Methods of tracking skin conditions using cyclolignan compounds

Inactive Publication Date: 2018-03-29
M ALPHABET 1
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While these topical pharmacologic treatments are at times effective, many are limited by the adverse side-effect profile including extreme irritation (ingenol mebutate and fluorouracil), modest efficacy (imiquimod), and systemic toxicity (cantharidin).

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods of tracking skin conditions using cyclolignan compounds
  • Methods of tracking skin conditions using cyclolignan compounds
  • Methods of tracking skin conditions using cyclolignan compounds

Examples

Experimental program
Comparison scheme
Effect test

examples

[0101]To date, 56 patients have been studied to determine the efficacy of picropodophyllin in treating actinic keratoses. The patients were randomized into four groups, and the patients in each group were treated with a solution containing either 0.5%, 1.25%, or 2.0% picropodophyllin (w / v) in propylene glycol, or a placebo constituting only the vehicle propylene glycol. The picropodophyllin solution was prepared in 100% propylene glycol solution. The solutions were prepared aseptically following GMP protocols. The affected areas of the body variously included the scalp, face, arms, and legs. Without knowing which one of the four solutions they were applying, the subjects self-applied one of the solutions to the skin. After initial application, the subjects gently massaged the solutions into their skin. This was done twice daily for 1 week. Lesions (actinic keratosis) were palpated and visualized by a trained lesion counter who is a board certified dermatologist. The same investigato...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
areaaaaaaaaaaa
areaaaaaaaaaaa
areaaaaaaaaaaa
Login to view more

Abstract

The present invention includes compositions and methods for the treatment of skin conditions by administration of a cyclolignan such as picropodophyllin and / or a derivative, metabolite, analog, prodrug, pharmaceutically acceptable salt, or hydrate thereof.

Description

RELATED APPLICATIONS[0001]This application is a Divisional application of U.S. patent application Ser. No. 14 / 691,238, filed Apr. 20, 2015, which is a U.S. national phase application filed under 35 U.S.C. § 371 of International Application No.: PCT / US2014 / 037523, which was filed May 9, 2014, and which claims the benefit of the filing date of U.S. Provisional Application No. 61 / 822,072, which was filed on May 10, 2013. For the purpose of any U.S. application that may claim the benefit of U.S. Provisional Application No. 61 / 822,072, the contents of that earlier filed application are hereby incorporated by reference in their entirety.FIELD OF THE INVENTION[0002]The present invention is directed to methods of treating various skin conditions by administering to a patient a composition that includes a cyclolignan compound such as picropodophyllin, either alone or in combination with one or more additional active ingredients.BACKGROUND OF THE INVENTION[0003]Hyperproliferative skin disease...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/365A61K45/06
CPCA61K45/06A61K31/365A61K31/22A61K31/4745A61K31/513A61K47/10A61K9/08A61P17/00A61P17/08A61P17/10A61P17/12A61P35/00A61K2300/00
Inventor FEIN, HOWARDBERLIN, JOSHUA M.
Owner M ALPHABET 1
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap