Cancer Therapy
a gene therapy and cancer technology, applied in the field of cancer gene therapy, can solve the problems of affecting the survival rate of patients, the outcome of normal death, and the major cause of mortality of cancer, and achieve the effect of improving the efficacy of adenoviral-based gene therapy treatmen
Inactive Publication Date: 2017-01-26
GLIOTHERAPY
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AI Technical Summary
Benefits of technology
The present invention is based on a study that shows that giving antigens to a patient together with a pre-existing immunoresponsiveness to those antigens can make gene therapy treatment for glioma more effective. This means that by combining these approaches, researchers hope to be able to better target and treat brain tumors.
Problems solved by technology
Cancers are a major cause of mortality.
High grade gliomas are particularly devastating malignant tumours, for which there is currently no effective cure and for which the outcome is normally fatal.
Certain treatments can prolong survival, but they do not cure the cancer.
Currently most available cancer medicines are generally very toxic and many do not readily reach the brain tumour.
They often cause severe side effects that can reduce the patient's quality of life significantly.
It was found that the treatment induced tumour regression and prolonged survival, but was ineffective in rats that were pre-immunised with the vector.
Method used
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Experimental program
Comparison scheme
Effect test
Embodiment Construction
[0015]Without wishing to be bound by theory, it is proposed that when an immunostimulant is administered with a viral vector-based gene therapy for cancer, reactions between the components create a local environment that is conductive to recruitment of additional anti-neoplastic cell processors, such as the generation of immune responses directed against the neoplastic cells. Therefore, in contrast to the findings of most the prior art cited above, it has been found in the present invention that pre-existing immunoresponsiveness to adenoviral vectors will enhance its sufficiency for the treatment of cancer.
[0016]The skilled person will know how to carry out the invention described in the claims. The gene therapy “Cerepro” is in the public domain and suitable dosages, methods of administration etc are known. Information relevant to the present invention is also disclosed in EP1135513, which is incorporated herein by reference.
[0017]Suitable dosages and methods of administration for t...
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Abstract
The prior art largely suggests that immune competence in a cancer patient would destroy an antigenic viral vector before it transfects host cells with a transgene-rendering therapy futile. We surprisingly found the opposite is true: cancer patients with competent immune systems obtain the most therapeutic benefit from antigenic viral vector, apparently because the antigenic viral vector, apart from transfecting cells with a transgene, induces a humoral immune response, which in turn attacks cells bearing cancer antigen. Our new therapy works particularly well in combination with cytotoxic chemotherapeutic drugs.
Description
FIELD OF THE INVENTION[0001]The present invention relates to gene therapies for cancer.BACKGROUND OF THE INVENTION[0002]Cancers are a major cause of mortality. High grade gliomas are particularly devastating malignant tumours, for which there is currently no effective cure and for which the outcome is normally fatal. Certain treatments can prolong survival, but they do not cure the cancer.[0003]Malignant glioma is a cancerous tumour that is confined to the brain and only rarely spreads further. The current standard therapy involves surgically removing the solid tumour mass and initiating radiotherapy and / or chemotherapy. Even when the solid tumour mass is being removed, pre-cancerous or isolated cancerous cells can exist in the brain. In the majority of these patients, a new tumour grows and a repeat operation is frequently required. Currently most available cancer medicines are generally very toxic and many do not readily reach the brain tumour. They often cause severe side effects...
Claims
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IPC IPC(8): A61K48/00A61K31/495G01N33/50C12N7/00G01N33/68A61K38/45A61K39/235
CPCA61K48/0083C12Y207/01021A61K38/45A61K31/495A61K39/235G01N2800/52G01N33/6854G01N33/5005C12N2710/10343A61K2039/577C12N2710/10334C12N7/00A61K48/005A61K2039/53A61K2039/555C12N2799/022G01N33/505A61P35/00A61P37/04A61K39/001162A61K2300/00
Inventor FARRIES, TIMOTHYECKLAND, DAVID
Owner GLIOTHERAPY