the active ingredients of the medicine is very meaningful.

[0004] Chinese invention patent publication number CN102114218A discloses a Chinese medicine for tonifying kidney, strengthening yang and resisting fatigue and its preparation method. The invention is prepared by the following method: weighing yam, wolfberry, Euryale ferox, Alpinia oxyphylla, cinnamon, mulberry and black sesame by weight, selecting the above component raw materials, taking 30% of the total weight for crushing, and sieving through a 100-mesh sieve to obtain fine powder; taking 70% of the total weight and adding water to extract twice, adding 10 times the weight of water for the first time, decocting for 2 hours, and adding 8 times the weight of water for the second time, decocting for 1.5 hours, filtering the extracts of the two decoctions with a 160-180 mesh sieve respectively, and concentrating the filtrate to a thick extract with a density of 1.26-1.32g / cm 3 , mix the thick extract with the above-mentioned fine powder to make pills, dry them, and package them to obtain pills.

[0005] Another Chinese invention patent publication number CN1272055A discloses a method for preparing a Chinese medicine preparation for invigorating the kidney, strengthening yang, and prolonging life. The Chinese medicine preparation is prepared from the following raw materials in percentage by weight: 0.5-10% of pilose antler, 0.1-3% of deer penis, 0.3-5% of dog penis, 3-20% of pig testicles, 2-30% of sea rice, 3-20% of dog bones, 3-20% of seahorse, 0.1-3% of gecko, 1-15% of prepared rehmannia root, 1-15% of tortoise shell glue, 3-30% of polygonatum, 5-30% of processed polygonum multiflorum, 3-30% of cornus officinalis, 1-15% of ginseng, 2-20% of cnidium monnieri, 1-15% of epimedium, and 1-15% of stalactite.

[0006] Another Chinese invention patent publication number CN101664499A discloses a Xianhuo Bushen Buji mixture, the raw materials of the active ingredients of the invented medicine are composed of 72-120 parts of original silkworm moth, 40-65 parts of epimedium (roasted), 56-100 parts of Cynomorium songaricum, 16-30 parts of Morinda officinalis (processed), 40-65 parts of Curculigo, 16-30 parts of Cuscuta, 48-90 parts of Allium sativum seeds, 16-30 parts of Eucommia (processed), 32-60 parts of Rehmannia glutinosa, 24-45 parts of processed Polygonum multiflorum, 24-45 parts of Lycium barbarum, 16-30 parts of ginseng and 24-45 parts of Poria.

[0007] However, the Chinese medicine preparation prepared by the above invention patent has a low cure rate for treating kidney deficiency and has an insignificant anti-fatigue effect. In view of this, the art urgently needs to provide a Chinese medicine composition that has a more significant effect on treating kidney deficiency, tonifying the kidney and strengthening yang, and anti-fatigue. Summary of the invention

[0008] In view of the problems existing in the prior art, the present invention provides a Chinese medicine composition for strengthening sexual function and resisting fatigue, a preparation method and application thereof, and a pharmaceutical preparation.

[0009] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0010] A Chinese medicine composition for strengthening yang and resisting fatigue, comprising the following components: Cistanche deserticola, epimedium, pilose antler, gecko, cynomorium songaricum, yam, psoralea corylifolia, dog kidney, Morinda officinalis, polygonatum, polygonatum multiflorum, aconite root, saffron, ginseng, astragalus, angelica, okra, wolfberry, royal jelly, L-carnitine and ginkgo leaf extract.

[0011] Preferably, the Chinese medicine composition comprises the following components by weight: 70-90 parts of Cistanche deserticola, 40-60 parts of Epimedium, 15-25 parts of Pilose Antler, 50-60 parts of Gecko, 24-36 parts of Cynomorium songaricum, 40-60 parts of Dioscorea opposita, 15-25 parts of Psoralea corylifolia, 20-30 parts of Cynomorium wilfordii, 16-20 parts of Morinda officinalis, 50-60 parts of Polygonatum sibiricum, 32-38 parts of Polygonum multiflorum, 15-20 parts of Aconite, 15-25 parts of Saffron, 45-55 parts of Ginseng, 45-55 parts of Astragalus, 15-20 parts of Angelica sinensis, 10-20 parts of Okra, 10-20 parts of Lycium barbarum, 30-45 parts of Royal Jelly, 5-12 parts of L-carnitine and 15-25 parts of Ginkgo biloba extract.

[0012] More preferably, the Chinese medicine composition comprises the following components by weight: 75-85 parts of Cistanche deserticola, 55-60 parts of Epimedium, 18-22 parts of Deer Antler, 52-58 parts of Gecko, 25-30 parts of Cynomorium songaricum, 45-55 parts of Dioscorea opposita, 18-25 parts of Psoralea corylifolia, 22-28 parts of Cynomorium wilfordii, 18-20 parts of Morinda officinalis, 52-58 parts of Polygonatum sibiricum, 34-36 parts of Polygonum multiflorum, 18-20 parts of Aconite, 15-20 parts of Saffron, 45-50 parts of Ginseng, 40-55 parts of Astragalus, 18-20 parts of Angelica sinensis, 12-18 parts of Okra, 12-18 parts of Lycium barbarum, 32-42 parts of Royal Jelly, 6-10 parts of L-carnitine and 16-20 parts of Ginkgo biloba extract.

[0013] Further preferably, the Chinese medicine composition comprises the following components by weight: 80 parts of Cistanche deserticola, 60 parts of Epimedium, 20 parts of Pilose Antler, 55 parts of Gecko, 30 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium wilfordii, 18 parts of Morinda officinalis, 56 parts of Polygonatum sibiricum, 35 parts of Polygonum multiflorum, 18 parts of Aconite, 20 parts of Saffron, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 16 parts of Okra, 15 parts of Lycium barbarum, 40 parts of Royal Jelly, 10 parts of L-carnitine and 20 parts of Ginkgo biloba extract.

[0014] Preferably, the dosage form of the Chinese medicine composition is pills, capsules, tablets, granules or oral liquid preparations.

[0015] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0016] Add water to the extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonatum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves, boil the extracts, filter, combine the decoctions, concentrate them into an extract, add royal jelly and L-carnitine, and dry them to obtain the product.

[0017] Preferably, the relative density of the extract at 50-60° C. is 1.35-1.40, the amount of water added is 8-10 times the weight of the medicinal material, the number of decoctions is 2-3 times, the decoction time is 2-3 hours, and the drying is vacuum drying or freeze drying.

[0018] The present invention also provides a pharmaceutical preparation, which comprises the above-mentioned traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the above-mentioned preparation method and pharmaceutically acceptable excipients.

[0019] Preferably, the auxiliary materials include excipients, disintegrants, flavoring agents, preservatives and colorants.

[0020] The present invention also provides the use of the above-mentioned Chinese medicine composition or the Chinese medicine composition prepared by the above-mentioned preparation method or the above-mentioned pharmaceutical preparation in the preparation of aphrodisiac and anti-fatigue drugs.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] (1) The present invention provides a Chinese medicine composition for strengthening yang and resisting fatigue, which utilizes the synergistic effect of epimedium, saffron and L-carnitine, and has been confirmed by animal experiments to have good fatigue-relieving and yang-strengthening effects.

[0023] (2) The Chinese medicine composition of the present invention significantly improves the efficacy in anti-fatigue and kidney-tonifying and yang-strengthening by adding Polygonum multiflorum and Ginkgo biloba leaf extracts.

[0024] (3) The present invention is formulated into a compound preparation according to the theory of TCM compatibility and the theory of integration of Chinese and Western medicine. The drug composition is neither warm nor dry, has the effects of tonifying the kidney and strengthening yang and anti-fatigue, has significant efficacy, mild effect, and no toxic side effects. The preparation method is simple, and it is an ideal drug for tonifying the kidney and strengthening yang and anti-fatigue. DETAILED DESCRIPTION

[0025] It is worth noting that the raw materials used in the present invention are all common commercially available products, among which ginkgo leaf extract, with an effective substance content of 10:1, was purchased from Shanxi Zhenke Biotechnology Co., Ltd.; snow lotus extract, with an effective substance content of 20:1, was purchased from Xi'an Shizeyuan Biotechnology Co., Ltd.; and ginsenoside content in ginsenoside dry powder was 80%, which was purchased from Xi'an Wanfang Biotechnology Co., Ltd.

[0026] Example 1

[0027] A Chinese medicine composition for strengthening yang and resisting fatigue consists of the following components by weight: 80 parts of Cistanche deserticola, 60 parts of Epimedium, 20 parts of Pilose Antler, 55 parts of Gecko, 30 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium wilfordii, 18 parts of Morinda officinalis, 56 parts of Polygonatum sibiricum, 35 parts of Polygonum multiflorum, 18 parts of Aconite, 20 parts of Saffron, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 16 parts of Okra, 15 parts of Lycium barbarum, 40 parts of Royal Jelly, 10 parts of L-carnitine and 20 parts of Ginkgo biloba extract.

[0028] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0029] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonatum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil for 3 times, each time for 2 hours, with the amount of water added being 8 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.38 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0030] Example 2

[0031] A Chinese medicine composition for strengthening yang and resisting fatigue consists of the following components by weight: 75 parts of Cistanche deserticola, 55 parts of Epimedium, 22 parts of Pilose Antler, 58 parts of Gecko, 25 parts of Cynomorium songaricum, 55 parts of Dioscorea opposita, 18 parts of Psoralea corylifolia, 22 parts of Cynomorium wilfordii, 20 parts of Morinda officinalis, 52 parts of Polygonatum sibiricum, 36 parts of Polygonum multiflorum, 20 parts of Aconite, 15 parts of Saffron, 50 parts of Ginseng, 55 parts of Astragalus, 18 parts of Angelica sinensis, 18 parts of Okra, 12 parts of Lycium barbarum, 32 parts of Royal Jelly, 6 parts of L-carnitine and 16 parts of Ginkgo biloba extract.

[0032] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0033] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil twice, each time for 3 hours, with the amount of water added being 10 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.35 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0034] Example 3

[0035] A Chinese medicine composition for strengthening yang and resisting fatigue consists of the following components by weight: 70 parts of Cistanche deserticola, 40 parts of Epimedium, 25 parts of Pilose Antler, 60 parts of Gecko, 24 parts of Cynomorium songaricum, 40 parts of Dioscorea opposita, 15 parts of Psoralea corylifolia, 30 parts of Cynomorium songaricum, 16 parts of Morinda officinalis, 50 parts of Polygonatum sibiricum, 38 parts of Polygonum multiflorum, 15 parts of Aconite, 15 parts of Saffron, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 10 parts of Okra, 10 parts of Lycium barbarum, 30 parts of Royal Jelly, 12 parts of L-carnitine and 15 parts of Ginkgo biloba extract.

[0036] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0037] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil twice, each time for 3 hours, with the amount of water added being 10 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.40 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0038] Example 4

[0039] A Chinese medicine composition for strengthening yang and resisting fatigue consists of the following components by weight: 90 parts of Cistanche deserticola, 60 parts of Epimedium, 15 parts of Pilose Antler, 50 parts of Gecko, 36 parts of Cynomorium songaricum, 60 parts of Dioscorea opposita, 25 parts of Psoralea corylifolia, 20 parts of Dog Kidney, 20 parts of Morinda officinalis, 60 parts of Polygonatum sibiricum, 32 parts of Polygonum multiflorum, 20 parts of Aconite, 25 parts of Saffron, 55 parts of Ginseng, 55 parts of Astragalus, 15 parts of Angelica sinensis, 20 parts of Okra, 20 parts of Lycium barbarum, 45 parts of Royal Jelly, 5 parts of L-carnitine and 25 parts of Ginkgo biloba extract.

[0040] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0041] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonatum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil for 3 times, each time for 3 hours, with the amount of water added being 10 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.40 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0042] Comparative Example 1

[0043] Compared with Example 1, the only difference is that the formula does not contain Epimedium.

[0044] A Chinese medicine composition for strengthening yang and resisting fatigue consists of the following components by weight: 80 parts of Cistanche deserticola, 20 parts of pilose antler, 55 parts of gecko, 30 parts of Cynomorium songaricum, 50 parts of yam, 20 parts of psoralea corylifolia, 25 parts of dog kidney, 18 parts of Morinda officinalis, 56 parts of polygonatum, 35 parts of polygonatum, 18 parts of aconite, 60 parts of saffron, 45 parts of ginseng, 45 parts of astragalus, 20 parts of angelica, 16 parts of okra, 15 parts of wolfberry, 40 parts of royal jelly, 30 parts of L-carnitine and 20 parts of ginkgo leaf extract.

[0045] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0046] Add extracts of Cistanche deserticola, pilose antler, gecko, Cynomorium songaricum, yam, psoralea corylifolia, dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonum multiflorum, Aconite root, saffron, ginseng, astragalus, angelica, okra, wolfberry and ginkgo leaf to water and boil for 3 times, each time for 2 hours, with the amount of water added being 8 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.38 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0047] Comparative Example 2

[0048] Compared with Example 1, the only difference is that the formula does not contain saffron and L-carnitine.

[0049] A Chinese medicine composition for strengthening yang and resisting fatigue is composed of the following components by weight: 80 parts of Cistanche deserticola, 90 parts of Epimedium, 20 parts of Pilose Antler, 55 parts of Gecko, 30 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium wilfordii, 18 parts of Morinda officinalis, 56 parts of Polygonatum sibiricum, 35 parts of Polygonum multiflorum, 18 parts of Aconite, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 16 parts of Okra, 15 parts of Lycium barbarum, 40 parts of Royal Jelly and 20 parts of Ginkgo biloba leaf extract.

[0050] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0051] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonatum multiflorum, Aconite root, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil for 3 times, each time for 2 hours, with the amount of water added being 8 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.38 at 50°C, then add royal jelly and freeze-dry to obtain the product.

[0052] Comparative Example 3

[0053] Compared with Example 1, the only difference is that the formula does not contain saffron.

[0054] A Chinese medicine composition for strengthening yang and resisting fatigue, comprising the following components by weight: 80 parts of Cistanche deserticola, 60 parts of Epimedium, 20 parts of Pilose Antler, 55 parts of Gecko, 30 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium wilfordii, 18 parts of Morinda officinalis, 56 parts of Polygonatum sibiricum, 35 parts of Polygonum multiflorum, 18 parts of Aconite, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 16 parts of Okra, 15 parts of Lycium barbarum, 40 parts of Royal Jelly, 30 parts of L-carnitine and 20 parts of Ginkgo biloba leaf extract.

[0055] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0056] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonatum multiflorum, Aconite root, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil for 3 times, each time for 2 hours, with the amount of water added being 8 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.38 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0057] Comparative Example 4

[0058] Compared with Example 1, the only difference is that the formula does not contain L-carnitine.

[0059] A Chinese medicine composition for strengthening yang and resisting fatigue consists of the following components by weight: 80 parts of Cistanche deserticola, 60 parts of Epimedium, 20 parts of Pilose Antler, 55 parts of Gecko, 30 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium wilfordii, 18 parts of Morinda officinalis, 56 parts of Polygonatum sibiricum, 35 parts of Polygonum multiflorum, 18 parts of Aconite, 30 parts of Saffron, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 16 parts of Okra, 15 parts of Lycium barbarum, 40 parts of Royal Jelly and 20 parts of Ginkgo biloba leaf extract.

[0060] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0061] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil for 3 times, each time for 2 hours, with the amount of water added being 8 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.38 at 50°C, then add royal jelly and freeze-dry to obtain the product.

[0062] Comparative Example 5

[0063] Compared with Example 1, the only difference is that the ginkgo leaf extract is replaced by the snow lotus extract.

[0064] A Chinese medicine composition for strengthening yang and resisting fatigue consists of the following components by weight: 80 parts of Cistanche deserticola, 60 parts of Epimedium, 20 parts of Pilose Antler, 55 parts of Gecko, 30 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium wilfordii, 18 parts of Morinda officinalis, 56 parts of Polygonatum sibiricum, 35 parts of Polygonum multiflorum, 18 parts of Aconite, 20 parts of Saffron, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 16 parts of Okra, 15 parts of Lycium barbarum, 40 parts of Royal Jelly, 10 parts of L-carnitine and 20 parts of Saussurea involucrata extract.

[0065] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0066] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonatum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Saussurea involucrata to water and boil for 3 times, each time for 2 hours, with the amount of water added being 8 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.38 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0067] Comparative Example 6

[0068] Compared with Example 1, the only difference is that Polygonum multiflorum is replaced by Cuscuta australis.

[0069] A Chinese medicine composition for strengthening yang and resisting fatigue consists of the following components by weight: 80 parts of Cistanche deserticola, 60 parts of Epimedium, 20 parts of Pilose Antler, 55 parts of Gecko, 30 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium wilfordii, 18 parts of Morinda officinalis, 56 parts of Polygonatum sibiricum, 35 parts of Cuscuta aconite, 18 parts of Aconite root, 20 parts of Saffron, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 16 parts of Okra, 15 parts of Lycium barbarum, 40 parts of Royal Jelly, 10 parts of L-carnitine and 20 parts of Ginkgo biloba leaf extract.

[0070] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0071] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Cuscuta aconite, Saffron, ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil for 3 times, each time for 2 hours, with the amount of water added being 8 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.38 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0072] Comparative Example 7

[0073] Compared with Example 1, the only difference is that the formula ratio is different.

[0074] A Chinese medicine composition for strengthening yang and resisting fatigue, comprising the following components by weight: 50 parts of Cistanche deserticola, 90 parts of Epimedium, 40 parts of Pilose Antler, 65 parts of Gecko, 20 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium officinale, 30 parts of Morinda officinalis, 60 parts of Polygonatum sibiricum, 45 parts of Polygonum multiflorum, 20 parts of Aconite, 30 parts of Saffron, 30 parts of Ginseng, 45 parts of Astragalus, 30 parts of Angelica sinensis, 14 parts of Okra, 12 parts of Lycium barbarum, 45 parts of Royal Jelly, 20 parts of L-carnitine and 30 parts of Ginkgo biloba leaf extract.

[0075] The preparation method of the above-mentioned Chinese medicine composition is as follows:

[0076] Add extracts of Cistanche deserticola, Epimedium, Deer antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog kidney, Morinda officinalis, Polygonatum sibiricum, Polygonatum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaves to water and boil for 3 times, each time for 2 hours, with the amount of water added being 8 times the weight of the medicinal materials. Filter after boiling, combine the decoctions, concentrate into an extract with a relative density of 1.38 at 50°C, then add royal jelly and L-carnitine, and freeze-dry to obtain the product.

[0077] Test Example 1 Anti-fatigue test

[0078] 1. Research object: The aphrodisiac and anti-fatigue Chinese medicine compositions prepared in Examples 1-4 and Comparative Examples 1-7.

[0079] 2. Experimental animals: 130 SPF-grade healthy Kunming strain male mice, weighing 18-22 g, were provided by the Experimental Animal Center of China Medical University, license number: SYXK(Su)2023-0019. The mice were housed in a controlled environment (temperature 23±1°C, humidity 50±10%) with a 12h / 12h light / dark cycle (light on from 8 am to 8 pm), with free access to food and were acclimated in the observation room for one week before the experiment.

[0080] 3. Animal modeling: SPF male mice were intraperitoneally injected with 0.4 mg / mL estradiol benzoate diluted in soybean oil at a rate of 0.1 mL / 10 g once a day for 15 consecutive days to create a kidney yang deficiency model.

[0081] 4. Grouping and administration: The mice were randomly divided into 14 groups, 10 in each group, namely, blank group, model group, positive control group (ginseng soap powder) 0.05g / kg, Example 1-4 group and Comparative Example 1-7 group. Except for the blank group, the remaining groups of mice were all subjected to animal modeling. Before use, the Chinese medicine composition prepared from ginseng soap powder, Example 1-4 group and Comparative Example 1-7 group was prepared into a 0.1g / mL suspension using normal saline, and intragastric administration was performed between 9:00-10:00 every day, with an intragastric volume of 0.2mL / 20g; the blank group was irrigated with an equal volume of normal saline, and the administration was continued for 21 days, once a day.

[0082] On the 22nd day, the mice were tested for weighted swimming: the mice were loaded with lead wire (the weight of the lead wire was 6% of the weight of the mice) at their tails, and were placed in a 40cm×60cm×40cm pool for swimming, with a water depth of 30cm and a water temperature of 30±0.5℃. A stopwatch was used to record the time from the start of swimming to exhaustion (the mice could not float to the surface after sinking for 10s), which was taken as the exhaustive swimming time of the mice, and the results were averaged. After the exhaustive swimming time was measured, the mice were killed, the livers were removed, and the content of liver glycogen and muscle glycogen was detected by colorimetry.

[0083] 5. Experimental results: The results are shown in Table 1. It can be seen from Table 1 that the exhaustive swimming time, liver glycogen content and muscle glycogen content of the positive control group, Examples 1-4 and Comparative Examples 1-7 experimental groups are better than those of the model group. Compared with the model group, the Example 1-4 group has a statistically significant difference (P<0.05). In addition, the exhaustive swimming time, liver glycogen and muscle glycogen content of Comparative Examples 1-4 are all worse than those of Example 1, indicating that there is a synergistic effect between Epimedium, Saffron and L-carnitine, so that the Chinese medicine composition of the present invention has a good fatigue relief effect; the exhaustive swimming time, liver glycogen and muscle glycogen content of Comparative Examples 5-7 are also worse than those of Example 1, indicating that only specific Chinese medicine compositions will have a good anti-fatigue effect.

[0084] Table 1 Anti-fatigue test results

[0085]

[0086] Note: Compared with the model group, # Indicates P<0.05.

[0087] Test Example 2 Kidney-tonifying Pharmacology Experiment

[0088] 1. Research object: The aphrodisiac and anti-fatigue Chinese medicine compositions prepared in Example 1 and Comparative Examples 1-7.

[0089] 2. Experimental animals: Same as in Test Example 1.

[0090] 3. Animal modeling: Same as Test Example 1.

[0091] 4. Grouping and administration: SPF male mice were divided into 11 groups: blank group, model group, positive control group, Example 1 and Comparative Examples 1-7, with 10 mice in each group. Except for the blank group, the mice in the other groups were subjected to animal modeling. The positive control group was subcutaneously injected with 2 mg / kg of testosterone propionate every day; the Example 1 and Comparative Examples 1-7 groups were gavaged with 200 mg / kg every day; the blank group and the model group were given an equal volume of normal saline. The drug was administered continuously for 14 days, once a day. On the 15th day, the mice in each group were killed by cervical dislocation, and the testicles and seminal vesicles of the mice were removed. The organ index was calculated according to the following formula and the average value was taken.

[0092] Organ index (%) = organ weight ÷ body weight × 100%

[0093] 5. Experimental results: The results are shown in Table 2. Compared with the model group, the testicular index and seminal vesicle index of the positive control group, Example 1 and Comparative Examples 1-7 were all increased, but the testicular index of Example 1 was significantly increased (P<0.05), indicating that the Chinese medicine composition of the present invention can improve the symptoms of hyposexuality in mice with kidney yang deficiency, and the overall effect is better than that of the positive control drug.

[0094] Table 2 Organ index results

[0095] serial number Testicular index (%) Seminal vesicle index (%) Blank group <![CDATA[0.82±0.15 # ]]> <![CDATA[0.65±0.08 # ]]> Model Group 0.29±0.04 0.18±0.01 Positive control group 0.44±0.06 0.25±0.02 Example 1 <![CDATA[0.78±0.10 # ]]> <![CDATA[0.56±0.05 # <!-- 7 -->]]> Comparative Example 1 0.54±0.07 0.38±0.03 Comparative Example 2 0.47±0.05 0.28±0.05 Comparative Example 3 0.52±0.04 0.34±0.02 Comparative Example 4 0.50±0.08 0.30±0.04 Comparative Example 5 0.46±0.06 0.27±0.03 Comparative Example 6 0.48±0.04 0.30±0.02 Comparative Example 7 0.50±0.07 0.32±0.06

[0096] Note: Compared with the model group, # Indicates P<0.05.

[0097] In summary, the present invention is formulated into a compound preparation according to the theory of TCM compatibility and the theory of integration of Chinese and Western medicine. The drug composition is neither warm nor dry, has the effects of tonifying the kidney and strengthening yang and anti-fatigue, has significant efficacy, mild effect, and no toxic side effects. The preparation method is simple, and it is an ideal drug for tonifying the kidney and strengthening yang and anti-fatigue.

[0098] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A Chinese medicine composition for strengthening sexual function and resisting fatigue, characterized in that: The Chinese medicine composition comprises the following components: Cistanche deserticola, epimedium, pilose antler, gecko, cynomorium songaricum, yam, psoralea corylifolia, dog kidney, Morinda officinalis, polygonatum sibiricum, polygonatum multiflorum, aconite root, saffron, ginseng, astragalus, angelica, okra, wolfberry, royal jelly, L-carnitine and ginkgo leaf extract.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises the following components by weight: 70-90 parts of Cistanche deserticola, 40-60 parts of Epimedium, 15-25 parts of Pilose Antler, 50-60 parts of Gecko, 24-36 parts of Cynomorium songaricum, 40-60 parts of Dioscorea opposita, 15-25 parts of Psoralea corylifolia, 20-30 parts of Cynomorium wilfordii, 16-20 parts of Morinda officinalis, 50-60 parts of Polygonatum sibiricum, 32-38 parts of Polygonum multiflorum, 15-20 parts of Aconite, 15-25 parts of Saffron, 45-55 parts of Ginseng, 45-55 parts of Astragalus, 15-20 parts of Angelica sinensis, 10-20 parts of Okra, 10-20 parts of Lycium barbarum, 30-45 parts of Royal Jelly, 5-12 parts of L-carnitine and 15-25 parts of Ginkgo biloba extract.

3. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition comprises the following components by weight: 75-85 parts of Cistanche deserticola, 45-55 parts of Epimedium, 18-22 parts of Pilose Antler, 52-58 parts of Gecko, 25-30 parts of Cynomorium songaricum, 45-55 parts of Dioscorea opposita, 18-25 parts of Psoralea corylifolia, 22-28 parts of Cynomorium wilfordii, 18-20 parts of Morinda officinalis, 52-58 parts of Polygonatum sibiricum, 34-36 parts of Polygonum multiflorum, 18-20 parts of Aconite, 15-20 parts of Saffron, 45-50 parts of Ginseng, 40-55 parts of Astragalus, 18-20 parts of Angelica sinensis, 12-18 parts of Okra, 12-18 parts of Lycium barbarum, 32-42 parts of Royal Jelly, 6-10 parts of L-carnitine and 16-20 parts of Ginkgo biloba extract.

4. The Chinese medicine composition according to claim 3, characterized in that: The Chinese medicine composition includes the following components by weight: 80 parts of Cistanche deserticola, 50 parts of Epimedium, 20 parts of Pilose Antler, 55 parts of Gecko, 30 parts of Cynomorium songaricum, 50 parts of Dioscorea opposita, 20 parts of Psoralea corylifolia, 25 parts of Cynomorium wilfordii, 18 parts of Morinda officinalis, 56 parts of Polygonatum sibiricum, 35 parts of Polygonum multiflorum, 18 parts of Aconite, 20 parts of Saffron, 45 parts of Ginseng, 45 parts of Astragalus, 20 parts of Angelica sinensis, 16 parts of Okra, 15 parts of Lycium barbarum, 40 parts of Royal Jelly, 10 parts of L-carnitine and 20 parts of Ginkgo biloba extract.

5. The Chinese medicine composition according to claim 1, characterized in that: The dosage form of the Chinese medicine composition is pills, capsules, tablets, granules or oral liquid preparations.

6. A method for preparing the Chinese medicine composition according to any one of claims 1 to 5, characterized in that: The method comprises the following steps: boiling Cistanche deserticola, Epimedium, Deer Antler, Gecko, Cynomorium songaricum, Chinese yam, Psoralea corylifolia, Dog Kidney, Morinda officinalis, Polygonatum sibiricum, Polygonatum multiflorum, Aconite root, Saffron, Ginseng, Astragalus, Angelica sinensis, Okra, Lycium barbarum and Ginkgo biloba leaf extracts with water, filtering, combining the decoctions, concentrating them into extracts, adding royal jelly and L-carnitine, and drying to obtain the extracts.

7. The preparation method according to claim 6, characterized in that: The relative density of the extract at 50-60° C. is 1.35-1.40, the amount of water added is 8-10 times the weight of the medicinal material, the number of decoctions is 2-3 times, the decoction time is 2-3 hours, and the drying is vacuum drying or freeze drying.

8. A pharmaceutical preparation, characterized in that The pharmaceutical preparation comprises the Chinese medicine composition according to any one of claims 1 to 5 or the Chinese medicine composition prepared by the preparation method according to any one of claims 6 to 7 and pharmaceutically acceptable excipients.

9. The pharmaceutical preparation according to claim 8, characterized in that The auxiliary materials include excipients, disintegrants, flavoring agents, preservatives and colorants.

10. Use of the Chinese medicine composition according to any one of claims 1 to 5, or the Chinese medicine composition prepared by the preparation method according to any one of claims 6 to 7, or the pharmaceutical preparation according to any one of claims 8 to 9 in the preparation of aphrodisiac and anti-fatigue drugs.

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