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Methods of tracking skin conditions using cyclolignan compounds

Inactive Publication Date: 2018-03-29
M ALPHABET 1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

While these topical pharmacologic treatments are at times effective, many are limited by the adverse side-effect profile including extreme irritation (ingenol mebutate and fluorouracil), modest efficacy (imiquimod), and systemic toxicity (cantharidin).

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  • Methods of tracking skin conditions using cyclolignan compounds
  • Methods of tracking skin conditions using cyclolignan compounds
  • Methods of tracking skin conditions using cyclolignan compounds

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[0101]To date, 56 patients have been studied to determine the efficacy of picropodophyllin in treating actinic keratoses. The patients were randomized into four groups, and the patients in each group were treated with a solution containing either 0.5%, 1.25%, or 2.0% picropodophyllin (w / v) in propylene glycol, or a placebo constituting only the vehicle propylene glycol. The picropodophyllin solution was prepared in 100% propylene glycol solution. The solutions were prepared aseptically following GMP protocols. The affected areas of the body variously included the scalp, face, arms, and legs. Without knowing which one of the four solutions they were applying, the subjects self-applied one of the solutions to the skin. After initial application, the subjects gently massaged the solutions into their skin. This was done twice daily for 1 week. Lesions (actinic keratosis) were palpated and visualized by a trained lesion counter who is a board certified dermatologist. The same investigato...

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Abstract

The present invention includes compositions and methods for the treatment of skin conditions by administration of a cyclolignan such as picropodophyllin and / or a derivative, metabolite, analog, prodrug, pharmaceutically acceptable salt, or hydrate thereof.

Description

RELATED APPLICATIONS[0001]This application is a Divisional application of U.S. patent application Ser. No. 14 / 691,238, filed Apr. 20, 2015, which is a U.S. national phase application filed under 35 U.S.C. § 371 of International Application No.: PCT / US2014 / 037523, which was filed May 9, 2014, and which claims the benefit of the filing date of U.S. Provisional Application No. 61 / 822,072, which was filed on May 10, 2013. For the purpose of any U.S. application that may claim the benefit of U.S. Provisional Application No. 61 / 822,072, the contents of that earlier filed application are hereby incorporated by reference in their entirety.FIELD OF THE INVENTION[0002]The present invention is directed to methods of treating various skin conditions by administering to a patient a composition that includes a cyclolignan compound such as picropodophyllin, either alone or in combination with one or more additional active ingredients.BACKGROUND OF THE INVENTION[0003]Hyperproliferative skin disease...

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/365A61K45/06
CPCA61K45/06A61K31/365A61K31/22A61K31/4745A61K31/513A61K47/10A61K9/08A61P17/00A61P17/08A61P17/10A61P17/12A61P35/00A61K2300/00
Inventor FEIN, HOWARDBERLIN, JOSHUA M.
Owner M ALPHABET 1
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