Method of treating pain

a pain treatment and pain technology, applied in the field of pain treatment, can solve problems such as neuropathy pain, and achieve the effect of treating, preventing, and reducing pain in mammals

Inactive Publication Date: 2019-05-09
POSEIDA THERAPEUTICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The patent describes methods for using a chemical compound to treat, reduce, or prevent pain in mammals. This compound can specifically target a specific protein called TRPC4. The technical effect of this invention is to provide an effective treatment for pain that targets the root cause of the pain rather than just reducing the symptoms.

Problems solved by technology

Inflammation and trauma are major causes of nerve injuries.
The genetic disorders causing distorted connectivity, structure or survival of neurons may also result in neuropathic pain.

Method used

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  • Method of treating pain
  • Method of treating pain
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Definitions

[0019]The present invention may be understood more readily by reference to the following detailed description of preferred embodiments of the invention and any Examples included therein and to any Figures and description thereof. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods, devices, and materials are now described. All references, publications, patents, patent applications, and commercial materials mentioned herein are incorporated herein by reference for the purpose of describing and disclosing the materials and / or methodologies which are reported in the publications which might be used in connection with the invention. Nothing herein is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention.

[0020]Before the present compounds, compositions, articles, devices, and / or methods are d...

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Abstract

The instant application discloses methods of treating, reducing, or preventing pain in a mammal, which may include administering a compound capable of modulating a transient receptor potential channel. In one aspect, the TRP channel may be TRPC4. Types of pain contemplated by the present disclosure include acute, chronic, neuropathic, and nociceptive pain.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of and claims priority to PCT Application No. PCT / US12 / 69753, filed Dec. 14, 2012, which claims priority to U.S. Provisional Application No. 61 / 576,619, filed Dec. 16, 2011, both of which are incorporated in their entirety by reference herein. This application also incorporates by reference U.S. Provisional Patent Application Ser. No. 61 / 235,534, filed Aug. 20, 2009, U.S. Provisional Patent Application Ser. No. 61 / 247,612, filed Oct. 1, 2009, and PCT / US10 / 46151, filed Aug. 20, 2010.FIELD AND BACKGROUND OF INVENTION[0002]Mammalian transient receptor potential (TRP) channels are described as six-transmembrane (6-TM) cation-permeable channels. TRP channels control the gating of voltage-dependent Ca2+, K+, and Cl−, and are characterized as calcium-permeable channels with polymodal activation properties. TRP protein structure is thought to be a channel forming structure composed of six transmembrane (TM) doma...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07D215/38A61K45/06A61K31/00A61K31/4709
CPCC07D215/38A61K45/06A61K31/00A61K31/4709A61P29/02
Inventor OSTERTAG, ERIC M.CRAWFORD, JOHN STUART
Owner POSEIDA THERAPEUTICS INC
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