Ultrafiltration system

Abstract

The present disclosure relates to an ultrafiltration system, including: a raw material tank, configured to store a raw material solution of a biological product; a replacement tank, configured to store a replacement solution; a cleaning tank, configured to store a cleaning solution; an ultrafiltration membrane package, configured to filter the raw material solution; a switching device, connected to the raw material tank, the replacement tank and the cleaning tank, and in fluid communication with the ultrafiltration membrane package, configured to selectively switch or close the fluid communication relationship between the raw material tank, the replacement tank and the cleaning tank and the ultrafiltration membrane package; a fluid drive unit, which is arranged in series on the flow path between the ultrafiltration membrane package and the switching device. Through this ultrafiltration system, automatic switching of different solutions can be achieved, manual operations can be minimized, and labor costs can be reduced.

Description

Technical Field

[0001] The present disclosure relates to the field of bioengineering, and in particular to an ultrafiltration system. Background Art

[0002] In the process of preparing biological products, it is often necessary to concentrate, purify, dialyze, replace, etc. The traditional liquid dead-end filtration is mostly microporous filtration, in which the flow direction of the liquid is consistent with the filtration direction. As the filtration proceeds, the thickness of the filter cake layer or gel layer formed on the surface of the filter membrane gradually increases, and the flow rate gradually decreases. Tangential flow is a filtration form in which the liquid flow direction is perpendicular to the filtration direction. Summary of the invention

[0003] The inventors have found through research that the tangential flow ultrafiltration process of the related art requires frequent replacement of corresponding solution connectors according to different solutions required in the ultrafiltration step, which results in high labor costs.

[0004] In view of this, an embodiment of the present disclosure provides an ultrafiltration system that can minimize manual operations.

[0005] In one aspect of the present disclosure, there is provided an ultrafiltration system comprising:

[0006] A raw material solution tank, configured to store a raw material solution of a biological product;

[0007] a replacement fluid tank configured to store replacement fluid;

[0008] a cleaning liquid tank configured to store cleaning liquid;

[0009] An ultrafiltration membrane package, configured to filter the raw material solution;

[0010] A switching device, connected to the raw material liquid tank, the replacement liquid tank and the cleaning liquid tank, and in fluid communication with the ultrafiltration membrane package, and configured to selectively switch or close the fluid communication relationship between the raw material liquid tank, the replacement liquid tank and the cleaning liquid tank and the ultrafiltration membrane package;

[0011] The fluid driving unit is arranged in series on the flow path between the ultrafiltration membrane package and the switching device.

[0012] In some embodiments, the switching device comprises:

[0013] A switching valve having a plurality of pipe ports and fluid outlets, wherein the plurality of pipe ports are respectively connected to the raw material liquid tank, the replacement liquid tank and the cleaning liquid tank through pipelines;

[0014] A liquid collecting tank, connected to the fluid outlet of the switching valve through a pipeline, and connected to the fluid driving unit and the ultrafiltration membrane package through pipelines respectively;

[0015] The controller is connected to the switching valve and the fluid driving unit by signals, and is configured to control the switching and opening and closing of the switching valve, and to control the opening and closing of the fluid driving unit.

[0016] In some embodiments, the ultrafiltration system comprises:

[0017] The first liquid level sensor is located in the raw material liquid tank and is configured to detect the liquid level of the raw material liquid tank, wherein the controller is connected to the first liquid level sensor signal and is configured to switch the switching valve to a state where the raw material liquid tank is connected to the liquid collecting tank and start the fluid driving unit when receiving a first preset liquid level signal emitted by the first liquid level sensor.

[0018] In some embodiments, the ultrafiltration system comprises:

[0019] a waste liquid tank, connected to the waste liquid outlet of the ultrafiltration membrane package, and configured to collect waste liquid flowing out of the ultrafiltration membrane package;

[0020] The second liquid level sensor is located in the waste liquid tank and is configured to detect the liquid level of the waste liquid tank, wherein the controller is connected to the second liquid level sensor signal and is configured to stop the fluid driving unit when receiving a second preset liquid level signal emitted by the second liquid level sensor, and to continue the operation of the fluid driving unit when receiving a no liquid level signal emitted by the second liquid level sensor.

[0021] In some embodiments, the ultrafiltration system comprises:

[0022] a third liquid level sensor, located in the replacement fluid tank and configured to detect a liquid level of the replacement fluid tank;

[0023] a finished liquid tank, connected to the finished liquid outlet of the liquid collecting tank, and configured to collect the finished liquid flowing out of the liquid collecting tank;

[0024] A liquid discharge solenoid valve is arranged in series on the flow path between the finished liquid outlet of the liquid collecting tank and the finished liquid tank;

[0025] The first liquid level sensor is located in the raw material liquid tank and is configured to detect the liquid level of the raw material liquid tank, wherein the controller is signal-connected with the first liquid level sensor, the third liquid level sensor and the drain solenoid valve, and is configured to switch the switching valve to a state where the replacement liquid tank and the collection tank are in flow, and start the fluid drive unit when receiving a no liquid level signal from the first liquid level sensor, and to enable the fluid drive unit to continue running for a first preset time before opening the drain solenoid valve when receiving a no liquid level signal from the third liquid level sensor.

[0026] In some embodiments, the ultrafiltration system comprises:

[0027] A fourth liquid level sensor is located in the cleaning liquid tank and is configured to detect the liquid level of the cleaning liquid tank, wherein the controller is connected to the fourth liquid level sensor signal and is configured to close the drain solenoid valve after being opened for a second preset time, and then switch the switching valve to a state in which the cleaning liquid tank is connected to the liquid collecting tank, and start the fluid drive unit, and when receiving a no liquid level signal from the fourth liquid level sensor, the fluid drive unit is operated for a third preset time and then closed.

[0028] In some embodiments, the ultrafiltration system comprises:

[0029] a waste liquid tank, connected to the waste liquid outlet of the ultrafiltration membrane package, and configured to collect waste liquid flowing out of the ultrafiltration membrane package;

[0030] A waste liquid solenoid valve is arranged in series on the flow path between the ultrafiltration membrane package outlet and the waste liquid tank;

[0031] The fourth liquid level sensor is located in the cleaning liquid tank and is configured to detect the liquid level of the cleaning liquid tank, wherein the controller is connected to the waste liquid solenoid valve and the fourth liquid level sensor signal, and is configured to close the waste liquid solenoid valve when receiving a no liquid level signal from the fourth liquid level sensor.

[0032] In some embodiments, the ultrafiltration system comprises:

[0033] The one-way stop valve is arranged in series on the flow path between the ultrafiltration membrane package and the liquid collecting tank, and is unidirectionally conducted from the liquid collecting tank to the ultrafiltration membrane package.

[0034] In some embodiments, the ultrafiltration system comprises:

[0035] The refrigeration component is located at the bottom of at least one of the raw liquid tank, the replacement liquid tank and the cleaning liquid tank.

[0036] In some embodiments, the ultrafiltration system comprises:

[0037] A touch screen is connected to the controller signal.

[0038] In some embodiments, the ultrafiltration system comprises:

[0039] A housing, wherein the ultrafiltration membrane package, the fluid drive unit, the liquid collecting tank, the switching valve and the controller are all arranged in the housing.

[0040] In some embodiments, the ultrafiltration system comprises:

[0041] A placement plate is arranged in the shell, wherein the controller, the raw material liquid tank, the replacement liquid tank and the cleaning liquid tank are all fixedly arranged above the placement plate, and the collecting tank, the ultrafiltration membrane package and the fluid driving unit are all arranged below the placement plate.

[0042] In some embodiments, the ultrafiltration system comprises:

[0043] A partition plate, located below the placement plate;

[0044] The refrigeration component is located at the bottom of at least one of the raw material liquid tank, the replacement liquid tank and the cleaning liquid tank, and is located between the placement plate and the partition plate.

[0045] Therefore, according to the embodiment of the present disclosure, the ultrafiltration system does not require the user to frequently switch the solution interface through the switching device, that is, it can automatically complete the selective switching or closing of the connection relationship between different solution tanks and ultrafiltration membrane packages, thereby minimizing manual operations and reducing labor costs. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] The accompanying drawings, which constitute a part of the specification, illustrate embodiments of the present disclosure and, together with the description, serve to explain the principles of the present disclosure.

[0047] The present disclosure may be more clearly understood from the following detailed description with reference to the accompanying drawings, in which:

[0048] Figure 1 is a schematic diagram of the overall structure of an ultrafiltration system according to some embodiments of the present disclosure;

[0049] Figure 2 is a schematic diagram of an ultrafiltration system according to some embodiments of the present disclosure from a top view;

[0050] Figure 3 (a) and (b) are schematic diagrams of the internal structure of the ultrafiltration system at different viewing angles according to some embodiments of the present disclosure.

[0051] It should be understood that the size of each part shown in the accompanying drawings is not drawn according to the actual proportional relationship. In addition, the same or similar reference numerals represent the same or similar components. DETAILED DESCRIPTION

[0052] Various exemplary embodiments of the present disclosure will now be described in detail with reference to the accompanying drawings. The description of the exemplary embodiments is merely illustrative and is in no way intended to limit the present disclosure and its application or use. The present disclosure can be implemented in many different forms and is not limited to the embodiments described herein. These embodiments are provided to make the present disclosure thorough and complete and to fully express the scope of the present disclosure to those skilled in the art. It should be noted that unless otherwise specifically stated, the relative arrangement of the components and steps, the composition of the materials, the numerical expressions and the numerical values ​​set forth in these embodiments should be interpreted as being merely exemplary and not as limiting.

[0053] The words "first", "second" and similar words used in this disclosure do not indicate any order, quantity or importance, but are only used to distinguish different parts. The words "include" or "comprise" and similar words mean that the elements before the word include the elements listed after the word, and do not exclude the possibility of including other elements. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change in a preset manner.

[0054] In the present disclosure, when a specific device is described as being located between a first device and a second device, there may or may not be an intermediate device between the specific device and the first device or the second device. When a specific device is described as being connected to other devices, the specific device may be directly connected to the other device without an intermediate device, or may not be directly connected to the other device but have an intermediate device.

[0055] All terms (including technical terms or scientific terms) used in the present disclosure have the same meanings as those understood by ordinary technicians in the field to which the present disclosure belongs, unless otherwise specifically defined. It should also be understood that terms defined in general dictionaries, such as general dictionaries, should be interpreted as having meanings consistent with their meanings in the context of the relevant technology, and should not be interpreted in an idealized or extremely formal sense, unless explicitly defined herein.

[0056] Technologies, methods, and equipment known to ordinary technicians in the relevant art may not be discussed in detail, but where appropriate, the technologies, methods, and equipment should be considered as part of the specification.

[0057] Figure 1 is a schematic diagram of the overall structure of an ultrafiltration system according to some embodiments of the present disclosure. Figure 1 In some embodiments, the ultrafiltration system includes: a raw material liquid tank 1, a replacement liquid tank 2, a cleaning liquid tank 3, an ultrafiltration membrane package 4, a switching device and a fluid driving unit 5.

[0058] The raw material liquid tank 1 is configured to store the raw material solution of the biological product, the replacement liquid tank 2 is configured to store the replacement liquid required in the ultrafiltration process, the cleaning liquid tank 3 is configured to store the cleaning liquid, and the ultrafiltration membrane package 4 is configured to filter the raw material solution.

[0059] The switching device is connected to the raw liquid tank 1, the replacement liquid tank 2 and the cleaning liquid tank 3, and is fluidly connected to the ultrafiltration membrane package 4. It is configured to selectively switch or close the fluid connection relationship between the raw liquid tank 1, the replacement liquid tank 2 and the cleaning liquid tank 3 and the ultrafiltration membrane package 4.

[0060] The fluid driving unit 5 is arranged in series on the flow path between the ultrafiltration membrane package 4 and the switching device, and can drive the solution required in the ultrafiltration process to enter the ultrafiltration membrane package 4.

[0061] At the beginning of the ultrafiltration process, the raw liquid, replacement liquid and cleaning liquid are respectively poured into the corresponding raw liquid tank 1, replacement liquid tank 2 and cleaning liquid tank 3, and the flow state between the required solution and the ultrafiltration membrane package 4 during the ultrafiltration process is selected by the switching device, and the fluid driving unit 5 controls the required solution to flow into the ultrafiltration membrane package 4 for corresponding operations.

[0062] Compared with the related art, when selecting different solutions, it is necessary to manually connect the ultrafiltration membrane package 4 with different solution tanks through pipelines. Frequent operations consume a lot of manpower. The present embodiment can complete the switching or closing of the flow relationship between the raw material liquid tank 1, the replacement liquid tank 2 and the cleaning liquid tank 3 and the ultrafiltration membrane package 4 through a switching device, thereby minimizing manual operations and saving labor costs.

[0063] Figure 2 is a schematic diagram of an ultrafiltration system according to some embodiments of the present disclosure, viewed from a top view. Figure 3 (a) and (b) are schematic diagrams of the internal structure of the ultrafiltration system according to some embodiments of the present disclosure at different viewing angles. Figure 1 , Figure 2 and Figure 3 (a), in some embodiments, the switching device includes: a switching valve 6, a liquid collecting tank 7 and a controller 8. The switching valve 6 has a plurality of pipe ports 23 and fluid outlets, and the plurality of pipe ports 23 are respectively connected to the raw material liquid tank 1, the replacement liquid tank 2 and the cleaning liquid tank 3 through pipelines. The liquid collecting tank 7 is connected to the fluid outlet of the switching valve 6 through a pipeline, and is respectively connected to the fluid drive unit 5 and the ultrafiltration membrane package 4 through pipelines. The controller 8 is connected to the switching valve 6 and the fluid drive unit 5 by signal, and is configured to control the switching and opening and closing of the switching valve 6, and to control the opening and closing of the fluid drive unit 5.

[0064] The controller 8 connects the connection port 23 of the switching valve 6 to the solution tank required in the ultrafiltration process, and causes the fluid driving unit 5 to drive the required solution to flow into the ultrafiltration membrane package 4 through the liquid collecting tank 7 for ultrafiltration.

[0065] refer to Figure 1 and Figure 2 In some embodiments, the ultrafiltration system includes: a first liquid level sensor 9. The first liquid level sensor 9 is located in the raw material liquid tank 1 and is configured to detect the liquid level of the raw material liquid tank 1, wherein the controller 8 is connected to the first liquid level sensor 9 by signal, and is configured to switch the switching valve 6 to a state where the raw material liquid tank 1 is connected to the liquid collecting tank 7 and start the fluid driving unit 5 when receiving a first preset liquid level signal from the first liquid level sensor 9.

[0066] Compared with the related art which requires manual monitoring of the liquid level in the raw material tank 1, the present embodiment monitors the liquid level signal of the raw material tank 1 in real time through the first liquid level sensor 9, and sends the signal to the controller 8. The user can set the first preset liquid level according to the raw material liquid capacity value required for the ultrafiltration process. When the liquid level in the raw material tank 1 reaches the first preset liquid level, the controller 8 switches the switching valve 6 to the state where the raw material tank 1 is connected to the liquid collecting tank 7, and the driving unit drives the raw material liquid in the raw material tank 1 to enter the ultrafiltration membrane package 4 to start ultrafiltration. The ultrafiltration process can be started without manual operation.

[0067] refer to Figure 1 In some embodiments, the ultrafiltration system includes: a waste liquid tank 10 and a second liquid level sensor 11. The waste liquid tank 10 is connected to the waste liquid outlet of the ultrafiltration membrane package 4, and is configured to collect waste liquid flowing out of the ultrafiltration membrane package 4. The second liquid level sensor 11 is located in the waste liquid tank 10, and is configured to detect the liquid level of the waste liquid tank 10, wherein the controller 8 is connected to the second liquid level sensor 11 signal, and is configured to stop the operation of the fluid drive unit 5 when receiving the second preset liquid level signal emitted by the second liquid level sensor 11, and to continue the operation of the fluid drive unit 5 when receiving the no liquid level signal emitted by the second liquid level sensor 11.

[0068] Compared with the related art which requires manual control of the start and stop of the ultrafiltration process, in this embodiment, the user can set a second preset liquid level according to the capacity of the waste liquid tank 10. When the liquid level of the waste liquid tank 10 reaches the second preset liquid level, the controller 8 suspends the ultrafiltration process, at which time the waste liquid in the waste liquid tank 10 can be discharged. When the waste liquid tank 10 is emptied, the controller 8 resumes the ultrafiltration process.

[0069] refer to Figure 1 , Figure 2 and Figure 3(b), in some embodiments, the ultrafiltration system includes: a third liquid level sensor 12, a finished liquid tank 13, a drain solenoid valve 14 and a first liquid level sensor 9. The third liquid level sensor 12 is located in the replacement liquid tank 2, and is configured to detect the liquid level of the replacement liquid tank 2. The finished liquid tank 13 is connected to the finished liquid outlet of the collecting tank 7, and is configured to collect the finished liquid flowing out of the collecting tank 7. The drain solenoid valve 14 is arranged in series on the flow path between the finished liquid outlet of the collecting tank 7 and the finished liquid tank 13. The first liquid level sensor 9 is located in the raw liquid tank 1, and is configured to detect the liquid level of the raw liquid tank 1.

[0070] The controller 8 is signal-connected with the first liquid level sensor 9, the third liquid level sensor 12 and the drain solenoid valve 14, and is configured to switch the switching valve 6 to a state in which the replacement liquid tank 2 and the collecting tank 7 are in circulation and start the fluid driving unit 5 when receiving a no liquid level signal from the first liquid level sensor 9, and to open the drain solenoid valve 14 after the fluid driving unit 5 continues to operate for a first preset period of time when receiving a no liquid level signal from the third liquid level sensor 12.

[0071] Compared with the related art, which requires manual replacement of pipeline connections to complete the switching of different solutions required during the ultrafiltration process, this embodiment detects that the raw material liquid in the raw material tank 1 has all entered the ultrafiltration membrane package 4 through the first liquid level sensor 9, and automatically switches the membrane package to the connection with the replacement tank to start the replacement process. The user can set the third preset liquid level according to the capacity of the replacement liquid, and set the first preset time according to the length of time the drive unit continues to drive after the replacement is completed. When the third liquid level sensor 12 detects that the replacement liquid in the replacement tank 2 has all entered the ultrafiltration membrane package 4, the drive unit continues to run for the first preset time, and the drain solenoid valve 14 discharges the finished liquid in the liquid collecting tank 7.

[0072] refer to Figure 2 In some embodiments, the ultrafiltration system includes: a fourth liquid level sensor 15. The fourth liquid level sensor 15 is located in the cleaning liquid tank 3 and is configured to detect the liquid level of the cleaning liquid tank 3, wherein the controller 8 is connected to the fourth liquid level sensor 15 signal, and is configured to close the drain solenoid valve 14 after opening for a second preset time, and then switch the switching valve 6 to a state where the cleaning liquid tank 3 is connected to the liquid collecting tank 7, and start the fluid driving unit 5, and when receiving the no liquid level signal from the fourth liquid level sensor 15, the fluid driving unit 5 is closed after running for a third preset time.

[0073] Compared with the related art, which requires manual replacement of pipeline connections to complete the switching of different solutions required during the ultrafiltration process, in this embodiment, the user can set the second preset time according to the required drainage time of the drainage solenoid valve 14, and set the third preset time according to the required driving time of the driving unit after the cleaning is completed. In this embodiment, after the fourth liquid level sensor 15 detects that all the cleaning liquid in the cleaning liquid tank 3 has entered the ultrafiltration membrane package 4, the driving unit continues to run for the third preset time and then stops running.

[0074] refer to Figure 1 and Figure 3 (b), in some embodiments, the ultrafiltration system includes: a waste liquid tank 10, a waste liquid solenoid valve 16 and a fourth liquid level sensor 15. The waste liquid tank 10 is connected to the waste liquid outlet of the ultrafiltration membrane package 4 and is configured to collect waste liquid flowing out of the ultrafiltration membrane package 4. The waste liquid solenoid valve 16 is arranged in series on the flow path between the outlet of the ultrafiltration membrane package 4 and the waste liquid tank 10.

[0075] The fourth liquid level sensor 15 is located in the cleaning liquid tank 3 and is configured to detect the liquid level of the cleaning liquid tank 3, wherein the controller 8 is connected to the waste liquid solenoid valve 16 and the fourth liquid level sensor 15 signal, and is configured to close the waste liquid solenoid valve 16 when receiving the no liquid level signal emitted by the fourth liquid level sensor 15.

[0076] Compared with the related art which requires manual replacement of pipeline connections to complete the switching of different solutions required during the ultrafiltration process, this embodiment stops discharging waste liquid after the fourth liquid level sensor 15 detects that all the cleaning liquid in the cleaning liquid tank 3 has entered the ultrafiltration membrane package 4.

[0077] refer to Figure 3 (a), in some embodiments, the ultrafiltration system includes: a one-way stop valve 17. The one-way stop valve 17 is arranged in series on the flow path between the ultrafiltration membrane package 4 and the liquid collecting tank 7, and is one-way from the liquid collecting tank 7 to the ultrafiltration membrane package 4. After cleaning, the ultrafiltration membrane package 4 is filled with cleaning liquid, and the one-way stop valve 17 can prevent the cleaning liquid from flowing back.

[0078] refer to Figure 1 In some embodiments, the ultrafiltration system includes: a refrigeration component 18. The refrigeration component 18 is located at the bottom of at least one of the raw liquid tank 1, the replacement liquid tank 2 and the cleaning liquid tank 3.

[0079] Compared with the related art that requires low-temperature storage of solutions that lack storage conditions, this embodiment uses the refrigeration component 18 to continuously refrigerate the solution to maintain a certain temperature.

[0080] refer to Figure 2In some embodiments, the ultrafiltration system includes: a touch screen 19. The touch screen 19 is connected to the controller 8 by signal. The user can operate the controller 8 through the touch screen 19 to complete different instructions.

[0081] refer to Figure 1 In some embodiments, the ultrafiltration system includes: a housing 20. The housing 20, the ultrafiltration membrane package 4, the fluid drive unit 5, the liquid collecting tank 7, the switching valve 6 and the controller 8 are all arranged in the housing 20. In this embodiment, the ultrafiltration membrane package 4, the fluid drive unit 5, the liquid collecting tank 7, the switching valve 6 and the controller 8 are integrated together, so that the pipeline is hidden in the housing 20 to avoid entanglement.

[0082] refer to Figure 1 In some embodiments, the ultrafiltration system includes: a placement plate 21. The placement plate 21 is arranged in the housing 20, the controller 8, the raw material liquid tank 1, the replacement liquid tank 2 and the cleaning liquid tank 3 are all fixedly arranged above the placement plate 21, and the liquid collecting tank 7, the ultrafiltration membrane package 4 and the fluid driving unit 5 are all arranged below the placement plate 21.

[0083] refer to Figure 1 In some embodiments, the ultrafiltration system includes: a partition 22 and a refrigeration assembly 18. The partition 22 is located below the placement plate 21, separating the refrigeration assembly 18 from the raw liquid tank. The refrigeration assembly 18 is located at the bottom of at least one of the raw liquid tank 1, the replacement liquid tank 2, and the cleaning liquid tank 3, and is located between the placement plate 21 and the partition 22.

[0084] In some embodiments, the fluid driving unit 5 in the ultrafiltration system is a peristaltic pump.

[0085] In some embodiments, the refrigeration component 18 in the ultrafiltration system is a semiconductor refrigerator. The semiconductor component can maintain the solution at a certain temperature, which can be selected from 0 to 8° C. In addition, the semiconductor refrigerator is small in size, making the ultrafiltration system more compact. In other embodiments, the refrigeration component can also adopt other structures, such as a heat exchanger.

[0086] Referring to the above embodiments and Figure 1-Figure 3 (b) , the working process of an example of the ultrafiltration system of the present invention is described below.

[0087] Before the ultrafiltration starts, the raw material solution is poured into the raw material tank 1, the replacement solution is poured into the replacement tank 2, and the cleaning solution is poured into the cleaning tank 3, and each pipeline is connected to the corresponding solution connection port. Click Start on the touch screen 19, and the ultrafiltration system starts working.

[0088] When the controller 8 receives the first preset liquid level signal from the first liquid level sensor 9, the fluid drive unit 5 drives the raw material solution to enter the ultrafiltration membrane package 4 through the liquid collection tank 7, filters the inactivated virus solution, and the waste liquid flows into the waste liquid tank 10 through the waste liquid outlet of the ultrafiltration membrane package 4. When the controller 8 receives the second preset liquid level signal from the second liquid level sensor 11, the fluid drive unit 5 stops running until the waste liquid in the waste liquid tank 10 is emptied. The effective solution in the ultrafiltration membrane package 4 will return to the liquid collection tank 7 until the first liquid level sensor 9 sends a no liquid level signal, then the switching valve 6 switches the liquid collection tank 7 to a state of being connected to the replacement liquid tank 2, and the fluid drive unit 5 drives the replacement liquid to enter the ultrafiltration membrane package 4 through the liquid collection tank 7 for replacement. When the controller 8 receives the no liquid level signal from the third liquid level sensor 12, the fluid drive unit 5 continues to work for the first preset time and then opens the discharge solenoid valve 14 to discharge the finished liquid into the finished liquid tank 13. When the drain solenoid valve 14 discharges for a second preset time, the controller 8 closes the drain solenoid valve 14, switches the switching valve 6 to a state where the liquid collecting tank 7 is connected to the cleaning liquid tank 3, and cleans the pipeline. When the fourth liquid level sensor 15 sends a no liquid level signal, the fluid drive unit 5 continues to operate for a third preset time and then stops working, and the waste liquid solenoid valve 16 is closed.

[0089] The cleaning solution is stored in the pipeline and the ultrafiltration membrane package 4, and the refrigeration component 18 continuously refrigerates the raw material liquid tank 1, the replacement liquid tank 2 and the cleaning liquid tank 3 to keep each solution at a preset temperature.

[0090] So far, various embodiments of the present disclosure have been described in detail. In order to avoid obscuring the concept of the present disclosure, some details known in the art are not described. Based on the above description, those skilled in the art can fully understand how to implement the technical solution disclosed here.

[0091] Although some specific embodiments of the present disclosure have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustration only and are not intended to limit the scope of the present disclosure. It should be understood by those skilled in the art that the above embodiments may be modified or some technical features may be replaced by equivalents without departing from the scope and spirit of the present disclosure. The scope of the present disclosure is defined by the appended claims.

Claims

1. An ultrafiltration system, characterized in that: include: A raw material solution tank (1) configured to store a raw material solution of a biological product; A replacement fluid tank (2), configured to store replacement fluid; A cleaning liquid tank (3) configured to store cleaning liquid; An ultrafiltration membrane package (4) configured to filter the raw material solution; a switching device connected to the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3), and in fluid communication with the ultrafiltration membrane package (4), and configured to selectively switch or close the fluid communication relationship between the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3) and the ultrafiltration membrane package (4); A fluid driving unit (5) is arranged in series on the flow path between the ultrafiltration membrane package (4) and the switching device; Wherein, the switching device comprises: A switching valve (6) having a plurality of connecting ports (23) and a fluid outlet, wherein the plurality of connecting ports (23) are respectively connected to the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3) through pipelines; A liquid collecting tank (7) is connected to the fluid outlet of the switching valve (6) through a pipeline, and is connected to the fluid driving unit (5) and the ultrafiltration membrane package (4) through pipelines respectively; A controller (8) is signal-connected to the switching valve (6) and the fluid drive unit (5), and is configured to control the switching and opening and closing of the switching valve (6), and to control the opening and closing of the fluid drive unit (5).

2. The ultrafiltration system according to claim 1, characterized in that Also includes: The first liquid level sensor (9) is located in the raw material liquid tank (1) and is configured to detect the liquid level of the raw material liquid tank (1). The controller (8) is connected to the first liquid level sensor (9) by signal, and is configured to switch the switching valve (6) to a state in which the raw material liquid tank (1) is connected to the liquid collecting tank (7) and start the fluid driving unit (5) when receiving a first preset liquid level signal sent by the first liquid level sensor (9).

3. The ultrafiltration system according to claim 1, characterized in that Also includes: A waste liquid tank (10), which is in communication with the waste liquid outlet of the ultrafiltration membrane package (4) and is configured to collect waste liquid flowing out of the ultrafiltration membrane package (4); The second liquid level sensor (11) is located in the waste liquid tank (10) and is configured to detect the liquid level of the waste liquid tank (10). The controller (8) is connected to the signal of the second liquid level sensor (11), and is configured to stop the operation of the fluid drive unit (5) when receiving a second preset liquid level signal emitted by the second liquid level sensor (11), and to continue the operation of the fluid drive unit (5) when receiving a no liquid level signal emitted by the second liquid level sensor (11).

4. The ultrafiltration system according to claim 1, characterized in that Also includes: a third liquid level sensor (12), located in the replacement liquid tank (2), and configured to detect the liquid level of the replacement liquid tank (2); A finished liquid tank (13), which is in communication with the finished liquid outlet of the liquid collecting tank (7) and is configured to collect the finished liquid flowing out of the liquid collecting tank (7); a liquid discharge solenoid valve (14) arranged in series on a flow path between a finished liquid outlet of the liquid collecting tank (7) and the finished liquid tank (13); The first liquid level sensor (9) is located in the raw material liquid tank (1) and is configured to detect the liquid level of the raw material liquid tank (1). The controller (8) is signal-connected to the first liquid level sensor (9), the third liquid level sensor (12) and the liquid discharge solenoid valve (14), and is configured to, upon receiving a liquid-free signal from the first liquid level sensor (9), switch the switching valve (6) to a state where the replacement liquid tank (2) and the liquid collecting tank (7) are in fluid communication, and start the fluid drive unit (5); and, upon receiving a liquid-free signal from the third liquid level sensor (12), cause the fluid drive unit (5) to continue operating for a first preset time period before opening the liquid discharge solenoid valve (14).

5. The ultrafiltration system according to claim 4, characterized in that Also includes: A fourth liquid level sensor (15) is located in the cleaning liquid tank (3) and is configured to detect the liquid level of the cleaning liquid tank (3). The controller (8) is connected to the fourth liquid level sensor (15) by signal, and is configured to close the liquid discharge solenoid valve (14) after opening for a second preset time, then switch the switching valve (6) to a state in which the cleaning liquid tank (3) is connected to the liquid collecting tank (7), and start the fluid drive unit (5), and when receiving a liquid level absence signal from the fourth liquid level sensor (15), the fluid drive unit (5) is operated for a third preset time and then closed.

6. The ultrafiltration system according to claim 1, characterized in that Also includes: A waste liquid tank (10), which is in communication with the waste liquid outlet of the ultrafiltration membrane package (4) and is configured to collect waste liquid flowing out of the ultrafiltration membrane package (4); A waste liquid solenoid valve (16) is arranged in series on the flow path between the outlet of the ultrafiltration membrane package (4) and the waste liquid tank (10); A fourth liquid level sensor (15) is located in the cleaning liquid tank (3) and is configured to detect the liquid level of the cleaning liquid tank (3). The controller (8) is connected to the waste liquid solenoid valve (16) and the fourth liquid level sensor (15) by signal, and is configured to close the waste liquid solenoid valve (16) when receiving a liquid level absence signal from the fourth liquid level sensor (15).

7. The ultrafiltration system according to any one of claims 1 to 6, characterized in that Also includes: A one-way stop valve (17) is arranged in series on the flow path between the ultrafiltration membrane package (4) and the liquid collecting tank (7), and is one-way conductive from the liquid collecting tank (7) to the ultrafiltration membrane package (4).

8. The ultrafiltration system according to any one of claims 1 to 6, characterized in that Also includes: A refrigeration component (18) is located at the bottom of at least one of the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3).

9. The ultrafiltration system according to any one of claims 1 to 6, characterized in that: Also includes: The touch screen (19) is connected to the controller (8) via signals.

10. The ultrafiltration system according to any one of claims 1 to 6, characterized in that: Also includes: A housing (20), wherein the ultrafiltration membrane package (4), the fluid drive unit (5), the liquid collecting tank (7), the switching valve (6) and the controller (8) are all arranged in the housing.

11. The ultrafiltration system according to claim 10, characterized in that Also includes: A placement plate (21) is arranged in the housing, The controller (8), the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3) are all fixedly arranged above the placement plate, and the liquid collecting tank (7), the ultrafiltration membrane package (4) and the fluid driving unit (5) are all arranged below the placement plate.

12. The ultrafiltration system according to claim 11, characterized in that Also includes: A partition plate (22) located below the placement plate; A refrigeration component (18) is located at the bottom of at least one of the raw material liquid tank (1), the replacement liquid tank (2) and the cleaning liquid tank (3), and is located between the placement plate and the partition plate.

13. The ultrafiltration system according to any one of claims 1 to 6, characterized in that: The fluid driving unit (5) is a peristaltic pump.

14. The ultrafiltration system according to claim 8, characterized in that The refrigeration component is a semiconductor refrigerator.

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