A preparation method of compound glycyrrhizin tablets

Abstract

The present invention relates to the field of pharmaceutical technology, and in particular to a method for preparing compound glycyrrhizin tablets, comprising: taking a certain amount of glycine raw material, crushing it and then sieving it; taking a certain amount of ethanol, adding a certain amount of ethyl cellulose while stirring until it is added, stirring for a preset time, and then standing for a period of time to obtain an ethyl cellulose ethanol solution; pouring the sieved glycine raw material into an airflow mixing bin, chopping and dry mixing, adding a certain amount of ethyl cellulose ethanol solution for wet mixing and granulation to make soft material particles; continuing to granulate the soft material particles to make wet whole particles; drying the airflow mixing bin and then cooling it to make dry whole particles; adding a certain amount of magnesium stearate to the dry whole particles to mix them to generate an intermediate product; and coating the intermediate product after tableting to make compound glycyrrhizin tablets. The present invention changes the stirring process to airflow mixing, increases the detection of relevant preparation parameters in the airflow mixing bin, and improves the quality of compound glycyrrhizin tablets as a whole.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceuticals, and in particular to a method for preparing a compound glycyrrhizin tablet. Background Art

[0002] Compound glycyrrhizic acid tablets are a compound preparation composed of glycyrrhizic acid (glycyrrhizin), glycine, and DL-methionine. They have anti-inflammatory, anti-allergic, immunomodulatory, and liver cell proliferation-promoting effects.

[0003] Chinese patent application publication number CN106692086A discloses a compound glycyrrhizin tablet, which is a tablet made of glycyrrhizic acid monoammonium salt, glycine and DL-methionine as main raw materials, and fillers and disintegrants as auxiliary materials. The mass ratio of the main raw materials to the auxiliary materials is 1:1.7-2.8, the filler is mannitol and starch mixed in a mass ratio of 2:1, and the disintegrant is xanthan gum. The present invention also discloses a preparation method of the above-mentioned compound glycyrrhizin tablet, which comprises grinding, sieving, mixing and tableting in sequence.

[0004] It can be seen that the preparation method of the compound glycyrrhizin tablets has the following problems: during the mixing process, the ordinary wet mixing process cannot accurately guarantee the uniformity of the raw material content of the mixed intermediate product, resulting in inaccurate dosage when taking the compound glycyrrhizin tablets. Summary of the invention

[0005] To this end, the present invention provides a method for preparing a compound glycyrrhizin tablet, which is used to overcome the problem in the prior art that the ordinary wet mixing process cannot accurately ensure the uniformity of the raw material content of the mixed intermediate product during the mixing process, thereby resulting in an inaccurate dosage when taking the compound glycyrrhizin tablet.

[0006] To achieve the above object, the present invention provides a method for preparing compound glycyrrhizin tablets, comprising:

[0007] Take a certain amount of glycine raw material, crush it and then sieve it;

[0008] Take a certain amount of ethanol, add a certain amount of ethyl cellulose while stirring until the ethyl cellulose is added, stir for a preset time, and then let it stand for a period of time to obtain an ethyl cellulose ethanol solution;

[0009] The sieved glycine raw material is poured into an air flow mixing bin, chopped and dry mixed, and then a certain amount of ethyl cellulose ethanol solution is added for wet mixing and granulation to make soft material particles;

[0010] During the dry mixing process, the glycine raw material is cut according to the cutting speed, and the dry mixing time is adjusted according to the fragment images collected during the dry mixing process;

[0011] During the wet mixing process, the mixture after adding the ethyl cellulose ethanol solution is pelletized according to the pelletizing speed, and the wet mixing time is adjusted according to the collected particle photos of the soft material particles and the bottom photos of the warehouse during the wet mixing process;

[0012] During the dry mixing and wet mixing process, the pre-set mixed air flow pulse frequency is adjusted according to the actual dry mixing time and the actual wet mixing time, and the pre-set mixed air flow pulse frequency is adjusted according to the actual air pressure in the bin;

[0013] The soft material particles are further pelletized, and the preset pelletizing airflow pulse frequency is adjusted according to the collected pelletizing images to produce wet whole pellets;

[0014] The airflow mixing bin is dried, and the actual drying time is determined according to the actual temperature and actual humidity in the airflow mixing bin, and after the drying time is reached, the airflow mixing bin is cooled to form dry whole particles;

[0015] A certain amount of magnesium stearate is added to the dry whole granules and mixed to form an intermediate product;

[0016] According to the weight and batch of the intermediate product, the compound glycyrrhizic acid tablets are prepared by tableting and coating.

[0017] Furthermore, the process of pouring the sieved glycine raw material into the airflow mixing bin for shredding and dry mixing is as follows:

[0018] Pre-set cutting speed, dry mixing time and mixed air flow pulse frequency.

[0019] The glycine raw material is cut according to the cutting rotation speed, and the glycine raw material is air-stirred at a preset mixed air flow pulse frequency until the chopping time of the glycine raw material reaches the dry mixing time.

[0020] Furthermore, the process of adjusting the dry mixing time according to the collected fragment images during the dry mixing process is as follows;

[0021] Pre-set qualified fragment images and area difference thresholds,

[0022] The area difference is calculated based on the fragment image and the qualified fragment image, and the dry mixing time delay processing is performed on the glycine raw material whose area difference is greater than the area difference threshold and has reached the dry mixing time.

[0023] Further, a certain amount of ethyl cellulose ethanol solution is added for wet mixing and pelletizing.

[0024] Pre-set pelletizing speed and wet mixing time.

[0025] The mixture after adding the ethyl cellulose ethanol solution is pelletized according to the pelletizing rotation speed, and the mixture is air-stirred at a preset mixed air flow pulse frequency until the wet mixing process duration reaches the wet mixing duration.

[0026] Furthermore, according to the collected photos of the soft material particles and the photos of the warehouse bottom during the wet mixing process, the process of adjusting the wet mixing time is as follows:

[0027] Pre-set the surface qualified photos of soft material particles,

[0028] Based on the comparison between qualified surface photos and particle photos, combined with the photos of the silo bottom, the wet mixing time will be extended if the surface of the soft material particles is not smooth or there is dry powder at the bottom of the silo.

[0029] Furthermore, the process of adjusting the preset mixed air flow pulse frequency according to the actual dry mixing time and the actual wet mixing time is as follows:

[0030] Pre-set the air flow pulse frequency and mixed air flow pulse frequency adjustment parameters,

[0031] According to the difference between the actual dry mixing time and the preset dry mixing time, the difference between the actual wet mixing time and the preset wet mixing time, the airflow pulse adjustment frequency is calculated in combination with the mixed airflow pulse frequency adjustment parameter, and the mixed airflow pulse frequency is extended or shortened according to the airflow pulse adjustment frequency.

[0032] Furthermore, according to the actual air pressure in the chamber, the process of adjusting the preset mixed airflow pulse frequency is as follows:

[0033] Preset the air pressure threshold and the first air pressure value,

[0034] The air pressure difference is calculated according to the air pressure threshold and the actual air pressure in the chamber. When the air pressure difference is greater than the first air pressure value, the pulse frequency of the mixed airflow is adjusted to decrease.

[0035] Furthermore, the process of adjusting the preset pelletizing airflow pulse frequency according to the collected pelletizing image is as follows:

[0036] Pre-set the pelletizing size qualified threshold image and pelletizing airflow pulse frequency,

[0037] The pelletizing image is compared with the pelletizing size qualified threshold image. When the pelletizing image is larger than all pelletizing size qualified threshold images, the pelletizing airflow pulse frequency is adjusted to increase.

[0038] Furthermore, the process of determining the actual drying time according to the actual temperature and actual humidity in the airflow mixing chamber is as follows:

[0039] Preset drying temperature, drying humidity, temperature change prediction model and drying time;

[0040] The airflow mixing chamber is dried according to the drying temperature until the drying time is reached, and the actual temperature and the drying temperature are compared in real time. Based on the temperature change prediction model, the actual drying time for the airflow mixing chamber to reach the drying humidity is predicted according to the actual temperature change in the airflow mixing chamber, and the actual drying time overwrites the originally preset drying time.

[0041] Further, according to the weight and batch of the intermediate product, the tableting process is:

[0042] Preset tableting pressure range,

[0043] The tableting weight is calculated based on the weight of the intermediate product and the batch size, and the actual tableting pressure is controlled within the tableting pressure range to tablet the intermediate product.

[0044] Compared with the prior art, the beneficial effect of the present invention lies in that the present invention performs corresponding preparation process settings for the mixing process and the drying process in the preparation process of the compound glycyrrhizin tablets, and at the same time changes the stirring process of the original stirring blades into airflow mixing, that is, compressed air is ejected from the nozzle in a pulse cycle, so that the glycine raw material is turned and rolled in the airflow mixing bin, thereby achieving the effect of improving the mixing uniformity of the compound glycyrrhizin tablets, and the preparation process is efficient, low in unit energy consumption, and the effect of improving the short-time uniform mixing efficiency of large quantities of materials is achieved. Moreover, on this basis, the pressure, temperature, humidity in the airflow mixing bin and the image capture of each material in the mixing process are increased, thereby achieving the effect of improving the overall preparation efficiency of the compound glycyrrhizin tablets, and can realize automatic adjustment of the preparation process parameters of the compound glycyrrhizin tablets to ensure the qualified rate of the compound glycyrrhizin tablet products.

[0045] Furthermore, the present invention ejects compressed air from the nozzle in a pulsed cycle so that the glycine raw material is chopped by the cutting device during the tumbling process, thereby achieving the purpose of uniformly chopping the raw material and ensuring the uniform granulation content in the subsequent wet mixing process.

[0046] Furthermore, the present invention makes judgments based on captured fragment images and qualified fragment images during the dry mixing process, thereby extending the preset dry mixing time, reducing uneven raw materials during the dry mixing process, and thereby improving the qualified rate of finished product content.

[0047] Furthermore, the present invention sprays compressed air from the nozzle in a pulse cycle so that the mixture is chopped by the cutting device during the tumbling process, thereby achieving the purpose of uniform granulation.

[0048] Furthermore, the present invention combines the soft material particles with the photos of the warehouse bottom to judge whether the soft material particles are obvious and whether there is dry powder residue at the warehouse bottom, thereby achieving the effect of improving the utilization rate of raw materials and laying a foundation for subsequent pelletizing.

[0049] Furthermore, the present invention adjusts the pulse frequency of the mixed airflow according to the actual dry mixing time and the actual wet mixing time, thereby ensuring that the time for mixing the raw materials meets the requirements and improving the preparation efficiency of the compound glycyrrhizin tablets.

[0050] Furthermore, the present invention reduces the actual air pressure in the chamber by adjusting the mixed airflow pulse frequency, thereby ensuring that the air pressure in the airflow mixing chamber meets the requirements and that the mixing conditions in the airflow mixing chamber meet the requirements.

[0051] Furthermore, the present invention increases the frequency of the pelletizing airflow pulses by adjusting the pelletizing airflow pulse frequency, thereby increasing the flipping and rolling rate of the pelletizing in the airflow mixing chamber, and increasing the stirring speed of the cutting device at the same pelletizing speed, thereby reducing the size of the solid phase particles. BRIEF DESCRIPTION OF THE DRAWINGS

[0052] Figure 1 The flowchart of the preparation method of the compound glycyrrhizin tablets described in this embodiment;

[0053] Figure 2 This is a diagram of an airflow mixing device used in the mixing process in the preparation method of the compound glycyrrhizin tablets described in this embodiment;

[0054] Figure 3 The figure is a logical process diagram of the preparation method of the compound glycyrrhizin tablets described in this embodiment;

[0055] Figure 4 It is a logical process diagram of adjusting the pulse frequency of the mixed airflow in the preparation method of the compound glycyrrhizin tablets described in this embodiment;

[0056] In the figure, there are an air flow mixing chamber 1, a pulse gas circulation device 2, a temperature and humidity sensor 3, a pressure sensor 4, an ethyl cellulose ethanol solution chamber 5, a feed inlet 6, a mixing state display 7, and a cutting device 8. DETAILED DESCRIPTION

[0057] In order to make the objects and advantages of the present invention more clearly understood, the present invention is further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0058] The preferred embodiments of the present invention are described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are only used to explain the technical principles of the present invention and are not intended to limit the protection scope of the present invention.

[0059] It should be noted that, in the description of the present invention, terms such as "up", "down", "left", "right", "inside" and "outside" indicating directions or positional relationships are based on the directions or positional relationships shown in the drawings. This is merely for the convenience of description and does not indicate or imply that the device or element must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0060] In addition, it should be noted that in the description of the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0061] See also Figure 1 , Figure 2 , Figure 3 As shown, Figure 1 is a flow chart of the preparation method of the compound glycyrrhizin tablets described in this embodiment, Figure 2 FIG. 1 is a diagram of an airflow mixing device used in the mixing process in the preparation method of the compound glycyrrhizin tablets described in this embodiment. Figure 3 The figure is a logical process diagram of the preparation method of the compound glycyrrhizin tablets described in this embodiment.

[0062] Figure 2In the process, the glycine raw material enters the airflow mixing chamber 1 through the feed port 6, and then the feed port 6 is closed, the pulse gas circulation device 2 is turned on, and compressed air is ejected from the nozzle in a pulse circulation manner to make the glycine raw material flip and roll in the airflow mixing chamber 1, and the cutting device 8 is turned on to make the glycine raw material be chopped by the cutting device during the tumbling process until the dry mixing time is reached. During the dry mixing process, the mixing state display 7 captures the state of the raw materials in the airflow mixing bin 1. After observing that the expected crushing effect is achieved, the valve at the ethyl cellulose ethanol solution bin 5 is opened to allow the ethyl cellulose ethanol solution to fall into the chopped raw materials and mix with the chopped raw materials. At the same time, the pulse gas circulation device 2 and the cutting device 8 are turned on. The pulse gas circulation device 2 allows the glycine raw material and the ethyl cellulose ethanol solution to be wet mixed in the airflow mixing bin 1, and the cutting device 8 will chop the wet mixed mixture into particles. The drying fan outside the airflow mixing device is turned on to blow dry the airflow mixing bin 1 until the temperature in the airflow mixing bin 1 detected by the temperature and humidity sensor 3 reaches about 30.0°C and the humidity in the airflow mixing bin 1 reaches the preset humidity. The drying fan outside the airflow mixing bin 1 is turned off, and the inside of the airflow mixing device is cooled for 5 minutes before discharging. This embodiment does not involve the control of the drying fan and the cooling device outside the airflow mixing device. Therefore, Figure 2 The pulse gas circulation device 2 can not only compress the air and eject it from the nozzle in a pulse circulation manner, but also send negative pressure out of the airflow mixing chamber 1, thereby ensuring the pressure in the airflow mixing chamber 1.

[0063] The pressure sensor 4 detects the pressure in the airflow mixing bin 1 to prevent the pulse gas circulation device 2 from causing problems in the gas circulation of the airflow mixing bin 1, which may lead to excessive pressure in the airflow mixing bin 1; the temperature and humidity sensor 3 detects the actual temperature and humidity in the airflow mixing bin 1. During dry mixing, the mixing state display 7 captures the state of the raw materials in the airflow mixing bin 1 to generate fragment images; during wet mixing, the mixing state display 7 collects particle photos of soft material particles and bin bottom photos; during pelletizing of soft material particles, the mixing state display 7 collects pelletizing images.

[0064] The present invention provides a method for preparing a compound glycyrrhizin tablet, comprising:

[0065] Take a certain amount of glycine raw material, crush it and then sieve it;

[0066] Take a certain amount of ethanol, add a certain amount of ethyl cellulose while stirring until the ethyl cellulose is added, stir for a preset time, and then let it stand for a period of time to obtain an ethyl cellulose ethanol solution;

[0067] The sieved glycine raw material is poured into an air flow mixing bin, chopped and dry mixed, and then a certain amount of ethyl cellulose ethanol solution is added for wet mixing and granulation to make soft material particles;

[0068] During the dry mixing process, the glycine raw material is cut according to the cutting speed, and the dry mixing time is adjusted according to the fragment images collected during the dry mixing process;

[0069] During the wet mixing process, the mixture after adding the ethyl cellulose ethanol solution is pelletized according to the pelletizing speed, and the wet mixing time is adjusted according to the collected particle photos of the soft material particles and the bottom photos of the warehouse during the wet mixing process;

[0070] During the dry mixing and wet mixing process, the pre-set mixed air flow pulse frequency is adjusted according to the actual dry mixing time and the actual wet mixing time, and the pre-set mixed air flow pulse frequency is adjusted according to the actual air pressure in the bin;

[0071] The soft material particles are further pelletized, and the preset pelletizing airflow pulse frequency is adjusted according to the collected pelletizing images to produce wet whole pellets;

[0072] The airflow mixing bin is dried, and the actual drying time is determined according to the actual temperature and actual humidity in the airflow mixing bin, and after the drying time is reached, the airflow mixing bin is cooled to form dry whole particles;

[0073] A certain amount of magnesium stearate is added to the dry whole granules and mixed to form an intermediate product;

[0074] According to the weight and batch of the intermediate product, the compound glycyrrhizic acid tablets are prepared by tableting and coating.

[0075] The certain amount of raw materials is weighed according to production requirements.

[0076] In this embodiment, a method for preparing a compound glycyrrhizin tablet comprises:

[0077] Step S1, taking the required amount of glycine raw material for production, crushing it through a 60-mesh sieve for later use;

[0078] Step S2, taking 72.00 kg of ethanol and adding 3.00 kg of ethyl cellulose while stirring, continuing to stir for 20 minutes after the addition, and standing for 24 hours to obtain a 4% ethyl cellulose ethanol solution;

[0079] Step S3, pouring the sieved glycine raw material into the airflow mixing bin, turning on the cutting device and the pulse gas circulation device, dry mixing for 100 seconds, and adjusting the dry mixing time according to the collected fragment images during the dry mixing process, adding 37.5 kg of 4% ethyl cellulose ethanol solution for wet mixing and pelletizing to make soft material particles;

[0080] Step S4, continuing to pelletize the soft material particles, adjusting the preset pelletizing airflow pulse frequency according to the collected pelletizing images, and producing wet whole pellets;

[0081] Step S5, turning on the drying fan outside the airflow mixing device, setting the air inlet temperature to 80.0°C, drying the soft material particles for 15-20 minutes, making the final temperature of the material reach about 30.0°C, turning off the heating, measuring the humidity of the airflow mixing bin after it is qualified, cooling for 5 minutes and then discharging the material to obtain dry whole particles;

[0082] Step S6, adding a prescribed amount of magnesium stearate to the dry granules, setting the rotation speed to 6.0 rpm, and mixing for 25.0 min to generate an intermediate product;

[0083] Step S7, according to the weight and batch of the intermediate product, tableting and coating are performed to prepare compound glycyrrhizin tablets.

[0084] In step S3, it also includes:

[0085] Step S3-1, during the dry mixing process, the glycine raw material is cut according to a cutting speed of 1000 rpm, and the dry mixing time is adjusted according to the fragment images collected during the dry mixing process;

[0086] Step S3-2, during the wet mixing process, the mixture after adding the ethyl cellulose ethanol solution is pelletized at a pelletizing speed of 1500 rpm, and the wet mixing time is adjusted according to the collected particle photos of the soft material particles and the warehouse bottom photos during the wet mixing process, so that the sum of the wet mixing time and the dry mixing time is within the range of 360-500 seconds;

[0087] Step S3-3, during the dry mixing and wet mixing process, the preset mixed airflow pulse frequency is adjusted according to the actual dry mixing time and the actual wet mixing time, and the preset mixed airflow pulse frequency is adjusted according to the actual air pressure in the bin.

[0088] The present invention arranges the mixing process and the drying process in the preparation process of the compound glycyrrhizin tablets accordingly, and at the same time changes the stirring process of the original stirring blades into airflow mixing, that is, compressed air is ejected from a nozzle in a pulse cycle mode, so that the raw material of glycine turns and rolls in an airflow mixing bin, so as to achieve the effect of improving the mixing uniformity of the compound glycyrrhizin tablets, and the preparation process is efficient, the unit energy consumption is low, and the effect of improving the short-time uniform mixing efficiency of a large number of materials is achieved, and on this basis, the pressure, temperature, humidity in the airflow mixing bin and the image capture of each material in the mixing process are increased, so as to achieve the effect of improving the preparation efficiency of the compound glycyrrhizin tablets as a whole, and can realize automatic adjustment of the preparation process parameters of the compound glycyrrhizin tablets, so as to ensure the qualified rate of the compound glycyrrhizin tablet products.

[0089] See also Figure 3 Specifically, in this embodiment, the process of chopping and dry mixing the sieved glycine raw material is as follows:

[0090] Pre-set cutting speed, dry mixing time and mixed air flow pulse frequency.

[0091] The glycine raw material is cut according to the cutting rotation speed, and the glycine raw material is air-stirred at a preset mixed air flow pulse frequency until the chopping time of the glycine raw material reaches the dry mixing time.

[0092] The cutting speed is preset to 1000 rpm, the dry mixing time Gt1=100S, and the mixed air flow pulse frequency Qf1. At this time, the mixed air flow pulse frequency Qf1 can achieve the same effect as ordinary stirring at 100 rpm.

[0093] The invention sprays compressed air from a nozzle in a pulse cycle mode, so that the glycine raw material is chopped by a cutting device during the tumbling process, thereby achieving the purpose of uniformly chopping the raw material and ensuring the uniform granulation content in the subsequent wet mixing process.

[0094] See also Figure 3 , specifically, in this embodiment, the process of adjusting the dry mixing time according to the collected fragment images during the dry mixing process is;

[0095] Pre-set qualified fragment images and area difference thresholds,

[0096] The area difference is calculated based on the fragment image and the qualified fragment image, and the dry mixing time delay processing is performed on the glycine raw material whose area difference is greater than the area difference threshold and has reached the dry mixing time.

[0097] The present invention makes a judgment based on the captured fragment images and qualified fragment images during the dry mixing process, prolongs the preset dry mixing time, reduces the uneven raw materials during the dry mixing process, and thus improves the qualified rate of the finished product content.

[0098] See also Figure 3 Specifically, in this embodiment, the process of adding a certain amount of ethyl cellulose ethanol solution to wet mix and pelletize is as follows:

[0099] Pre-set pelletizing speed and wet mixing time.

[0100] The mixture after adding the ethyl cellulose ethanol solution is pelletized according to the pelletizing rotation speed, and the mixture is air-stirred at a preset mixed air flow pulse frequency until the wet mixing process duration reaches the wet mixing duration.

[0101] In this embodiment, the pelletizing speed is preset to be 1500 rpm and the wet mixing time St1 is preset to be 270 s.

[0102] The sum of the preset wet mixing time St1 and the preset dry mixing time Gt1 is within the range of 360-500S.

[0103] 37.5 kg of 4% ethyl cellulose ethanol solution was added, and the mixture after adding the ethyl cellulose ethanol solution was pelletized at a pelletizing speed of 1500 rpm, and the glycine raw material was air-stirred at a preset mixed air flow pulse frequency Qf1 until the wet mixing process duration reached the wet mixing duration St1.

[0104] The invention sprays compressed air from a nozzle in a pulse cycle mode, so that the mixture is chopped by a cutting device during the tumbling process, thereby achieving the purpose of uniform granulation.

[0105] See also Figure 3 Specifically, in this embodiment, according to the collected photos of the soft material particles and the photos of the warehouse bottom during the wet mixing process, the process of adjusting the wet mixing time is as follows:

[0106] Pre-set the surface qualified photos of soft material particles,

[0107] Based on the comparison between qualified surface photos and particle photos, combined with the photos of the silo bottom, the wet mixing time will be extended if the surface of the soft material particles is not smooth or there is dry powder at the bottom of the silo.

[0108] Pre-set surface qualified photos of soft material particles.

[0109] The present invention combines the soft material particles with the photos of the warehouse bottom to judge whether the soft material particles are obvious and whether there is dry powder residue at the warehouse bottom, thereby achieving the effect of improving the utilization rate of raw materials and laying a foundation for subsequent pelletizing.

[0110] See also Figure 4 As shown, Figure 4 The figure is a logical process diagram of adjusting the pulse frequency of the mixed airflow in the preparation method of the compound glycyrrhizin tablets described in this embodiment. Specifically, in this embodiment, the process of adjusting the preset pulse frequency of the mixed airflow according to the actual dry mixing time and the actual wet mixing time is as follows:

[0111] Pre-set the air flow pulse frequency and mixed air flow pulse frequency adjustment parameters,

[0112] According to the difference between the actual dry mixing time and the preset dry mixing time, the difference between the actual wet mixing time and the preset wet mixing time, the airflow pulse adjustment frequency is calculated in combination with the mixed airflow pulse frequency adjustment parameter, and the mixed airflow pulse frequency is extended or shortened according to the airflow pulse adjustment frequency.

[0113] The mixed airflow pulse frequency Qf1=50Hz and the mixed airflow pulse frequency adjustment parameter q1=0.1~0.3 are pre-set. The specific value of the mixed airflow pulse frequency adjustment parameter q1 is determined according to the difference ΔQ between the actual dry mixing time and the preset dry mixing time and the difference ΔSt between the actual wet mixing time and the preset wet mixing time. The specific value of the mixed airflow pulse frequency adjustment parameter q1 can be determined in the function f(ΔQt, ΔSt, q1).

[0114] In this embodiment, the actual dry mixing time Gt2=100S, and the actual wet mixing time St2=290S.

[0115] According to the difference ΔQt between the actual dry mixing time and the preset dry mixing time, ΔQt=Gt1-Gt2, and the difference ΔSt between the actual wet mixing time and the preset wet mixing time, ΔSt=St1-St2.

[0116] Airflow pulse adjustment frequency ΔQf, ΔQf = f(ΔQt, ΔSt, q1);

[0117] Among them, f(ΔQt, ΔSt, q1) is a function related to the airflow pulse adjustment frequency ΔQf and the mixed airflow pulse frequency adjustment parameter q1, the difference ΔQt between the actual dry mixing time and the preset dry mixing time, and the difference ΔSt between the actual wet mixing time and the preset wet mixing time.

[0118] The present invention adjusts the pulse frequency of the mixed airflow according to the actual dry mixing time and the actual wet mixing time, thereby ensuring that the time for mixing the raw materials meets the requirements and improving the preparation efficiency of the compound glycyrrhizin tablets.

[0119] Specifically, in this embodiment, according to the actual air pressure in the chamber, the process of adjusting the preset mixed airflow pulse frequency is as follows:

[0120] Preset the air pressure threshold and the first air pressure value,

[0121] The air pressure difference is calculated according to the air pressure threshold and the actual air pressure in the chamber. When the air pressure difference is greater than the first air pressure value, the pulse frequency of the mixed airflow is adjusted to decrease.

[0122] The air pressure threshold value Y0=0.8MPa and the first air pressure value Y1=0.7MPa are preset, and the actual air pressure in the warehouse is Sy1=1.7MPa.

[0123] The pressure difference ΔSy, ΔSy=Sy1-Y0, when the pressure difference ΔSy is greater than the first pressure value Y1, the mixed airflow pulse frequency Qf1 is adjusted to decrease.

[0124] The present invention reduces the actual air pressure in the chamber by adjusting the pulse frequency of the mixed airflow, thereby ensuring that the air pressure in the airflow mixing chamber meets the requirements and that the mixing conditions in the airflow mixing chamber meet the requirements.

[0125] See also Figure 3 Specifically, in this embodiment, the process of adjusting the preset pelletizing airflow pulse frequency according to the collected pelletizing image is as follows:

[0126] Pre-set the pelletizing size qualified threshold image and pelletizing airflow pulse frequency,

[0127] The pelletizing image is compared with the pelletizing size qualified threshold image. When the pelletizing image is larger than all pelletizing size qualified threshold images, the pelletizing airflow pulse frequency is adjusted to increase.

[0128] The pelletizing size qualified threshold image is a plurality of pelletizing range qualified images, and the pelletizing airflow pulse frequency Lf1 = 60 Hz. The pelletizing image is compared with the pelletizing size qualified threshold image, and when the pelletizing image is larger than all pelletizing size qualified threshold images, the pelletizing airflow pulse frequency Lf1 is adjusted to increase.

[0129] The present invention increases the frequency of pelletizing airflow pulses to increase the flipping and rolling rate of pellets in the airflow mixing bin, thereby increasing the stirring speed of the cutting device at the same pelletizing speed, thereby reducing the size of solid phase particles.

[0130] See also Figure 3 Specifically, in this embodiment, the process of determining the actual drying time according to the actual temperature and actual humidity in the airflow mixing chamber is as follows:

[0131] Preset drying temperature, drying humidity, temperature change prediction model and drying time;

[0132] The airflow mixing bin is dried according to the drying temperature until the drying time is reached, and the actual temperature and the drying temperature are compared in real time. According to the temperature change prediction model, the actual drying time of the airflow mixing bin to reach the drying humidity is predicted according to the actual temperature change of the airflow mixing bin, and the actual drying time is overwritten by the originally preset drying time. In this embodiment, the drying humidity is 5.0%, the drying temperature is 30.0°C, and the preset drying time is 17 minutes.

[0133] Specifically, in this embodiment, according to the weight and batch of the intermediate product, the tableting process is as follows:

[0134] Preset tableting pressure range,

[0135] The tableting weight is calculated based on the weight of the intermediate product and the batch size, and the actual tableting pressure is controlled within the tableting pressure range to tablet the intermediate product.

[0136] The calculation process of the tablet weight is: intermediate product weight × 1000 ÷ batch × 101% = tablet weight, and the tablet pressure range is 15-30KN.

[0137] In this embodiment, the weight of the intermediate product is 25 kg, and the batch size is 200,000 tablets. The tablet weight to be pressed this time is 0.025×1000×1000÷200000×101%=0.12625 g.

[0138] So far, the technical solutions of the present invention have been described in conjunction with the preferred embodiments shown in the accompanying drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

[0139] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A method for preparing a compound glycyrrhizin tablet, characterized in that: include, Take a certain amount of glycine raw material, crush it and then sieve it; Take a certain amount of ethanol, add a certain amount of ethyl cellulose while stirring until the ethyl cellulose is added, stir for a preset time, and then let it stand for a period of time to obtain an ethyl cellulose ethanol solution; The sieved glycine raw material is poured into an air flow mixing bin, chopped and dry mixed, and then a certain amount of ethyl cellulose ethanol solution is added for wet mixing and granulation to make soft material particles; During the dry mixing process, the glycine raw material is cut according to the cutting speed, and the dry mixing time is adjusted according to the fragment images collected during the dry mixing process; During the wet mixing process, the mixture after adding the ethyl cellulose ethanol solution is pelletized according to the pelletizing speed, and the wet mixing time is adjusted according to the collected particle photos of the soft material particles and the bottom photos of the warehouse during the wet mixing process; During the dry mixing and wet mixing process, the pre-set mixed air flow pulse frequency is adjusted according to the actual dry mixing time and the actual wet mixing time, and the pre-set mixed air flow pulse frequency is adjusted according to the actual air pressure in the bin; The soft material particles are further pelletized, and the preset pelletizing airflow pulse frequency is adjusted according to the collected pelletizing images to produce wet whole pellets; The airflow mixing bin is dried, and the actual drying time is determined according to the actual temperature and actual humidity in the airflow mixing bin, and after the drying time is reached, the airflow mixing bin is cooled to form dry whole particles; A certain amount of magnesium stearate is added to the dry whole granules and mixed to form an intermediate product; According to the weight and batch of the intermediate product, the compound glycyrrhizin tablets are prepared by tableting and coating; The process of adjusting the dry mixing time according to the collected fragment images during the dry mixing process is as follows; Pre-set qualified fragment images and area difference thresholds, Calculating the area difference between the fragment image and the qualified fragment image, and performing dry mixing time delay processing on the glycine raw material whose area difference is greater than the area difference threshold and has reached the dry mixing time; According to the collected photos of soft material particles and the bottom of the warehouse during the wet mixing process, the process of adjusting the wet mixing time is as follows: Pre-set the surface qualified photos of soft material particles, Based on the comparison between the qualified surface photos and the particle photos, and combined with the photos of the silo bottom, the wet mixing time can be extended if the surface of the soft material particles is not smooth or there is dry powder at the bottom of the silo; The process of adjusting the preset pelletizing airflow pulse frequency according to the collected pelletizing image is as follows: Pre-set the pelletizing size qualified threshold image and pelletizing airflow pulse frequency, The pelletizing image is compared with the pelletizing size qualified threshold image, and when the pelletizing image is larger than all the pelletizing size qualified threshold images, the pelletizing air flow pulse frequency is adjusted to increase; The pulse gas circulation device can not only compress the air to be ejected from the nozzle in a pulse circulation manner, but also send the negative pressure out of the airflow mixing chamber, thereby ensuring the pressure in the airflow mixing chamber; The pressure sensor detects the pressure in the airflow mixing bin to prevent the pulse gas circulation device from causing problems with the gas circulation in the airflow mixing bin, which would cause excessive pressure in the bin. The temperature and humidity sensors detect the actual temperature and humidity in the airflow mixing bin. During the dry mixing process, the mixing state display captures the state of the raw materials in the airflow mixing bin to generate fragment images. During the wet mixing process, the mixing state display collects particle photos of the soft material particles and photos of the bin bottom. During the pelletizing process, the mixing state display collects pelletizing images.

2. The method for preparing compound glycyrrhizin tablets according to claim 1, characterized in that: The process of pouring the sieved glycine raw material into the air flow mixing bin for shredding and dry mixing is as follows: Pre-set cutting speed, dry mixing time and mixed air flow pulse frequency. The glycine raw material is cut according to the cutting rotation speed, and the glycine raw material is air-stirred at a preset mixed air flow pulse frequency until the chopping time of the glycine raw material reaches the dry mixing time.

3. The method for preparing compound glycyrrhizin tablets according to claim 1, characterized in that: The process of adding a certain amount of ethyl cellulose ethanol solution, wet mixing and pelletizing is as follows: Pre-set pelletizing speed and wet mixing time. The mixture after adding the ethyl cellulose ethanol solution is pelletized according to the pelletizing rotation speed, and the mixture is air-stirred at a preset mixed air flow pulse frequency until the wet mixing process duration reaches the wet mixing duration.

4. The method for preparing compound glycyrrhizin tablets according to claim 1, characterized in that: The process of adjusting the preset mixed air flow pulse frequency according to the actual dry mixing time and the actual wet mixing time is as follows: Pre-set the air flow pulse frequency and mixed air flow pulse frequency adjustment parameters, According to the difference between the actual dry mixing time and the preset dry mixing time, the difference between the actual wet mixing time and the preset wet mixing time, the airflow pulse adjustment frequency is calculated in combination with the mixed airflow pulse frequency adjustment parameter, and the mixed airflow pulse frequency is extended or shortened according to the airflow pulse adjustment frequency.

5. The method for preparing compound glycyrrhizin tablets according to claim 4, characterized in that: According to the actual air pressure in the warehouse, the process of adjusting the preset mixed air flow pulse frequency is as follows: Preset the air pressure threshold and the first air pressure value, The air pressure difference is calculated according to the air pressure threshold and the actual air pressure in the chamber. When the air pressure difference is greater than the first air pressure value, the pulse frequency of the mixed airflow is adjusted to decrease.

6. The method for preparing compound glycyrrhizin tablets according to claim 1, characterized in that: The process of determining the actual drying time based on the actual temperature and humidity in the airflow mixing chamber is as follows: Preset drying temperature, drying humidity, temperature change prediction model and drying time; The airflow mixing chamber is dried according to the drying temperature until the drying time is reached, and the actual temperature and the drying temperature are compared in real time. Based on the temperature change prediction model, the actual drying time for the airflow mixing chamber to reach the drying humidity is predicted according to the actual temperature change in the airflow mixing chamber, and the actual drying time overwrites the originally preset drying time.

7. The method for preparing compound glycyrrhizin tablets according to claim 6, characterized in that: Depending on the weight and batch of the intermediate product, the tableting process is: Preset tableting pressure range, The tableting weight is calculated based on the weight of the intermediate product and the batch size, and the actual tableting pressure is controlled within the tableting pressure range to tablet the intermediate product.

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