Aqueous extract of compound traditional Chinese medicine for treating acute pancreatitis and preparation method thereof

Abstract

The invention discloses a compound traditional Chinese medicinal water extract for treating acute pancreatitis. Calculated in parts by weight, 22-27 parts of gardenia, 22-27 parts of paeonol, 22-27 parts of woody fragrance and 22-27 parts of magnolia 22-27 parts of Yuanhu, 35-45 parts of Radix Paeoniae Rubra, 35-45 parts of Rhubarb and 12-17 parts of Glauber's Salt as raw materials for preparation. The present invention selects 8 kinds of traditional Chinese medicine compositions as raw materials for preparation, and applies the prepared water extract to the medicine for treating acute pancreatitis. According to experiments, the prepared medicine can obviously relieve abdominal distension and intestinal paralysis during SAP, Thus, the symptoms of SAP can be significantly relieved, complications can be reduced, and the mortality rate can be reduced. After more than 5,000 cases of acute pancreatitis and more than 1,000 cases of acute severe pancreatitis (SAP), the treatment and summary have received good curative effect. The cure rate of SAP can reach 85.4%, and the mortality rate has dropped to 10.1%. The material source of the invention is wide, easy to obtain, and low in cost, and the preparation method adopted is simple and easy to implement and easy to industrialize.

Description

technical field

[0001] The invention relates to a medicine, in particular to a compound Chinese medicinal water extract for treating acute pancreatitis and a preparation method thereof. Background technique

[0002] Acute pancreatitis (SAP) is an inflammatory reaction in which pancreatic tissue is digested, edema, hemorrhage, and even necrosis after activation of pancreatic enzymes due to various causes. Clinically, it is characterized by acute epigastric pain, nausea, vomiting, fever, and increased blood trypsin. The degree of lesion varies from severity to severity. In mild cases, pancreatic edema is the main symptom, which is more common in clinical practice. The condition is often self-limited and the prognosis is good. It is also called mild acute pancreatitis. Pancreatic hemorrhage and necrosis in a small number of severe cases is often followed by infection, peritonitis and shock, etc., and the fatality rate is high, which is called severe acute pancreatitis. Clinic...

Examples

Embodiment 1

[0160] Embodiment 1 of the present invention: the preparation method of the compound Chinese medicinal water extract for the treatment of acute pancreatitis, gardenia 125g, paeonol 125g, woody 125g, magnolia officinalis 125g, yuanhu 125g, red peony root 200g, rhubarb 200g and mirabilite Mix 75g, add water 12 times the weight of the total mass of the mixed medicinal materials, heat to boil, then heat for 40 minutes, and filter after naturally cooling to room temperature to obtain about 3500ml of filtrate; add 10 times the total weight of the filtrate to the filtrate After decocting for 1 hour, then naturally cool to room temperature and filter to obtain about 4000ml of filtrate; pass the above filtrate through macroporous resin, collect about 6000ml of liquid, rinse with distilled water at a flow rate of 5mL / min, and rinse until the color is very After diluting, the collected liquid is about 5000ml, and a total of about 11000ml of water phase liquid is collected; the collected w...

Embodiment 2

[0161] Embodiment 2 of the present invention: the preparation method of the compound Chinese medicinal water extract for the treatment of acute pancreatitis, gardenia 125g, paeonol 125g, woody 125g, magnolia officinalis 125g, Yuanhu 125g, red peony root 200g, rhubarb 200g and mirabilite Mix 75g, add water 12 times the weight of the total mass of the mixed medicinal materials, heat to boil, then heat for 40 minutes, and filter after naturally cooling to room temperature to obtain about 3500ml of filtrate; add 10 times the total weight of the filtrate to the filtrate After decocting for 1 hour, then naturally cool to room temperature and filter to obtain about 4000ml of filtrate; pass the above filtrate through macroporous resin, collect about 6000ml of liquid, rinse with distilled water at a flow rate of 5mL / min, and rinse until the color is very After diluting, the collected liquid is about 5000ml, and a total of about 11000ml of aqueous phase liquid is collected; the collected...

Embodiment 3

[0162] Embodiment 3 of the present invention: take the water extract prepared in Embodiment 2 and pass through an 80-mesh sieve, add appropriate amount of dextrin and lactose, mix evenly according to the equal multiplication method, add HPMC solution to make soft material, granulate, dry, and prepare granules, divided into capsule shells to obtain capsules. The preparation is taken orally, 2-3 times a day, and the dose of each dose is 300-800 mg based on the active extract.

technical field

[0001] The invention relates to a medicine, in particular to a compound Chinese medicinal water extract for treating acute pancreatitis and a preparation method thereof. Background technique

[0002] Acute pancreatitis (SAP) is an inflammatory reaction in which pancreatic tissue is digested, edema, hemorrhage, and even necrosis after activation of pancreatic enzymes due to various causes. Clinically, it is characterized by acute epigastric pain, nausea, vomiting, fever, and increased blood trypsin. The degree of lesion varies from severity to severity. In mild cases, pancreatic edema is the main symptom, which is more common in clinical practice. The condition is often self-limited and the prognosis is good. It is also called mild acute pancreatitis. Pancreatic hemorrhage and necrosis in a small number of severe cases is often followed by infection, peritonitis and shock, etc., and the fatality rate is high, which is called severe acute pancreatitis. Clinic...

Examples

Embodiment 1

[0160] Embodiment 1 of the present invention: the preparation method of the compound Chinese medicinal water extract for the treatment of acute pancreatitis, gardenia 125g, paeonol 125g, woody 125g, magnolia officinalis 125g, yuanhu 125g, red peony root 200g, rhubarb 200g and mirabilite Mix 75g, add water 12 times the weight of the total mass of the mixed medicinal materials, heat to boil, then heat for 40 minutes, and filter after naturally cooling to room temperature to obtain about 3500ml of filtrate; add 10 times the total weight of the filtrate to the filtrate After decocting for 1 hour, then naturally cool to room temperature and filter to obtain about 4000ml of filtrate; pass the above filtrate through macroporous resin, collect about 6000ml of liquid, rinse with distilled water at a flow rate of 5mL / min, and rinse until the color is very After diluting, the collected liquid is about 5000ml, and a total of about 11000ml of water phase liquid is collected; the collected w...

Embodiment 2

[0161] Embodiment 2 of the present invention: the preparation method of the compound Chinese medicinal water extract for the treatment of acute pancreatitis, gardenia 125g, paeonol 125g, woody 125g, magnolia officinalis 125g, Yuanhu 125g, red peony root 200g, rhubarb 200g and mirabilite Mix 75g, add water 12 times the weight of the total mass of the mixed medicinal materials, heat to boil, then heat for 40 minutes, and filter after naturally cooling to room temperature to obtain about 3500ml of filtrate; add 10 times the total weight of the filtrate to the filtrate After decocting for 1 hour, then naturally cool to room temperature and filter to obtain about 4000ml of filtrate; pass the above filtrate through macroporous resin, collect about 6000ml of liquid, rinse with distilled water at a flow rate of 5mL / min, and rinse until the color is very After diluting, the collected liquid is about 5000ml, and a total of about 11000ml of aqueous phase liquid is collected; the collected...

Embodiment 3

[0162] Embodiment 3 of the present invention: take the water extract prepared in Embodiment 2 and pass through an 80-mesh sieve, add appropriate amount of dextrin and lactose, mix evenly according to the equal multiplication method, add HPMC solution to make soft material, granulate, dry, and prepare granules, divided into capsule shells to obtain capsules. The preparation is taken orally, 2-3 times a day, and the dose of each dose is 300-800 mg based on the active extract.

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