A detection box for chemiluminescent immunoassay analyzer

Abstract

The present invention discloses a detection box for a chemiluminescent immunoassay analyzer, which belongs to the field of immunoassay technology, and includes a detection box base, a conveying unit and a sample mixing unit are arranged above the detection box base, and the conveying unit includes a fixed slide plate arranged on the detection box base, a sliding track groove is opened on the fixed slide plate, and the sliding track groove is connected to a sample placement frame for placing test tubes through a mobile control component, and a pushing member for conveying the test tubes is arranged on the fixed slide plate. The present invention arranges a sample mixing tray, and arranges sample mixing placement ports around the sample mixing tray to place test tube samples, wraps and limits the test tubes through a flexible capsule arranged outside the sample mixing tray, and directly transfers the temperature to the test tubes through the heat exchange liquid in the flexible capsule, which can quickly and effectively realize the heat exchange of the test tubes, thereby ensuring the stability of the test tubes at various positions, and can accurately control the temperature of the test tubes by directly contacting the test tubes.

Description

Technical Field

[0001] The invention relates to the technical field of immune detection, in particular to a detection box for a chemiluminescent immune analyzer. Background Art

[0002] Chemiluminescent immunoassay, also known as chemiluminescent immunoassay, is an immunoassay method that directly labels antigens or antibodies with chemiluminescent agents. The immunoreaction system is to directly label the luminescent substance (generating excited intermediates under the excitation of the reactant) on the antigen (chemiluminescent immunoassay) or antibody (immunochemiluminescent assay), or the enzyme acts on the luminescent substrate;

[0003] After sampling of the test object, the sample is placed in a test tube, and the test tube is then transported to a test box through a transport component. In the test box, the sample in the test tube is adjusted to a test temperature according to different reaction requirements to speed up the reaction or preserve it. The existing temperature adjustment method is mainly controlled by a temperature control device designed in the test box, and the temperature of the sample in the test tube cannot be accurately controlled. In addition, when different tests are performed, when the demand error is large, it is often necessary to wait for the temperature in the test box to recover before the next test can be performed, which seriously affects the detection efficiency of the chemiluminescence immunoassay analyzer. Based on this, a test box for a chemiluminescence immunoassay analyzer is proposed. Summary of the invention

[0004] The purpose of the present invention is to solve the problem that the temperature adjustment method is mainly controlled by a temperature control device designed in a detection box, the temperature of the sample in the test tube cannot be accurately controlled, and when different tests are performed, when the required error is large, it is often necessary to wait for the temperature in the detection box to recover before the next detection test can be performed, which seriously affects the detection efficiency of the chemiluminescence immunoassay analyzer, and a detection box for a chemiluminescence immunoassay is proposed.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A detection box for a chemiluminescent immunoassay analyzer, comprising a detection box base, a conveying unit and a sample mixing unit are arranged above the detection box base, the conveying unit comprises a fixed slide plate arranged on the detection box base, a sliding track groove is opened on the fixed slide plate, the sliding track groove is connected to a sample placement frame for placing a test tube through a mobile control component, and a pushing member for conveying the test tube is arranged on the fixed slide plate;

[0007] The sample placement frame comprises an upper support and a lower support, wherein the upper support and the lower support are fixedly connected via a connecting column, a test tube delivery port is provided on the upper support, and a sliding release member is provided on the inner wall of the test tube delivery port;

[0008] The sample mixing unit comprises a supporting outer ring arranged on the base of the detection box, the inner wall of the supporting outer ring is rotatably connected with a sample mixing disk, the outer wall of the sample mixing disk is provided with a plurality of sample mixing placement openings, a sample mixing motor is arranged in the base of the detection box, the sample mixing motor controls the sample mixing disk to rotate through a driving member, and a heat exchange component for heating the test tube is arranged on the supporting outer ring;

[0009] The heat exchange assembly comprises two heat exchange end seats which are arranged on the outer side wall of the supporting outer ring and are arranged opposite to each other. The heat exchange end seats are in communication with a heat exchange body, and a pressure control valve is arranged on the heat exchange end seats.

[0010] Preferably, the heat exchanger includes a positioning and fixing ring arranged on two heat exchange end seats, the inner wall of the positioning and fixing ring is provided with a flexible sac, a heat exchange chamber is provided inside the flexible sac, the heat exchange chamber is connected to the heat exchange end seat, and a friction layer is provided on the inner wall of the flexible sac.

[0011] Preferably, the mobile control component includes a mounting cover arranged on a fixed slide rail plate, a mobile motor is arranged on the mounting cover, a mobile gear is fixedly connected to the output end of the mobile motor, the mobile gear is located in the mounting cover and passes through the slide rail groove, and a toothed slide rail plate located in the slide rail groove is arranged at the bottom of the lower bracket.

[0012] Preferably, a sliding groove is provided on the lower bracket, and the test tube delivery port is provided on the upper bracket and is provided through one side wall.

[0013] Preferably, the pushing member comprises a supporting end plate fixedly connected to the fixed slide rail plate, an electric push rod is arranged on the supporting end plate, an output end of the electric push rod is fixedly connected to a test tube pushing arc plate, and the test tube pushing arc plate is located between the upper bracket and the lower bracket.

[0014] Preferably, the sliding release member comprises a release slide groove provided on the upper bracket, and a release sliding block matched with the release slide groove is provided on the heat exchange end seat.

[0015] Preferably, a telescopic opening is provided on the inner wall of the test tube conveying port, and the inner wall of the telescopic opening is connected to a test tube limiter via a resistance spring, a transverse contact opening is provided on the test tube limiter, and the inner wall of the transverse contact opening is connected to a release rod via a release spring, and the release rod is provided with an inclined opening, and the inner wall of the telescopic opening is fixedly connected to an inclined rod adapted to the inclined opening.

[0016] Preferably, the driving member includes an annular tooth groove opened in the sample mixing disk, the output end of the sample mixing motor extends outward through the side wall of the detection box base and is fixedly connected with a driving gear, and the driving gear is meshed with the annular tooth groove.

[0017] Compared with the prior art, the present invention has the following beneficial effects:

[0018] 1. The present invention arranges a sample mixing tray and sample mixing placement openings around the sample mixing tray to place test tube samples, wraps and limits the test tubes through a flexible capsule arranged outside the sample mixing tray, and directly transfers the temperature to the test tubes through the heat exchange liquid in the flexible capsule, which can quickly and effectively achieve heat exchange for the test tubes, thereby ensuring the stability of the test tubes at various positions, and can accurately control the temperature of the test tubes by directly contacting the test tubes.

[0019] 2. When the sample mixing plate provided in the present invention rotates to mix the test tube samples, the test tubes arranged in the sample mixing placement port will rotate under the action of the wrapped flexible capsule, thereby achieving fast and effective sample mixing, and the rotating test tubes can contact the heat exchange liquid in the flexible capsule more evenly, ensuring the uniformity of the temperature in the test tubes. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the assembly structure of a detection box for a chemiluminescent immunoassay analyzer proposed by the present invention;

[0021] Figure 2 This is a schematic diagram of the main structure of a detection box for a chemiluminescent immunoassay analyzer proposed by the present invention;

[0022] Figure 3 This is a schematic diagram of the structure of a sample mixing unit in a detection box for a chemiluminescent immunoassay analyzer proposed by the present invention;

[0023] Figure 4 This is a schematic diagram of the structure of a transport unit in a detection box for a chemiluminescent immunoassay analyzer proposed by the present invention;

[0024] Figure 5 This is a schematic diagram of the cross-sectional structure of an upper bracket in a detection box for a chemiluminescent immunoassay analyzer proposed by the present invention;

[0025] Figure 6 for Figure 5 Schematic diagram of the enlarged structure at point A in the middle.

[0026] In the figure: 1. Test box base; 2. Fixed slide plate; 3. Sliding track groove; 4. Upper bracket; 5. Lower bracket; 6. Connecting column; 7. Test tube delivery port; 8. Support outer ring; 9. Mixing sample plate; 10. Mixing sample placement port; 11. Driving gear; 12. Heat exchange end seat; 13. Pressure control valve; 14. Positioning and fixing ring; 15. Flexible capsule; 16. Mounting cover; 17. Moving motor; 18. Moving gear; 19. Sliding groove; 20. Electric push rod; 21. Test tube push arc plate; 22. Release slide groove; 23. Release slider; 24. Test tube limiter; 25. Release rod; 26. Tilt mouth; 27. Tilt rod; 28. Annular tooth groove; 29. ​​Tooth slide plate. DETAILED DESCRIPTION

[0027] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0028] Example, see Figure 1-6 A detection box for a chemiluminescent immunoassay analyzer includes a detection box base 1, the detection box base 1 is the bottom of the detection box, a conveying unit and a sample mixing unit are arranged above the detection box base 1, the conveying unit and the sample mixing unit are both arranged inside the detection box, the conveying unit includes a fixed slide plate 2 arranged on the detection box base 1, a sliding track groove 3 is opened on the fixed slide plate 2, and the sliding track groove 3 is connected to a sample placement frame for placing a test tube through a mobile control component;

[0029] There are multiple sample placement racks, which can be taken out from the chemiluminescence immunoassay analyzer, and after the test tube samples are placed outside, they are taken into the detection box for testing.

[0030] Furthermore, the mobile control component includes a mounting cover 16 arranged on the fixed slide rail plate 2, and a mobile motor 17 is arranged on the mounting cover 16. The output end of the mobile motor 17 is fixedly connected to a mobile gear 18. The mobile gear 18 is located in the mounting cover 16 and penetrates into the sliding rail groove 3. A toothed slide rail plate 29 located in the sliding rail groove 3 is arranged at the bottom of the upper bracket 4.

[0031] It should be noted that under the action of the moving motor 17, the moving gear 18 will be driven to rotate. When the sample placement rack is installed on the fixed slide plate 2, the moving gear 18 arranged therein will contact with the toothed slide plate 29 on the upper bracket 4, thereby driving the sample placement rack to be transported step by step, so as to gradually transport the test tube samples thereon to the mixing unit.

[0032] A pushing member for transporting the test tube is arranged on the fixed slide plate 2, and the pushing member includes a supporting end plate fixedly connected to the fixed slide plate 2, and an electric push rod 20 is arranged on the supporting end plate. A test tube pushing arc plate 21 is fixedly connected to the output end of the electric push rod 20, and the test tube pushing arc plate 21 is located between the upper bracket 4 and the lower bracket 5.

[0033] The advantage of adopting the above structure is that when the test tube sample is gradually moved on the fixed slide plate 2 driven by the sample placement rack, the electric push rod 20 drives the test tube to push the arc plate 21 to move, thereby achieving the effect of pushing and transporting the test tube sample forward.

[0034] The sample placement rack includes an upper bracket 4 and a lower bracket 5. Furthermore, a sliding groove 19 is provided on the lower bracket 5. The setting of the sliding groove 19 can ensure the left and right limit of the test tube sample. When necessary, a matching groove that is compatible with the sliding groove 19 can also be provided on the support outer ring 8. The test tube conveying port 7 is set on the upper bracket 4 and is set to penetrate one side wall.

[0035] The upper bracket 4 and the lower bracket 5 are fixedly connected by a connecting column 6. The upper bracket 4 is provided with a test tube delivery port 7, and the inner wall of the test tube delivery port 7 is provided with a sliding release member;

[0036] Furthermore, the sliding release member includes a release groove 22 opened on the upper bracket 4, a release slider 23 matched with the release groove 22 is provided on the heat exchange end seat 12, a telescopic opening is opened on the inner wall of the test tube conveying port 7, and the inner wall of the telescopic opening is connected to a test tube limiter 24 through a resistance spring, a transverse contact opening is opened on the test tube limiter 24, and the inner wall of the transverse contact opening is connected to a release rod 25 through a release spring, an inclined opening 26 is opened on the release rod 25, and an inclined rod 27 matched with the inclined opening 26 is fixedly connected to the inner wall of the telescopic opening.

[0037] It should be noted that when the upper bracket 4 is being transported forward, the release rod 25 at the test tube transport port 7 will gradually come into contact with the release slider 23. When the upper bracket 4 is moving, the release slider 23 will push the test tube stopper 24 to move, driving the test tube stopper 24 to retract into the telescopic opening, opening the test tube transport port 7. At this time, the test tube is transported to the sample mixing placement port 10 on the sample mixing tray 9 by the test tube pusher.

[0038] Among them, when the release slider 23 is squeezed to the limit, the end of the test tube limiter 24 will contact the tilt rod 27, and the inclined surface of the tilt rod 27 will cooperate with the inclined mouth 26 on the release rod 25, so that the release rod 25 will retract, realize the separation from the release slider 23, realize the release of the limit, and the test tube limiter 24 will rebound and realize the retraction.

[0039] The sample mixing unit includes a supporting outer ring 8 arranged on the detection box base 1, and the inner wall of the supporting outer ring 8 is rotatably connected to a sample mixing disk 9, and the outer wall of the sample mixing disk 9 is provided with a plurality of sample mixing placement openings 10. A sample mixing motor is arranged in the detection box base 1, and the sample mixing motor is arranged inside the detection box base 1. The sample mixing motor controls the rotation of the sample mixing disk 9 through a driving member, and the sample mixing disk 9 is provided with a plurality of bearing devices for stable rotation. Furthermore, the driving member includes an annular tooth groove 28 opened in the sample mixing disk 9, and the output end of the sample mixing motor extends outward through the side wall of the detection box base 1, and is fixedly connected to a driving gear 11, and the driving gear 11 is meshed with the annular tooth groove 28.

[0040] The support outer ring 8 is provided with a heat exchange component for heating the test tube, and the heat exchange component includes two heat exchange end seats 12 arranged opposite to each other on the outer side wall of the support outer ring 8, the heat exchange end seats 12 are in communication with a heat exchange body, and a pressure control valve 13 is provided on the heat exchange end seats 12.

[0041] Furthermore, the heat exchanger includes a positioning and fixing ring 14 arranged on two heat exchange end seats 12, a flexible capsule 15 is arranged on the inner wall of the positioning and fixing ring 14, a heat exchange chamber is arranged inside the flexible capsule 15, the heat exchange chamber is connected to the heat exchange end seat 12, and a friction layer is arranged on the inner wall of the flexible capsule 15.

[0042] The advantage of adopting the above structure is that the setting of the friction layer can make the flexible capsule 15 wrap one side of the test tube in the sample mixing placement port 10 in the sample mixing plate 9 when the flexible capsule 15 expands under the action of the heat exchange liquid. At this time, when the sample mixing plate 9 rotates, the setting of the friction layer can make the test tube passively driven to rotate during the rotation of the sample mixing plate 9, so as to achieve the effect of sample mixing, and the temperature of the liquid in the flexible capsule 15 can directly contact the test tube, so as to quickly and effectively realize the heat exchange of the test tube, thereby ensuring the stability of the test tubes at various positions, and can accurately control the temperature of the test tubes by directly contacting the test tubes.

[0043] Compared with the existing methods, this solution can achieve a rapid heat exchange effect by replacing the liquid in the flexible capsule 15 during immune detection tests with large temperature differences, and can quickly and effectively implement the test process when dealing with different detection tests.

[0044] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A detection box for a chemiluminescent immunoassay analyzer, comprising a detection box base (1), characterized in that: A conveying unit and a sample mixing unit are arranged above the detection box base (1); the conveying unit comprises a fixed slide plate (2) arranged on the detection box base (1); a sliding track groove (3) is provided on the fixed slide plate (2); the sliding track groove (3) is connected to a sample placement frame for placing a test tube via a mobile control component; and a pushing member for conveying the test tube is arranged on the fixed slide plate (2); The sample placement frame comprises an upper support (4) and a lower support (5), wherein the upper support (4) and the lower support (5) are fixedly connected via a connecting column (6), a test tube delivery port (7) is provided on the upper support (4), and a sliding release member is provided on the inner wall of the test tube delivery port (7); The sample mixing unit comprises a supporting outer ring (8) arranged on the detection box base (1); the inner wall of the supporting outer ring (8) is rotatably connected to a sample mixing disk (9); the outer wall of the sample mixing disk (9) is provided with a plurality of sample mixing placement openings (10); a sample mixing motor is arranged in the detection box base (1); the sample mixing motor controls the sample mixing disk (9) to rotate via a driving member; and a heat exchange component for heating the test tube is arranged on the supporting outer ring (8); The heat exchange assembly comprises two heat exchange end seats (12) arranged opposite to each other on the outer side wall of the supporting outer ring (8), the heat exchange end seats (12) are in communication with a heat exchange body, and a pressure control valve (13) is arranged on the heat exchange end seats (12); The heat exchange body comprises a positioning and fixing ring (14) arranged on two heat exchange end seats (12); a flexible capsule (15) is arranged on the inner wall of the positioning and fixing ring (14); a heat exchange chamber is arranged inside the flexible capsule (15); the heat exchange chamber is communicated with the heat exchange end seats (12); and a friction layer is arranged on the inner wall of the flexible capsule (15); The mobile control assembly comprises a mounting cover (16) arranged on a fixed slide rail plate (2), a mobile motor (17) being arranged on the mounting cover (16), a mobile gear (18) being fixedly connected to an output end of the mobile motor (17), the mobile gear (18) being located in the mounting cover (16) and penetrating into the slide rail groove (3), and a toothed slide rail plate (29) being located in the slide rail groove (3) being arranged at the bottom of the lower bracket (5); The lower support (5) is provided with a sliding groove (19), and the test tube delivery port (7) is provided on the upper support (4) and is provided through one side wall; The pushing member comprises a supporting end plate fixedly connected to the fixed slide rail plate (2), an electric push rod (20) is arranged on the supporting end plate, an output end of the electric push rod (20) is fixedly connected to a test tube pushing arc plate (21), and the test tube pushing arc plate (21) is located between the upper bracket (4) and the lower bracket (5); The sliding release member comprises a release slide groove (22) provided on the upper bracket (4), and a release slider (23) adapted to the release slide groove (22) is provided on the heat exchange end seat (12); The inner wall of the test tube conveying port (7) is provided with a telescopic port, the inner wall of the telescopic port is connected to a test tube stopper (24) via a resisting spring, the test tube stopper (24) is provided with a transverse contact port, the inner wall of the transverse contact port is connected to a release rod (25) via a release spring, the release rod (25) is provided with an inclined port (26), and the inner wall of the telescopic port is fixedly connected to an inclined rod (27) adapted to the inclined port (26); The driving member comprises an annular tooth groove (28) provided in the sample mixing disk (9); the output end of the sample mixing motor extends outward through the side wall of the detection box base (1) and is fixedly connected to a driving gear (11); the driving gear (11) is meshedly connected to the annular tooth groove (28).

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