A method, device, medium and computer for controlling voltage of multipole mass spectrometer

Abstract

The present invention provides a voltage control method, device, medium and computer for a multipole mass spectrometer. The voltage control method for the multipole mass spectrometer comprises: applying a radio frequency signal to each electrode rod by using the oscillation circuit; adjusting the phase of the radio frequency signal on each electrode rod in each electrode rod group by using the phase shift circuit; wherein the phase difference between any two adjacent electrode rods is equal, and the sum of all phase differences between adjacent electrode rods in the electrode rod group is equal to #imgabs0#; the voltage control method of the present invention can make the ion motion trajectory superimposed and oscillate, thereby increasing the collision probability of ions in the multipole, and improving the focusing effect and the cooling effect. The method of the present application can reduce the size of the device under the premise of the same focusing effect, which is conducive to the miniaturization of material testing and analysis equipment, and can improve the resolution of existing material testing and analysis equipment without changing the size of the multipole collision cell.

Description

Technical Field

[0001] The present invention relates to the technical field of testing and analyzing the chemical and physical properties of materials, and more specifically, to a voltage control method, device, medium and computer for a multipole mass spectrometer. Background Art

[0002] As an important analytical technology, mass spectrometry mainly tests or analyzes materials by measuring the chemical or physical properties of materials. It is widely used in food safety, environmental monitoring, biomedicine and other fields. One of the core components of a mass spectrometer is the multipole, which focuses and guides ions into the mass spectrometer. Depending on the number of rods, the multipole device can be divided into quadrupole, hexapole, octopole, etc. The quadrupole is the most widely used. It consists of four parallel metal cylinders. By applying a radio frequency voltage of a specific frequency and amplitude, a directional alternating electric field can be generated, allowing ions to pass through the quadrupole device along a stable vibration trajectory. At the same time, the multipole can also be used to cause a large number of collisions between ions and gas molecules to achieve the heat dissipation and focusing effects of ions.

[0003] In order to improve the transmission efficiency of multipoles, people have explored a variety of technical means. For example, using a higher frequency RF voltage can increase the probability of collision between ions and gas molecules, thereby enhancing the cooling and focusing effects; optimizing the geometric structure of the multipole, such as using twisted or curved multipoles, can change the phase and path of ions during transmission and improve the transmission efficiency of the multipole.

[0004] The US patent (publication number: US09449804B2) proposes a dual-field multipole converging ion guide, a hyperbolic ion guide and related methods. This patent can effectively change the field shape in the rods and improve the ion transfer efficiency by twisting or bending the multipole rods. However, this method is not suitable for traditional parallel multipole rods; it cannot effectively improve the ion transfer efficiency of multipole rods placed parallel to each other. Summary of the invention

[0005] In view of the shortcomings of the prior art, the object of the present invention is to provide a method, device, medium and computer for controlling the voltage of a multipole mass spectrometer to overcome the disadvantage of the prior art that the transmission efficiency of parallel multipoles cannot be improved.

[0006] The above technical purpose of the present invention is achieved through the following technical solutions: a voltage control method for a multipole mass spectrometer, applied to a multipole collision cell, the multipole collision cell comprising: at least one electrode rod group, an oscillation circuit and a phase shift circuit; the electrode rod group comprises a plurality of electrode rods; the oscillation circuit is electrically connected to each of the electrode rods through the phase shift circuit; the plurality of electrode rods are parallel to each other and evenly distributed in a circle;

[0007] The multipole voltage control method comprises:

[0008] Using the oscillation circuit to apply a radio frequency signal to each of the electrode rods;

[0009] The phase shift circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group; wherein the phase difference between any two adjacent electrode rods is equal, and the phase difference between the corresponding two electrode rods in the two electrode rod groups distributed along the circumference is ; The phases of any two opposite electrode rods are the same or different .

[0010] In one embodiment, the electrode rod group includes a first electrode rod, a second electrode rod, a third electrode rod and a fourth electrode rod;

[0011] The step of applying a radio frequency signal to each of the electrode rods using the oscillation circuit specifically includes:

[0012] Applying a first radio frequency signal to the first electrode rod using the oscillation circuit;

[0013] applying a second radio frequency signal to the second electrode rod using the oscillation circuit;

[0014] applying a third radio frequency signal to the third electrode rod using the oscillation circuit;

[0015] applying a fourth radio frequency signal to the fourth electrode rod using the oscillation circuit;

[0016] The frequencies and amplitudes of the first RF signal, the second RF signal, the third RF signal and the fourth RF signal are all the same.

[0017] In one embodiment, the phase shifting circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group, specifically including:

[0018] Using the phase shift circuit to control the first radio frequency signal so as not to cause phase shift;

[0019] The phase shift circuit is used to control the phase shift of the second radio frequency signal. ;

[0020] The phase shift circuit is used to control the phase shift of the third radio frequency signal. ;

[0021] The phase shift circuit is used to control the phase shift of the fourth radio frequency signal. .

[0022] In one embodiment, applying a radio frequency signal to each of the electrode rods using the oscillating circuit specifically includes:

[0023] The frequency range of the radio frequency signal is .

[0024] In one embodiment, applying a radio frequency signal to each of the electrode rods using the oscillating circuit further comprises:

[0025] The radio frequency signal is a sine wave, a square wave or a composite wave, wherein the composite wave is obtained by combining a sine wave and a square wave.

[0026] In one embodiment, the multipole collision cell further comprises: an amplifier circuit for amplifying the amplitude of the radio frequency signal; the oscillation circuit is electrically connected to the electrode rod group after passing through the phase shift circuit and the amplifier circuit in sequence;

[0027] The multipole voltage control method further comprises:

[0028] The amplitude of the radio frequency signal is adjusted using the amplifier circuit.

[0029] In one embodiment, the multipole collision cell comprises: a first electrode rod group and a second electrode rod group;

[0030] The electrode rods in the first electrode rod group and the electrode rods in the second electrode rod group are parallel to each other and arranged in a circle;

[0031] The oscillation circuit is electrically connected to the two electrode rod groups respectively after passing through the phase shift circuit;

[0032] The multipole voltage control method further comprises:

[0033] The phase shift amplitudes of the radio frequency signals applied to the corresponding electrode rods in the first electrode rod group and the second electrode rod group are controlled to be equal.

[0034] In one embodiment, the amplifier circuit includes: a common-phase amplifier circuit and an inverting amplifier circuit;

[0035] The phase shift circuit is electrically connected to the first electrode rod and the second electrode rod through the in-phase amplifier circuit; the phase shift circuit is electrically connected to the third electrode rod and the fourth electrode rod through the inverting amplifier circuit;

[0036] The method of adjusting the phase of each electrode rod in each electrode rod group by using the phase shift circuit also includes:

[0037] Using the phase shift circuit to control the first radio frequency signal to prevent phase shift, and using the in-phase amplifier circuit to amplify the first radio frequency signal;

[0038] The phase shift circuit is used to control the phase shift of the second radio frequency signal. , using the in-phase amplifier circuit to amplify the shifted second radio frequency signal;

[0039] Using the phase shift circuit to control the third radio frequency signal so as not to cause phase shift, and using the inverting amplifier circuit to amplify the third radio frequency signal;

[0040] The phase shift circuit is used to control the phase shift of the fourth radio frequency signal. , using the inverting amplifier circuit to amplify the offset fourth radio frequency signal.

[0041] In one embodiment, the electrode rods in the electrode rod group are all cylindrical, and the diameter of the electrode rods is ; The length of the electrode rod is .

[0042] A multipole voltage control device, comprising:

[0043] A radio frequency signal generating unit; the radio frequency signal generating unit is used to apply a radio frequency signal to each of the electrode rods using the oscillation circuit;

[0044] A radio frequency signal phase shift unit; the radio frequency signal phase shift unit is used to use the phase shift circuit to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group; wherein the phase difference between any two adjacent electrode rods is equal, and the phase difference between the corresponding two electrode rods in the two electrode rod groups distributed along the circumference is ; The phases of any two opposite electrode rods are the same or different .

[0045] A computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the above-mentioned method for controlling the voltage of a multipole mass spectrometer is implemented.

[0046] A computer device comprises a memory and a processor, wherein the memory stores a computer program, and the processor implements the above-mentioned method for controlling voltage of a multipole mass spectrometer when executing the computer program.

[0047] In summary, the present invention has the following beneficial effects: a voltage control method for a multipole mass spectrometer, comprising: applying a radio frequency signal to each of the electrode rods using the oscillation circuit; adjusting the phase of the radio frequency signal on each electrode rod in each electrode rod group using the phase shift circuit; wherein the phase difference between any two adjacent electrode rods is equal, and the phase difference between the corresponding two electrode rods in the two electrode rod groups distributed along the circumference is ; The phases of any two opposite electrode rods are the same or different ; The voltage control method of the present invention can cause the ion motion trajectory to superimpose oscillations, thereby increasing the collision probability of ions in the multipole, improving the focusing effect and the cooling effect. The method of the present application can reduce the size of the equipment while maintaining the same focusing effect, which is helpful for the miniaturization of mass spectrometry equipment. Without changing the size of the multipole collision cell, the resolution of existing mass spectrometry equipment can be improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] Figure 1 A flow chart of a voltage control method for a multipole mass spectrometer of the present invention;

[0049] Figure 2 is a structural diagram of a multipole voltage control device in an embodiment of the present invention;

[0050] Figure 3 is an internal structure diagram of a computer device in an embodiment of the present invention;

[0051] Figure 4 A schematic diagram of the electric field distribution generated by the conventional voltage control method in Example 5;

[0052] Figure 5 A schematic diagram of the ion flight trajectory along the axial direction when the conventional voltage control method is adopted in Example 5;

[0053] Figure 6 This is a schematic diagram of the electric field distribution generated by the voltage control method of the present application in Example 5;

[0054] Figure 7 A schematic diagram of the axial flight trajectory of ions using the voltage control method of the present application in Example 5;

[0055] Figure 8 It is a structural schematic diagram of the multipole collision cell of the present invention;

[0056] Fig. 9 It is a schematic diagram of the structure of a multipole collision cell using in-phase and inverting amplifiers of the present invention;

[0057] Fig.10 It is a schematic diagram of the equipotential lines of the radio frequency electric field generated by the electrode rod after phase modulation of the present invention. DETAILED DESCRIPTION

[0058] In order to make the purpose, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the accompanying drawings. Several embodiments of the present invention are shown in the accompanying drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein.

[0059] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal connection of two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances. The terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features.

[0060] In the present invention, unless otherwise clearly specified and limited, the first feature being "above" or "below" the second feature may include the first and second features being in direct contact, or may include the first and second features being in contact not directly but through another feature between them. Moreover, the first feature being "above", "above" and "above" the second feature includes the first feature being directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature includes the first feature being directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature. The terms "vertical", "horizontal", "left", "right", "above", "below" and similar expressions are for illustrative purposes only, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as limiting the present invention.

[0061] Embodiment 1

[0062] In order to solve the defects in the prior art, the present invention provides a voltage control method for a multipole mass spectrometer, which is applied to a multipole collision cell, such as Figure 8As shown, the multipole collision cell comprises: at least one electrode rod group, an oscillation circuit and a phase shift circuit; the electrode rod group comprises a plurality of electrode rods; the oscillation circuit is electrically connected to each of the electrode rods through the phase shift circuit; the plurality of electrode rods are parallel to each other and evenly distributed in a circle;

[0063] like Figure 1 As shown, the multipole voltage control method includes:

[0064] Using the oscillation circuit to apply a radio frequency signal to each of the electrode rods;

[0065] The phase shift circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group; wherein the phase difference between any two adjacent electrode rods is equal, and the phase difference between the corresponding two electrode rods in the two electrode rod groups distributed along the circumference is ; The phases of any two opposite electrode rods are the same or different .

[0066] Specifically, in the field of traditional material property testing technology, mass spectrometry is a relatively common technical means. By ionizing the particles and making them charged, the mass number of the particles is measured, and then the composition and properties of the particles are analyzed. Multipoles can be used as channels for ion transmission in mass spectrometers. They can be set as paths for electric field-guided ions so that the ions can maintain a stable motion trajectory in the mass spectrometer. The multipoles can also be configured as ion selective filters as needed to screen and regulate ions with different mass-to-charge ratios. In this application, the voltage control method of the multipoles can be applied to traditional multipole collision cells with parallel electrodes and cylindrical electrode rods to improve the focusing effect and transfer efficiency of the multipole collision cell on ions. Among them, the oscillation circuit is used to generate a radio frequency signal of a certain frequency and a certain amplitude. The oscillation circuit can control the flight trajectory of ions in the multipole by adjusting the amplitude and frequency of the radio frequency signal. The radio frequency electric field helps to focus the ion beam, reduce the emittance of the ion beam, and improve the ion transmission efficiency and the resolution of mass spectrometry analysis. The radio frequency electric field can also be used to control the behavior of ions in the collision cell, promote the collision of ions with neutral gas molecules, and cause ion fragmentation, thereby providing molecular structure information. The phase shift circuit is used to adjust the phase of the radio frequency signal, so that the radio frequency signal between the multipoles has a certain difference, and then modulate the radio frequency signal electric field to improve the transmission effect of the multipole collision cell on ions.

[0067] In one embodiment, the electrode rod group includes a first electrode rod, a second electrode rod, a third electrode rod and a fourth electrode rod;

[0068] The step of applying a radio frequency signal to each electrode rod using the oscillating circuit comprises: applying a first radio frequency signal to the first electrode rod using the oscillating circuit; applying a second radio frequency signal to the second electrode rod using the oscillating circuit; applying a third radio frequency signal to the third electrode rod using the oscillating circuit; and applying a fourth radio frequency signal to the fourth electrode rod using the oscillating circuit.

[0069] The frequencies and amplitudes of the first RF signal, the second RF signal, the third RF signal and the fourth RF signal are all the same.

[0070] In a traditional multipole collision cell, the multipole rods are parallel to each other and have the same shape. Therefore, in order to ensure the uniformity of the radio frequency electric field generated by each electrode rod, it is necessary to control the frequency and amplitude of the radio frequency signal applied to each electrode rod to be the same to ensure that ions can pass through the multipole collision cell smoothly.

[0071] In one embodiment, the phase shifting circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group, specifically including:

[0072] Using the phase shift circuit to control the first radio frequency signal so as not to cause phase shift;

[0073] The phase shift circuit is used to control the phase shift of the second radio frequency signal. ;

[0074] The phase shift circuit is used to control the phase shift of the third radio frequency signal. ;

[0075] The phase shift circuit is used to control the phase shift of the fourth radio frequency signal. .

[0076] In the present application, the phase difference between adjacent electrode rods in the electrode rod group is For example, the second RF signal differs from the first RF signal by , the third RF signal differs from the second RF signal by , and so on, when there are multiple electrode rod groups, the phase difference between the first RF signal in the second electrode rod group and the fourth RF signal in the first electrode rod group is still .

[0077] In one embodiment, applying a radio frequency signal to each of the electrode rods using the oscillating circuit specifically includes: the frequency range of the radio frequency signal is .

[0078] In one embodiment, applying a radio frequency signal to each of the electrode rods using the oscillation circuit also includes: the radio frequency signal is a sine wave, a square wave, or a composite wave, wherein the composite wave is obtained by combining a sine wave and a square wave.

[0079] In one embodiment, Figure 8 As shown, the multipole collision cell also includes: an amplifier circuit for amplifying the amplitude of the radio frequency signal; the oscillation circuit is electrically connected to the electrode rod group after passing through the phase shift circuit and the amplifier circuit in sequence; the multipole voltage control method also includes: adjusting the amplitude of the radio frequency signal using the amplifier circuit.

[0080] In the present application, since the phases on the electrode rod group are repeated, the electrode rods with the same phase of the radio frequency signal can be connected to the same amplifier circuit. By adjusting the amplitude of the radio frequency signal through the amplifier circuit, the strength and controllability of the electric field generated by the radio frequency signal are enhanced, which helps to more effectively manipulate ions.

[0081] In one embodiment, the multipole collision cell comprises: a first electrode rod group and a second electrode rod group;

[0082] The electrode rods in the first electrode rod group and the electrode rods in the second electrode rod group are parallel to each other and arranged in a circle;

[0083] The oscillation circuit is electrically connected to the two electrode rod groups respectively after passing through the phase shift circuit;

[0084] The multipole voltage control method further comprises:

[0085] The phase shift amplitudes of the radio frequency signals applied to the corresponding electrode rods in the first electrode rod group and the second electrode rod group are controlled to be equal.

[0086] In practical applications, by increasing the number of electrode rod groups, the mass range of the multipole collision cell can be further improved, the detection resolution of complex samples can be effectively improved, and the space charge effect (that is, the mutual influence between ions in the ion beam) can be reduced.

[0087] In one embodiment, Fig. 9 As shown, the amplifier circuit includes: a common-phase amplifier circuit and an inverting amplifier circuit; the phase shift circuit is electrically connected to the first electrode rod and the second electrode rod through the common-phase amplifier circuit; the phase shift circuit is electrically connected to the third electrode rod and the fourth electrode rod through the inverting amplifier circuit;

[0088] The method of using the phase shift circuit to adjust the phase of each electrode rod in each electrode rod group also includes: using the phase shift circuit to control the first radio frequency signal to not have a phase shift, and using the in-phase amplifier circuit to amplify the first radio frequency signal; using the phase shift circuit to control the phase shift of the second radio frequency signal , using the in-phase amplifier circuit to amplify the offset second RF signal; using the phase shift circuit to control the third RF signal to not have a phase shift, and using the inverting amplifier circuit to amplify the third RF signal; using the phase shift circuit to control the phase shift of the fourth RF signal , using the inverting amplifier circuit to amplify the offset fourth radio frequency signal.

[0089] In actual use, since the radio frequency signal of the present application is a sine wave signal or a rectangular wave signal, the connection ports of the phase shift circuit can be reduced by using a common-phase amplifier. If only the phase shift circuit is used to control the phase shift of the radio frequency signal, three phase shift circuits are required to adjust the phase of the radio frequency signal on the second electrode rod, the third electrode rod and the fourth electrode rod respectively; however, if a common-phase amplifier and an inverting amplifier are used, the number of phase shift circuits can be reduced. When the first radio frequency signal is not offset, there is no need to use a phase shift circuit, and the first radio frequency signal can be directly amplified using a common-phase amplifier circuit; when the third radio frequency signal needs to be offset by π phases, the original signal can be directly amplified using an inverting amplifier; similarly, when the second radio frequency signal needs to be adjusted, a phase shift circuit is used to adjust the phase of the second radio frequency signal to shift backward. , and amplify the shifted RF signal using a common-phase amplifier to retain the phase of the original signal; when the fourth RF signal needs to adjust the phase, the shifted second RF signal can be directly amplified by inversion to obtain the fourth RF signal.

[0090] By using the same-phase amplifier circuit and the inverting amplifier circuit, the design cost of the circuit can be reduced, and the defects of the traditional equipment that the number of phase shift circuits is insufficient and the phase shift cannot be provided in sufficient levels can be avoided. Compared with the use of the phase shift circuit, the circuit design using the same-phase and inverting amplifier circuits is relatively simple, easy to implement and maintain; due to the simplicity of the circuit, the inverting amplifier is usually low in cost. The inverting amplifier can be easily integrated into the existing circuit design without the need for complex circuit modification, which helps to miniaturize the equipment and products; Gain and phase control: The inverting amplifier can not only adjust the phase of the signal, but also provide gain control. After using the phase shift circuit, the same-phase amplifier is also needed to amplify the amplitude of the electrical signal. Therefore, for the circuit that needs to adjust the signal amplitude and phase at the same time, the number of circuit components can be reduced.

[0091] In one embodiment, in order to ensure that the ion transmission efficiency and focusing effect are maximized, the shape and size of the electrode rods can be limited. The electrode rods in the electrode rod group are all cylindrical. The cylindrical electrode rods can generate a more uniform spatial electric field. The diameter of the electrode rod is ; The length of the electrode rod is .

[0092] In one embodiment, the multipole collision cell further comprises: a VGA amplitude modulation circuit; the phase shift circuit is connected to an amplifier after passing through the VGA amplitude modulation circuit, and the VGA amplitude modulation circuit is used to convert a digital control signal into an analog signal.

[0093] In one embodiment, the multipole collision cell further includes: a feedback circuit; the feedback circuit is used to detect the phase of the radio frequency signal on each electrode rod, and provide feedback control to the phase shift circuit according to the phase of the radio frequency signal on the electrode rod, and the input end of the feedback circuit is connected to the amplifier; the output end of the feedback circuit is connected to the VGA amplitude modulation circuit.

[0094] Embodiment 2

[0095] See also Figure 2 , a multipole mass spectrometer voltage control device, the multipole voltage control device comprising:

[0096] A radio frequency signal generating unit 1; the radio frequency signal generating unit 1 is used to apply a radio frequency signal to each of the electrode rods using the oscillation circuit;

[0097] The RF signal phase shift unit 2 is used to adjust the phase of the RF signal on each electrode rod in each electrode rod group by using the phase shift circuit; wherein the phase difference between any two adjacent electrode rods is equal, and the phase difference between the corresponding two electrode rods in the two electrode rod groups distributed along the circumference is ; The phases of any two opposite electrode rods are the same or different .

[0098] For the specific definition of the voltage control device of the multipole mass spectrometer, please refer to the definition of the multipole voltage control method in the above text, which will not be repeated here. Each module in the above multipole voltage control device can be implemented in whole or in part by software, hardware and a combination thereof. The above modules can be embedded in or independent of the processor in the computer device in the form of hardware, or can be stored in the memory of the computer device in the form of software, so that the processor can call and execute the operations corresponding to the above modules.

[0099] Those skilled in the art will understand that Figure 2The structure shown in the figure is merely a block diagram of a portion of the structure related to the scheme of the present application, and does not constitute a limitation on the scheme of the present application. The specific multipole mass spectrometer voltage control device may include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0100] Embodiment 3

[0101] A computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the multipole voltage control method as described in Example 1 is implemented.

[0102] Embodiment 4

[0103] In one embodiment, a computer device is provided. The computer device may be a server, and its internal structure diagram may be as follows: Figure 3 As shown. The computer device includes a processor, a memory, a network interface and a database connected through a system bus. Among them, the processor of the computer device is used to provide computing and control capabilities. The memory of the computer device includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system, a computer program and a database. The internal memory provides an environment for the operation of the operating system and the computer program in the non-volatile storage medium. When the computer program is executed by the processor, a voltage control method for a multipole mass spectrometer device is implemented.

[0104] Those skilled in the art will understand that Figure 3 The structure shown in the figure is only a block diagram of a part of the structure related to the solution of the present application, and does not constitute a limitation on the computer device to which the solution of the present application is applied. The specific computer device may include more or fewer components than those shown in the figure, or combine certain components, or have a different arrangement of components.

[0105] In one embodiment, a computer device is provided, including a memory and a processor, wherein a computer program is stored in the memory, and when the processor executes the computer program, the following steps are implemented:

[0106] Using the oscillation circuit to apply a radio frequency signal to each of the electrode rods;

[0107] The phase shift circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group; wherein the phase difference between any two adjacent electrode rods is equal, and the phase difference between the corresponding two electrode rods in the two electrode rod groups distributed along the circumference is ; The phases of any two opposite electrode rods are the same or different .

[0108] In one embodiment, the electrode rod group includes a first electrode rod, a second electrode rod, a third electrode rod and a fourth electrode rod;

[0109] The step of applying a radio frequency signal to each of the electrode rods using the oscillation circuit specifically includes:

[0110] Applying a first radio frequency signal to the first electrode rod using the oscillation circuit;

[0111] applying a second radio frequency signal to the second electrode rod using the oscillation circuit;

[0112] applying a third radio frequency signal to the third electrode rod using the oscillation circuit;

[0113] applying a fourth radio frequency signal to the fourth electrode rod using the oscillation circuit;

[0114] The frequencies and amplitudes of the first RF signal, the second RF signal, the third RF signal and the fourth RF signal are all the same.

[0115] In one embodiment, the phase shifting circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group, specifically including:

[0116] Using the phase shift circuit to control the first radio frequency signal so as not to cause phase shift;

[0117] The phase shift circuit is used to control the phase shift of the second radio frequency signal. ;

[0118] The phase shift circuit is used to control the phase shift of the third radio frequency signal. ;

[0119] The phase shift circuit is used to control the phase shift of the fourth radio frequency signal. .

[0120] In one embodiment, applying a radio frequency signal to each of the electrode rods using the oscillating circuit specifically includes:

[0121] The frequency range of the radio frequency signal is .

[0122] In one embodiment, applying a radio frequency signal to each of the electrode rods using the oscillating circuit further comprises:

[0123] The radio frequency signal is a sine wave, a square wave or a composite wave, wherein the composite wave is obtained by combining a sine wave and a square wave.

[0124] In one embodiment, the multipole collision cell further comprises: an amplifier circuit for amplifying the amplitude of the radio frequency signal; the oscillation circuit is electrically connected to the electrode rod group after passing through the phase shift circuit and the amplifier circuit in sequence;

[0125] The multipole voltage control method further comprises:

[0126] The amplitude of the radio frequency signal is adjusted using the amplifier circuit.

[0127] In one embodiment, the multipole collision cell comprises: a first electrode rod group and a second electrode rod group;

[0128] The electrode rods in the first electrode rod group and the electrode rods in the second electrode rod group are parallel to each other and arranged in a circle;

[0129] The oscillation circuit is electrically connected to the two electrode rod groups respectively after passing through the phase shift circuit;

[0130] The multipole voltage control method further comprises:

[0131] The phase shift amplitudes of the radio frequency signals applied to the corresponding electrode rods in the first electrode rod group and the second electrode rod group are controlled to be equal.

[0132] In one embodiment, the amplifier circuit includes: a common-phase amplifier circuit and an inverting amplifier circuit;

[0133] The phase shift circuit is electrically connected to the first electrode rod and the second electrode rod through the in-phase amplifier circuit; the phase shift circuit is electrically connected to the third electrode rod and the fourth electrode rod through the inverting amplifier circuit;

[0134] The method of adjusting the phase of each electrode rod in each electrode rod group by using the phase shift circuit also includes:

[0135] Using the phase shift circuit to control the first radio frequency signal to prevent phase shift, and using the in-phase amplifier circuit to amplify the first radio frequency signal;

[0136] The phase shift circuit is used to control the phase shift of the second radio frequency signal. , using the in-phase amplifier circuit to amplify the shifted second radio frequency signal;

[0137] Using the phase shift circuit to control the third radio frequency signal so as not to cause phase shift, and using the inverting amplifier circuit to amplify the third radio frequency signal;

[0138] The phase shift circuit is used to control the phase shift of the fourth radio frequency signal. , using the inverting amplifier circuit to amplify the offset fourth radio frequency signal.

[0139] In one embodiment, the electrode rods in the electrode rod group are all cylindrical, and the diameter of the electrode rods is ; The length of the electrode rod is .

[0140] Embodiment 5

[0141] Furthermore, the present application also provides a simulation experiment, in which two sets of electrode rods are used, that is, a multipole collision cell with eight electrode rods, different radio frequency signals are applied to the electrode rods, and the flight trajectories of the ions therein are recorded. In this embodiment, the simulated ion mass is The initial kinetic energy is ; The initial position is The radius of the axial ring is ; The effective field radius is and the length of the electrode rod is ;

[0142] Among them, Figure 4 , Figure 5 As shown in , the RF signal applied to the electrode rods is specifically: the phase difference of the RF signal between every two electrode rods is , the amplitude of the RF signal on the electrode rod is: ; The frequency of the RF signal is .

[0143] Among them, Figure 6 , Figure 7 As shown in , the radio frequency signal applied to the electrode rods is the radio frequency signal described in Example 1, wherein the radio frequency signal phase difference between every two electrode rods is , the amplitude of the RF signal on the electrode rod is: ; The frequency of the RF signal is .

[0144] Figure 4 , Figure 6 This is a cross-sectional view of a multipole collision cell. The eight circles arranged in a ring are the cross-sections of the eight electrode rods. The light-colored lines are schematic diagrams of the equipotential lines of the electric field generated by the electrode rods; the dark-colored lines in the middle are the flight trajectories of the ions. Figure 5 , Figure 7 is the flight trajectory of the ions along the axial direction.

[0145] By analyzing the flight trajectory of ions, we can know that Figure 6After the ions in the sample pass through the multipole collision cell, the discrete radius is smaller and the focusing effect is better. By analyzing the number of ions, it can be seen that the ion passing rate is close to 100%. In the comparative example, the probability of the multipole collision cell transmitting ions is only about half, and the focusing effect of the ions after passing through the multipole is not obvious. Figure 7 It can be seen from the figure that the ions in the embodiment have a more obvious oscillation effect in the multipole collision cell and a longer flight path, and the ions can fully collide with the gas molecules during the flight.

[0146] Those skilled in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above-mentioned methods. Among them, any reference to memory, storage, database or other media used in the embodiments provided in this application may include non-volatile and / or volatile memory. Non-volatile memory may include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM) or flash memory. Volatile memory may include random access memory (RAM) or external cache memory. As an illustration and not limitation, RAM is available in many forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM).

[0147] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0148] The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims

1. A method for controlling voltage of a multipole mass spectrometer, characterized in that: Applied to a multipole collision cell, the multipole collision cell comprises: two groups of electrode rods, an oscillation circuit and a phase shift circuit; the electrode rod group comprises a plurality of electrode rods; the oscillation circuit is electrically connected to each of the electrode rods through the phase shift circuit; the plurality of electrode rods are parallel to each other and evenly distributed in a circle; The multipole mass spectrometer voltage control method comprises: Using the oscillation circuit to apply a radio frequency signal to each of the electrode rods; The phase shift circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group; wherein the phase difference between any two adjacent electrode rods is equal, and the phase difference between the corresponding two electrode rods in the two electrode rod groups distributed along the circumference is ; The phases of any two opposite electrode rods are the same or different ; The multipole collision cell comprises: a first electrode rod group and a second electrode rod group; the electrode rods in the first electrode rod group and the electrode rods in the second electrode rod group are parallel to each other and arranged in a circle; the oscillation circuit is electrically connected to the two electrode rod groups respectively through the phase shift circuit; the multipole voltage control method further comprises: controlling the phase shift amplitudes of the radio frequency signals applied to the corresponding electrode rods in the first electrode rod group and the second electrode rod group to be equal; The electrode rod group comprises a first electrode rod, a second electrode rod, a third electrode rod and a fourth electrode rod; the use of the oscillating circuit to apply a radio frequency signal to each of the electrode rods respectively comprises: using the oscillating circuit to apply a first radio frequency signal to the first electrode rod; using the oscillating circuit to apply a second radio frequency signal to the second electrode rod; using the oscillating circuit to apply a third radio frequency signal to the third electrode rod; using the oscillating circuit to apply a fourth radio frequency signal to the fourth electrode rod; wherein the frequencies and amplitudes of the first radio frequency signal, the second radio frequency signal, the third radio frequency signal and the fourth radio frequency signal are the same; The phase shift circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group, specifically comprising: using the phase shift circuit to control the first radio frequency signal to not have a phase shift; using the phase shift circuit to control the phase shift of the second radio frequency signal ; Using the phase shift circuit to control the phase shift of the third radio frequency signal ; Using the phase shift circuit to control the phase shift of the fourth radio frequency signal ; The multipole collision cell also includes: an amplifier circuit for amplifying the amplitude of the radio frequency signal; the oscillation circuit is electrically connected to the electrode rod group after passing through the phase shift circuit and the amplifier circuit in sequence; the multipole voltage control method also includes: using the amplifier circuit to adjust the amplitude of the radio frequency signal; the amplifier circuit includes: a common-phase amplifier circuit and an inverting amplifier circuit; the phase shift circuit is electrically connected to the first electrode rod and the second electrode rod after passing through the common-phase amplifier circuit; the phase shift circuit is electrically connected to the third electrode rod and the fourth electrode rod after passing through the inverting amplifier circuit; the phase of each electrode rod in each group of electrode rods is adjusted by using the phase shift circuit, and also includes: using the phase shift circuit to control the first radio frequency signal not to have a phase shift, and using the common-phase amplifier circuit to amplify the first radio frequency signal; using the phase shift circuit to control the phase shift of the second radio frequency signal , using the in-phase amplifier circuit to amplify the offset second RF signal; using the phase shift circuit to control the third RF signal to not have a phase shift, and using the inverting amplifier circuit to amplify the third RF signal; using the phase shift circuit to control the phase shift of the fourth RF signal , using the inverting amplifier circuit to amplify the offset fourth radio frequency signal.

2. A method for controlling voltage of a multipole mass spectrometer according to claim 1, characterized in that: The step of applying a radio frequency signal to each of the electrode rods using the oscillation circuit specifically includes: The frequency range of the radio frequency signal is .

3. A method for controlling voltage of a multipole mass spectrometer according to claim 2, characterized in that: The step of applying a radio frequency signal to each of the electrode rods using the oscillation circuit also includes: The radio frequency signal is a sine wave or a square wave.

4. A multipole voltage control device, applied to a multipole collision cell, characterized in that: include: A radio frequency signal generating unit; the radio frequency signal generating unit is used to apply a radio frequency signal to each electrode rod using an oscillation circuit; A radio frequency signal phase shift unit; the radio frequency signal phase shift unit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group by using a phase shift circuit; wherein the phase difference between any two adjacent electrode rods is equal, and the phase difference between the corresponding two electrode rods in any two adjacent electrode rod groups is ; The phases of any two opposite electrode rods are the same or different ; The multipole collision cell comprises: a first electrode rod group and a second electrode rod group; the electrode rods in the first electrode rod group and the electrode rods in the second electrode rod group are parallel to each other and arranged in a circle; the oscillation circuit is electrically connected to the two electrode rod groups respectively through the phase shift circuit; the phase shift amplitudes of the radio frequency signals applied to the corresponding electrode rods in the first electrode rod group and the second electrode rod group are controlled to be equal; The electrode rod group comprises a first electrode rod, a second electrode rod, a third electrode rod and a fourth electrode rod; the use of the oscillating circuit to apply a radio frequency signal to each of the electrode rods respectively comprises: using the oscillating circuit to apply a first radio frequency signal to the first electrode rod; using the oscillating circuit to apply a second radio frequency signal to the second electrode rod; using the oscillating circuit to apply a third radio frequency signal to the third electrode rod; using the oscillating circuit to apply a fourth radio frequency signal to the fourth electrode rod; wherein the frequencies and amplitudes of the first radio frequency signal, the second radio frequency signal, the third radio frequency signal and the fourth radio frequency signal are the same; The phase shift circuit is used to adjust the phase of the radio frequency signal on each electrode rod in each electrode rod group, specifically comprising: using the phase shift circuit to control the first radio frequency signal to not have a phase shift; using the phase shift circuit to control the phase shift of the second radio frequency signal ; Using the phase shift circuit to control the phase shift of the third radio frequency signal ; Using the phase shift circuit to control the phase shift of the fourth radio frequency signal ; The multipole collision cell also includes: an amplifier circuit for amplifying the amplitude of the radio frequency signal; the oscillation circuit is electrically connected to the electrode rod group after passing through the phase shift circuit and the amplifier circuit in sequence; the multipole voltage control method also includes: using the amplifier circuit to adjust the amplitude of the radio frequency signal; the amplifier circuit includes: a common-phase amplifier circuit and an inverting amplifier circuit; the phase shift circuit is electrically connected to the first electrode rod and the second electrode rod after passing through the common-phase amplifier circuit; the phase shift circuit is electrically connected to the third electrode rod and the fourth electrode rod after passing through the inverting amplifier circuit; the phase of each electrode rod in each group of electrode rods is adjusted by using the phase shift circuit, and also includes: using the phase shift circuit to control the first radio frequency signal not to have a phase shift, and using the common-phase amplifier circuit to amplify the first radio frequency signal; using the phase shift circuit to control the phase shift of the second radio frequency signal , using the in-phase amplifier circuit to amplify the offset second RF signal; using the phase shift circuit to control the third RF signal to not have a phase shift, and using the inverting amplifier circuit to amplify the third RF signal; using the phase shift circuit to control the phase shift of the fourth RF signal , using the inverting amplifier circuit to amplify the offset fourth radio frequency signal.

5. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, a voltage control method for a multipole mass spectrometer device as claimed in any one of claims 1 to 3 is implemented.

6. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that: When the processor executes the computer program, the method for controlling voltage of a multipole mass spectrometer device as claimed in any one of claims 1 to 3 is implemented.

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