Composition for promoting vascular circulation and enhancing breast tissue development, preparation method and use thereof

Abstract

The present invention discloses a composition for promoting blood vessel circulation and enhancing breast tissue development, and its preparation method and use, which belongs to the technical field of composition. The composition comprises the following raw materials: papaya powder, black bean powder, ginseng powder, carob extract, kudzu root powder and royal jelly powder; the weight ratio of carob extract, kudzu root powder and royal jelly powder is 2-8:7-13:7-13. The preparation method comprises breaking and crushing papaya powder, black bean powder, ginseng powder, kudzu root powder and royal jelly powder, and mixing with carob extract; or breaking and crushing papaya powder, black bean powder, ginseng powder, kudzu root powder, royal jelly powder, grape seed extract and mulberry powder, and mixing with carob extract, collagen peptide, wheat germ and thymus protein peptide. The present invention starts with the root cause of breast flatness and sagging, and reasonably proportions, and makes breast enhancement and breast beauty effects faster and more comprehensive by deep repair, activation and nourishment of ovarian and breast tissue cells.

Description

Technical Field

[0001] The present invention relates to the technical field of compositions, and in particular to a composition for promoting blood vessel circulation and enhancing breast tissue development, and a preparation method and application thereof. Background Art

[0002] Breasts are a female's secondary sexual characteristics and one of the unique signs of female beauty. Most women want to have full, well-proportioned, soft and elastic breasts. However, a variety of factors, such as nutrient deficiency or imbalanced nutrient ratios, improper bra wearing, lack of exercise, endocrine disorders, etc., can cause the breast skin to become loose, fat to decrease, connective tissue tension to become unbalanced, mammary glands to stop developing or atrophy, and eventually lead to flat and sagging breasts.

[0003] Breast augmentation can help achieve or maintain the desired breast size through internal and external treatments. In recent years, various breast augmentation methods have been used, such as surgery, drugs, physical therapy, etc. However, due to reasons such as surgical failure, adverse drug reactions, and uncertain efficacy, people are reluctant to do so. Therefore, how to choose a safe and effective breast augmentation method has become the focus of the problem.

[0004] CN113679042A discloses a composition with breast enhancement function, including kudzu root, ginseng, angelica, pomegranate peel, cordyceps, oyster and kaempferia galanga. The components of the composition have synergistic effects, have obvious breast enhancement effect, and have no toxic side effects.

[0005] CN109170845A discloses a breast enlargement composition and a preparation method thereof. The breast enlargement composition is prepared from the following raw materials in parts by weight: 30-50 parts of green papaya, 15-30 parts of ginseng, 30-50 parts of kudzu root, 20-35 parts of potato, and 10-30 parts of winter sophora. The invention selects raw materials with specific proportions for compounding. Among them, the flavonoids and phytosterols contained in green papaya and kudzu root can stimulate glands and endocrine, make the pituitary gland release hormones, act on the ovaries, feedback activate breast cells, and promote breast development. Ginseng including ginseng, red ginseng, and Korean ginseng regulates the body's qi and blood, draws blood to the chest, and makes the chest qi and blood more abundant. Potatoes provide effective nutrients and ingredients for breast growth. The above substances produce synergistic effects to achieve the effect of breast enlargement.

[0006] In summary, the above-mentioned breast enhancement compositions use food or traditional Chinese medicine as raw materials and have good safety, but they still have problems such as high cost and slow effect. How to develop more competitive breast enhancement products is still the focus of current research and development. Summary of the invention

[0007] In order to solve the above technical problems, the present invention provides a composition for promoting vascular circulation and enhancing breast tissue development, and a preparation method and use thereof.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions:

[0009] In a first aspect, the present invention provides a composition for promoting blood vessel circulation and enhancing breast tissue development, comprising the following raw materials: papaya powder, black bean powder, ginseng powder, carob extract, kudzu root powder and royal jelly powder.

[0010] Wherein, the weight ratio of the carob extract, kudzu root powder and royal jelly powder is 2-8:7-13:7-13; preferably 4-6:9-11:9-11; more preferably 4-6:9-10:10-11; more preferably 5:10:10.

[0011] In some embodiments, the composition comprises the following raw materials by weight: 8-12 parts of papaya powder, 12-18 parts of black bean powder, 0.5-1.5 parts of ginseng powder, 0.2-0.8 parts of carob extract, 0.7-1.3 parts of kudzu root powder and 0.7-1.3 parts of royal jelly powder;

[0012] Preferably, 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.2-0.8 parts of carob extract, 0.7-1.3 parts of kudzu root powder and 0.7-1.3 parts of royal jelly powder;

[0013] More preferably, 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.4-0.6 parts of carob extract, 0.9-1.1 parts of kudzu root powder and 0.9-1.1 parts of royal jelly powder;

[0014] More preferably, 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.4-0.6 parts of carob extract, 0.9-1 parts of kudzu root powder and 1-1.1 parts of royal jelly powder;

[0015] Further preferably, 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.5 parts of carob extract, 1 part of kudzu root powder and 1 part of royal jelly powder.

[0016] In some embodiments, the composition further comprises at least one of grape seed extract, mulberry powder, collagen peptide, wheat germ, and thymus peptide.

[0017] In some embodiments, the amount of grape seed extract in the composition is 0.1-0.8 parts by weight. For example, the amount of grape seed extract can be selected from any value among 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8 or a range between any two values.

[0018] In some embodiments, the amount of mulberry powder in the composition is 1.5-3.0 parts by weight. For example, the amount of mulberry can be selected from any value among 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, or a range between any two values.

[0019] In some embodiments, the amount of collagen peptide in the composition is 0.5-1.5 parts by weight. For example, the amount of collagen peptide can be selected from any point value among 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, or a range value between any two points.

[0020] In some embodiments, the amount of wheat germ in the composition is 0.5-1.5 parts by weight. For example, the amount of wheat germ can be selected from any point value among 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, or a range value between any two points.

[0021] In some embodiments, the amount of thymoprotein peptide in the composition is 0.5-1.5 parts by weight. For example, the amount of thymoprotein peptide can be selected from any point value among 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5 or the range value between any two points.

[0022] In some embodiments, the composition comprises, by weight, 8-12 parts of papaya powder, 12-18 parts of black bean powder, 0.5-1.5 parts of ginseng powder, 0.2-0.8 parts of carob extract, 0.7-1.3 parts of kudzu root powder, 0.7-1.3 parts of royal jelly powder, 0.1-0.8 parts of grape seed extract, 1.5-3.0 parts of mulberry powder, 0.5-1.5 parts of collagen peptide, 0.5-1.5 parts of wheat germ and 0.5-1.5 parts of thymus protein peptide.

[0023] In some embodiments, the composition comprises the following raw materials, by weight: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.2-0.8 parts of carob extract, 0.7-1.3 parts of kudzu root powder, 0.7-1.3 parts of royal jelly powder, 0.1-0.8 parts of grape seed extract, 1.5-3.0 parts of mulberry powder, 0.5-1.5 parts of collagen peptide, 0.5-1.5 parts of wheat germ and 0.5-1.5 parts of thymus protein peptide.

[0024] In some embodiments, the composition comprises the following raw materials, by weight: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.4-0.6 parts of carob extract, 0.9-1.1 parts of kudzu root powder, 0.9-1.1 parts of royal jelly powder, 0.1-0.8 parts of grape seed extract, 1.5-3.0 parts of mulberry powder, 0.5-1.5 parts of collagen peptide, 0.5-1.5 parts of wheat germ and 0.5-1.5 parts of thymus protein peptide.

[0025] In some embodiments, the composition comprises, by weight, 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.5 parts of carob extract, 1 part of kudzu root powder, 1 part of royal jelly powder, 0.1-0.8 parts of grape seed extract, 1.5-3.0 parts of mulberry powder, 0.5-1.5 parts of collagen peptide, 0.5-1.5 parts of wheat germ and 0.5-1.5 parts of thymus protein peptide.

[0026] In a second aspect, the present invention provides a method for preparing the above-mentioned composition, comprising the following steps: breaking and crushing papaya powder, black bean powder, ginseng powder, kudzu root powder and royal jelly powder, and mixing them with carob extract.

[0027] In some embodiments, the preparation method further comprises the following step: crushing the grape seed extract, kudzu root powder and mulberry powder, and mixing them with collagen peptide, wheat germ and thymus protein peptide.

[0028] In some embodiments, the preparation method further comprises the following steps: breaking and crushing papaya powder, black bean powder, ginseng powder, kudzu root powder, royal jelly powder, grape seed extract and mulberry powder, and mixing them with carob extract, collagen peptide, wheat germ and thymus protein peptide.

[0029] In a third aspect, the present invention provides use of the composition in preparing breast enhancement products.

[0030] In a fourth aspect, the present invention provides a breast enhancement product comprising the above composition.

[0031] In some specific embodiments, the breast enhancement product further comprises a medically acceptable auxiliary material.

[0032] In some specific embodiments, the breast enhancement product of the present invention is in the form of granules, powder or blocks.

[0033] The beneficial effects of the present invention are:

[0034] (1) The present invention utilizes carob extract, kudzu root powder and royal jelly powder in a specific ratio for compounding. Carob is rich in chiro-inositol, which has special physiological functions such as regulating hormone balance, regulating menstrual disorders, and anti-oxidation, anti-aging, and anti-inflammatory. Royal jelly has the function of regulating endocrine system and promoting breast development. Kudzu root can promote blood circulation and provide effective nutrients and ingredients for breast growth. The combination of the three can achieve a faster breast enhancement and breast beauty effect.

[0035] (2) The present invention starts from the root cause of flat and sagging breasts, comprehensively strengthens and supplements multiple nutrients and breast enhancement and beauty factors, and rationally proportions them. By deeply repairing, activating and nourishing ovarian and breast tissue cells, the breast enhancement and beauty effects are faster and more comprehensive. DETAILED DESCRIPTION

[0036] The following examples are only used to help understand the method of the present invention and its core idea. It should be noted that for those of ordinary skill in the art, without departing from the principles of the present invention, the present invention may also be subjected to several improvements and modifications, which also fall within the scope of protection of the claims of the present invention. The following description of the disclosed embodiments enables professionals and technicians in this field to implement or use the present invention. It will be apparent to professionals and technicians in this field that various modifications to these embodiments, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to these embodiments shown herein, but may be applied to a wider range consistent with the principles and novel features disclosed herein. Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those generally understood by those of ordinary skill in the art to which the present invention belongs.

[0037] Hereinafter, examples and comparative examples of the present invention will be shown to explain the composition of the present invention in more detail, but the present invention is not limited thereto.

[0038] The present invention does not limit the sources of the raw materials used. Unless otherwise specified, the raw materials used in the present invention are common commercial products in the technical field.

[0039] The purchase information of raw materials is shown in Table 1.

[0040] Table 1

[0041]

[0042] Example 1 Composition for promoting vascular circulation and enhancing breast tissue development

[0043] The raw materials are as follows: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.5 parts of carob extract, 1 part of kudzu root powder and 1 part of royal jelly powder.

[0044] The preparation method is as follows: papaya powder, black bean powder, ginseng powder, kudzu root powder and royal jelly powder are crushed, passed through 500 meshes, and mixed with carob extract.

[0045] Example 2 Composition for promoting vascular circulation and enhancing breast tissue development

[0046] The raw materials are as follows: 8 parts of papaya powder, 18 parts of black bean powder, 0.5 parts of ginseng powder, 0.2 parts of carob extract, 1.3 parts of kudzu root powder and 0.7 parts of royal jelly powder.

[0047] The preparation method is the same as Example 1.

[0048] Example 3 Composition for promoting vascular circulation and enhancing breast tissue development

[0049] The raw materials are as follows: 12 parts of papaya powder, 12 parts of black bean powder, 1.5 parts of ginseng powder, 0.8 parts of carob extract, 0.7 parts of kudzu root powder and 1.3 parts of royal jelly powder.

[0050] The preparation method is the same as Example 1.

[0051] Example 4 Composition for promoting vascular circulation and enhancing breast tissue development

[0052] The raw materials are as follows: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.5 parts of carob extract, 1 part of kudzu root powder, 1 part of royal jelly powder, 0.1 parts of grape seed extract, 3.0 parts of mulberry powder, 0.5 parts of collagen peptide, 0.5 parts of wheat germ and 1.5 parts of thymus protein peptide.

[0053] The preparation method is as follows: papaya powder, black bean powder, ginseng powder, kudzu root powder, royal jelly powder, grape seed extract and mulberry powder are crushed and pulverized, passed through 500 meshes, and mixed with carob extract, collagen peptide, wheat germ and thymus protein peptide.

[0054] Example 5 Composition for promoting vascular circulation and enhancing breast tissue development

[0055] The raw materials are as follows: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.5 parts of carob extract, 1 part of kudzu root powder, 1 part of royal jelly powder, 0.8 parts of grape seed extract, 1.5 parts of mulberry powder, 1.5 parts of collagen peptide, 1.5 parts of wheat germ and 0.5 parts of thymus protein peptide.

[0056] The preparation method is the same as Example 4.

[0057] Comparative Example 1 Composition for promoting vascular circulation and enhancing breast tissue development

[0058] The only difference between this comparative example and Example 1 is that the carob extract is replaced with kudzu root powder.

[0059] The raw materials are as follows: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 1.5 parts of kudzu root powder and 1 part of royal jelly powder.

[0060] The preparation method is as follows: papaya powder, black bean powder, ginseng powder, kudzu root powder and royal jelly powder are crushed, passed through 500 meshes and mixed.

[0061] Comparative Example 2 Composition for promoting vascular circulation and enhancing breast tissue development

[0062] The difference between this comparative example and Example 1 is that the weight ratios of the carob extract, kudzu root powder and royal jelly powder are different.

[0063] The raw materials are as follows: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.9 parts of carob extract, 1.5 parts of kudzu root powder and 0.1 parts of royal jelly powder.

[0064] The preparation method is as follows: papaya powder, black bean powder, ginseng powder, kudzu root powder and royal jelly powder are crushed, passed through 500 meshes, and mixed with carob extract.

[0065] The technical effects achieved by the present invention are described in detail below in conjunction with specific embodiments.

[0066] Test Example 1: Verification of the effect of the composition on promoting vascular circulation and enhancing breast tissue development

[0067] 1. Experimental Animals

[0068] SD rats, female, 28 days old, were purchased from Zhejiang Weitonglihua Experimental Animal Technology Co., Ltd.

[0069] 2. Test methods

[0070] SD rats were randomly divided into 8 groups according to body weight, including a normal group, Example 1, 2, 3, 4, 5, and Comparative Example 1 and 2, with 8 rats in each group. After 3 days of adaptive feeding, each group except the normal group was intragastrically gavaged with the composition prepared in the corresponding Example or Comparative Example at a daily gavage dose of 40 mg / kg, and the normal group was gavaged with an equal volume of physiological saline for 2 consecutive weeks.

[0071] After the last administration, the mice were fasted but not watered for 12 h, anesthetized with intraperitoneal injection of 10% chloral hydrate, blood was collected from the abdominal aorta, and centrifuged at 3000 rpm for 10 min. The upper serum was collected and the estradiol and progesterone levels in the serum were detected using Elisa kits (purchased from Nanjing Jiancheng Bioengineering Research Institute Co., Ltd.).

[0072] The results are shown in Table 2.

[0073] Table 2

[0074]

[0075] Note: In the same column, different letters indicate that the data between the groups have significant differences (P < 0.05), and the same letters indicate that the data between the groups have no significant differences (P > 0.05).

[0076] The development of the mammary gland is mainly regulated by estrogen and progesterone. Estradiol can stimulate mammary gland growth and significantly increase the number of progesterone receptors in mammary gland cells. Estradiol and progesterone work synergistically to promote the development of mammary alveoli. To a certain extent, the levels of estradiol and progesterone can reflect the level of mammary gland development.

[0077] The results showed that compared with the normal group, the levels of estradiol and progesterone in the serum of SD rats in Examples 1-5 were significantly increased (P<0.05), indicating that the composition prepared in the examples of the present invention has the effect of promoting mammary gland development.

[0078] Compared with the normal group, the levels of estradiol and progesterone in the serum of SD rats in the comparative example 1-2 group showed an increasing trend, but there was no significant difference (P>0.05), indicating that the composition prepared in the comparative example of the present invention does not have the effect of promoting mammary gland development.

[0079] Test Example 2: Breast Enlargement Effect Verification

[0080] Volunteers aged 20-30 years with a breast axis (the distance from the breast base to the nipple) less than 5 cm and a chest circumference less than 1 / 3 of the hip circumference were selected. They had not undergone any breast augmentation treatment within three months.

[0081] The volunteers were randomly divided into 2 groups, with 20 people in each group. The drug-treated group orally took the composition prepared in Example 1, and the control group orally took the composition prepared in Comparative Example 2, once a day, with a dosage of 6.4 mg / kg, for 2 months. After the experiment, the chest circumference was measured.

[0082] The results are shown in Table 3.

[0083] The criteria for judging efficacy are:

[0084] Significant effect: breast volume increased by more than 30%;

[0085] Effective: Breast volume increased by 25-30%;

[0086] Improvement: Breast volume increased by 10-25%;

[0087] Ineffective: No change in breast volume.

[0088] Effective rate: (number of effective patients + number of effective patients + number of patients with improvement)*100 / total number of patients.

[0089] Table 3

[0090]

[0091] The results showed that the effective rate of the drug-treated group was significantly higher than that of the control group, indicating that the composition provided in the embodiment of the present invention can significantly promote the growth of breast tissue and has the effect of breast enhancement.

[0092] Compared with the control group, it can be seen that when the dosage of carob extract, kudzu root powder and royal jelly powder in the composition is changed, the breast enhancement effect of the prepared composition is significantly deteriorated, indicating that the carob extract, kudzu root powder and royal jelly powder with a specific dosage relationship in the technical scheme claimed to be protected by the present invention cooperate with each other to significantly promote the growth of breast tissue and make the breast enhancement and breast beauty effect more significant.

[0093] The above is a further description of the present invention in conjunction with specific embodiments, but these embodiments are merely exemplary and do not constitute any limitation on the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solution of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the scope of protection of the present invention.

Claims

1. A composition for enhancing breast tissue development, characterized in that: The invention is composed of the following raw materials by weight: 8-12 parts of papaya powder, 12-18 parts of black bean powder, 0.5-1.5 parts of ginseng powder, 0.2-0.8 parts of carob extract, 0.7-1.3 parts of kudzu root powder and 0.7-1.3 parts of royal jelly powder.

2. The composition according to claim 1, characterized in that The invention is composed of the following raw materials by weight: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.2-0.8 parts of carob extract, 0.7-1.3 parts of kudzu root powder and 0.7-1.3 parts of royal jelly powder.

3. A composition for enhancing breast tissue development, characterized in that: The invention is composed of the following raw materials by weight: 8-12 parts of papaya powder, 12-18 parts of black bean powder, 0.5-1.5 parts of ginseng powder, 0.2-0.8 parts of carob extract, 0.7-1.3 parts of kudzu root powder, 0.7-1.3 parts of royal jelly powder, 0.1-0.8 parts of grape seed extract, 1.5-3.0 parts of mulberry powder, 0.5-1.5 parts of collagen peptide, 0.5-1.5 parts of wheat germ and 0.5-1.5 parts of thymus protein peptide.

4. The composition according to claim 3, characterized in that The invention is composed of the following raw materials by weight: 10 parts of papaya powder, 15 parts of black bean powder, 1 part of ginseng powder, 0.2-0.8 parts of carob extract, 0.7-1.3 parts of kudzu root powder, 0.7-1.3 parts of royal jelly powder, 0.1-0.8 parts of grape seed extract, 1.5-3.0 parts of mulberry powder, 0.5-1.5 parts of collagen peptide, 0.5-1.5 parts of wheat germ and 0.5-1.5 parts of thymus protein peptide.

5. The method for preparing the composition according to any one of claims 1 to 4, characterized in that: The method comprises the following steps: breaking papaya powder, black bean powder, ginseng powder, kudzu root powder and royal jelly powder into powder, and mixing them with carob extract; Or papaya powder, black bean powder, ginseng powder, kudzu root powder, royal jelly powder, grape seed extract and mulberry powder are broken into powder and mixed with carob extract, collagen peptide, wheat germ and thymus protein peptide.

6. Use of the composition according to any one of claims 1 to 4 or the composition prepared by the preparation method according to claim 5 in preparing breast enhancement products.

7. A breast enhancement product, characterized in that: A composition comprising the composition according to any one of claims 1 to 4 or a composition prepared by the preparation method according to claim 5.

8. The breast enhancement product according to claim 7, characterized in that: The breast enlargement product is in the form of granules, powder or blocks.

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