An impedance electrode conductive glue beneficial to cell activity and preparation method thereof

Abstract

The present invention provides an impedance electrode conductive glue that is beneficial to cell activity and a preparation method thereof. The impedance electrode conductive glue comprises the following components and their mass percentages: glycerol 45.56% to 45.70%, methacrylic acid amide 15.16% to 15.24%, ethylene glycol 2.50% to 2.75%, potassium hydroxide 4.6% to 5.00%, potassium chloride 2.22% to 2.36%, diethylene glycol diacrylate 0.27% to 0.284%, benzoin dimethyl ether 0.054% to 0.066%, and pure water 28.94% to 29.15%. By adopting the technical solution of the present invention, the conductive glue obtained has a stable AC impedance of 80 to 100Ω, which meets the requirements of the industry standard; in the in vitro cytotoxicity test, the cell survival rate can reach up to 87.8%, which is 70% higher than the regulatory requirements; and the conductive glue repeatedly contacts human skin and has good touch comfort.

Description

Technical Field

[0001] The invention relates to the technical field of conductive glue, and in particular to an impedance electrode conductive glue that is beneficial to cell activity and a preparation method thereof. Background Art

[0002] Impedance electrodes are metal conductors used to capture various bioelectric phenomena in the human body, also known as guide electrodes. Its impedance, polarization characteristics, stability, etc. have a great influence on the accuracy of measurement. Disposable impedance electrodes are used as a supporting device for ECG equipment and are mainly used in ECG detection and monitoring. Currently, disposable impedance electrodes have been widely used in operating rooms, anesthesia departments, ICU wards, cardiology departments, cardiac surgery departments and emergency centers.

[0003] The main component of disposable impedance electrodes is conductive glue, which comes in two types: liquid glue and solid glue. Liquid glue has strong penetration and moisturizing effect on the skin, and can provide very fast and stable ECG waveforms; and liquid glue is suitable for ECG diagnosis and monitoring for people with dry, rough skin, heavy hair and low temperature environments. For example: the elderly, manual laborers, and dry and low-temperature areas. Solid glue itself is sticky. Even if the user applies pressure or moves a large amplitude, the conductive glue will not instantly detach from the skin surface, causing the electrical signal to disappear instantly; so solid glue is generally suitable for ECG diagnosis and monitoring during exercise. For example: sports treadmill, dynamic Holter, professional athlete ECG test, etc.

[0004] As the only connection point between the detection equipment and the human body, the conductive glue must have and meet the following requirements of laws and regulations and industry standards: safety and non-toxicity, excellent conductivity and no external electromagnetic interference, comfortable touch on human skin, etc. Compared with physical therapy electrode conductive glue and ECG electrode conductive glue, the formula of impedance conductive glue is obviously different from the first two in order to achieve better conductive performance. However, conductive glue is obtained by mixing multiple chemicals in a certain ratio. The change in the proportion of one or several chemicals has a huge impact on the physical and chemical properties of the colloid after UV curing, especially its cytotoxicity and the comfort of human skin touch, which will affect cell activity. Summary of the invention

[0005] In response to the above technical problems, the present invention discloses an impedance electrode conductive glue that is beneficial to cell activity and a preparation method thereof. While taking into account the AC impedance, it has a higher cell survival rate and a good user experience.

[0006] To this end, the technical solution adopted by the present invention is:

[0007] The invention discloses an impedance electrode conductive glue which is beneficial to cell activity. The components contained in the conductive glue and their mass percentages are as follows: 45.56% to 45.70% glycerol, 15.16% to 15.24% methacrylic acid amide, 2.50% to 2.75% ethylene glycol, 4.6% to 5.00% potassium hydroxide, 2.22% to 2.36% potassium chloride, 0.27% to 0.284% diethylene glycol diacrylate, 0.054% to 0.066% benzoin dimethyl ether, and 28.94% to 29.15% pure water.

[0008] As a further improvement of the present invention, the components of the impedance electrode conductive glue that is beneficial to cell activity and their mass percentages are: 45.56% to 45.70% glycerol, 15.16% to 15.24% methacrylic acid amide, 2.50% to 2.64% ethylene glycol, 4.84% to 5.00% potassium hydroxide, 2.22% to 2.36% potassium chloride, 0.27% to 0.284% diethylene glycol diacrylate, 0.054% to 0.066% benzoin dimethyl ether, and 28.94% to 29.06% pure water.

[0009] As a further improvement of the present invention, the components of the impedance electrode conductive glue that is beneficial to cell activity and their mass percentages are: 45.65% glycerol, 15.2% methacrylic acid amide, 2.58% ethylene glycol, 4.92% potassium hydroxide, 2.3% potassium chloride, 0.28% diethylene glycol diacrylate, 0.064% benzoin dimethyl ether, and 29% pure water.

[0010] The present invention also discloses a method for preparing the impedance electrode conductive glue that is beneficial to cell activity as described above, comprising the following steps: weighing methyl methacrylate, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate, and benzoin dimethyl ether according to the formula amount, dissolving them in pure water, then adding glycerol, and stirring them thoroughly to obtain a clear and transparent colloid.

[0011] Compared with the prior art, the present invention has the following beneficial effects:

[0012] First, the conductive adhesive obtained by adopting the technical solution of the present invention has a stable AC impedance of 80-100Ω, which meets the requirement of the industry standard of ≤3000Ω, and in the "in vitro cytotoxicity" test, the cell survival rate can reach up to 87.8%, which is 70% higher than the regulatory requirement. Moreover, the conductive adhesive repeatedly contacts human skin without any strange feeling or residue, has good touch comfort, and the colloid is clear and transparent without irritating odor.

[0013] Second, the conductive adhesive of the technical solution of the present invention has a high formula tolerance, is safe and non-toxic, has excellent conductive properties, and is not affected by external electromagnetic interference. DETAILED DESCRIPTION

[0014] The preferred embodiments of the present invention are described in further detail below.

[0015] Example 1

[0016] The invention discloses an impedance electrode conductive glue which is beneficial to cell activity. The components are weighed according to the total mass of the conductive glue of 500g. The components are: 145.030g of pure water, 228.250g of glycerol, 76.000g of methacrylic acid amide, 12.900g of ethylene glycol, 24.600g of potassium hydroxide, 11.500g of potassium chloride, 1.400g of diethylene glycol diacrylate, and 0.320g of benzoin dimethyl ether. Methacrylic acid amide, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate, and benzoin dimethyl ether are dissolved in pure water, stirred evenly, and then glycerol is added and stirred fully to obtain a clear and transparent colloid without irritating odor.

[0017] Example 2

[0018] The invention discloses an impedance electrode conductive glue which is beneficial to cell activity. The components are weighed according to the total mass of the conductive glue of 500g. The components are: 145.380g of pure water, 228.250g of glycerol, 76.000g of methacrylic acid amide, 12.550g of ethylene glycol, 24.600g of potassium hydroxide, 11.500g of potassium chloride, 1.400g of diethylene glycol diacrylate, and 0.320g of benzoin dimethyl ether. Methacrylic acid amide, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate, and benzoin dimethyl ether are dissolved in pure water, stirred evenly, and then glycerol is added and stirred fully to obtain a clear and transparent colloid without irritating odor.

[0019] Example 3

[0020] The invention discloses an impedance electrode conductive glue which is beneficial to cell activity. The components are weighed according to the total mass of the conductive glue of 500g, and the components are: 145.730g of pure water, 228.250g of glycerol, 76.000g of methacrylic acid amide, 13.800g of ethylene glycol, 23.000g of potassium hydroxide, 11.500g of potassium chloride, 1.400g of diethylene glycol diacrylate, and 0.320g of benzoin dimethyl ether. Methacrylic acid amide, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate, and benzoin dimethyl ether are dissolved in pure water, stirred evenly, and then glycerol is added and stirred fully to obtain a clear and transparent colloid without irritating odor.

[0021] Comparative Example 1

[0022] An impedance electrode conductive glue is provided. Each component is weighed according to the total mass of the conductive glue of 500g. The components are: 146.430g of pure water, 228.250g of glycerol, 79.500g of methacrylic acid amide, 8.000g of ethylene glycol, 24.600g of potassium hydroxide, 11.500g of potassium chloride, 1.400g of diethylene glycol diacrylate, and 0.320g of benzoin dimethyl ether. Methacrylic acid amide, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate, and benzoin dimethyl ether are dissolved in pure water, stirred evenly, and then glycerol is added and stirred fully to obtain a colloid.

[0023] Comparative Example 2

[0024] An impedance electrode conductive glue is provided. The components are weighed according to the total mass of the conductive glue of 500g. The components are: 146.270g of pure water, 228.250g of glycerol, 82.500g of methacrylic acid amide, 6.600g of ethylene glycol, 23.000g of potassium hydroxide, 11.500g of potassium chloride, 1.400g of diethylene glycol diacrylate, and 0.480g of benzoin dimethyl ether. Methacrylic acid amide, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate, and benzoin dimethyl ether are dissolved in pure water, stirred evenly, and then glycerol is added and stirred fully to obtain a colloid.

[0025] Comparative Example 3

[0026] An impedance electrode conductive glue is provided. The components are weighed according to the total mass of the conductive glue of 500g. The components are: 151.270g of pure water, 228.250g of glycerol, 72.500g of methacrylic acid amide, 13.600g of ethylene glycol, 21.000g of potassium hydroxide, 11.500g of potassium chloride, 1.400g of diethylene glycol diacrylate, and 0.480g of benzoin dimethyl ether. Methacrylic acid amide, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate, and benzoin dimethyl ether are dissolved in pure water, stirred evenly, and then glycerol is added and stirred fully to obtain a colloid.

[0027] Comparative Example 4

[0028] An impedance electrode conductive glue is provided. The components are weighed according to the total mass of the conductive glue of 500g. The components are: 146.150g of pure water, 228.250g of glycerol, 75.000g of methacrylic acid amide, 15.380g of ethylene glycol, 22.000g of potassium hydroxide, 11.500g of potassium chloride, 1.400g of diethylene glycol diacrylate, and 0.320g of benzoin dimethyl ether. Methacrylic acid amide, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate, and benzoin dimethyl ether are dissolved in pure water, stirred evenly, and then glycerol is added and stirred fully to obtain a colloid.

[0029] Thirty samples of the above-mentioned embodiment and comparative example were prepared respectively, and AC impedance and cell viability tests were performed. The test methods were respectively in accordance with industry standard YY / T 0196-2005 and national standard GB / T 16886.5-2017. In addition, human skin touch detection was performed on different people, and the results are shown in Table 1.

[0030]

[0031] By comparing the above embodiments and comparative examples, it can be seen that the conductive adhesive using the technical solution of the present invention has a higher cell survival rate while taking into account the conductive performance, and has no strange feeling or residue after repeated contact with human skin, and has good touch comfort.

[0032] The above contents are further detailed descriptions of the present invention in combination with specific preferred embodiments, and it cannot be determined that the specific implementation of the present invention is limited to these descriptions. For ordinary technicians in the technical field to which the present invention belongs, several simple deductions or substitutions can be made without departing from the concept of the present invention, which should be regarded as falling within the protection scope of the present invention.

Claims

1. An impedance electrode conductive glue that is beneficial to cell activity, characterized in that: It is composed of the following components, with the mass percentage of each component being: glycerol 45.56%~45.70%, methacrylic acid amide 15.16%~15.24%, ethylene glycol 2.50%~2.75%, potassium hydroxide 4.6%~5.00%, potassium chloride 2.22%~2.36%, diethylene glycol diacrylate 0.27%~0.284%, benzoin dimethyl ether 0.054%~0.066%, and pure water 28.94%~29.15%.

2. The impedance electrode conductive glue beneficial to cell activity according to claim 1, characterized in that: It is composed of the following components, with the mass percentage of each component being: glycerol 45.56%~45.70%, methacrylic acid amide 15.16%~15.24%, ethylene glycol 2.50%~2.64%, potassium hydroxide 4.84%~5.00%, potassium chloride 2.22%~2.36%, diethylene glycol diacrylate 0.27%~0.284%, benzoin dimethyl ether 0.054%~0.066%, and pure water 28.94%~29.06%.

3. The impedance electrode conductive glue beneficial to cell activity according to claim 2, characterized in that: It is composed of the following components, with the mass percentage of each component being: 45.65% glycerol, 15.2% methacrylic acid amide, 2.58% ethylene glycol, 4.92% potassium hydroxide, 2.3% potassium chloride, 0.28% diethylene glycol diacrylate, 0.064% benzoin dimethyl ether, and 29.006% pure water.

4. The method for preparing the impedance electrode conductive glue beneficial to cell activity according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: weighing methyl methacrylic acid amide, ethylene glycol, potassium hydroxide, potassium chloride, diethylene glycol diacrylate and benzoin dimethyl ether according to the formula amount, dissolving them in pure water, then adding glycerin, and stirring them fully to obtain a clear and transparent colloid.

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