Polyester catalyst with antibacterial and osteogenic activity and preparation method thereof

Abstract

The invention provides a polyester catalyst with antibacterial and osteogenic activity, which is prepared by the following steps: carrying out pre-polycondensation on dicarboxylic acid or dibasic ester and excessive dihydric alcohol to fully react to form a prepolymer; and carrying out transesterification on the prepolymer by using a zinc catalyst, and simultaneously reducing the pressure to continuously remove small molecular byproducts. Compared with the prior art, the invention has the following prominent advantages: (1) the invention provides a novel transesterification catalyst, zinc is an important metal element in a living body, has the characteristics of no toxicity and absorbability, has biological activity and has a promoting effect on proliferation of bone osteoblasts of a human body, and meanwhile, zinc ions have a bactericidal effect, so that the catalyst is a novel transesterification catalyst; and the catalyst is low in cost, can be used massively, and can be applied to the field of biomedicine. And (2) the aliphatic polyester prepared by the invention has the characteristics of degradability and strong safety, and has good market space and value.

Description

technical field

[0001] The invention belongs to the technical field of degradable polyester synthesis, specifically relates to a polyester catalyst with antibacterial and osteogenic activity and a preparation method, and is a novel transesterification catalyst and polyester synthesis method for degradable polyester. Background technique

[0002] Degradable materials are a class of products that can be degraded into small molecules that are harmless to the environment under the action of factors such as light, heat, oxygen, water, and microorganisms in the natural environment. At present, countries all over the world are vigorously carrying out research on such products. In the current research on degradable materials, polyester degradable materials occupy an important position. Since the aliphatic polyester polymer chain contains ester bonds, it is easily hydrolyzed or degraded by microorganisms into small molecules such as water and carbon dioxide. For example, the surgic...

Examples

Embodiment 1

[0019] (1) Add 0.35 grams of zinc powder to a 250 mL three-necked flask equipped with a mechanical stirrer, a thermometer, a nitrogen inlet tube, a condenser, a water separator, etc., add 20 grams of succinic acid, 15 grams of 1,4 -Butanediol, fed with argon, gradually heated to 180°C, reacted under 100r.p.m stirring, the water produced was removed through the water separator, and the reaction was stopped when no water was produced.

[0020] (2) Raise the temperature to 230°C, connect the oil pump to evacuate at the same time, the pressure is 0.1-200Pa, and carry out the polycondensation reaction for 12 hours under 100r.p.m stirring, and the obtained intrinsic viscosity is 0.91dL / g (chloroform is used as the solvent), and the molecular weight is 50kDa. Optically non-active, fully biodegradable polybutylene succinate.

Embodiment 2～5

[0022] The synthesis process is the same as in Example 1, except that the succinic acid in the polyester synthesis process is replaced by glutaric acid, adipic acid, pimelic acid, and suberic acid. The molecular weight of the obtained polyester is between 20kDa and 60kDa.

Embodiment 6～9

[0024] The synthesis process is the same as in Example 1, except that the butanediol in the polyester synthesis process is replaced by pentanediol, hexanediol, heptanediol, octanediol, and the molecular weight of the obtained polyester is 15kDa to 50kDa.

technical field

[0001] The invention belongs to the technical field of degradable polyester synthesis, specifically relates to a polyester catalyst with antibacterial and osteogenic activity and a preparation method, and is a novel transesterification catalyst and polyester synthesis method for degradable polyester. Background technique

[0002] Degradable materials are a class of products that can be degraded into small molecules that are harmless to the environment under the action of factors such as light, heat, oxygen, water, and microorganisms in the natural environment. At present, countries all over the world are vigorously carrying out research on such products. In the current research on degradable materials, polyester degradable materials occupy an important position. Since the aliphatic polyester polymer chain contains ester bonds, it is easily hydrolyzed or degraded by microorganisms into small molecules such as water and carbon dioxide. For example, the surgic...

Examples

Embodiment 1

[0019] (1) Add 0.35 grams of zinc powder to a 250 mL three-necked flask equipped with a mechanical stirrer, a thermometer, a nitrogen inlet tube, a condenser, a water separator, etc., add 20 grams of succinic acid, 15 grams of 1,4 -Butanediol, fed with argon, gradually heated to 180°C, reacted under 100r.p.m stirring, the water produced was removed through the water separator, and the reaction was stopped when no water was produced.

[0020] (2) Raise the temperature to 230°C, connect the oil pump to evacuate at the same time, the pressure is 0.1-200Pa, and carry out the polycondensation reaction for 12 hours under 100r.p.m stirring, and the obtained intrinsic viscosity is 0.91dL / g (chloroform is used as the solvent), and the molecular weight is 50kDa. Optically non-active, fully biodegradable polybutylene succinate.

Embodiment 2～5

[0022] The synthesis process is the same as in Example 1, except that the succinic acid in the polyester synthesis process is replaced by glutaric acid, adipic acid, pimelic acid, and suberic acid. The molecular weight of the obtained polyester is between 20kDa and 60kDa.

Embodiment 6～9

[0024] The synthesis process is the same as in Example 1, except that the butanediol in the polyester synthesis process is replaced by pentanediol, hexanediol, heptanediol, octanediol, and the molecular weight of the obtained polyester is 15kDa to 50kDa.