Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
a technology of tumor necrosis factor and binding ligands, which is applied in the direction of antibody ingredients, anti-mimetics/scaffolds, pharmaceutical non-active ingredients, etc., can solve the problems of tumor regression, renal impairment and hypertension
Inactive Publication Date: 2004-10-28
PEPTECH
View PDF96 Cites 14 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
While TNF infusion into cancer patients in stage 1 clinical trials has resulted in tumour regression, side-effects such as thrombocytopaenia, lymphocytopaenia, hepatotoxicity, renal impairment and hypertension have also been reported.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0001]This application is a continuation of application Serial No. 09 / 736,630, now U.S. Pat. No. 6,593,457, filed December13, 2000, which is a continuation of application Serial No. 09 / 364,039 (now U.S. Patent No. 6,416,757), filed July 30, 1999, which is a continuation of application Serial No. 08 / 823,893, filed March 17, 1997 (now U.S. Patent No. 5,959,087), which is a continuation of application Serial No. 08 / 344,133, filed November 23, 1994 (now U.S. Patent No. 5,644,034), which is a continuation-in-part of application Serial No. 07 / 828,956, filed February 18, 1992 (now abandoned), which is a national phase filing of PCT / AU90 / 00337, filed August 7, 1990, which claims the benefit of Australian applications AU PJ5662, filed August 7, 1989, and AU PJ7576, filed November 24, 1989, the disclosures of which are incorporated herein by reference in their entirety.
[0002]The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that u...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
PUM
Property
Measurement
Unit
temperature
aaaaa
aaaaa
pH
aaaaa
aaaaa
diameter
aaaaa
aaaaa
Login to view more
Abstract
Abstract of the Disclosure The present invention relates to ligands which bind to human tumour necrosis factor alpha (TNF) in a manner such that upon binding of these ligands to TNF the biological activity of TNF is modified. In preferred forms the ligand binds to TNF in a manner such that the induction of endothelial procoagulant activity of the TNF is inhibited; the binding of TNF to receptors on endothelial cells is inhibited; the induction of fibrin deposition in the tumour and tumour regression activities of the TNF are enhanced; and-the cytotoxicity and receptor binding activities of the TNF are unaffected or enhanced on tumour cells. The ligand is preferably an antibody, F(ab) fragment, single domain antibody (dABs) single chain antibody or a serum binding protein. It is preferred, however, that the ligand is a monoclonal antibody or F(ab) fragment thereof.
Description
Detailed Description of the Invention[0001]This application is a continuation of application Serial No. 09 / 736,630, now U.S. Pat. No. 6,593,457, filed December13, 2000, which is a continuation of application Serial No. 09 / 364,039 (now U.S. Patent No. 6,416,757), filed July 30, 1999, which is a continuation of application Serial No. 08 / 823,893, filed March 17, 1997 (now U.S. Patent No. 5,959,087), which is a continuation of application Serial No. 08 / 344,133, filed November 23, 1994 (now U.S. Patent No. 5,644,034), which is a continuation-in-part of application Serial No. 07 / 828,956, filed February 18, 1992 (now abandoned), which is a national phase filing of PCT / AU90 / 00337, filed August 7, 1990, which claims the benefit of Australian applications AU PJ5662, filed August 7, 1989, and AU PJ7576, filed November 24, 1989, the disclosures of which are incorporated herein by reference in their entirety.[0002]The present invention relates to ligands which bind to human tumour necrosis facto...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to view more
Patent Type & Authority Applications(United States)